iLIVER最新文献

{"title":"The analysis of the adherence of liver transplant recipients to immunosuppressant treatment, their self-control, and self-management in the post-transplantation period","authors":"Fadime Çınar ,&nbsp;Semra Bulbuloglu","doi":"10.1016/j.iliver.2023.05.001","DOIUrl":"https://doi.org/10.1016/j.iliver.2023.05.001","url":null,"abstract":"<div><h3>Background and amis</h3><p>In our study, it was aimed to investigate the adherence of liver transplant recipients to immunosuppressant therapy, their self-control, and their self-management in the post-transplantation period.</p></div><div><h3>Methods</h3><p>The sample of this descriptive and cross-sectional study was composed of liver transplant recipients. The personal information form, Immunosuppressant Therapy Adherence Scale, and the Liver Self-Control and Self-Management Scale were used to collect data, and descriptive statistical methods, independent samples t-test and one-way analysis of variance analysis was used to analyze the collected data.</p></div><div><h3>Results</h3><p>In light of the data collected in this study, it was identified that, of all recipients, 73.6% were 45–64 years old, 72.5% were male, 25.2% were workers, and 44.6% had equivalent income and expenses. It was observed that the recipients did not fully adhere to the immunosuppressant therapy regimen, and their self-control and self-management levels were below the medium level.</p></div><div><h3>Conclusion</h3><p>The social support system of liver transplant recipients is very important. Recipients with a good social support system can receive caregiver support from their relatives, thereby supporting their self-control and self-management. Both liver transplant patients and the people providing care to them should be simultaneously provided with training programs and given information, and both groups should be supported in treatment and care processes.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 2","pages":"Pages 97-102"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49735245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered expression in liver cancer with various hepatic blood flow occlusions: A pilot RNA sequencing study","authors":"Xuning Wang ,&nbsp;Lili Zhang ,&nbsp;Maolin Xu ,&nbsp;Bin Shi","doi":"10.1016/j.iliver.2023.04.001","DOIUrl":"https://doi.org/10.1016/j.iliver.2023.04.001","url":null,"abstract":"<div><h3>Background and aims</h3><p>Hepatocellular carcinoma is one of the most common cancers worldwide. Previous studies have reported he influence of various hepatic blood flow occlusions on tumor behavior, which is mainly mediated by liver ischemia-reperfusion. Although some genes and pathways have been determined, the whole transcriptome after various hepatic blood flow occlusions is lacking.</p></div><div><h3>Methods</h3><p>We systematically explored transcriptome changes after various hepatic blood flow occlusions, including sham operation (SO; <em>n</em> = 10), occlusion of the portal triad (OPT; <em>n</em> = 10), and occlusion of the portal vein (OPV; <em>n</em> = 10), by RNA-sequencing.</p></div><div><h3>Results</h3><p>HE sections and TUNEL assays showed different liver injury among groups. We identified the top altered genes and pathways. Compared with the SO group, 96 genes were altered in OPV, with 81 upregulated and 15 downregulated genes. The top 5 upregulated genes were <em>Pdk4</em>, <em>Serpina12</em>, <em>Depp1</em>, <em>Igfbp1</em>, and <em>Mup22</em>. The top 5 downregulated genes were <em>Sprr1a</em>, <em>Serpinb2</em>, <em>Tnc</em>, <em>Cdkn3</em>, and <em>Cenpu</em>. Compared with the SO group, there were 20 differentially expressed genes in OPT, with 18 upregulated and 2 downregulated genes. The top 5 upregulated genes were <em>C7</em>, <em>Zbtb16</em>, <em>Gabrp</em>, <em>Pdk4</em>, and <em>Mmrn1</em>. The top 2 downregulated genes were <em>Krt20</em> and <em>Sis</em>. Compared with the OPV group, 72 differentially expressed genes were in OPT, with 39 upregulated and 33 downregulated genes. The top 5 upregulated genes were <em>Hspa1b</em>, <em>Hbb-bs</em>, <em>Phf19</em>, <em>Ddias</em>, and <em>Rad54b</em>. The top 5 downregulated genes were <em>Cish</em>, <em>Socs2</em>, <em>Slc25a30</em>, <em>Rgs3</em>, and <em>Hsd3b5</em>.</p></div><div><h3>Conclusion</h3><p>Various surgical methods have an obvious influence on the transcriptome of tumors.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 2","pages":"Pages 103-108"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and complications of transarterial chemoembolization alone or in combination with different protocols for hepatocellular carcinoma: A Bayesian network meta-analysis of randomized controlled trials","authors":"Jingxin Yan ,&nbsp;Manjun Deng ,&nbsp;Ting Li ,&nbsp;Changhao Dong ,&nbsp;Minglan Wang ,&nbsp;Shunyu Kong ,&nbsp;Yingxing Guo ,&nbsp;Haining Fan","doi":"10.1016/j.iliver.2023.03.002","DOIUrl":"https://doi.org/10.1016/j.iliver.2023.03.002","url":null,"abstract":"<div><h3>Background and aims</h3><p>Transarterial chemoembolization (TACE) is the standard treatment for most intermediate-to-advanced stage hepatocellular carcinoma. With the ongoing development of interventional therapies, TACE in combination with different protocols is being explored. A network meta-analysis to collect recent evidence in this field is required.</p></div><div><h3>Methods</h3><p>We searched PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Embase, Chinese National Knowledge Infrastructure database, Cochrane Library, and Wanfang database from their inception to May 2022 for randomized controlled trials (RCTs) that reported TACE in combination with different protocols for hepatocellular carcinoma.</p></div><div><h3>Results</h3><p>In total, 67 RCTs assessing eight combination treatments were included. The quality of primary outcomes was from moderate to low. The Bayesian network meta-analysis confirmed that TACE combined with iodine-125 seed implantation had the highest probability of 1-year survival rate and TACE combined with sorafenib had the highest probability of 2-year survival rate. TACE alone had the highest probability of incidence of fever, TACE combined with sorafenib had the highest probability of incidence of pain and TACE combined with percutaneous ethanol injection had the highest probability of incidence of nausea and vomiting.</p></div><div><h3>Conclusion</h3><p>This Bayesian network meta-analysis found that TACE combined with iodine-125 seed and TACE combined with sorafenib may benefit patients in terms of 1-year survival and 2-year survival, respectively. To confirm this conclusion, high-quality and well-designed RCTs with a larger sample size are needed.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 2","pages":"Pages 130-141"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The transjugular intrahepatic portosystemic shunt: Smaller stent diameters are required to optimize pressure response","authors":"Martin Rössle ,&nbsp;Dominik Bettinger ,&nbsp;Robert Thimme ,&nbsp;Michael Schultheiss","doi":"10.1016/j.iliver.2023.05.004","DOIUrl":"https://doi.org/10.1016/j.iliver.2023.05.004","url":null,"abstract":"<div><h3>Background and aims</h3><p>The present treatment goal of the transjugular intrahepatic portosystemic shunt (TIPS) is a portosystemic pressure gradient of ≤12 mmHg or its reduction by &gt;50%. This study relates the stent diameter to the reduction of the pressure gradient and attempts to predict the appropriate stent diameter necessary to reach the treatment goal.</p></div><div><h3>Methods</h3><p>Pressure response, super response, and poor response were investigated in 208 de-novo TIPS patients and defined as post-TIPS gradients between &gt;6 and 12 mmHg, ≤6 mmHg, or not reaching the goal (&gt;12 mmHg, reduction &lt;50%), respectively. Pressures were related to the smallest stent diameters measured by planimetry of the radiographic image.</p></div><div><h3>Results</h3><p>Responders (65%), super responders (26%), or poor responders (9%) had comparable stent diameters of 7.2 ± 1.0 mm, but different post-TIPS gradients (9.7 ± 1.9 mmHg, 4.5 ± 1.5 mmHg, and 14.2 ± 1.4 mmHg, <em>p</em> &lt; 0.001), relative reduction of pre-TIPS gradients (51.7 ± 11.4%, 73.6 ± 11.1%, and 34.0 ± 9.1%, <em>p</em> &lt; 0.001), and specific reduction per mm of stent diameter (7.5 ± 2.0%/mm, 10.1 ± 2.0%/mm, and 4.8 ± 1.4%/mm, <em>p</em> &lt; 0.001). Prediction of the stent diameter required to reach response was not possible. Only two super responders had a stent diameter of &lt;6 mm. Super and poor responders differed by the increase in the right atrial pressure (+5.0 mmHg vs. +3.1 mmHg, <em>p</em> = 0.026) and reduction in the portal vein pressure (−8.6 mmHg vs. −4.6 mmHg, <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Most patients reached the treatment goal with stent diameters of &lt;8 mm. Overtreatment (super response, gradient ≤6 mmHg) can be prevented by stent diameters as small as 6 mm. The individual response was not related to the stent diameter and not predictable. Cardiac dysfunction may play an important role by its effect on the right atrial (preload) and portal pressure (afterload).</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 2","pages":"Pages 89-96"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of surgical application of the ligamentum teres hepatis: a review","authors":"Yibulayin Aini ,&nbsp;Tiemin Jiang ,&nbsp;Hao Wen","doi":"10.1016/j.iliver.2023.01.005","DOIUrl":"https://doi.org/10.1016/j.iliver.2023.01.005","url":null,"abstract":"<div><p>Ligamentum teres hepatis (LTH), a normal anatomical tissue in the liver, is frequently observed during abdominal surgery. Its unique positional and structural characteristics give it a wide range of potential clinical applications, including but not limited to repairing peptic perforation, preventing hemorrhage, treating hiatal hernia, and strengthening the biliary/pancreatic intestine anastomosis to prevent biliary and pancreatic leak. The current review summarizes kinds of methods of using LTH in abdominal surgery, especially some new clinical applications in recent years, involving various organs and fields. At the same time, domestic and foreign literature and research in the past five years are cited to demonstrate the feasibility of these applications. This review may guide surgeons to think and explore more new applications of LTH in all surgery fields.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 1","pages":"Pages 50-55"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of perceived stress and psychological well-being in liver recipients having immunosuppressive therapy","authors":"Semra Bulbuloglu ,&nbsp;Pınar Harmanci ,&nbsp;Fatma Eti Aslan","doi":"10.1016/j.iliver.2023.01.001","DOIUrl":"https://doi.org/10.1016/j.iliver.2023.01.001","url":null,"abstract":"<div><h3>Background and aims</h3><p>In this study, the relationship between perceived stress and psychological well-being was analyzed in liver transplant recipients having immunosuppressive therapy.</p></div><div><h3>Methods</h3><p>This study was performed as descriptive research with 134 patients who had liver transplantation at the organ transplantation institute of a training and research hospital (<em>n</em> = 134). The Perceived Stress Scale and the Psychological Well-Being Scale were used for the data collection. The research data were analyzed by using the Statistical Package for Social Science 25.0.</p></div><div><h3>Results</h3><p>Of all participant liver transplant recipients, 22.4% were aged 18–27 years and 48–57 years and 80.6% were males. Besides, the participant liver transplant recipients used immunosuppressive drugs such as prednisolone (92.53%), tacrolimus (61.9%), and mycophenolate mofetil (52.98%). It was found that there was a statistically significant relationship between psychological well-being and perceived stress.</p></div><div><h3>Conclusion</h3><p>In this study, it was discerned that perceived stress affected psychological well-being negatively. It is of importance to realize the stress experienced by liver transplant recipients and enhance their psychological well-being. In the process following transplant surgery, the liver transplant recipients should be carefully followed and efforts to improve patient outcomes should be made.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 1","pages":"Pages 10-15"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free fatty acid-induced miR-22 inhibits gluconeogenesis via SIRT-1-mediated PGC-1α expression in nonalcoholic fatty liver disease","authors":"Ajay K. Yadav ,&nbsp;Teja Naveen Sata ,&nbsp;Daksh Verma ,&nbsp;Amrendra K. Sah ,&nbsp;Amit K. Mishra ,&nbsp;Mrinalini ,&nbsp;Md. Musa Hossain ,&nbsp;Kishor Pant ,&nbsp;Senthil K. Venugopal","doi":"10.1016/j.iliver.2023.01.002","DOIUrl":"https://doi.org/10.1016/j.iliver.2023.01.002","url":null,"abstract":"<div><h3>Background and aims</h3><p>Free fatty acids (FFAs) are one of the important regulators of the progression of nonalcoholic fatty liver disease. The FFAs are shown to modulate the metabolic status of the liver by modulating several cellular pathways in hepatocytes. Here, we elucidated the role of miR-22 in modulating FFAs-mediated gluconeogenesis.</p></div><div><h3>Methods</h3><p>Huh7 and WRL68 cells were transfected with nonspecific miRNA, miR-22 premiRs or anti-miR-22 oligos followed by incubation with palmitic acid, oleic acid, and linoleic acid (300 μM each) for 48 and 72 h after transfection. The expression of miR-22 was performed using real-time polymerase chain reaction and Western blots were performed for SIRT-1, PGC-1α, PEPCK, and glucose-6-phosphatase. Three groups of C57BL/6 mice (6 mice per group) were fed with standard diet, choline sufficient <span>l</span>-amino acid defined diet or choline-deficient <span>l</span>-amino acid defined (CDAA) diet for 6, 18, 32, or 54 weeks. Triglycerides content was measured in the serum. Expression of miR-22 and the protein expression of gluconeogenic enzymes were analyzed in the tissue samples.</p></div><div><h3>Results</h3><p>Incubation of miR-22-transfected cells with FFAs inhibited the expression of SIRT-1, PGC-1α, PEPCK, and glucose-6-phosphatase, while miR-22 expression was increased. These changes were reversed when the cells were transfected with anti-miR-22 oligos. CDAA-fed mice showed the significant increase in triglycerides content and miR-22 expression, while there was an inhibition of SIRT-1, PGC-1α, PEPCK, and glucose-6-phosphatase expression in CDAA-fed mice.</p></div><div><h3>Conclusions</h3><p>These data confirm that FFAs inhibited gluconeogenesis via miR-22-mediated inhibition of SIRT-1, which in turn inhibited PGC-1α in hepatic cells.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 1","pages":"Pages 1-9"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular Carcinoma Gene Expression: The New Era, Where It goes?","authors":"Nourhan Badwei","doi":"10.1016/j.iliver.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.iliver.2022.12.001","url":null,"abstract":"<div><p>Hepatocellular carcinoma is known to be a common primary liver malignancy and a serious leading cause of cancer-related mortality globally. Hence, ongoing recent advances in the genetic field regarding hepatocellular carcinoma paid researchers great attention to identifying various biomarkers to act as diagnostic and prognostic tools for the early detection of hepatocellular carcinoma and also developing targeted therapeutic agents that are indicated and available for advanced stages of hepatocellular carcinomas, however, their antitumor efficacy remains limited and under investigations. Therefore, our review summarized the genetic studies of liver cancer focusing on the somatic mutations, copy number variations, and epigenetic modifications that represent early alterations and oncodrivers in hepatocarcinogenesis, Moreover, the identification of genetic signatures and proteomic targets through hepatocellular carcinoma-related genome-wide screening, to show the ongoing clinical application of such analysis to facilitate diagnosis, prognosis and management of patients with hepatocellular carcinoma for a better outcome.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 1","pages":"Pages 36-40"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49735243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of biological big data and radiomics in hepatocellular carcinoma","authors":"Guoxu Fang ,&nbsp;Jianhui Fan ,&nbsp;Zongren Ding ,&nbsp;Yongyi Zeng","doi":"10.1016/j.iliver.2023.01.003","DOIUrl":"https://doi.org/10.1016/j.iliver.2023.01.003","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC), one of the most common gastrointestinal cancers, has been considered a worldwide threat due to its high incidence and poor prognosis. In recent years, with the continuous emergence and promotion of new sequencing technologies in omics, genomics, transcriptomics, proteomics, and liquid biopsy are used to assess HCC heterogeneity from different perspectives and become a hotspot in the field of tumor precision medicine. In addition, with the continuous improvement of machine learning algorithms and deep learning algorithms, radiomics has made great progress in the field of ultrasound, CT and MRI for HCC. This article mainly reviews the research progress of biological big data and radiomics in HCC, and it provides new methods and ideas for the diagnosis, prognosis, and therapy of HCC.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 1","pages":"Pages 41-49"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A high level of secreted phosphoprotein 1 is associated with macrophage infiltration and poor prognosis in hepatocellular carcinoma","authors":"Jianping Song ,&nbsp;Jingxian Sun ,&nbsp;Shuhong Jing ,&nbsp;Tingxiao Zhang ,&nbsp;Jianlei Wang ,&nbsp;Yanfeng Liu","doi":"10.1016/j.iliver.2023.01.004","DOIUrl":"https://doi.org/10.1016/j.iliver.2023.01.004","url":null,"abstract":"<div><h3>Background and aims</h3><p>Secreted phosphoprotein 1 (<em>SPP1</em>) functions in several physiological processes. The role of SPP1 expression in the prognosis and tumor immunity of hepatocellular carcinoma (HCC) is unknown. The aim of this study was to investigate the expression pattern of SPP1 in HCC and its correlation with prognosis and tumor immunity.</p></div><div><h3>Methods</h3><p>Clinical and gene expression data of The Cancer Genome Atlas-liver hepatocellular carcinoma (LIHC) cohort and 11 other HCC datasets were collected. The Kaplan–Meier method and Cox regression analysis were used to analyze the prognostic value of <em>SPP1</em>. The DESeq2 package in R was used to analyze <em>SPP1</em>-related genes. Gene Ontology analysis and gene set enrichment analysis were used to determine the biological function of <em>SPP1</em> in HCC. The single sample Gene Set Enrichment Analysis (ssGSEA) method was used to analyze the immune infiltrates of HCC. Illumina human methylation 450 data and level 3 HTSeq-FPKM data from The Cancer Genome Atlas-LIHC were used to analyze the effects of DNA methylation level on <em>SPP1</em> expression.</p></div><div><h3>Results</h3><p><em>SPP1</em> was overexpressed in HCC and correlated with T stage, histological grade, adjacent hepatic tissue inflammation, and vascular invasion in HCC. The analysis of survival rates indicated that high <em>SPP1</em> levels were associated with poor overall survival in HCC. Functional analysis showed that <em>SPP1</em> is related to tumor immunity, especially macrophage infiltration. Aberrant demethylation of the promoter region is one of the mechanisms underlying the increase of <em>SPP1</em> in HCC.</p></div><div><h3>Conclusion</h3><p>Our results indicate that <em>SPP1</em> is an independent prognostic factor for HCC and is correlated with the clinical features and macrophage infiltration in HCC.</p></div>","PeriodicalId":100657,"journal":{"name":"iLIVER","volume":"2 1","pages":"Pages 26-35"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49717370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}