Journal of Cellular Immunotherapy最新文献_第2页

Immunomodulatory function of mesenchymal stem cells: regulation and application 间充质干细胞的免疫调节功能:调控及应用

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI: 10.1016/j.jocit.2018.09.001

Gaojing Qu , Xiaolin Xie , Xianyu Li , Yun Chen , Natalia De Isla , Céline Huselstein , Jean-François Stoltz , Yinping Li

引用次数: 18

The discriminant role of mechanics during cell migration 力学在细胞迁移中的鉴别作用

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI: 10.1016/j.jocit.2018.09.007

Rachele Allena

引用次数: 2

Influence of the liver vascular distribution on its overall mechanical behavior: A first approach to multiscale fluid-structure homogenization 肝脏血管分布对其整体力学行为的影响:多尺度流体结构均匀化的第一种方法

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI: 10.1016/j.jocit.2018.09.008

Daniel George , Majid Baniassadi , Yannick Hoarau , Michaël Kugler , Yves Rémond

引用次数: 3

Defining a scaffold for ligament tissue engineering: What has been done, and what still needs to be done 定义韧带组织工程的支架:已经做了什么，还有什么需要做

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI: 10.1016/j.jocit.2018.09.002

Cédric Laurent , Xing Liu , Natalia De Isla , Xiong Wang , Rachid Rahouadj

{"title":"Defining a scaffold for ligament tissue engineering: What has been done, and what still needs to be done","authors":"Cédric Laurent , Xing Liu , Natalia De Isla , Xiong Wang , Rachid Rahouadj","doi":"10.1016/j.jocit.2018.09.002","DOIUrl":"10.1016/j.jocit.2018.09.002","url":null,"abstract":"<div><p>Tissue engineering is a promising alternative to current surgical methods for ligament repair. However, despite a large variety of reported scaffolds for ligament, tissue-engineered solutions struggle to reach the clinics. The issue of proposing a scaffold meeting the key requirements for ligament tissue engineering is still largely open. In this article, a brief up-to-date review is proposed concerning what has been done and what still needs to be done in order to propose a suitable scaffold structure and material for ligament tissue engineering. A particularly focus is made on the selection of and structures, biomaterials and their functionalization, on the characterization of the initial and evolutive scaffold properties, and on the challenge of anchoring it within bone tunnels. The interest of computational approaches in the definition of suited scaffolds is also presented. We thus propose to list the remaining steps that should permit in the forthcoming years to propose a bioactive composite bone-ligament-bone scaffold to regenerate ligaments.</p></div>","PeriodicalId":100761,"journal":{"name":"Journal of Cellular Immunotherapy","volume":"4 1","pages":"Pages 4-9"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jocit.2018.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80799631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Circulating endothelial progenitors in vascular repair 血管修复中的循环内皮祖细胞

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI: 10.1016/j.jocit.2018.09.004

Guillaume Ha , Ségolène Ferratge , Sina Naserian, Richard Proust, Anne-Charlotte Ponsen, Nassim Arouche, Georges Uzan

{"title":"Circulating endothelial progenitors in vascular repair","authors":"Guillaume Ha , Ségolène Ferratge , Sina Naserian, Richard Proust, Anne-Charlotte Ponsen, Nassim Arouche, Georges Uzan","doi":"10.1016/j.jocit.2018.09.004","DOIUrl":"10.1016/j.jocit.2018.09.004","url":null,"abstract":"<div><p>Endothelial progenitor cells (EPCs) display pro-angiogenic properties that confer to them a therapeutic potential for treating ischemic lesions. In culture, EPCs generate Endothelial Colony Forming Cells (ECFCs) that have endothelial features but still retain properties of stem/progenitor cells. EPCs can be obtained either from cord blood (CB) or adult blood (AB). For clinical perspectives, both CB-ECFCs and AB-ECFCs have advantages and inconveniences. On one hand, CB-ECFCs are allogenic, with potential immune rejection, but are more clonogenic, proliferative and angiogenic than AB-ECFCs. We have found that these cells display high inter-individual variation in terms of clonogenic profile. Low clonogenic CB-ECFCs had functional properties similar to those of AB-ECFCs. Conversely, a high initial clonogenicity was associated to an enhanced proliferation, angiogenic potential and to an increased expression of genes linked to stem cell-ness. Selecting CB-ECFCs according the initial clonogenicity represent a relevant marker of their potential efficacy on vascular repair. On the other hand, AB-ECFCs are autologous, and should be immunologically well tolerated, but these cells give rise to only few colonies, proliferate less and are less angiogenic than CB-ECFCs. In order to go further in CB-/AB- characterization, we have analyzed the mechanisms of AB-ECFC premature senescence, and shown that GDF15 had pivotal role in this context. Taken together, these new data constitute important steps toward clinical use of EPCs.</p></div>","PeriodicalId":100761,"journal":{"name":"Journal of Cellular Immunotherapy","volume":"4 1","pages":"Pages 13-17"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jocit.2018.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78484733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Influence of mechanical forces on bone: Introduction to mechanobiology and mechanical adaptation concept 机械力对骨骼的影响:机械生物学导论和机械适应概念

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI: 10.1016/j.jocit.2018.09.003

Jean-François Stoltz , Jacques Magdalou , Daniel George , Yun Chen , Yinping Li , Natalia De Isla , Xiaohua He , Yves Remond

{"title":"Influence of mechanical forces on bone: Introduction to mechanobiology and mechanical adaptation concept","authors":"Jean-François Stoltz , Jacques Magdalou , Daniel George , Yun Chen , Yinping Li , Natalia De Isla , Xiaohua He , Yves Remond","doi":"10.1016/j.jocit.2018.09.003","DOIUrl":"10.1016/j.jocit.2018.09.003","url":null,"abstract":"<div><p>Mechanical forces (Pressure, shear or elongation) are now considered to be a determining factor in our understanding of many physiopathological mechanisms. These forces influence the cellular metabolism and can lead to tissue remodelling by triggering a cascaded of reactions on cells (mechanotransduction). The first observations of bone adaptation were realized by 2 German surgeons Meyer (1866) and Wolf (1869). They suggested that “the spongiosa showed a well-motivated architecture with is closely connected with the statics and mechanisms of bone”. In 1880, W. Roux introduced <em>the concept of functional adaptation;</em> which can be defined as a quantitative autoregulation controlled by stimuli.</p><p>In this paper, the influence mechanical forces on bone are summarized and the role of matrix elasticity or scaffold and signaling pathways by which the microenvironment determines the maturation. The <em>in vivo</em> consequences of these adaptive phenomena are described (increased of bone mass seen in athletes of loss of bone tissue during immobilization or bed rest after fracture or also in the astronauts after a long stay in space).</p></div>","PeriodicalId":100761,"journal":{"name":"Journal of Cellular Immunotherapy","volume":"4 1","pages":"Pages 10-12"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jocit.2018.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75054231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Cell nutriments and motility for mechanobiological bone remodeling in the context of orthodontic periodontal ligament deformation 在正畸牙周韧带变形的情况下，细胞营养和机械生物学骨重塑的运动性

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI: 10.1016/j.jocit.2018.09.006

Daniel George , Rachele Allena , Yves Rémond

引用次数: 14

The biomechanical properties of 44 human digital collateral nerves from fresh frozen cadavers 新鲜冷冻尸体44条指侧神经的生物力学特性

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI: 10.1016/j.jocit.2018.09.009

Santiago Salazar Botero , Sophie Honecker , Hamdi Jmal , Nadia Bahlouli , Philippe A. Liverneaux , Sybille Facca

{"title":"The biomechanical properties of 44 human digital collateral nerves from fresh frozen cadavers","authors":"Santiago Salazar Botero , Sophie Honecker , Hamdi Jmal , Nadia Bahlouli , Philippe A. Liverneaux , Sybille Facca","doi":"10.1016/j.jocit.2018.09.009","DOIUrl":"10.1016/j.jocit.2018.09.009","url":null,"abstract":"<div><p>Nerve repair and regeneration continue to be disappointing nowadays. Despite big transformations and technical progress, we still have bad clinical results from nerve repair. This study offers a materials point of view of the human digital collateral nerve biomechanical characteristics to create a technical specifications chart for nerve repair.</p><p>Forty-four human digital collateral nerves were harvested, preserved immersen in NaCl 0.9% solution until tested. They were all mounted and oriented same way and they were pulled at 6 mm/min. Density was measured with a pycnometer after the tensile test. The values of maximum stress, maximum strain, Young Modulus, density, specific stress and specific modulus were calculated.</p><p>The obtained results are presented in Table I. We did not find statistically significant differences between fingers. Density has a not statistical correlation with nerve biomechanics.</p><p>Goldberg et al. were the unique authors to make a judicious characterization of human digital collateral nerves biomechanics. They found different results perhaps a different tensile test setup. The fracture zone found in their work was inverted compared to our work. The biomechanical characteristics of peripheral nerves have a lot of dispersion as digital collateral nerves have. Density cannot homogenize the values because of its little or lack of correlation with the biomechanical properties of human digital collateral nerves.</p><p>In conclusion, this study presented a complete spectra of values to characterize human digital collateral nerves. This data could be used to understand human digital collateral nerves biomechanics create models, and optimize nerve repair.</p></div>","PeriodicalId":100761,"journal":{"name":"Journal of Cellular Immunotherapy","volume":"4 1","pages":"Pages 38-40"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jocit.2018.09.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89506746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Periodontal ligament histology for orthodontic bone remodeling: First quantification 正畸骨重塑牙周韧带组织学:首次量化

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI: 10.1016/j.jocit.2018.09.010

Delphine Wagner , Hanane El Hafci , Morad Bensidhoum , Hervé Petite , Yves Bolender , Yves Rémond , Daniel George

{"title":"Periodontal ligament histology for orthodontic bone remodeling: First quantification","authors":"Delphine Wagner , Hanane El Hafci , Morad Bensidhoum , Hervé Petite , Yves Bolender , Yves Rémond , Daniel George","doi":"10.1016/j.jocit.2018.09.010","DOIUrl":"10.1016/j.jocit.2018.09.010","url":null,"abstract":"<div><p>Tooth movements are driven by biological control, mainly localized in the periodontal ligament (PDL). This biology is influenced by compression and tension of the PDL under applied external mechanical loads. The aim of this study is to histologically quantify the cellular density of fibroblasts, osteocytes, osteoblasts, osteoclasts, and vascular elements present in the PDL to use to predict tooth movements. We performed histological analyses on porcine samples, with PMMA-embedded blocks cut to a thickness of 100 μm. We measured the density of the vascular elements (av. 8.2/100 μm<sup>2</sup>), the fibroblasts in the PDL (av. 15.8/100 μm<sup>2</sup>), osteocytes (av. 8/100 μm<sup>2</sup>), osteoblasts (av. 1.8/100 μm<sup>2</sup>) in bone and multinuclear cells (av. 1/100 μm<sup>2</sup>). These data would serve to implement predictive numerical model of bone remodelling during orthodontic tooth movement. This issue has priority in orthodontics to be able to anticipate the biological reactions and thus limit the undesirable side effects.</p></div>","PeriodicalId":100761,"journal":{"name":"Journal of Cellular Immunotherapy","volume":"4 1","pages":"Pages 41-43"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jocit.2018.09.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81599749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

WITHDRAWN: G protein-coupled receptor 120 in mediating the regulation effect of saturated and unsaturated long-chain fatty acid on human adipocytes 撤回:G蛋白偶联受体120介导饱和和不饱和长链脂肪酸对人脂肪细胞的调节作用

Journal of Cellular Immunotherapy Pub Date : 2018-03-03 DOI: 10.1016/J.JOCIT.2018.02.002

Zhen Li, Xuefeng Li, Yuwen Wu, Qi Huang, Li Sun, J. Stoltz, Z. Dai

引用次数: 0