Jornal de Pediatria (Vers?o em Português)最新文献

{"title":"Endoscopic and histological characteristics in patients with eosinophilic esophagitis responsive and non‐responsive to proton pump inhibitors","authors":"Gabriela Guimarães Vieira ,&nbsp;Luciana Bandeira Mendez Ribeiro ,&nbsp;Sabine Kruger Truppel ,&nbsp;Nelson Augusto Rosário Filho ,&nbsp;Mário César Vieira","doi":"10.1016/j.jpedp.2019.05.028","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.05.028","url":null,"abstract":"<div><h3>Objective</h3><p>To compare endoscopic and histologic features of pediatric patients with eosinophilic esophagitis (EoE) responding to proton pump inhibitor (PPI) to those not responding to PPI.</p></div><div><h3>Methods</h3><p>Endoscopic reports and photographs of patients with symptoms of esophageal dysfunction and ≥15 eosinophils per high-powered field (eos/hpf) in esophageal biopsies prior to PPI trial were reviewed. Patients were classified as responsive to PPI (PPIREoE) or non-responsive to PPI (PPINREoE) according to response totreatment (&lt;15 eos/hpf) at second endoscopy after 8 weeks.</p></div><div><h3>Results</h3><p>Of the 231 patients (72.3% male), 64 (27.7%) were responsive to the proton pump inhibitors. Edema (77.3% <em>vs</em>. 62.5%, p<!--> <!-->=<!--> <!-->0.031) and vertical lines (69.5% <em>vs</em>. 51.6%, p<!--> <!-->=<!--> <!-->0.014) were more frequent in PPINREoE patients. An eosinophil count in the mid‐esophagus ≥ 35 eos/HPF (25.1% <em>vs</em>. 12.5%) was more frequent in these patients (p<!--> <!-->=<!--> <!-->0.001). Those with eosinophil count &lt;<!--> <!-->15 eos/HPF in the mid‐esophagus at the first endoscopy were more likely to respond to treatment with proton pump inhibitors compared to patients with 15‐34 eos/HPF (p<!--> <!-->=<!--> <!-->0.004, OR: 3.26, 95% CI: 1.46‐7.24) and to patients with ≥ 35 eos/HPF (p<!--> <!-->=<!--> <!-->0.006, OR: 3.20, 95% CI: 1.39‐7.41).</p></div><div><h3>Conclusion</h3><p>Edema and vertical lines at the endoscopy and a higher eosinophil count in the mid‐esophagus were more frequent in patients who were non‐responsive to proton pump inhibitors. As there were no significant differences in the other findings between the groups, it cannot be affirmed that these characteristics are sufficient to differentiate between PPINREoE and PPIREoE patients.</p></div>","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 5","pages":"Pages 638-643"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.05.028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137091817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with leprosy in children contacts of notified adults in an endemic region of Midwest Brazil","authors":"Thaísa S.V. Rodrigues ,&nbsp;Luciane C. Gomes ,&nbsp;Denise C.B. Cortela ,&nbsp;Eliane A. Silva ,&nbsp;Cristiane A.L. Silva ,&nbsp;Silvana M.B. Ferreira","doi":"10.1016/j.jpedp.2019.04.012","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.04.012","url":null,"abstract":"<div><h3>Objectives</h3><p>To analyze the factors associated with leprosy in children who were intradomiciliary contacts of notified adults with the disease in an endemic municipality in Mato Grosso, Brazil.</p></div><div><h3>Method</h3><p>Case–control study with 204 children under 15 years of age, living in an endemic municipality. Cases (<em>n</em> <!-->=<!--> <!-->40) were considered as the children with leprosy registered at the National Information System of Notifiable Diseases in 2014 and 2015, who were intradomiciliary contacts of at least one adult diagnosed with the disease in the family, and as a control group (<em>n</em> <!-->=<!--> <!-->164) of children living within a radius of up to 100<!--> <!-->m of the notified cases. Data were obtained through medical file analysis, interviews, and blood samples for anti‐PGL‐I serological test by the ELISA method. The binary logistic regression technique was used, with <em>p</em> <!-->≤<!--> <!-->0.05.</p></div><div><h3>Results</h3><p>After adjustments, the following were associated with leprosy: age (95% CI: 1.24–9.39, <em>p</em> <!-->=<!--> <!-->0.018), area of residence (95% CI: 1.11–6.09, <em>p</em> <!-->=<!--> <!-->0.027), waste disposal (95% CI: 1.91–27.98, <em>p</em> <!-->=<!--> <!-->0.004), family history of the disease (95% CI: 3.41–22.50, <em>p</em> <!-->=<!--> <!-->0.000), and time of residence (95% CI: 1.45–7.78, <em>p</em> <!-->=<!--> <!-->0.005).</p></div><div><h3>Conclusion</h3><p>Factors associated with the disease indicate greater vulnerability of children aged 8–14 years, associated with living conditions and time of residence, as well as the family history of the disease.</p></div>","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 5","pages":"Pages 593-599"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.04.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91984346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of intervention on nutritional status, consumption of processed foods, and quality of life of adolescents with excess weight","authors":"Fabiana A. Poll ,&nbsp;Fernanda Miraglia ,&nbsp;Helen F. D’avila ,&nbsp;Cézane P. Reuter ,&nbsp;Elza D. Mello","doi":"10.1016/j.jpedp.2019.05.026","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.05.026","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the impact of a nutritional intervention on nutritional status, ultra‐processed food consumption, and quality of life of adolescents with excess weight.</p></div><div><h3>Methods</h3><p>Experimental study with adolescent students with excess weight, divided into two groups, an intervention group and a control group. The nutritional intervention lasted six months, with an educational and motivational approach. Nutritional status (waist circumference and body mass index), quality of life, and ultra‐processed food consumption were evaluated before and after the period.</p></div><div><h3>Results</h3><p>Sixty‐two adolescents with overweight or obesity participated in the study, 37 in the intervention group and 25 in the control group, aged 13.2<!--> <!-->±<!--> <!-->1.5 years in intervention group, and 13.0<!--> <!-->±<!--> <!-->1.8 years in control group, both of which had a higher female participation. There were changes in the body mass index (intervention group Δ: −0.81<!--> <!-->±<!--> <!-->2.28, control group Δ: −0.64<!--> <!-->±<!--> <!-->1.28) and in the waist circumference for intervention group (Δ:−3.31<!--> <!-->±<!--> <!-->5.47). For the pre‐ and post‐ultra‐processed food consumption, there was a significant reduction in the consumption of soft drinks in the intervention group (Δ: −0.07 [−0.27 to 0.00]), instant noodles (Δ: −0.03 [−0.07 to 0.00]), and sandwich cookies (Δ: −0.06 [−0.26 to 0.00]). The quality of life increased in the intervention group and decreased in the control group, with no intra‐ (<em>p</em> <!-->=<!--> <!-->0.162) or intergroup statistical relevance in the pre‐ (<em>p</em> <!-->=<!--> <!-->0.426) and post‐ (0.249) intervention period, with a reduction in the emotional domain score, with a significant variation in the intervention group (pre and post; Δ: −19.0<!--> <!-->±<!--> <!-->40.6).</p></div><div><h3>Conclusion</h3><p>There was a decrease in body mass index and waist circumference (central obesity being more often related to insulin resistance), reduction of ultra‐processed food consumption (soft drinks, sandwich cookies, and instant noodles), and a tendency toward quality of life improvement (however, there was a decrease in the domains of emotional and school quality of life).</p></div>","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 5","pages":"Pages 621-629"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.05.026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137091397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the FTO gene polymorphism and obesity in Brazilian adolescents from the Northeast region","authors":"Liliane dos Santos Rodrigues ,&nbsp;Alcione Miranda dos Santos ,&nbsp;Mayara Ingrid Sousa Lima ,&nbsp;Vanda Maria Ferreira Simões ,&nbsp;Silma Regina Pereira","doi":"10.1016/j.jpedp.2019.05.027","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.05.027","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the association between the <em>FTO</em> gene polymorphism with obesity in Brazilian adolescents from the Northeast region.</p></div><div><h3>Method</h3><p>This was a case‐control study with adolescents aged 18 to 19 years. The case group consisted of 378 obese individuals and the control group of 378 non‐obese individuals. Obesity was measured by percentage of body fat using the air displacement plethysmography technique. The study variables included data on socioeconomics, demographics, lifestyle, physical activity, waist circumference, waist‐to‐height ratio, and body mass index. To identify the rs9939609 polymorphism of the <em>FTO</em> gene, blood samples were obtained for genomic DNA extraction by the real‐time PCR (Polymerase Chain Reaction) technique. Categorical variables were compared between the groups by the chi‐squared test. The normality of the anthropometric measurements body mass index, waist circumference, waist‐to‐height ratio, and percentage of body fat was evaluated by the Shapiro‐Wilk test. Comparison of the anthropometric measurements, stratified by the polymorphism genotypes, was performed by the Kruskall‐Wallis test. The Hardy‐Weinberg equilibrium was calculated. The significance level was set at 5%.</p></div><div><h3>Results</h3><p>The variables gender, age, and physical activity showed significant differences between the groups (p &lt; 0.001). The samples of obese and non‐obese adolescents were in Hardy‐Weinberg equilibrium (p = 0.0515). There was no significant difference between the genotypic (p = 0.719) and allelic frequencies (p = 0.812) regarding the case and control groups. When comparing the anthropometric measurements according to the genotypes (AA, AT, and TT), no significant difference was observed for body mass index (p = 0.337), waist circumference (p = 0.3473), percentage of body fat (p = 0.7096), and waist‐to‐height ratio (p = 0.2584).</p></div><div><h3>Conclusion</h3><p>The excess adiposity of the study adolescents was not influenced by their genotype.</p></div>","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 5","pages":"Pages 630-637"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.05.027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137091399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zero tolerance for asthma deaths in children","authors":"Alessandro Fiocchi,&nbsp;Rocco Valluzzi,&nbsp;Lamia Dahdah","doi":"10.1016/j.jpedp.2019.08.001","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.08.001","url":null,"abstract":"","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 4","pages":"Pages 403-405"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136905132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of pediatric cardiopulmonary resuscitation","authors":"Tania Miyuki Shimoda‐Sakano ,&nbsp;Cláudio Schvartsman ,&nbsp;Amélia Gorete Reis","doi":"10.1016/j.jpedp.2019.08.004","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.08.004","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze the main epidemiological aspects of prehospital and hospital pediatric cardiopulmonary resuscitation and the impact of scientific evidence on survival.</p></div><div><h3>Source of data</h3><p>This was a narrative review of the literature published at PubMed/MEDLINE until January 2019 including original and review articles, systematic reviews, meta‐analyses, annals of congresses, and manual search of selected articles.</p></div><div><h3>Synthesis of data</h3><p>The prehospital and hospital settings have different characteristics and prognoses. Pediatric prehospital cardiopulmonary arrest has a three‐fold lower survival rate than cardiopulmonary arrest in the hospital setting, occurring mostly at home and in children under 1 year. Higher survival appears to be associated with age progression, shockable rhythm, emergency medical care, use of automatic external defibrillator, high‐quality early life support, telephone dispatcher‐assisted cardiopulmonary resuscitation, and is strongly associated with witnessed cardiopulmonary arrest. In the hospital setting, a higher incidence was observed in children under 1 year of age, and mortality increased with age. Higher survival was observed with shorter cardiopulmonary resuscitation duration, occurrence on weekdays and during daytime, initial shockable rhythm, and previous monitoring. Despite the poor prognosis of pediatric cardiopulmonary resuscitation, an increase in survival has been observed in recent years, with good neurological prognosis in the hospital setting.</p></div><div><h3>Conclusions</h3><p>A great progress in the science of pediatric cardiopulmonary resuscitation has been observed, especially in developed countries. The recognition of the epidemiological aspects that influence cardiopulmonary resuscitation survival may direct efforts towards more effective actions; thus, studies in emerging and less favored countries remains a priority regarding the knowledge of local factors.</p></div>","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 4","pages":"Pages 409-421"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136905134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross‐cultural adaptation and validation of the universal Portuguese‐version of the Pediatric Functional Assessment of Chronic Illness Therapy – Fatigue (pedsFACIT‐F)","authors":"Karla P. Fernandes ,&nbsp;Bruno S. Teixeira ,&nbsp;Benjamin J. Arnold ,&nbsp;Tânia M. da S. Mendonça ,&nbsp;Sthela M. Oliveira ,&nbsp;Carlos Henrique M. da Silva","doi":"10.1016/j.jpedp.2019.05.004","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.05.004","url":null,"abstract":"<div><h3>Objective</h3><p>To cross‐culturally adapt and validate the universal Portuguese version of the Pediatric Functional Assessment of Chronic Illness Therapy – Fatigue (pedsFACIT‐F).</p></div><div><h3>Method</h3><p>The universal Portuguese version of the pedsFACIT‐F was cross‐culturally adapted and validated in 323 children and adolescents aged 8–18 years, 173 healthy individuals, and 150 with chronic diseases (cancer, juvenile idiopathic arthritis, and diabetes). Reliability (internal consistency and test–retest reliability) was assessed. Item response theory model assumptions were evaluated using confirmatory and exploratory factor analyses. Items were calibrated using a graded response model. Differential item functioning was assessed regarding age, gender, and clinical condition (healthy <em>vs.</em> chronic diseases).</p></div><div><h3>Results</h3><p>No major cultural adaptations were needed. Internal consistency (Cronbach's alpha<!--> <!-->=<!--> <!-->0.84) and test–retest reliability (intraclass correlation coefficient<!--> <!-->=<!--> <!-->0.92) were good. CFA (CFI<!--> <!-->=<!--> <!-->0.92, TLI<!--> <!-->=<!--> <!-->0.90, RMSEA<!--> <!-->=<!--> <!-->0.097) and CFE analysis confirmed sufficient unidimensionality. The data also fit the GRM and demonstrated good coverage of the fatigue construct (threshold parameters range: −1.42 to 4.56). No items demonstrated significant differential item functioning.</p></div><div><h3>Conclusion</h3><p>The universal Portuguese version of the pedsFACIT‐F provides a reliable, precise, and valid measure after being assessed by robust psychometric properties. Stability of the measurement properties of the pedsFACIT‐F scale allows its use to assess fatigue in clinical research in Portuguese‐speaking children and adolescents.</p></div>","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 4","pages":"Pages 456-463"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136905131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and impact of asthma in schoolchildren in the city of Caxias do Sul‐RS","authors":"Daniel Zacaron ,&nbsp;Cristian Roncada ,&nbsp;Rossano Sartori Dal Molin ,&nbsp;Marcus Herbert Jones ,&nbsp;Paulo Condessa Pitrez","doi":"10.1016/j.jpedp.2019.04.002","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.04.002","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze the prevalence and impact of asthma in schoolchildren from the city of Caxias do Sul, RS, Brazil.</p></div><div><h3>Methods</h3><p>Cross‐sectional observational and case‐control study with children and adolescents between 7 and 15 years old, from public schools in Caxias do Sul/RS. The study is composed of two phases: Phase I analyzed the prevalence of asthma in the delimited population investigating 1915 schoolchildren; Phase II quality of life questionnaires, asthma control and classification (for the asthmatic group), physical activity, school performance, pulmonary function tests and anthropometric measures were applied to 266 asthmatics and 288 controls.</p></div><div><h3>Results</h3><p>The estimated prevalence of asthma was 16.1%. In the comparison between asthmatics and nonasthmatics premature birth (p &lt;<!--> <!-->0.001) and diagnosis of another chronic disease at birth (p &lt;<!--> <!-->0.001) were found. Regarding pulmonary function, significant differences were found in the values between groups in FEV₁, FEV₁/FVC and forced expiratory flow in the 25 and 75% moments (FEF_25‐75%), being that asthmatics presented lower values. Among asthmatics, 133 (50.8%) did not have the disease controlled. In the anthropometric variables, significant differences were observed, with higher values in controls, in the waist‐to‐height ratio (p<!--> <!-->=<!--> <!-->0.009) and in the perception of health (p &lt;<!--> <!-->0.001). Quality of life is lower in asthmatics in the physical well‐being domain (p<!--> <!-->=<!--> <!-->0.001) and in the total score (p<!--> <!-->=<!--> <!-->0.016). The total school performance score did not present a statistically significant difference between the study groups.</p></div><div><h3>Conclusion</h3><p>The prevalence of asthma is similar to that of other industrialized urban centers and may negatively affect some areas of the development of schoolchildren.</p></div>","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 4","pages":"Pages 479-486"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136905258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermoregulatory and perceptual responses of lean and obese fit and unfit girls exercising in the heat","authors":"Carolina de Ávila Rodrigues,&nbsp;Gabriela Tomedi Leites,&nbsp;Flavia Meyer","doi":"10.1016/j.jpedp.2019.05.008","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.05.008","url":null,"abstract":"<div><h3>Objective</h3><p>To verify the thermoregulatory and perceptual responses of obese and lean girls, either fit or unfit, exercising in the heat at a similar rate of metabolic heat production per unit body mass.</p></div><div><h3>Methods</h3><p>A total of 34 pubescent girls were allocated in four groups: 12 obese fit, 9 obese unfit, 5 lean fit, and 8 lean unfit. The obese groups (13.2<!--> <!-->±<!--> <!-->1.4 years, 40.5%<!--> <!-->±<!--> <!-->5.8% fat by DXA) differed in their aerobic fitness (<span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover><msub><mi>O</mi><mrow><mn>2</mn><mi>p</mi><mi>e</mi><mi>a</mi><mi>k</mi></mrow></msub></mrow></math></span> 76.0<!--> <!-->±<!--> <!-->8.1 vs. 56.6<!--> <!-->±<!--> <!-->5.8<!--> <!-->mL.kg<!--> <!-->muscle<!--> <!-->mass^‐1.min⁻¹), as well as the lean groups (13.1<!--> <!-->±<!--> <!-->1.6 years, 24.0%<!--> <!-->±<!--> <!-->4.8% fat) (<span><math><mrow><mover><mi>V</mi><mo>˙</mo></mover><msub><mi>O</mi><mrow><mn>2</mn><mi>p</mi><mi>e</mi><mi>a</mi><mi>k</mi></mrow></msub></mrow></math></span> 74.5<!--> <!-->±<!--> <!-->2.9 vs. 56.2<!--> <!-->±<!--> <!-->5.0<!--> <!-->mL.kg<!--> <!-->muscle mass⁻¹ <!-->min⁻¹). Girls cycled two bouts of 25<!--> <!-->min with a 10<!--> <!-->min rest in between, at ∼5.4<!--> <!-->W.kg⁻¹ in the heat (36<!--> <!-->°C and 40% relative humidity) and they were kept euhydrated. Rectal and skin temperatures and heart rate were measured every 5<!--> <!-->min. Perceptual responses were evaluated throughout the exercise.</p></div><div><h3>Results</h3><p>Initial rectal temperature was higher in the obese subjects compared to the lean subjects (37.5<!--> <!-->±<!--> <!-->0.3 and 37.2<!--> <!-->±<!--> <!-->0.3<!--> <!-->°C). No difference was observed among the girls whom were obese (eight fit or unfit) and lean (also fit or unfit) throughout the exercise in rectal temperature (37.6<!--> <!-->±<!--> <!-->0.2, 37.5<!--> <!-->±<!--> <!-->0.3, 37.5<!--> <!-->±<!--> <!-->0.3, 37.4<!--> <!-->±<!--> <!-->0.3<!--> <!-->°C, respectively), skin temperature (34.8<!--> <!-->±<!--> <!-->0.8, 35.1<!--> <!-->±<!--> <!-->1.0, 34.4<!--> <!-->±<!--> <!-->0.9, 35.2<!--> <!-->±<!--> <!-->0.9<!--> <!-->°C), and heart rate (128<!--> <!-->±<!--> <!-->18; 118<!--> <!-->±<!--> <!-->12, 130<!--> <!-->±<!--> <!-->16, 119<!--> <!-->±<!--> <!-->16<!--> <!-->beats<!--> <!-->min⁻¹). No differences were observed in perceptual responses among groups.</p></div><div><h3>Conclusion</h3><p>Regardless of the adiposity or aerobic fitness, pubescent girls had similar thermoregulatory and perceptual responses while cycling in the heat at similar metabolic heat production.</p></div>","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 4","pages":"Pages 464-471"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.05.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136905495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannose‐binding lectin gene polymorphism and its effect on short term outcomes in preterm infants","authors":"Pelin Dogan ,&nbsp;Hilal Ozkan ,&nbsp;Nilgun Koksal ,&nbsp;Haluk Barbaros Oral ,&nbsp;Onur Bagci ,&nbsp;Ipek Guney Varal","doi":"10.1016/j.jpedp.2019.05.015","DOIUrl":"https://doi.org/10.1016/j.jpedp.2019.05.015","url":null,"abstract":"<div><h3>Objective</h3><p>Mannose‐binding lectin, which belongs to the collectin family, is an acute‐phase reactant that activates the complement system. This study aimed to investigate the effect of <em>MBL2</em> gene polymorphism on short‐term outcomes in preterm infants.</p></div><div><h3>Method</h3><p>Infants of &lt;37 gestational weeks who were admitted to the neonatal intensive care unit during a two‐year period were enrolled in this prospective study. The neonates were categorized into two groups according to their <em>MBL2</em> genotypes. Normal <em>MBL2</em> genotype was defined as <em>MBL2</em> wild‐type (AA genotype), whereas mutant <em>MBL2</em> genotype was defined as <em>MBL2</em> variant‐type (AO/OO genotype). The relationship between <em>MBL2</em> genotype and short‐term morbidity and mortality was evaluated.</p></div><div><h3>Results</h3><p>During the two‐year study period, 116 preterm infants were enrolled in this study. In <em>MBL2</em> variant‐type, mannose‐binding lectin levels were significantly lower and incidences of mannose‐binding lectin deficiency (MBL level<!--> <!-->&lt;<!--> <!-->700<!--> <!-->ng/mL) were higher (<em>p</em> <!-->&lt;<!--> <!-->0.001). In this group, the prevalence of respiratory distress syndrome and mortality was significantly higher (<em>p</em> <!-->&lt;<!--> <!-->0.001, <em>p</em> <!-->=<!--> <!-->0.03 respectively). In the <em>MBL2</em> wild‐type group, the prevalence of necrotizing enterocolitis (NEC) was higher (<em>p</em> <!-->=<!--> <!-->0.01). Logistic regression analyses revealed that <em>MBL2</em> variant‐type had a significant effect on respiratory distress syndrome development (odds ratio, 5.1; 95% confidence interval, 2.2–11.9; <em>p</em> <!-->&lt;<!--> <!-->0.001).</p></div><div><h3>Conclusions</h3><p><em>MBL2</em> variant‐type and mannose‐binding lectin deficiency are important risk factors for respiratory distress syndrome development in preterm infants. Additionally, there is an association between <em>MBL2</em> wild‐type and NEC. Further studies on this subject are needed.</p></div>","PeriodicalId":100742,"journal":{"name":"Jornal de Pediatria (Vers?o em Português)","volume":"96 4","pages":"Pages 520-526"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jpedp.2019.05.015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136905257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}