Periodontal ligament histology for orthodontic bone remodeling: First quantification

Journal of Cellular Immunotherapy Pub Date : 2018-09-01 DOI:10.1016/j.jocit.2018.09.010

Delphine Wagner , Hanane El Hafci , Morad Bensidhoum , Hervé Petite , Yves Bolender , Yves Rémond , Daniel George

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引用次数: 6

Abstract

Tooth movements are driven by biological control, mainly localized in the periodontal ligament (PDL). This biology is influenced by compression and tension of the PDL under applied external mechanical loads. The aim of this study is to histologically quantify the cellular density of fibroblasts, osteocytes, osteoblasts, osteoclasts, and vascular elements present in the PDL to use to predict tooth movements. We performed histological analyses on porcine samples, with PMMA-embedded blocks cut to a thickness of 100 μm. We measured the density of the vascular elements (av. 8.2/100 μm²), the fibroblasts in the PDL (av. 15.8/100 μm²), osteocytes (av. 8/100 μm²), osteoblasts (av. 1.8/100 μm²) in bone and multinuclear cells (av. 1/100 μm²). These data would serve to implement predictive numerical model of bone remodelling during orthodontic tooth movement. This issue has priority in orthodontics to be able to anticipate the biological reactions and thus limit the undesirable side effects.

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正畸骨重塑牙周韧带组织学:首次量化

牙齿运动受生物控制，主要局限于牙周韧带(PDL)。这种生物学受到施加外部机械载荷下PDL的压缩和张力的影响。本研究的目的是组织学上量化PDL中存在的成纤维细胞、骨细胞、成骨细胞、破骨细胞和血管成分的细胞密度，用于预测牙齿运动。我们对猪样本进行了组织学分析，pmma嵌入块切割成100 μm的厚度。我们测量了血管元件(av. 8.2/100 μm2)、PDL中的成纤维细胞(av. 15.8/100 μm2)、骨细胞(av. 8/100 μm2)、成骨细胞(av. 1.8/100 μm2)和多核细胞(av. 1/100 μm2)的密度。这些数据将有助于实现正畸牙齿移动过程中骨重塑的预测数值模型。这个问题在正畸学中是优先考虑的，以便能够预测生物反应，从而限制不良的副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Cellular Immunotherapy

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