Human Pathology Reports最新文献_第3页

A large and predominantly cystic breast adenomyoepithelioma in a 35-year-old female: A rare case report and mini review of literature 一例35岁女性大且以囊性为主的乳腺腺肌瘤：一例罕见病例报告及文献复习

Human Pathology Reports Pub Date : 2026-03-01 Epub Date: 2025-12-06 DOI: 10.1016/j.hpr.2025.300811

Birhanu Kassie Reta , Demelash Darota Dojamo , Melaku Abay Muluneh , Seblewengel Maru Wubalem , Musie Negasi Gebreslase , Menal Hassen Abdella , Seyoum Berihun Derbew , Dori Woldu , Gebrehiwot Teklehaimanot Gebrezgabher

{"title":"A large and predominantly cystic breast adenomyoepithelioma in a 35-year-old female: A rare case report and mini review of literature","authors":"Birhanu Kassie Reta , Demelash Darota Dojamo , Melaku Abay Muluneh , Seblewengel Maru Wubalem , Musie Negasi Gebreslase , Menal Hassen Abdella , Seyoum Berihun Derbew , Dori Woldu , Gebrehiwot Teklehaimanot Gebrezgabher","doi":"10.1016/j.hpr.2025.300811","DOIUrl":"10.1016/j.hpr.2025.300811","url":null,"abstract":"<div><h3>Introduction</h3><div>Adenomyoepithelioma (AME) of the breast is a very rare biphasic tumor composed of epithelial and myoepithelial cells in varying proportions. Usually present as a circumscribed solid nodule, with rare occurrences of cystic or papillary areas. AME with a prominent cystic feature is extremely rare. This case report is aimed at emphasizing that AMEs can entirely be cystic, so that radiologists and pathologists should consider it as a possibility whenever they encounter a cystic breast lesion.</div></div><div><h3>Case presentation</h3><div>A 35-year-old woman presented with a painful breast lump of six months’ duration. A breast ultrasound scan revealed a 9 cm multilocular cystic mass with a focal area of solid masses arising from the cyst wall projecting into the cyst cavity. Initial fine needle aspiration cytology (FNAC) was non-diagnostic since the aspirate was only cyst content. Later the ultrasound-guided FNAC suggested AME. Complete excision of the mass with a wide margin was done, and subsequent histopathologic examination and immunohistochemistry confirmed the diagnosis of benign AME with free margins.</div></div><div><h3>Conclusion</h3><div>Even though it is extremely rare, AME may appear predominantly cystic with a focal solid area. Preoperative FNAC should be done with ultrasound guidance to make sure the solid area is sampled. AME should be considered in the list of differential diagnoses for cystic breast lesions.</div></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"43 ","pages":"Article 300811"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Pediatric erythroblastic sarcoma/pure erythroid leukemia with NFIA-CBFA2T3 translocation: Report of two cases, including a case with TP53 mutation, and review of the literature 小儿红母细胞肉瘤/纯红系白血病合并NFIA-CBFA2T3易位：报告2例，包括1例TP53突变，并复习文献

Human Pathology Reports Pub Date : 2025-11-01 Epub Date: 2025-10-30 DOI: 10.1016/j.hpr.2025.300803

Antonello Cardoni , Evelina Rogges , Sabrina Rossi , Rita De Vito , Emma Rullo , Silvia Vallese , Sabina Barresi , Isabella Giovannoni , Chantal Tancredi , Viola Alesi , Aurore Coulomb , Valeria Ceolin , Francesco Saglio , Marco Leone , Franca Fagioli , Solenne Le Louet , Arnaud Petit , Sabah Boudjemaa , Rita Alaggio

{"title":"Pediatric erythroblastic sarcoma/pure erythroid leukemia with NFIA-CBFA2T3 translocation: Report of two cases, including a case with TP53 mutation, and review of the literature","authors":"Antonello Cardoni , Evelina Rogges , Sabrina Rossi , Rita De Vito , Emma Rullo , Silvia Vallese , Sabina Barresi , Isabella Giovannoni , Chantal Tancredi , Viola Alesi , Aurore Coulomb , Valeria Ceolin , Francesco Saglio , Marco Leone , Franca Fagioli , Solenne Le Louet , Arnaud Petit , Sabah Boudjemaa , Rita Alaggio","doi":"10.1016/j.hpr.2025.300803","DOIUrl":"10.1016/j.hpr.2025.300803","url":null,"abstract":"<div><div>Pure erythroid leukemia is a rare neoplasm that occurs predominantly in adults, mostly as secondary to cytotoxic chemotherapy and frequently with biallelicabnormalities. Reports in pediatric patients are even rarer and show neoplasm arising “de novo”, frequent extramedullary sarcomatous presentation and a different molecular profile from the adult counterpart, including frequent gene fusions and no evidence of biallelic <em>TP53</em> alterations. We describe two cases of pediatric erythroid leukemia / sarcoma with the <em>NFIA::CBFA2T3</em> fusion, one of which harbored a <em>TP53</em> mutation,with a review of the literature of pediatric cases with the same fusion and with the analogous <em>NFIA::CBFA2T1</em> fusion.</div></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"42 ","pages":"Article 300803"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Three cases of invasive solid papillary carcinoma of the breast displaying a wide variety of histological patterns with diagnostic challenges 三例乳腺浸润性实体乳头状癌表现出多种多样的组织学模式，诊断困难

Human Pathology Reports Pub Date : 2025-11-01 Epub Date: 2025-10-29 DOI: 10.1016/j.hpr.2025.300802

Hiroshi Kobayashi , Saori Takashima , Riuko Ohashi , Tetsuya Tada , Yoshiro Otsuki

{"title":"Three cases of invasive solid papillary carcinoma of the breast displaying a wide variety of histological patterns with diagnostic challenges","authors":"Hiroshi Kobayashi , Saori Takashima , Riuko Ohashi , Tetsuya Tada , Yoshiro Otsuki","doi":"10.1016/j.hpr.2025.300802","DOIUrl":"10.1016/j.hpr.2025.300802","url":null,"abstract":"<div><div>We report three cases of invasive solid papillary carcinoma (SPC) of the breast that exhibited a broad spectrum of histological patterns, posing significant diagnostic challenges in the biopsy and mastectomy specimens. Although initially diagnosed as invasive breast carcinoma of no special type (IBC-NST) on biopsy, the resected specimens revealed the characteristic features of SPC, including solid growth patterns with delicate fibrovascular cores, in addition to tubular and glandular structures. The tumors consisted predominantly of intricately confluent nodules with well-circumscribed, rather than ragged, contours immunohistochemically lacking myoepithelial lining. Within these nodules, we observed rosettes, tubules, cribriform-like glands, and IBC-NST-like nests at the periphery of the confluent areas. These structures led to misinterpretation on biopsy. Both the confluent nodules and peripheral nests were diffusely positive for synaptophysin and INSM1. Additionally, compact, round, non-confluent nodules with sparse or invisible fibrovascular cores were also present. They immunohistochemically demonstrated diffuse neuroendocrine differentiation and preservation of myoepithelial linings.</div><div>We propose that the confluent nodules with well-circumscribed contours and IBC-NST-like nests represent invasive SPC, while the non-confluent nodules correspond to SPC in situ (SPCIS) or neuroendocrine ductal carcinoma in situ. Differentiating invasive SPC from IBC-NST is crucial in breast pathology. The key lies in recognizing the distinctive morphology of invasive SPC and its frequent coexistence with SPCIS.</div></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"42 ","pages":"Article 300802"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A camouflaging mystery: solid-tubulocystic variant of intrahepatic cholangiocarcinoma 一个伪装的谜团：肝内胆管癌的固体管性变异型

Human Pathology Reports Pub Date : 2025-11-01 Epub Date: 2025-09-30 DOI: 10.1016/j.hpr.2025.300797

Shannon Zhang , Nazmul Hasan , John Han , Gianna Kroening , Zeljka Jutric , Ali Afsari , Shirin Attarian , Jennifer Valerin

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A rare NAB2ex6::STAT6ex3 fusion identified in a large pelvic epithelioid and cystic high-risk solitary fibrous tumor (SFT) 罕见的NAB2ex6::STAT6ex3融合在大盆腔上皮样囊性高危孤立性纤维瘤（SFT）中发现

Human Pathology Reports Pub Date : 2025-11-01 Epub Date: 2025-11-27 DOI: 10.1016/j.hpr.2025.300806

Jhuma Nandi , Mary Peeples , Ruth D. Stephenson , Lauren Gottshall , Saum Ghodoussipour , Murray Becker , Gregory M. Riedlinger , Lin Li

引用次数: 0

An incidental B-lymphoblastic leukemia/lymphoma in a prophylactic salpingo-oophorectomy from a patient with germline BRCA1 mutation 一种系BRCA1突变患者行预防性输卵管卵巢切除术后偶发b淋巴母细胞白血病/淋巴瘤

Human Pathology Reports Pub Date : 2025-11-01 Epub Date: 2025-09-19 DOI: 10.1016/j.hpr.2025.300795

Ukuemi Edema , Alexander Chan

引用次数: 0

Immunoexpression of MED12 in lobular carcinoma in situ confined within fibroadenoma of breast MED12在乳腺纤维腺瘤小叶原位癌中的免疫表达

Human Pathology Reports Pub Date : 2025-11-01 Epub Date: 2025-11-10 DOI: 10.1016/j.hpr.2025.300804

James W. Perry , Kenneth A. Iczkowski , Cooley G. Pantazis , Amanda M. Burns

引用次数: 0

A case of angioimmunoblastic T-cell lymphoma coexisting with castleman disease 血管免疫母细胞t细胞淋巴瘤合并castleman病1例

Human Pathology Reports Pub Date : 2025-11-01 Epub Date: 2025-10-11 DOI: 10.1016/j.hpr.2025.300798

Lianshan Zhan , Long Wang , Hongyan Wu , Zhongjiao Chen , Lina Wang

{"title":"A case of angioimmunoblastic T-cell lymphoma coexisting with castleman disease","authors":"Lianshan Zhan , Long Wang , Hongyan Wu , Zhongjiao Chen , Lina Wang","doi":"10.1016/j.hpr.2025.300798","DOIUrl":"10.1016/j.hpr.2025.300798","url":null,"abstract":"<div><h3>Background</h3><div>Angioimmunoblastic T-cell lymphoma (AITL) is a rare, mature T-cell lymphoma with diagnostic challenges. Its coexistence with Castleman disease (CD) is exceptionally uncommon and complicates diagnosis and management.</div></div><div><h3>Case presentation</h3><div>We report a 67-year-old male with bilateral cervical lymphadenopathy. Imaging showed enlarged lymph nodes with prominent vascularity and a “rim sign.” Initial pathology suggested CD, with preserved lymph node architecture, atrophic germinal centers, and “lollipop” structures. Further evaluation, however, revealed diffuse proliferation of atypical T-cells.</div></div><div><h3>Diagnostic findings</h3><div>Immunohistochemistry showed atypical cells expressing follicular helper T-cell markers (CD10, PD1, BCL6). Molecular analysis confirmed monoclonal TCRγ gene rearrangement, and flow cytometry identified an abnormal CD4 + CD7 − T-cell clone. These findings established the diagnosis of AITL coexisting with CD.</div></div><div><h3>Conclusion</h3><div>This case highlights the high diagnostic hurdles of coexisting AITL and CD, emphasizing the critical need for comprehensive morphological, immunophenotypic, and molecular analyses for accurate diagnosis and optimal patient management.</div></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"42 ","pages":"Article 300798"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A novel fusion of EWSR1::PRKD1 in cribriform adenocarcinoma of salivary glands: A rare case report EWSR1::PRKD1在涎腺筛状腺癌中的融合：一个罕见的病例报告

Human Pathology Reports Pub Date : 2025-11-01 Epub Date: 2025-10-23 DOI: 10.1016/j.hpr.2025.300801

Zecra Yahia

{"title":"A novel fusion of EWSR1::PRKD1 in cribriform adenocarcinoma of salivary glands: A rare case report","authors":"Zecra Yahia","doi":"10.1016/j.hpr.2025.300801","DOIUrl":"10.1016/j.hpr.2025.300801","url":null,"abstract":"<div><div>Cribriform adenocarcinoma of the salivary glands (CASG) represents an underappreciated epithelial malignancy characterized by distinctive histologic patterns and recurrent <em>PRKD</em> gene fusions. We report a novel case of CASG in a 62-year-old female presenting with a 13-month indolent tongue lesion. Histopathological examination revealed neoplastic proliferation with cribriform, solid, and papillary architectural patterns, notable for prominent clear cell morphology. Immunohistochemical profiling demonstrated strong positivity for cytokeratins, PRKD1, p63, and p21, while remaining negative for p40, TTF-1 and myoepithelial markers. Fluorescence in situ hybridization confirmed <em>PRKD1</em> and <em>EWSR1</em> gene rearrangement using the corresponding break-apart probes, and next-generation sequencing identified a novel <em>EWSR1::PRKD1</em> fusion—the first reported instance of this genetic alteration in CASG. This fusion expands the molecular spectrum of CASG beyond previously documented <em>PRKD</em> gene rearrangements and hotspot mutations. Complete surgical excision achieved excellent oncologic control with no recurrence over 38 months of follow-up.</div></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"42 ","pages":"Article 300801"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leiomyosarcoma of the right gonadal vein; A case report with review of literature 右性腺静脉平滑肌肉瘤；病例报告一篇，并附文献复习

Human Pathology Reports Pub Date : 2025-11-01 Epub Date: 2025-09-09 DOI: 10.1016/j.hpr.2025.300793

Abrar G. Alghamdi , Deema Anaam , Khalid Alwadi

{"title":"Leiomyosarcoma of the right gonadal vein; A case report with review of literature","authors":"Abrar G. Alghamdi , Deema Anaam , Khalid Alwadi","doi":"10.1016/j.hpr.2025.300793","DOIUrl":"10.1016/j.hpr.2025.300793","url":null,"abstract":"<div><div>Leiomyosarcoma (LMS) is a malignant tumor of smooth muscle cells. When the tumor originates from a blood vessel, it arises from the smooth muscle cells in the tunica media of the vessel wall. Approximately 15 % of soft tissue sarcomas originate in the retroperitoneum (Kotilingam et al., 2006) [<span><span>1</span></span>]. However, LMS of the gonadal vein is extremely rare, with fewer than 15 documented cases. This emphasizes not only its rarity but also the narrow insight into its clinical behaviour and management. Here, we discuss a 42-year-old female patient who presented to our institution with a palpable abdominal mass that had been noticeable for two months. A computed tomography (CT) scan of her abdomen and pelvis revealed a large, irregular right adnexal mass measuring approximately 13 cm, with areas of necrosis and cystic degeneration, resulting in a heterogenous appearance. During surgical resection, the mass appeared to originate from the gonadal vein. Histopathological examination confirmed a diagnosis of leiomyosarcoma. In this article, we review the clinical, radiologic, and histopathologic features of gonadal vein leiomyosarcoma, along with a review of similar case reports.</div></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"42 ","pages":"Article 300793"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0