Human Pathology Reports最新文献_第2页

Updates and challenges in diagnostic cytopathology: Exploring current advances and future perspectives 诊断细胞病理学的最新进展和挑战：探索当前的进展和未来的观点

Human Pathology Reports Pub Date : 2024-11-01 DOI: 10.1016/j.hpr.2024.300757

Xiaoying Liu, Xin Jing, Zhongren Zhou

引用次数: 0

Between ‘NET’ and ‘CoGNET’: A biphasic Neuroendocrine-Gangliocytic tumor of the pancreas 介于 "NET "和 "CoGNET "之间：胰腺双相神经内分泌-神经节细胞肿瘤

Human Pathology Reports Pub Date : 2024-10-08 DOI: 10.1016/j.hpr.2024.300763

Binny Khandakar , Moreen Ng , Laura Baum , Marie E. Robert

{"title":"Between ‘NET’ and ‘CoGNET’: A biphasic Neuroendocrine-Gangliocytic tumor of the pancreas","authors":"Binny Khandakar , Moreen Ng , Laura Baum , Marie E. Robert","doi":"10.1016/j.hpr.2024.300763","DOIUrl":"10.1016/j.hpr.2024.300763","url":null,"abstract":"<div><div>While neuroendocrine tumors of the pancreas are increasing in incidence, neural derived tumors are only rarely found in this organ. Paragangliomas, neuronal and nerve sheath tumors of the pancreas are limited to small series or case reports. The newly named composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET), formerly gangliocytic paraganglioma, occurs almost exclusively in the second part of the duodenum and periampullary region but has been reported in the pancreas. At the time of this writing four pancreatic CoGNETs have been reported in the pancreatic head, ranging in size from 2.2 to 5.3 cm; three in females, with a mean age of 63 years (range, 50–74 years). Herein, we report the clinico-pathologic findings of a 58-year-old male presenting with a low-grade neuroendocrine tumor showing focal gangliocytic differentiation within the head of pancreas that does not fit precisely into existing tumor classifications, having some but not all elements of CoGNET. The morphology and immunohistochemical profile of the tumor are presented in the context of the differential diagnosis and prior literature.</div></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"38 ","pages":"Article 300763"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of hematological parameters among smokers and nonsmokers in Basra city, Iraq 伊拉克巴士拉市吸烟者与非吸烟者血液学参数比较研究

Human Pathology Reports Pub Date : 2024-09-17 DOI: 10.1016/j.hpr.2024.300762

Safa Mohammed Hussein, Huda Hasan Aziz, Wurood Hameed Abed, Kadhim Fadhil Kadhim

{"title":"Comparative study of hematological parameters among smokers and nonsmokers in Basra city, Iraq","authors":"Safa Mohammed Hussein, Huda Hasan Aziz, Wurood Hameed Abed, Kadhim Fadhil Kadhim","doi":"10.1016/j.hpr.2024.300762","DOIUrl":"10.1016/j.hpr.2024.300762","url":null,"abstract":"<div><h3>Background</h3><p>Hematological parameters are significantly affected by both immediate and prolonged exposure to smoking. The objective of this investigation is to evaluate the influence of cigarette smoking on hematological parameters among male students enrolled at Basrah University in Iraq.</p></div><div><h3>Methods</h3><p>The study comprised a total of seventy male participants, divided into two groups: smokers (n = 35) and nonsmokers (n = 35). Each participant provided a 5 ml venous blood sample to analyze the complete blood count using a hematology analyzer (Spinreact, Spincell 3).</p></div><div><h3>Results</h3><p>Cigarette smokers exhibit notably elevated levels of Red Blood Cells (RBC) counts, Hemoglobin (HGB), Red Cell Distribution Width-CV (RDW-CV), granulocytes%, and platelets%, whereas Mean Corpuscular Volume (MCV) and lymphocytes% are notably lower among smokers. On the other hand, Hematocrit percentage (HCT), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), and White Blood Cells (WBC) counts show no significant difference between cigarette smokers and nonsmokers. In contrast, Red Cell Distribution Width-SD (RDW-SD), Mid-range cell percentage (MID%), Mean Platelet Volume (MPV), Distribution Width (PDW), Platelet Plateletcrit percentage (PCT), Platelet-Lymphocyte Cell Ratio (P_LCR) and Platelet-Lymphocyte Cell Count (P_LCC) demonstrate no substantial variance between the two groups at the statistical significance threshold.</p></div><div><h3>Conclusion</h3><p>This investigation concludes that tobacco cigarette smoking leads to detrimental alterations in hematological parameters, posing health risks.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"38 ","pages":"Article 300762"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000343/pdfft?md5=8d0ae631b7e687a2a514bc1ef9c7b3db&pid=1-s2.0-S2772736X24000343-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First description of a primary SMARCA4-deficient carcinoma of the salivary glands 首次描述原发性 SMARCA4 缺失的唾液腺癌

Human Pathology Reports Pub Date : 2024-09-10 DOI: 10.1016/j.hpr.2024.300761

David Oestreicher , Irina Kostyuchek , Philipp Ströbel , Dirk Beutner , Tobias Dombrowski

{"title":"First description of a primary SMARCA4-deficient carcinoma of the salivary glands","authors":"David Oestreicher , Irina Kostyuchek , Philipp Ströbel , Dirk Beutner , Tobias Dombrowski","doi":"10.1016/j.hpr.2024.300761","DOIUrl":"10.1016/j.hpr.2024.300761","url":null,"abstract":"<div><p>SMARCA4-deficient neoplasms have been identified in several organs, including the lung, thorax, esophagus and ovary. In some cases, SMARCA4-deficient neoplasms are associated with specific histologic subtypes, such as small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). These tumors are often high-grade and aggressive, with a propensity for early metastasis and poor prognosis. SMARCA4 (also known as BRG1) is a chromatin-remodeling protein that plays an important role in gene expression regulation. SMARCA4 loss results in altered expression of cell cycle regulators and DNA damage response genes, leading to genomic instability and oncogenesis. We describe the first clinical case of a SMARCA4-deficient carcinoma of the salivary glands, found in a rapidly growing parotid lesion<u>.</u> Initially, the tumor had ipsilateral cervical lymph node metastases without any distant metastases. After tumor surgery with total parotidectomy and neck dissection on the left side, adjuvant radiotherapy was performed. Shortly after completion of radiotherapy, re-staging by a CT scan showed metastases at multiple sites. Immunotherapy with a PDL1 inhibitor and additional palliative radiotherapy for the bony metastases was then initiated.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"38 ","pages":"Article 300761"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000331/pdfft?md5=575807af1b90e6856858c6708552dbc8&pid=1-s2.0-S2772736X24000331-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of Urinothorax: A rare Complication of Percutaneous nephrolithotomy and literature review 尿气胸的诊断：经皮肾取石术的罕见并发症及文献综述

Human Pathology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.hpr.2024.300760

Chiara Cocelli , Shuyue Ren

引用次数: 0

Spinal cord findings in a long-term survivor of Duchenne muscular dystrophy 一名杜兴氏肌肉萎缩症长期存活者的脊髓检查结果

Human Pathology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.hpr.2024.300759

Ruruka Imaizumi , Tomoko Yamamoto , Kenta Masui , Keiko Ishigaki , Takatoshi Sato , Terumi Murakami , Minobu Shichiji , Kumiko Ishiguro , Atsushi Kurata

{"title":"Spinal cord findings in a long-term survivor of Duchenne muscular dystrophy","authors":"Ruruka Imaizumi , Tomoko Yamamoto , Kenta Masui , Keiko Ishigaki , Takatoshi Sato , Terumi Murakami , Minobu Shichiji , Kumiko Ishiguro , Atsushi Kurata","doi":"10.1016/j.hpr.2024.300759","DOIUrl":"10.1016/j.hpr.2024.300759","url":null,"abstract":"<div><p>Duchenne muscular dystrophy (DMD) is the most common type of muscular dystrophy, but the spinal cord is rarely examined. Here we report a case of DMD with interesting spinal cord findings. In a 37-year-old man with DMD accompanied by hypoxic encephalopathy from the age of 32 years, autopsy showed amyotrophic lateral sclerosis-like pyramidal tract degeneration over the entire spinal cord, presumably due to hypoxic encephalopathy. Furthermore, anterior horn cells exhibited Wallerian degeneration-like changes. To investigate more about the pathogenesis, an immunohistochemical study using anti-synaptophysin, glutamic acid decarboxylase (GAD), postsynaptic density protein-95 (PSD-95) and choline acetyltransferase (ChAT) antibodies was performed. Immunostaining for synaptophysin showed that the number of synapses around anterior horn cell were decreased, contrary to the finding of teenage DMD, in which the number of synapses were increased, probably due to the reaction toward the reduced anterior horn cell activity. The decrease of synapses of the present case may be mainly due to hypoxic encephalopathy, based on the degeneration of the pyramidal tract. Another interesting finding is that GAD was strongly positive in the cytoplasm of anterior horn cells, which may be explained by Wallerian degeneration-like mechanism. Moreover, the expression of PSD-95 is increased in anterior horn cells. Compensation for postsynaptic damage can be considered, since dystrophin is necessary for maintaining the post-synaptic maintenance. There were no apparent differences in ChAT immunostaining. Further investigation is necessary whether these findings are characteristic of long-term surviving cases accompanied by hypoxic encephalopathy.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"37 ","pages":"Article 300759"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000318/pdfft?md5=be5bb75195d62a7164b23a863a35a1d1&pid=1-s2.0-S2772736X24000318-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A molecularly-confirmed extraskeletal myxoid chondrosarcoma with dual gene rearrangements, EWSR1::NR4A3 and HAPLN1::EDIL3 fusion 一种经分子证实的骨外肌软骨肉瘤，具有双基因重排，即 EWSR1::NR4A3 和 HAPLN1::EDIL3 融合

Human Pathology Reports Pub Date : 2024-09-01 DOI: 10.1016/j.hpr.2024.300758

Dong Ren , Katherine Wei , Ryan O’connell

{"title":"A molecularly-confirmed extraskeletal myxoid chondrosarcoma with dual gene rearrangements, EWSR1::NR4A3 and HAPLN1::EDIL3 fusion","authors":"Dong Ren , Katherine Wei , Ryan O’connell","doi":"10.1016/j.hpr.2024.300758","DOIUrl":"10.1016/j.hpr.2024.300758","url":null,"abstract":"<div><h3>Background</h3><p>Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal neoplasm with uncertain origin that is commonly seen in the lower extremities. Due to lack of specific clinical presentation, radio-pathologic and immunohistochemical (IHC) findings, the diagnosis of EMC is challenging.</p></div><div><h3>Case report</h3><p>Here we report a 60-year-old female presenting with a slow-growing tender mass on the right medial knee over the last 10 years. Histological evaluation of the resected specimen showed a subcutaneous multi-lobular lesion composed of uniform bland small oval to spindle shaped cells interconnected to arrange in cords and clusters in abundant myxoid matrix. Necrosis was identified in 10 % of the specimen. IHC staining showed that the tumor cells were weak and patchy positive for INSM1 and NSE and rarely positive for EMA. DNA and RNA next-generation sequencing reveal a dual gene rearrangement, including EWSR1::NR4A3 and HAPLN1::EDIL3 fusion. The combination of histopathologic and molecular findings supports the diagnosis of EMC.</p></div><div><h3>Conclusion</h3><p>This is the first reported case, to the best of our knowledge, of EMC with dual gene fusions. Although diagnostic and prognostic significance of HAPLN1::EDIL3 fusion and coexistence of HAPLN1::EDIL3 fusion and EWSR1::NR4A3 fusion in EMC remains unknown at this time, our hope that this case will be helpful to broaden the spectrum of known gene fusion variants in EMC, and augment the awareness and interest of researcher in investigating the impact of individual HAPLN1::EDIL3 fusion and dual gene rearrangement of HAPLN1::EDIL3 fusion and EWSR1::NR4A3 fusion on clinical behavior of EMC.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"37 ","pages":"Article 300758"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000306/pdfft?md5=ed7931e829a0deef317f8014eb01ac78&pid=1-s2.0-S2772736X24000306-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Something old, something new: Cervical cytopathology in the new era 新旧交替：新时代的宫颈细胞病理学

Human Pathology Reports Pub Date : 2024-08-27 DOI: 10.1016/j.hpr.2024.300756

Rawan Tahboub , Javier Sanchez-Ortiz , Mia Lai , Jennifer L. Clark , Tianle Zou

{"title":"Something old, something new: Cervical cytopathology in the new era","authors":"Rawan Tahboub , Javier Sanchez-Ortiz , Mia Lai , Jennifer L. Clark , Tianle Zou","doi":"10.1016/j.hpr.2024.300756","DOIUrl":"10.1016/j.hpr.2024.300756","url":null,"abstract":"<div><p>Papanicolaou (Pap) smear on cervical cells heralded the revolution of modern cytopathology in the middle of the 19th century, and cervical screening is now considered one of medicine’s greatest success stories. While routine cervical cytology has significantly reduced the incidence of cervical cancer worldwide, it is not without limitations. Although the specificity of Pap smear to detect high-grade intraepithelial lesion (HSIL)/cervical intraepithelial neoplasia (CIN) 2–3 is consistently high, the sensitivity ranges broadly from 34 % to 94 % <span><span>[1]</span></span>. Given the rapid evolution in understanding the etiologic role of high-risk human papillomavirus (hrHPV) in cervical cancer development, the clinical guidelines have transitioned from “evidence-based” to “risk-stratified” algorithms. Primary hrHPV testing as a more sensitive test for high-risk cervical lesion (CIN2+) detection is considered the preferred screening test in some guidelines, but due to its low specificity, a follow-up triage test is needed to reduce unnecessary colposcopy referrals. Candidates for the triage test include cytology, biomarkers such as P16/Ki67 dual stain (DS), and hrHPV genotyping. This review discusses the advantages and potential issues with primary hrHPV testing and dual stain, the current American Society of Colposcopy and Cervical Pathology (ASCCP) guideline with a focus on new endocervical curettage (ECC) guidelines, as well as the new World Health Organization (WHO) classification of endocervical adenocarcinoma and the impact on cervical cytopathology.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"37 ","pages":"Article 300756"},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000288/pdfft?md5=eace1a8fa0ed4b3e8101f4fcdca576db&pid=1-s2.0-S2772736X24000288-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142084361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of secretory breast carcinoma with extensive in situ carcinoma components: Clinical and histopathologic analysis 具有广泛原位癌成分的分泌型乳腺癌的特征：临床和组织病理学分析

Human Pathology Reports Pub Date : 2024-08-03 DOI: 10.1016/j.hpr.2024.300755

Tom Z. Liang , Qingqing Ding , Lavinia P. Middleton , Yun Wu , Aysegul A. Sahin

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Kikuchi-Fujimoto disease in the regional lymph nodes in a patient with concurrent malignant phyllodes tumour 一名并发恶性植物瘤患者的区域淋巴结出现菊地-藤本氏病

Human Pathology Reports Pub Date : 2024-07-30 DOI: 10.1016/j.hpr.2024.300750

Ciara Murray , Rosemarie Tremblay-LeMay , Jan Delabie , Andrea Covelli , Susan J. Done

引用次数: 0