JFO Open Ophthalmology最新文献

{"title":"Effects of Sahaj Samadhi Meditation on health-related quality of life of glaucoma patients: A feasibility study","authors":"Monali S. Malvankar-Mehta ,&nbsp;Hyunsoo (Jason) Jang ,&nbsp;Brian Yu ,&nbsp;Cindy Hutnik","doi":"10.1016/j.jfop.2025.100164","DOIUrl":"10.1016/j.jfop.2025.100164","url":null,"abstract":"<div><h3>Background</h3><div>Glaucoma is a leading cause of irreversible blindness, with a growing body of literature linking it to mental disorders. This study aimed to investigate the effects of Sahaj Samadhi Meditation (SSM) on depression, anxiety, sleep quality, and community integration in patients with glaucoma.</div></div><div><h3>Methods</h3><div>A prospective feasibility study was conducted with 28 participants aged 18 and older, including those with mild to severe glaucoma and glaucoma suspects. Participants were divided into two groups: one receiving treatment as usual (TAU) and the other receiving TAU plus Sahaj Samadhi Meditation (SSM). The SSM group participated in a structured 4-day group session and were instructed to meditate regularly on their own. Assessments were conducted on vision-related quality of life (VRQOL), depressive symptoms, anxiety, sleep quality, and community integration at baseline and at the 24-week follow-up. Feasibility outcomes were measured, and statistical analysis was performed using STATA 18.0.</div></div><div><h3>Results</h3><div>The SSM group showed a significant reduction in depression and improvement in sleep quality compared to the control group. Additionally, the SSM group experienced a reduction in anxiety symptoms. However, there were no significant differences in VRQOL, and community integration between the two groups. No adverse effects were reported.</div></div><div><h3>Conclusions</h3><div>SSM may help reduce depressive symptoms and improve sleep quality in glaucoma patients. It may also alleviate anxiety symptoms. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"10 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding previously published articles","authors":"","doi":"10.1016/j.jfop.2025.100165","DOIUrl":"10.1016/j.jfop.2025.100165","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"10 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic neuritis induced by Pembrolizumab treatment for recurrent vulvar cancer","authors":"Ariel Cohen ,&nbsp;Yonah Levy ,&nbsp;Kristy Ward","doi":"10.1016/j.jfop.2025.100162","DOIUrl":"10.1016/j.jfop.2025.100162","url":null,"abstract":"<div><h3>Purpose</h3><div>To describe a novel case of optic neuritis induced after pembrolizumab treatment for recurrent vulvar cancer.</div></div><div><h3>Background</h3><div>Immunotherapy is becoming increasingly important as a therapy for cases of vulvar cancer that are resistant to standard treatment.</div></div><div><h3>Case presentation</h3><div>A 53-year-old female with a history of recurrent vulvar cancer presented with sudden-onset progressive vision loss in both eyes for four weeks. Initially patient was thought to have brain metastases based on imaging, but after a thorough workup, the diagnosis of optic neuritis was made. Pembrolizumab therapy was immediately ceased, and high-dose corticosteroids were used to treat the patient effectively and reverse her symptoms.</div></div><div><h3>Conclusions</h3><div>Several cases of CNS toxicity and optic neuritis have been reported with the use of pembrolizumab immunotherapy but, to our knowledge, this is the first reported case to have occurred in the setting of recurrent vulvar cancer. In these cases it is important to have prompt discontinuation of the offending agent and treatment with high-dose corticosteroid course.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"10 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal innervation and neurotisation: a review of current concepts","authors":"Christian P. Pappas","doi":"10.1016/j.jfop.2025.100163","DOIUrl":"10.1016/j.jfop.2025.100163","url":null,"abstract":"<div><div>The cornea is the most richly innervated tissue within the body, the complexity of which reflects the critical role of visual preservation to survival. Sensation is provided almost solely by innervation of the ophthalmic nerve, where any insult along the afferent sensory pathway may result in the development of neurotrophic keratopathy, a vision-threatening condition. We review the current model of corneal sensory and autonomic innervation and explore the typical aetiologic and pathogenic features of neurotrophic keratopathy. Special attention is given to corneal neurotisation, an effective microsurgical treatment for moderate to severe neurotrophic keratopathy refractory to non-surgical management techniques, and its role in the reinnervation of the asensate cornea by direct or indirect transplantation of healthy nerve tissue.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"10 ","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple stellate keratitis during immune checkpoint inhibitor therapy","authors":"Isana Nakajima,&nbsp;Hideki Tsuji","doi":"10.1016/j.jfop.2025.100157","DOIUrl":"10.1016/j.jfop.2025.100157","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of lymphedema distichiasis syndrome","authors":"Deepsekhar Das,&nbsp;Sahil Agrawal,&nbsp;Manu Muraleekrishna,&nbsp;Poornima Chauhan","doi":"10.1016/j.jfop.2025.100156","DOIUrl":"10.1016/j.jfop.2025.100156","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract co-existing with glaucoma: A case of Klippel-Trénaunay Syndrome","authors":"Shubham Manchanda,&nbsp;Savleen Kaur,&nbsp;Sushmita Kaushik,&nbsp;Jaspreet Sukhija","doi":"10.1016/j.jfop.2025.100158","DOIUrl":"10.1016/j.jfop.2025.100158","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143337609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-nepotism policies and resident selection at Canadian medical schools","authors":"Edsel Ing ,&nbsp;Michael Balas ,&nbsp;Ahmed Al-Asmar","doi":"10.1016/j.jfop.2024.100151","DOIUrl":"10.1016/j.jfop.2024.100151","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term outcomes of angle, filtering, and combined angle and filtering surgery for primary congenital glaucoma","authors":"Nader Bayoumi ,&nbsp;Mahmoud Morsy ,&nbsp;Mohamed Fouad ,&nbsp;Eman Nabil Elsayed","doi":"10.1016/j.jfop.2024.100145","DOIUrl":"10.1016/j.jfop.2024.100145","url":null,"abstract":"<div><h3>Purpose</h3><div>To report on long term follow-up of surgical results in primary congenital glaucoma (PCG).</div></div><div><h3>Study design</h3><div>Retrospective chart review.</div></div><div><h3>Methods</h3><div>The charts of all children presenting with and operated on for PCG in Alexandria Main University Hospital between 2005 and 2013 and completing at least 8 years of follow-up were reviewed. Data extracted included demographic characteristics, prenatal history, glaucoma diagnosis, preoperative, intraoperative and postoperative data. Success was defined as an IOP ≤ 16 mmHg with no vision-threatening complications and no signs of progression (progressive increase in corneal diameter, axial length (AL), or cup/disc (C/D) ratio).</div></div><div><h3>Results</h3><div>The records of 65 eyes of 41 children were reviewed. The mean ± standard deviation of the age at presentation was 5.9 ± 4.1 months and of follow-up was 128.3 ± 18.4 months. The most common presentation was cloudy cornea (53.7%). The total glaucoma surgical procedures were 96 (1.5 ± 0.8 procedures per eye, with 71% undergoing only 1 procedure). The most common initial glaucoma surgery was combined angle and filtering surgery with antimetabolite (56, 86.2%). At the final follow-up, IOP, AL and C/D ratio (12.4 ± 6.1 mmHg, 26.49 ± 3.5 mm and 0.3 ± 0.3) were statistically significantly different from preoperative values (19.0 ± 5.9 mmHg, 22.69 ± 1.86 mm and 0.5 ± 0.3) (p &lt; 0.001, p &lt; 0.001 and p = 0.001 respectively). The mean ± standard deviation best corrected visual acuity (BCVA) was 0.44 ± 0.3 decimal. The BCVA inter-eye difference was &gt;0.2 in 56.25%. The mean ± standard deviation of the Mean Deviation (MD) and Pattern Standard Deviation (PSD) were -5.88 ± 2.9 and 3.22 ± 1.74 dB respectively. At the last follow-up, the success rate was 80%.</div></div><div><h3>Conclusions</h3><div>Combined angle and filtering surgery with antimetabolite was successful for long term control of PCG. Refractive errors and amblyopia occur in over half of the operated eyes.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen boost transepithelial corneal collagen crosslinking: 2-year ultrastructural results","authors":"Valentine Saunier ,&nbsp;Pierre Legout ,&nbsp;Nathalie Thiery ,&nbsp;Pierre Fournie ,&nbsp;David Touboul","doi":"10.1016/j.jfop.2024.100153","DOIUrl":"10.1016/j.jfop.2024.100153","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess ultrastructural corneal changes induced by oxygen boost transepithelial crosslinking (OBXL) and its efficacy at 2 years.</div></div><div><h3>Methods</h3><div>This pilot cohort study was conducted at the French National Reference Keratoconus Center in patients with progressive keratoconus. Corneal transepithelial CXL with an additional source of oxygen delivered through the goggles was performed. All patients who underwent surgery had an evaluation preoperatively, between 1 and 3 mo postoperatively, and at 6, 12 and 24 mo postoperatively.</div><div>Biomechanical (Corvis ST), topographical (CASIA-2), and microstructural changes (using In Vivo Confocal Microscopy and Anterior Segment OCT) following this new technique were assessed. We also evaluated visual acuity and eye rubbing behavior.</div></div><div><h3>Results</h3><div>Ten eyes of ten patients were enrolled, with a mean age of 23.8 ± 4.9 years. A visible demarcation line was observed on AS-OCT with a mean depth of 414 μm ± 80.91 (89 % of the total thickness). We also noticed an anterior hyperreflective band with a mean depth of 214 ± 42.95 μm. At 6, 12 and 24 mo postoperatively, the Kmax, Kmin, Cyl and Corneal Thinnest Point were stable (p &gt; 0.05). At 24 mo, there was significant improvement in BCVA. Compared to baseline, at the first postoperative visit, corneal sub-basal nerve density decreased, and keratocyte apoptosis was observed in all patients. Regarding eye rubbing, the number of patients who rubbed their eyes frequently decreased after CXL.</div></div><div><h3>Conclusion</h3><div>This study confirmed the histological effects of OBXL and a deep corneal interaction that is effective in stabilizing keratoconus.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}