Journal of Allergy and Hypersensitivity Diseases最新文献

{"title":"A French consensus proposal: Analytical performance targets for total and allergen-specific IgE and total tryptase","authors":"Anne Sarrat ,&nbsp;Joana Vitte ,&nbsp;Yannick Chantran ,&nbsp;Céline Beauvillain ,&nbsp;Marie-Alexandra Alyanakian ,&nbsp;Pol-André Apoil ,&nbsp;Lionel Chollet ,&nbsp;Arnaud Cirée ,&nbsp;Clotilde Amiot ,&nbsp;Erwan Dumontet ,&nbsp;Mylène de Saint-Jore ,&nbsp;Bertrand Evrard ,&nbsp;Lorna Garnier ,&nbsp;Angélique Grenier ,&nbsp;Valérie Guérin-El Khourouj ,&nbsp;Caroline Hémont ,&nbsp;Anthony Léon ,&nbsp;Delphine Mariotte ,&nbsp;Moïse Michel ,&nbsp;Pascale Nicaise-Roland ,&nbsp;Julien Goret","doi":"10.1016/j.jahd.2025.100037","DOIUrl":"10.1016/j.jahd.2025.100037","url":null,"abstract":"<div><div>Precision medicine allows thorough characterization of patients endotype in allergy and anaphylaxis, thanks to progress in diagnostic tests and biomarkers. Allergy tests must therefore offer reliable, robust, and proficient quantitative results in each patient. These requirements have led to the development of quality assurance programs for allergy laboratory assays and their implementation in virtually all clinical laboratories performing in vitro allergy diagnosis and follow-up. However, consensus analytical performance targets for allergy assays have not yet been established. Here, the multicentric French network of public clinical laboratories and the Working Group on in vitro allergy diagnosis of the French Society of Allergy define performance criteria for specific and total IgE and tryptase tests.</div></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"5 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"10.1016/j.jahd.2024.100028","DOIUrl":"10.1016/j.jahd.2024.100028","url":null,"abstract":"","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"3 ","pages":"Article 100028"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunology & Allergy referral patterns in Hong Kong following the COVID-19 pandemic: A 8-year longitudinal analysis","authors":"Gordon K.H. Chu ,&nbsp;Emily M. Lee ,&nbsp;James K.Y. Hooi ,&nbsp;Jane C.Y. Wong ,&nbsp;Valerie Chiang ,&nbsp;Philip H. Li","doi":"10.1016/j.jahd.2024.100023","DOIUrl":"10.1016/j.jahd.2024.100023","url":null,"abstract":"<div><h3>Background</h3><div>In 2018, Hong Kong established its first public adult clinical immunology and allergy (IA) team. The COVID-19 outbreak in early 2020 disrupted services for IA patients. This study aims to assess case burden among non-COVID-19-related referrals at our center before and after the COVID-19 pandemic and identify changing service needs.</div></div><div><h3>Methods</h3><div>The study included the first 1000 adult patients seen at our clinic, divided into “pre-COVID-19” (Jan 2018–Dec 2019) and “post-COVID-19” (Jan 2020–Dec 2022) groups. Clinical data were compared between these cohorts.</div></div><div><h3>Results</h3><div>Of the first 1000 cases, allergy and immunology cases were equally represented. There was a significant increase in allergy referrals in the post-COVID19 cohort, particularly a 7 % rise in drug allergy cases. Conversely, immunology referrals decreased significantly.</div></div><div><h3>Conclusion</h3><div>Referral trends shifted towards allergy cases, especially drug allergies, after COVID-19. It is essential to implement effective protocols to manage the increased allergy burden and enable primary care providers to handle low-risk cases.</div></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"3 ","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying urbanome profiles as potential determinants of asthma and allergies","authors":"Marwan El Homsi ,&nbsp;Luciana Kase Tanno ,&nbsp;Isabella Annesi-Maesano","doi":"10.1016/j.jahd.2024.100015","DOIUrl":"10.1016/j.jahd.2024.100015","url":null,"abstract":"<div><h3>Introduction</h3><div>Urban environmental factors - the so-called urbanome - have a major influence on the health of city dwellers, including allergic and respiratory health that strongly depend on urban lifestyle and setting. Using data from a cross-sectional study, we describe the urbanome of Montpellier, France, as perceived by city dwellers, and identify associated profiles of exposure in view of prevention against allergic and respiratory diseases.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted in the Montpellier metropolitan area between November 2022 and September 2023, involving 397 participants aged 18 to 80 years drawn from the general population. Urbanome data were collected using a standardized self-report questionnaire. Fifteen factors were used to identify exposure profiles using a hierarchical clustering on principal components (HCPC) analysis based on a multiple correspondence analysis (MCA) taking gender and smoking into account.</div></div><div><h3>Results</h3><div>Traffic air pollution (94.39 %), noise disturbance (74.94 %), vegetation around home in private area (67.42 %), sport activity (60.20 %), and passive smoking (50.82 %) were the most reported urbanome factors. Two separate clusters were identified, one containing well-known risk factors for allergic or respiratory diseases such as air and noise pollution and the other factors protective for allergic or respiratory diseases such as green spaces. Allergy diagnosis was commoner in the risk factors cluster (34.48 % versus 52.38 %, <em>p</em> = 0.011).</div></div><div><h3>Conclusions</h3><div>Data collected in Montpellier showed two patterns of urbanome perception, including risk and protective factors respectively. Such information is useful for promoting prevention measures. Studies with larger numbers of participants, a greater number of more objectively measured environmental factors are needed to further investigate the associations between urbanome and health.</div></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"3 ","pages":"Article 100015"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple hypothesis testing in allergy and hypersensitivity diseases investigation: a pedagogical perspective","authors":"Hugo Guillermou ,&nbsp;Christophe Abraham ,&nbsp;Isabella Annesi-Maesano ,&nbsp;Nicolas Molinari","doi":"10.1016/j.jahd.2024.100014","DOIUrl":"10.1016/j.jahd.2024.100014","url":null,"abstract":"<div><h3>Background</h3><div>Allergy and hypersensitivity diseases (AHD) are multifactorial diseases affecting different organs of the human body and with different level of severity. Therefore, multiple hypothesis testing is a common practice in AHD investigation. However, this increases the probability of rejecting a true null hypothesis, meaning there's no effect, the so-called risk of type 1 error or alpha risk. We present here how to control global alpha risk in the case of multiple comparisons or multitesting in AHD investigations to minimize the risk of drawing false positive conclusions.</div></div><div><h3>Methods</h3><div>Four methods for controlling global alpha risk, namely Bonferroni, Sidak, Holm–Bonferroni, and Benjamini–Hochberg, were applied to simulated and real data. Their performance was assessed through false negative, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).</div></div><div><h3>Results</h3><div>The Bonferroni method was found to be the most conservative, while the Benjamini–Hochberg method had the most power. The Holm–Bonferroni method was a compromise between statistical power and control of false positives.</div></div><div><h3>Conclusions</h3><div>Controlling global alpha risk is crucial in multiple comparisons like they are needed in AHD investigation, and different methods are available to achieve it. Researchers should choose the method that best suits their study, considering the assumptions and objectives.</div></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"3 ","pages":"Article 100014"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P values or not? How journals can promote better statistical reporting in exploratory research","authors":"Alessandro Marcon","doi":"10.1016/j.jahd.2024.100022","DOIUrl":"10.1016/j.jahd.2024.100022","url":null,"abstract":"","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"3 ","pages":"Article 100022"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-fatal food anaphylaxis: From epidemiological data to care challenges","authors":"Guillaume Pouessel ,&nbsp;Sylvie Leroy ,&nbsp;Antoine Deschildre","doi":"10.1016/j.jahd.2024.100018","DOIUrl":"10.1016/j.jahd.2024.100018","url":null,"abstract":"<div><h3>Introduction</h3><div>Near-fatal and fatal anaphylaxis induced by food is a critical event for the patient/caregivers but is also a challenge for the physician/allergist for both acute and long-term care. We aimed to describe the epidemiology of food-induced near-fatal anaphylaxis (NFA), the key factors that may impact their approach, and its management.</div></div><div><h3>Methods</h3><div>In this narrative review, we have focused on food-induced NFA moving from epidemiological data and risk factors to management using a search of PubMed online databank.</div></div><div><h3>Results</h3><div>NFA is not well-defined in the literature. Food-induced anaphylaxis mortality rate is estimated less than 0.3 deaths per million persons-years in the general population. Refractory anaphylaxis also appears to be rare (&lt; 2 % of anaphylaxis cases). Food-induced NFA are mostly observed in children but can also occur in adults, even the elderly. While most countries report peanut/tree nuts being frequently involved in NFA, seafood or milks are reported in other countries.</div><div>Prior anaphylaxis, asthma diagnosis, IgE sensitization or basophil activation tests are not good predictors of NFA whereas adolescence/young adulthood are associated with a higher risk of severe outcome. However there remain major knowledge gaps regarding risk factors of NFA, including the impact of asthma.</div><div>There is a clear room for improvement in the prevention and management of NFA to focus on: prompt adrenaline use in prehospital care, innovations regarding alternative forms of injectable adrenaline, prevention at school, therapeutic education, food allergen avoidance and adequate labelling. Some patients may benefit from immunotherapy and/or biologicals in the context of personalized care.</div></div><div><h3>Conclusion</h3><div>A collaborative research is needed to address knowledge gaps in anaphylaxis, even more for food-induced NFA. We need to go further in identifying biomarkers, pathophysiologic pathways, genetic factors that may be associated with an increased risk of NFA. Novel therapeutic options should be envisaged in these patients.</div></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"3 ","pages":"Article 100018"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma and coagulation: A (seemingly) strange couple and its pathophysiological and clinical implications","authors":"Annalisa Castagna ,&nbsp;Gianenrico Senna ,&nbsp;Giuseppe Argentino ,&nbsp;Marco Caminati ,&nbsp;Simonetta Friso ,&nbsp;Nicola Martinelli","doi":"10.1016/j.jahd.2024.100012","DOIUrl":"10.1016/j.jahd.2024.100012","url":null,"abstract":"<div><p>Asthma is a heterogeneous disease characterized by chronic inflammation and variable airway remodeling, determining a range of clinical presentations defined by respiratory symptoms and airway involvement. Inflammation, driven by both adaptive and innate immune responses, plays a key role in the pathophysiology of asthma. Other crucial biological pathways, including the coagulation cascade, are closely and two-way entwined with inflammatory processes. Such interconnections represent the molecular bases explaining the asthma-related alterations of haemostatic balance, which are usually shifted to procoagulant states, leading to pathophysiological and clinical implications. Many different chronic inflammatory conditions have also been associated with prothrombotic diathesis and an increased risk of venous thromboembolism, but in asthma, these bidirectional interconnections appear particularly evident. A growing number of studies in the last decades have addressed the bidirectional relationship between asthma pathways and coagulation mechanisms. This narrative review summarises the molecular/biological proofs and clinical/epidemiological evidence linking asthma and coagulation. This relationship is not limited to the inflammatory-driven processes leading to procoagulant states and, therefore, to an increased risk of thrombosis in patients with asthma but it is also related to the extra-haemostatic effects of coagulation factors, which may modulate asthma pathways and even influence the development of respiratory manifestations. Consistent with the former issue, several epidemiological studies demonstrated a compelling association between asthma and an increased risk of venous thromboembolism, independent of potential confounding factors. Regarding the latter issue, it appears biologically suggestive and therapeutically intriguing that, at least in animal models, many anticoagulant drugs have been shown to reduce airway hyperresponsiveness/remodeling and improve respiratory performance in the setting of asthma. Certainly, such therapeutic approaches, whose effectiveness has yet to be fully demonstrated in humans and whose bleeding-related side effects represent a major concern about their use, remain only speculative in clinical practice and we are still very far from their hypothetical application. Anyway, a more thorough understanding of molecular mechanisms connecting asthma, allergic inflammation, coagulation, and thrombosis may allow a better knowledge of asthma pathophysiology, potentially paving the way towards innovative therapeutic approaches and leading to better strategies in the overall management of patients with asthma.</p></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"2 ","pages":"Article 100012"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950312424000125/pdfft?md5=6e7804fd07a44d7cff30341109a849b3&pid=1-s2.0-S2950312424000125-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy and hypersensitivity diseases in space: physiological changes, clinical aspects, and mechanisms with countermeasures","authors":"Brigitte Godard","doi":"10.1016/j.jahd.2024.100007","DOIUrl":"https://doi.org/10.1016/j.jahd.2024.100007","url":null,"abstract":"<div><p>Allergy and hypersensitivity diseases are important topics worldwide. The development of allergies in humans has become increasingly common and is expected to increase in the next future, the incidence is expected to reach 50% of the worldwide adult population. Space is not left out in this phenomenon. Having allergies requires further care, considering that astronauts spend time far away from home, working with widely diverse materials for science experiments and repairing stations. A history of atopy is checked during the selection process and can request further investigation to make sure the crew and mission will not be impacted. It is not itself a disqualifying criterion: it has to be balanced with all other parameters. Space is a very extreme environment for the body that increases the risk to develop allergy or hypersensitivity. This article focuses on the specificity of space by reviewing the very challenging and extreme environment of space: microgravity, radiation, isolation and other specificity of the International Space Station. Space-related clinical diseases, including allergies, and the mechanisms and countermeasures used in space to avoid major clinical events were also reviewed. One of the major consequences of space in the topic of allergy is the change in the immune system. If the immune system is altered, the capacity for recovery is impacted, and more critical infections can be expected in space. Further studies are needed to ensure the safety of next interplanetary travel to space. In this review new countermeasures are mentioned, they seem promising but need further research on human bodies to ensure safe travel to space.</p></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"2 ","pages":"Article 100007"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950312424000071/pdfft?md5=b16475c850498e9d9fd2877060b07efa&pid=1-s2.0-S2950312424000071-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish allergy management: Should fish be completely avoided? The pros and cons debate","authors":"Agnes Sze-Yin Leung ,&nbsp;Naoko Fusayasu ,&nbsp;Laura Argiz Álvarez ,&nbsp;Yanjun Gu ,&nbsp;Motohiro Ebisawa ,&nbsp;Gary Wing-Kin Wong","doi":"10.1016/j.jahd.2024.100008","DOIUrl":"10.1016/j.jahd.2024.100008","url":null,"abstract":"","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"2 ","pages":"Article 100008"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950312424000083/pdfft?md5=d428891186f801c4c7f85e1a1ac61d23&pid=1-s2.0-S2950312424000083-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141406652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}