A French consensus proposal: Analytical performance targets for total and allergen-specific IgE and total tryptase

Journal of Allergy and Hypersensitivity Diseases Pub Date : 2025-01-01 DOI:10.1016/j.jahd.2025.100037

Anne Sarrat , Joana Vitte , Yannick Chantran , Céline Beauvillain , Marie-Alexandra Alyanakian , Pol-André Apoil , Lionel Chollet , Arnaud Cirée , Clotilde Amiot , Erwan Dumontet , Mylène de Saint-Jore , Bertrand Evrard , Lorna Garnier , Angélique Grenier , Valérie Guérin-El Khourouj , Caroline Hémont , Anthony Léon , Delphine Mariotte , Moïse Michel , Pascale Nicaise-Roland , Julien Goret

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引用次数: 0

Abstract

Precision medicine allows thorough characterization of patients endotype in allergy and anaphylaxis, thanks to progress in diagnostic tests and biomarkers. Allergy tests must therefore offer reliable, robust, and proficient quantitative results in each patient. These requirements have led to the development of quality assurance programs for allergy laboratory assays and their implementation in virtually all clinical laboratories performing in vitro allergy diagnosis and follow-up. However, consensus analytical performance targets for allergy assays have not yet been established. Here, the multicentric French network of public clinical laboratories and the Working Group on in vitro allergy diagnosis of the French Society of Allergy define performance criteria for specific and total IgE and tryptase tests.

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法国共识提案：总IgE和过敏原特异性IgE和总胰蛋白酶的分析性能指标

由于诊断测试和生物标志物的进步，精确医学允许对过敏和过敏反应患者的内型进行彻底的表征。因此，过敏试验必须为每位患者提供可靠、稳健和熟练的定量结果。这些要求导致了过敏实验室检测的质量保证程序的发展，并在几乎所有进行体外过敏诊断和随访的临床实验室中实施。然而，过敏测定的一致分析性能指标尚未建立。在这里，法国多中心公共临床实验室网络和法国过敏学会体外过敏诊断工作组确定了特异性和总IgE和胰蛋白酶测试的性能标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Allergy and Hypersensitivity Diseases

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