Development and ex vivo / in vitro evaluation of sodium alginate/ hydroxypropyl methylcellulose films for dermal and/or transdermal delivery of p-hydroxycinnamic acid
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Abstract
Objective
Skin diseases and chronic wounds are health problems that require solutions for health systems due to their high costs and difficulties in effective and rapid treatment. Hydroxycinnamic acid and its derivatives are powerful antioxidant molecules with widespread applications in medicine, cosmetics, and food industry. In this study, p-hydroxycinnamic acid was used as a potent agent for the management of skin diseases and other disorders.
Method
Herein, sodium alginate and hydroxypropylmethylcellulose-based films loaded with p-hydroxycinnamic acid at various concentrations were prepared by solvent-casting method and characterized in terms of mechanical, physicochemical, bioadhesive properties, and in vitro release kinetic modelling.
Results
The masses of the films were found to be between 16.933 ± 1.108 mg and 15.200 ± 0.432 mg and thicknesses between 135 ± 4 μm and 163 ± 6 μm. F1 formulation with higher sodium alginate concentration exhibited higher moisture absorption and moisture loss percentages (18.373% ± 2.610% and 8.281% ± 1.834%). In terms of water absorption, it was observed that F3 had up to 100% and F1 had the lowest absorption capacity. However, F1 degraded in a shorter time compared to other films. In terms of mechanical properties, F1 has shown that it has higher tensile strength, reaches 100% by providing continuous release with in vitro release studies, and has the highest bioadhesion. In addition, as a result of FTIR analysis and ex vivo permeation and penetration studies, the formulation F1 proved that it is suitable for dermal applications.
Conclusion
The developed formulations exhibited desired dermal film properties, making it a promising treatment option for dermal applications.
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