JFO Open Ophthalmology最新文献

{"title":"Oxygen boost transepithelial corneal collagen crosslinking: 2-year ultrastructural results","authors":"Valentine Saunier ,&nbsp;Pierre Legout ,&nbsp;Nathalie Thiery ,&nbsp;Pierre Fournie ,&nbsp;David Touboul","doi":"10.1016/j.jfop.2024.100153","DOIUrl":"10.1016/j.jfop.2024.100153","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess ultrastructural corneal changes induced by oxygen boost transepithelial crosslinking (OBXL) and its efficacy at 2 years.</div></div><div><h3>Methods</h3><div>This pilot cohort study was conducted at the French National Reference Keratoconus Center in patients with progressive keratoconus. Corneal transepithelial CXL with an additional source of oxygen delivered through the goggles was performed. All patients who underwent surgery had an evaluation preoperatively, between 1 and 3 mo postoperatively, and at 6, 12 and 24 mo postoperatively.</div><div>Biomechanical (Corvis ST), topographical (CASIA-2), and microstructural changes (using In Vivo Confocal Microscopy and Anterior Segment OCT) following this new technique were assessed. We also evaluated visual acuity and eye rubbing behavior.</div></div><div><h3>Results</h3><div>Ten eyes of ten patients were enrolled, with a mean age of 23.8 ± 4.9 years. A visible demarcation line was observed on AS-OCT with a mean depth of 414 μm ± 80.91 (89 % of the total thickness). We also noticed an anterior hyperreflective band with a mean depth of 214 ± 42.95 μm. At 6, 12 and 24 mo postoperatively, the Kmax, Kmin, Cyl and Corneal Thinnest Point were stable (p &gt; 0.05). At 24 mo, there was significant improvement in BCVA. Compared to baseline, at the first postoperative visit, corneal sub-basal nerve density decreased, and keratocyte apoptosis was observed in all patients. Regarding eye rubbing, the number of patients who rubbed their eyes frequently decreased after CXL.</div></div><div><h3>Conclusion</h3><div>This study confirmed the histological effects of OBXL and a deep corneal interaction that is effective in stabilizing keratoconus.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement between multimodal imaging in extensive macular atrophy with pseudodrusen: case report","authors":"Marina García-López,&nbsp;Alejandro Alcaide-Costa,&nbsp;Santiago Abengoechea Hernández","doi":"10.1016/j.jfop.2024.100152","DOIUrl":"10.1016/j.jfop.2024.100152","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-nepotism policies and resident selection at Canadian medical schools","authors":"Edsel Ing ,&nbsp;Michael Balas ,&nbsp;Ahmed Al-Asmar","doi":"10.1016/j.jfop.2024.100151","DOIUrl":"10.1016/j.jfop.2024.100151","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating AI-based administrative assistants in Ophthalmology: a path to enhanced practice efficiency","authors":"Mohammad Shayyan Wasim ,&nbsp;Vethushan Ramalingam ,&nbsp;Michael Balas","doi":"10.1016/j.jfop.2024.100150","DOIUrl":"10.1016/j.jfop.2024.100150","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PAX6 related congenital aniridia with normal iris","authors":"Giulia Marchione ,&nbsp;Alejandra Daruich ,&nbsp;Matthieu P. Robert ,&nbsp;Sophie Valleix ,&nbsp;Dominique Bremond-Gignac","doi":"10.1016/j.jfop.2024.100147","DOIUrl":"10.1016/j.jfop.2024.100147","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degenerative myopic foveoschisis with topical intra-ocular pressure lowering medicines as alternative to surgical intervention","authors":"Ali Hadi Al Hassany,&nbsp;Ayad Al-Bermani","doi":"10.1016/j.jfop.2024.100141","DOIUrl":"10.1016/j.jfop.2024.100141","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"8 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shedding light on congenital aniridia: an in-depth study of two cases","authors":"Sara Ben Addou Idrissi,&nbsp;Hassan Moutei,&nbsp;Ahmed Bennis,&nbsp;Fouad Chraibi,&nbsp;Meriem Abdellaoui,&nbsp;Idriss Benatiya Andaloussi","doi":"10.1016/j.jfop.2024.100146","DOIUrl":"10.1016/j.jfop.2024.100146","url":null,"abstract":"<div><div>Congenital aniridia is a rare ocular disorder characterized by the partial or complete absence of iris tissue. Although the classic form is associated with a range of ocular abnormalities, including foveal and optic nerve hypoplasia, nystagmus, and cataracts, it is the onset of glaucoma, cataracts, and keratopathy that most significantly impair vision in affected patients. Typically caused by mutations in the PAX6 gene, which encodes the paired box protein Pax-6, aniridia can also be associated with systemic conditions such as WAGR syndrome. This study emphasizes the importance of comprehensive ophthalmic examination and genetic testing in diagnosing and managing aniridia, particularly when associated with systemic conditions. Multidisciplinary management and regular follow-up are essential to monitor for potential complications, including Wilms' tumor, ensuring optimal care for affected patients.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"8 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term outcomes of angle, filtering, and combined angle and filtering surgery for primary congenital glaucoma","authors":"Nader Bayoumi ,&nbsp;Mahmoud Morsy ,&nbsp;Mohamed Fouad ,&nbsp;Eman Nabil Elsayed","doi":"10.1016/j.jfop.2024.100145","DOIUrl":"10.1016/j.jfop.2024.100145","url":null,"abstract":"<div><h3>Purpose</h3><div>To report on long term follow-up of surgical results in primary congenital glaucoma (PCG).</div></div><div><h3>Study design</h3><div>Retrospective chart review.</div></div><div><h3>Methods</h3><div>The charts of all children presenting with and operated on for PCG in Alexandria Main University Hospital between 2005 and 2013 and completing at least 8 years of follow-up were reviewed. Data extracted included demographic characteristics, prenatal history, glaucoma diagnosis, preoperative, intraoperative and postoperative data. Success was defined as an IOP ≤ 16 mmHg with no vision-threatening complications and no signs of progression (progressive increase in corneal diameter, axial length (AL), or cup/disc (C/D) ratio).</div></div><div><h3>Results</h3><div>The records of 65 eyes of 41 children were reviewed. The mean ± standard deviation of the age at presentation was 5.9 ± 4.1 months and of follow-up was 128.3 ± 18.4 months. The most common presentation was cloudy cornea (53.7%). The total glaucoma surgical procedures were 96 (1.5 ± 0.8 procedures per eye, with 71% undergoing only 1 procedure). The most common initial glaucoma surgery was combined angle and filtering surgery with antimetabolite (56, 86.2%). At the final follow-up, IOP, AL and C/D ratio (12.4 ± 6.1 mmHg, 26.49 ± 3.5 mm and 0.3 ± 0.3) were statistically significantly different from preoperative values (19.0 ± 5.9 mmHg, 22.69 ± 1.86 mm and 0.5 ± 0.3) (p &lt; 0.001, p &lt; 0.001 and p = 0.001 respectively). The mean ± standard deviation best corrected visual acuity (BCVA) was 0.44 ± 0.3 decimal. The BCVA inter-eye difference was &gt;0.2 in 56.25%. The mean ± standard deviation of the Mean Deviation (MD) and Pattern Standard Deviation (PSD) were -5.88 ± 2.9 and 3.22 ± 1.74 dB respectively. At the last follow-up, the success rate was 80%.</div></div><div><h3>Conclusions</h3><div>Combined angle and filtering surgery with antimetabolite was successful for long term control of PCG. Refractive errors and amblyopia occur in over half of the operated eyes.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"9 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography (OCT) and OCT Angiography in Stages 3 and 4 proliferative sickle cell retinopathy","authors":"Ogugua Ndubuisi Okonkwo ,&nbsp;Adekunle Olubola Hassan ,&nbsp;Oyekunle Idris ,&nbsp;Arinze Anthony Onwuegbuna ,&nbsp;Toyin Akanbi ,&nbsp;Chineze Agweye ,&nbsp;Utam Ashibel","doi":"10.1016/j.jfop.2024.100144","DOIUrl":"10.1016/j.jfop.2024.100144","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate macular findings in Goldberg stages 3 and 4 proliferative sickle cell retinopathy (PSCR) using optical coherence tomography (OCT) and OCT Angiography.</div></div><div><h3>Methods</h3><div>A case-control study using retrospective OCT and OCTA data from PSCR eyes (cases) and prospective data from age and sex-matched normal (controls). OCTA data included vessel density (VD) in the superficial capillary vascular plexus (SCP) and deep capillary vascular plexus (DCP), foveal avascular zone (FAZ) characterization, including the shape (in the SCP &amp; DCP), size (area covered), and perimeter. OCT data were whole, superior, and inferior hemi-retina thickness for the superficial and deep retina.</div></div><div><h3>Results</h3><div>There were 38 OCT / OCTA scans of PSCR eyes of 21 SCD patients; ten eyes were excluded for not meeting inclusion criteria. We analyzed nineteen (19) patients (ten unilateral and 9 bilateral), 28 eyes, nine SS eyes (32%), and nineteen SC eyes (68%). The controls consisted of 29 eyes of 16 normal subjects (three unilateral and 13 bilateral). The commonest FAZ shape in PSCR was “irregular” in 14 eyes (50%), followed by “round” in 11 eyes (39.3%) versus controls, the commonest shape “round” in 18 eyes (62%), followed by “irregular” 9 eyes (31%) (p = 0.165). FAZ area and perimeter were larger in PSCR (p &gt; 0.05). The deep and superficial VD was reduced in PSCR. The mean whole deep VD for cases was 48.9 ± 6.1 versus 52.9 ± 6.4 for controls (p = 0.019). Mean whole superficial VD for cases was 47.4 ± 5.5 versus 49.8 ± 3.4 for controls (p = 0.058).</div><div>Retina thickness in the whole, superior and inferior hemi-retina, for superficial and deep retina, was higher in PSCR compared to controls (p &lt; 0.05). Superficial whole thickness for cases and controls were 287.0 μm [IQR 35.3 μm] versus 273.0 μm [IQR 18 μm] respectively (p = 0.008). Deep whole thickness for cases and controls was 287.0 μm [IQR 35.25 μm] versus 273.0 μm [IQR 18 μm] (p = 0.008).</div><div>VD was reduced in SS compared to SC eyes (deep whole VD: 50.28 ± 6.01 vs 46.78 ± 5.80) (p = 0.139). Retina thickness in SS was reduced relative to SC. Peripheral retinal laser photocoagulation did not affect VD, though it was associated with a thinner macula.</div></div><div><h3>Conclusion</h3><div>OCT/OCTA of stage 3 and 4 PSCR revealed reduced VD in the DCP and SCP. Despite the thin temporal retina in SCD, there is a thicker whole, superior, and inferior hemiretina in both the superficial and deep retina. An irregularly shaped FAZ is common, a reflection of abnormal microcapillary loss in the perifoveal area.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"8 ","pages":"Article 100144"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142537122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe ocular involvement in pembrolizumab-aggravated toxic epidermal necrolysis","authors":"Isana Nakajima,&nbsp;Hideki Tsuji","doi":"10.1016/j.jfop.2024.100143","DOIUrl":"10.1016/j.jfop.2024.100143","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"8 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}