JFO Open Ophthalmology最新文献

{"title":"Efficacy and safety of intracameral epinephrine as mydriatic agent in cataract surgery: A systematic review","authors":"Fahad Butt ,&nbsp;Mohamad Tarek Madani ,&nbsp;Salem Abu Al-Burak ,&nbsp;Thanansayan Dhivagaran ,&nbsp;Brendan K. Tao ,&nbsp;Amit Garg ,&nbsp;Cindy Hutnik ,&nbsp;Monali S. Malvankar-Mehta","doi":"10.1016/j.jfop.2025.100169","DOIUrl":"10.1016/j.jfop.2025.100169","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the efficacy, safety, and cost implications of using epinephrine (Epi) as an additive in balanced salt solution (BSS) during cataract surgery, focusing on intraoperative pupil dilation, side effects, and cost considerations.</div></div><div><h3>Methods</h3><div>Searches were conducted across multiple databases, including EMBASE, MEDLINE, CINAHL, and Web of Science, up to October 17, 2024. Eligibility criteria included studies assessing intracameral epinephrine for achieving or maintaining mydriasis, and reporting outcomes related to efficacy, adverse effects, intraoperative complications, and cost implications.</div></div><div><h3>Results</h3><div>Of the 476 articles screened, 23 met the inclusion criteria, involving 4262 cataract surgeries were included. Intracameral epinephrine consistently maintained pupil dilation, with reported average pupil sizes ranging from 6.9 mm to 7.2 mm, significantly reducing the need for additional mechanical dilation interventions (reported incidence &lt;1% in some studies). Its use reduced the incidence of intraoperative floppy iris syndrome (IFIS) in high-risk patients. It minimized complications such as posterior capsular rupture and iris prolapse. Combination therapy with adjunctive agents like NSAIDs or lidocaine further improved dilation stability and reduced intraoperative miosis. Safety data revealed no significant impact on heart rate or blood pressure, demonstrating hemodynamic stability. Cost analyses highlighted savings from reduced surgical times (i.e., ∼13.5 min vs. ∼17.2 min with epinephrine alone) and decreased use of pupil expansion devices, resulting in estimated savings of over $19,000 in high-volume centers.</div></div><div><h3>Conclusion</h3><div>Intracameral epinephrine effectively supports stable pupil dilation and reduces intraoperative complications in cataract surgery. It offers a safe and cost-effective alternative to traditional mydriatic agents, particularly when combined with adjunctive medications. However, given the considerable advancements in surgical techniques over time, caution should be exercised when interpreting findings from earlier studies. Additionally, the cost of epinephrine preparation, alongside its potential endothelial toxicity at higher concentrations, highlights the need for further research into the feasibility of using BSS without epinephrine in routine practice.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"11 ","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of dual ocular toxocariasis in an adult","authors":"Taoufik Abdellaoui ,&nbsp;Adil Bouzidi ,&nbsp;Said Iferkhass ,&nbsp;Aziz EL Ouafi","doi":"10.1016/j.jfop.2025.100179","DOIUrl":"10.1016/j.jfop.2025.100179","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"11 ","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topographic, pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconus","authors":"Rajneesh Dhiman,&nbsp;Barkha Gupta,&nbsp;Arun Kumar Jain,&nbsp;Amit Gup,&nbsp;Jagat Ram,&nbsp;Chintan Malhotra","doi":"10.1016/j.jfop.2024.100126","DOIUrl":"10.1016/j.jfop.2024.100126","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare topographic, pachymetric and epithelial distribution patterns of clinically unaffected fellow eyes of patients with asymmetric keratoconus (AKC) with those of normal controls and keratoconic fellow eyes.</div></div><div><h3>Methods</h3><div>A prospective, observational study was conducted at a tertiary care center, in which twenty-five clinically unaffected fellow eyes in patients with AKC were compared to 25 keratoconic fellow eyes and 67 normal controls. Pachymetric and epithelial thicknesses in the central 2 mm and 8 octants in the 2–5 mm and 5–7 mm zones were compared using Spectral Domain Optical Coherence Tomography (SDOCT). Scheimpflug derived topography was also compared.</div></div><div><h3>Results</h3><div>Mean simulated keratometry of fellow eyes (43.6D ± 1.34 D) was comparable to that of control eyes (43.85D ± 1.57 D) (p &gt; 0.99) and less than that of keratoconic eyes (47.08D ± 4.62 D) (p = 0.004). Central corneal and epithelial thicknesses of fellow eyes (474.28 ± 40.27 μm, 52.76 ± 7.45 μm, respectively) were less than in control eyes (505.97 ± 30.12 μm, 60.48 ± 8.37 μm) (p &lt; 0.001 and p = 0.006, respectively) but comparable to those of keratoconic eyes (470.48 ± 44.19 μm, 52.48 ± 8.00 μm) (p &gt; 0.99). Pachymetric differences of radially opposite octants in the 2–5 mm zone demonstrated thinning in the inferior and inferotemporal octants of fellow eyes which was greater than that seen in control eyes (p = 0.017 and 0.04, respectively)</div></div><div><h3>Conclusion</h3><div>Reduced central epithelial thickness and greater pachymetric differences in radially opposite octants of the mid-peripheral cornea may be suggestive of susceptibility to ectasia despite normal topography.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"11 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of willingness to accept glaucoma surgery among glaucoma patients at a quaternary hospital in Ghana","authors":"Samuel Ira Kuma ,&nbsp;Yaw Akye Essuman ,&nbsp;Benjamin Abaidoo ,&nbsp;Vera Adobea Essuman ,&nbsp;Mildred Johnson ,&nbsp;Naa Naamuah Tagoe","doi":"10.1016/j.jfop.2025.100177","DOIUrl":"10.1016/j.jfop.2025.100177","url":null,"abstract":"<div><h3>Purpose</h3><div>Glaucoma, an optic neuropathy and major cause of avoidable irreversible blindness worldwide, has public health implications for the quality of life of affected individuals. Surgery is usually indicated when medical treatments fail or as primary treatment in severe disease. Anecdotally, willingness to accept glaucoma surgery among patients at the Lions International Eye Centre (LIEC), Korle Bu Teaching Hospital (KBTH) is low. This study thus sought to determine the predictors of willingness to accept glaucoma surgery among glaucoma patients at the LIEC, KBTH.</div></div><div><h3>Materials and methods</h3><div>This was a cross-sectional, hospital-based study among adult patients with glaucoma at the LIEC, KBTH from July 2022 to February 2024. Data were analyzed using SPSS version 26. Descriptive and inferential statistics were performed on the data. P-values &lt;0.05 were considered statistically significant.</div></div><div><h3>Results</h3><div>We included 240 participants, consisting of 122 (50.8%) females and 118 (49.2%) males.</div><div>The majority (180, 75.0%) were aged ≥ 48 years. Ninety-eight (40.8%) had lived with glaucoma for ≥ 5 years. Most participants (149, 62.1%) were willing to accept surgery as a treatment option. Fear of surgery (53, 22.1%) and blindness (50, 20.8%) were reasons provided for non-acceptance of surgery. Educational level, residential area, and family history of glaucoma were associated with knowledge about glaucoma (<em>p</em> &lt; 0.05). Male gender (AOR = 2.0; CI = 1.0−3.3; p = 0.036) and presence of comorbidities (AOR = 0.4; CI = 0.2−0.7; p = 0.002) were predictors of willingness to accept glaucoma surgery.</div></div><div><h3>Conclusions</h3><div>Most glaucoma patients at the Korle Bu Teaching Hospital were willing to accept glaucoma surgery. Male gender and presence of comorbidities predicted willingness to accept glaucoma surgery. Consequently, there is a need for increased education on the necessity of glaucoma surgery.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"11 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal Stivant® (a biosimilar to bevacizumab) alone versus combined with triamcinolone in center-involved diabetic macular edema","authors":"Arash Daneshtalab ,&nbsp;Meysam Shekofteh ,&nbsp;Hesam Fat’hi-zadeh ,&nbsp;Mohammad Taher Rajabi ,&nbsp;Seyed Mohsen Rafizadeh ,&nbsp;Amirhossein Aghajani ,&nbsp;Shaghayegh Esfandiarifard ,&nbsp;Zahra Akbari ,&nbsp;Mahsa Sardarinia ,&nbsp;Kaveh Jamalipour Soufi ,&nbsp;Amin Zand","doi":"10.1016/j.jfop.2025.100173","DOIUrl":"10.1016/j.jfop.2025.100173","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the effects of intravitreal Stivant® (a biosimilar to bevacizumab) alone and in combination with triamcinolone acetonide in center-involved diabetic macular edema (DME).</div></div><div><h3>Methods</h3><div>In this randomized controlled study, patients with center-involved DME (central macular thickness [CMT] &gt; 300 μm) were assigned to receive either intravitreal Stivant® 1.25 mg alone (IVS group) or in combination with triamcinolone acetonide 1 mg (IVST group). The regimen consisted of injections every 4 weeks, administered three times. Changes in best-corrected visual acuity (BCVA) and CMT from baseline to follow-up visits were compared between the groups.</div></div><div><h3>Results</h3><div>Of the 140 enrolled participants, 70 eyes of 70 patients were assigned to each group. By week 12, both groups showed improvements in BCVA and CMT compared to baseline values (<em>P</em>s &lt; 0.001). BCVA (in logarithm of the minimum angle of resolution [logMAR] scale) improved more in the IVST group (0.75 ± 0.62 logMAR) compared to the IVS group (0.92 ± 0.93 logMAR, <em>P</em> &lt; 0.001) at week 4. However, by week 12, BCVA did not differ between the two groups (<em>P</em> = 0.089). Similarly, although the IVST group demonstrated a higher reduction in mean CMT (−143.40 ± 58.28 μm) compared to the IVS group (−92.19 ± 52.31 μm, <em>P</em> &lt; 0.001) at week 4, this effect did not persist at the next follow-up visits.</div></div><div><h3>Conclusion</h3><div>In eyes with center-involved DME, IVST is more effective in reducing CMT and improving BCVA than IVS up to 1 month, but this superiority does not persist over time.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"11 ","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal foreign body: Management and clinical simulation training","authors":"Gilles Terlonge,&nbsp;Allison Gilbert,&nbsp;Alexandre Ghuysen","doi":"10.1016/j.jfop.2025.100172","DOIUrl":"10.1016/j.jfop.2025.100172","url":null,"abstract":"<div><div>For patients with eye injuries, especially corneal foreign bodies, care pathways may vary depending on many circumstances. Mild cases can progress rapidly within hours and threaten the functional prognosis. Various clinical practitioners may be consulted for urgent care in this context. Each provider will propose specific care according to their resources and level of specialization. A well-codified management strategy and adequate training of healthcare providers might ensure improved standards of care for patients. Several classification tools for corneal foreign bodies are available. Removal is the mainstay of treatment, and several techniques are described, particularly in cases of metallic foreign bodies. The use of slit-lamp magnification should be considered in most cases. Various clinical simulation models have already been tested. We present herein an original model that takes advantage of affordability and realistic visual and tactile feedback, as well as innovative early recognition of iatrogenic corneal perforation and realistic interference from the upper eyelid.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"11 ","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-life evaluation of the home vision monitoring application Odysight® in primary and secondary prevention of exudative maculopathies","authors":"Auberie Bonjean ,&nbsp;Mathieu Lehmann ,&nbsp;Laura Moyal ,&nbsp;Pascale Massin ,&nbsp;Bénédicte Dupas","doi":"10.1016/j.jfop.2025.100166","DOIUrl":"10.1016/j.jfop.2025.100166","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the performance of the Odysight® self-monitoring tool for primary and secondary prevention of exudative maculopathies.</div></div><div><h3>Methods</h3><div>A one-year retrospective evaluation was conducted in a private practice. An alert was considered significant (SA) when patient was symptomatic, and non significant (NSA) when the patient was asymptomatic and the VA drop was refuted by an additional test carried out the next day.</div></div><div><h3>Results</h3><div>Of the 92 patients who received a prescription, 44 (48%) downloaded and used the application and were analyzed. At the end of the year, there were 24 (55.8%) active patients. 29 alerts were generated, 13 were considered as NSA, and no anticipated appointment was given. The remaining 16 alerts were SA, 6 (21%) of them were true positive, i.e, revelealed a disease activity on OCT, leading to anticipated injection (representing 9.3% of the patients). 83% of the true positive alerts were generated by eyes with retinal vein occlusion (RVO). Eleven false negative events occurred (6 (55%) for AMD, 4 (36%) for RVO, 1 (9%) for myopic MNV). No primary exudation occured, although 7 false positive alerts were generated. The overall sensitivity of alerts for detecting OCT recurrence was 35.3% (95% CI [12.6; 58]), specificity was 93% (95% CI [90.3; 95.8]), positive predictive value was 20.7% (95% CI [6; 35.7]), and negative predictive value was 96.5% (95% CI [94.5; 98.6]). Sensitivity was higher for RVO (55.6% (95% CI [26.7; 81.1]) than for AMD (14.3% (95% CI [2.6; 51.3]).</div></div><div><h3>Conclusion</h3><div>In this real-life experimentation of Odysight, half of the patients used the application after initial prescription. Participation was low among diabetics. Odysight® allowed about 10% of the cohort to receive earlier intravitreal injection, albeit with a high number of false positives. Sensitivity was low in secondary prevention for AMD, and better for patients with RVO. Additional use in primary prevention may be questionable.</div></div>","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"10 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitreous hemorrhage complicating toxoplasmic retinochoroiditis in a child: Case report","authors":"Mahjoub Ahmed ,&nbsp;Nesrine Zaafrane ,&nbsp;Marouane Harrath ,&nbsp;Ilhem Sellem ,&nbsp;Mohamed Mahmoudi ,&nbsp;Skander Soudani ,&nbsp;Amira Atig ,&nbsp;Mohamed Ghorbel ,&nbsp;Nadia Ben Abdesslem","doi":"10.1016/j.jfop.2025.100161","DOIUrl":"10.1016/j.jfop.2025.100161","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"10 ","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging of morning glory disc anomaly: Report of two cases","authors":"Ahmed Mahjoub ,&nbsp;Chaima Mefteh ,&nbsp;Ilhem Sellem ,&nbsp;Nesrine Zaafrane ,&nbsp;Sarra El Mansouri ,&nbsp;Skander Soudani ,&nbsp;Aymen Mabrouk ,&nbsp;Amira Atig ,&nbsp;Mohamed Ghorbel ,&nbsp;Nadia Ben Abdesslem","doi":"10.1016/j.jfop.2025.100167","DOIUrl":"10.1016/j.jfop.2025.100167","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"10 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired lens coloboma following iridectomy","authors":"Arnav Panigrahi,&nbsp;Shikha Gupta,&nbsp;Viney Gupta","doi":"10.1016/j.jfop.2024.100128","DOIUrl":"10.1016/j.jfop.2024.100128","url":null,"abstract":"","PeriodicalId":100740,"journal":{"name":"JFO Open Ophthalmology","volume":"10 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}