Squamous cell carcinoma arising in sacrococcygeal teratoma in an adult: A case report

Human Pathology Reports Pub Date : 2025-03-31 DOI:10.1016/j.hpr.2025.300773

Yasushi Tanaka , Ryota Nakanishi , Hirokuni Hazama , Taro Mori , Tetsuro Kawazoe , Kensuke Kudou , Yoko Zaitsu , Yuichi Hisamatsu , Koji Ando , Eiji Oki , Shinichi Aishima , Yoshinao Oda , Tomoharu Yoshizumi

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引用次数: 0

Abstract

Sacrococcygeal teratomas (SCT) with malignant transformation to squamous cell carcinoma are extremely rare, with only few cases reported in the literature. Herein, we report on a case of a primary sacrococcygeal mature cystic teratoma with malignant transformation into a squamous cell carcinoma. A 53-year-old woman presented with dysuria and lower abdominal pain caused by a huge SCT. Computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT findings were suggestive of SCT with malignant transformation. The treatment involved robotic-assisted laparoscopic abdominoperineal resection and bilateral lymph node dissection. Histopathology revealed squamous cell carcinoma within the teratoma. Postoperatively, the patient underwent six cycles of paclitaxel-carboplatin chemotherapy and showed no signs of recurrence during the 1-year follow-up.

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Human Pathology Reports

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0.60

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0.00%

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