Human Pathology Reports最新文献_第4页

Ovarian microcystic stromal tumor: Review of a rare entity with recent updates 卵巢微囊基质瘤：罕见病例回顾与最新进展

Human Pathology Reports Pub Date : 2024-06-01 DOI: 10.1016/j.hpr.2024.300744

Yan Li , Shuang Niu

{"title":"Ovarian microcystic stromal tumor: Review of a rare entity with recent updates","authors":"Yan Li , Shuang Niu","doi":"10.1016/j.hpr.2024.300744","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300744","url":null,"abstract":"<div><p>Microcystic stromal tumors (MCSTs) are rare ovarian stromal tumors. They harbor <em>CTNNB1</em> or <em>APC</em> mutations, resulting in β-catenin nuclear expression. Morphologically, they characteristically consist of tumor cells with small round nuclei, inconspicuous nucleoli, moderate amount of eosinophilic or vacuolated cytoplasm. Cells can form solid nests and sheets, small or sometimes large cystic structures. Background stroma is often myxoid with foci of fibrosis. In addition to the nuclear β-catenin stain, the tumor cells are characteristically negative for inhibin and calretinin, but positive for CD10, CyclinD1, WT1 and FOXL2. To date, all MCST cases treated with oophorectomy or more extensive surgery have followed benign clinical courses. However, two of the four cases treated with ovarian cystectomy/tumor resection recurred in the residual ovary and local extraovarian involvement several years after ovarian cystectomy, which indicates MCST has the potential to recur and spread locally. This article is aimed to review the literature about MCST to summarize its morphology, immunophenotype, molecular alteration as well as clinical behavior.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300744"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000161/pdfft?md5=ff2ea2fd3cad5b4baf2e09422215336d&pid=1-s2.0-S2772736X24000161-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary gland Cytology, the new and the Old, a Pattern-Based approach 唾液腺细胞学，新与旧，基于模式的方法

Human Pathology Reports Pub Date : 2024-04-20 DOI: 10.1016/j.hpr.2024.300742

Shuo Niu, Yanjun Hou

引用次数: 0

Cytologic assessment of thyroid nodules – Updates in 2023 Bethesda reporting system, diagnostic challenges and pitfalls 甲状腺结节的细胞学评估--2023 年贝塞斯达报告系统的更新、诊断挑战和陷阱

Human Pathology Reports Pub Date : 2024-04-20 DOI: 10.1016/j.hpr.2024.300743

Xiaobing Jin, Xin Jing

引用次数: 0

Decoding lymph nodes: The crucial role of cytopathologists in diagnosing possible lymphoma 解码淋巴结：细胞病理学家在诊断可能的淋巴瘤中的关键作用

Human Pathology Reports Pub Date : 2024-04-17 DOI: 10.1016/j.hpr.2024.300740

Udit K Naik, Y. Helen Zhang

引用次数: 0

The utility of molecular studies on pancreatic cystic lesions: A comprehensive review 胰腺囊肿病变分子研究的实用性：全面回顾

Human Pathology Reports Pub Date : 2024-04-11 DOI: 10.1016/j.hpr.2024.300741

Rong Xia , Xiaoying Liu , Cristina H. Hajdu , Wenqing Cao , James N. Kaz , Tamas Gonda , Aylin Simsir

{"title":"The utility of molecular studies on pancreatic cystic lesions: A comprehensive review","authors":"Rong Xia , Xiaoying Liu , Cristina H. Hajdu , Wenqing Cao , James N. Kaz , Tamas Gonda , Aylin Simsir","doi":"10.1016/j.hpr.2024.300741","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300741","url":null,"abstract":"<div><p>Pancreatic cystic lesions, frequently detected in abdominal imaging, pose diagnostic challenges due to their varying malignancy potential. This review article focuses on the crucial role of molecular diagnostics in differentiating these lesions, with an emphasis on the significance of <em>KRAS</em> and <em>GNAS</em> mutations identified through endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). The use of next-generation sequencing (NGS) is highlighted for its precision in detecting genetic changes, crucial for accurate diagnosis and guiding management decisions.</p><p>Integration of molecular studies into standardized reporting for pancreaticobiliary cytopathology is also discussed, enhancing diagnostic accuracy. The potential of precision oncology, informed by molecular insights, is explored for targeted treatments of pancreatic cystic lesions.</p><p>Commercial platforms like PancreaSeq® Genomic Classifier and PancraGEN® are assessed for their effectiveness in analyzing pancreatic cystic fluid, proving beneficial in cases where traditional methods fall short.</p><p>In summary, molecular studies are indispensable in evaluating pancreatic cystic lesions, offering a pathway to more personalized treatment and management strategies in patient-centered care.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300741"},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000136/pdfft?md5=d9247f2a17e6528a0255145a63cf2ac4&pid=1-s2.0-S2772736X24000136-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates and challenges in serous fluid cytopathology 浆液细胞病理学的更新与挑战

Human Pathology Reports Pub Date : 2024-03-25 DOI: 10.1016/j.hpr.2024.300738

Hannah H. Chen , Xiaoying Liu , Qun Wang

{"title":"Updates and challenges in serous fluid cytopathology","authors":"Hannah H. Chen , Xiaoying Liu , Qun Wang","doi":"10.1016/j.hpr.2024.300738","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300738","url":null,"abstract":"<div><p>Serous fluids, encompassing pleural, pericardial, and peritoneal fluids, exhibit a wide spectrum of neoplastic and non-neoplastic conditions. Malignant effusions commonly result from metastasis, particularly from adenocarcinomas, and less frequently from primary malignant mesothelioma. Cytologic assessment of serous effusions remains an invaluable tool, especially with the expanding role of ancillary techniques available to resolve diagnostically challenging cases. The recently introduced International System for Reporting Serous Fluid Cytopathology (TIS) establishes a standardized reporting system with five distinct diagnostic categories: nondiagnostic (ND), negative for malignancy (NFM), atypia of undetermined significance (AUS), suspicious for malignancy (SFM), and malignant (MAL). Understanding the distribution of malignancy in serous fluids by site of origin in effusion cytology is important, especially in patients with an unknown primary. Immunohistochemistry (IHC) combined with clinical and radiologic data plays a crucial role in confirming malignancy, establishing the primary site, determining the stage, predicting prognosis, monitoring recurrence, and influencing medical management. This review aims to provide an overview of TIS reporting system, emphasizing its malignant category. It provides updates on the distribution of malignancies in serous fluids and discusses valuable IHC panels based on differential diagnosis, addressing challenging cases within this context.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300738"},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000100/pdfft?md5=d443fce159aed6e6b1613f9f5c399145&pid=1-s2.0-S2772736X24000100-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140209043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the horizon: The world health organization reporting system for liver cytopathology 在地平线上航行：世界卫生组织肝脏细胞病理学报告系统

Human Pathology Reports Pub Date : 2024-03-23 DOI: 10.1016/j.hpr.2024.300737

Yan Gao, Y. Helen Zhang

{"title":"Navigating the horizon: The world health organization reporting system for liver cytopathology","authors":"Yan Gao, Y. Helen Zhang","doi":"10.1016/j.hpr.2024.300737","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300737","url":null,"abstract":"<div><p>The upcoming World Health Organization (WHO) Reporting System in Liver Cytopathology marks the first internationally applicable system for diverse medical infrastructure settings. This system categorizes cases into five groups: Insufficient/Inadequate/Nondiagnostic, Benign, Atypical, Suspicious for Malignancy, and Malignant. Each category is associated with a risk of malignancy (ROM), guiding recommendations for further diagnostic testing to achieve specific diagnoses or refine differential diagnoses and follow-up management. The primary goal is to enhance and standardize cytopathology reporting, improve communication between cytopathologists and clinicians, and ultimately elevate patient care. The online WHO System provides direct access to the WHO Classification for Tumours 5th Edition. This review delves into the latest classification guidelines, addresses terminology standardization, navigates diagnostic complexities, and aligns patient management options with cytopathological interpretations, contributing to an overall enhancement of patient care.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300737"},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000094/pdfft?md5=6b2e0d3133feee7deebc5220b7c295fc&pid=1-s2.0-S2772736X24000094-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant Brenner tumor of the ovary: Pathologic evaluation, molecular insights and clinical management 卵巢恶性布伦纳瘤：病理评估、分子研究和临床治疗

Human Pathology Reports Pub Date : 2024-03-23 DOI: 10.1016/j.hpr.2024.300739

Tiannan Wang , Wei Huang , Brian S Finkelman , Huina Zhang

引用次数: 0

Updates and challenges in pancreatic cytopathology 胰腺细胞病理学的更新与挑战

Human Pathology Reports Pub Date : 2024-03-22 DOI: 10.1016/j.hpr.2024.300736

Patrick Yang , Liying Han , Zhongren Zhou

{"title":"Updates and challenges in pancreatic cytopathology","authors":"Patrick Yang , Liying Han , Zhongren Zhou","doi":"10.1016/j.hpr.2024.300736","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300736","url":null,"abstract":"<div><p>The World Health Organization (WHO) has recently introduced an international approach to standardize reporting of pancreaticobiliary cytopathology. The WHO Reporting system for Pancreaticobiliary Cytopathology (WHO system) introduces two distinct categories for non-invasive premalignant lesions of the ductal system, based on cytomorphological grading: “pancreatic neoplasm of low risk/grade” (PaN-low) and “pancreatic neoplasm of high risk/grade” (PaN-high). This reclassification aims to provide a more precise assessment of risks of malignancy (ROM) for different neoplastic categories. The WHO system focuses on the diagnostic categories, their associated ROM, and recommended management per category.</p><p>Pancreatic neoplasms comprise various histological types, each displaying distinct background features that can assist in the diagnostic process. Recognizing background features like mucin background, necrotic background, desmoplastic stroma, cancer-associated fibroblasts, and stromal fragments presents notable challenges. Certain background features may overlap across histological types.</p><p>In this review, we present a summary of the key updates in the WHO system and highlight diagnostic challenges associated with background features.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300736"},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000082/pdfft?md5=9ae5a9ecdaa95b3111706cea9a316c0f&pid=1-s2.0-S2772736X24000082-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic mesenchymal neoplasms diagnosed by endoscopic ultrasound-guided fine needle aspiration/biopsy: A concise review 通过内镜超声引导下细针穿刺/活组织检查诊断出的胰腺间质肿瘤：简明综述

Human Pathology Reports Pub Date : 2024-03-20 DOI: 10.1016/j.hpr.2024.300734

Qun Wang , Xiaoying Liu , Min Cui , Xiaoqin Zhu , Hannah H. Chen

{"title":"Pancreatic mesenchymal neoplasms diagnosed by endoscopic ultrasound-guided fine needle aspiration/biopsy: A concise review","authors":"Qun Wang , Xiaoying Liu , Min Cui , Xiaoqin Zhu , Hannah H. Chen","doi":"10.1016/j.hpr.2024.300734","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300734","url":null,"abstract":"<div><p>The mesenchymal tumors of the pancreas account for approximately 1–2% of all pancreatic neoplasms and they are not commonly encountered in our daily practice. When these rare entities are seen during endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) with rapid onsite evaluation (ROSE) or EUS-guided fine-needle biopsy (FNB) specimens sampled from the pancreas, it is usually difficult to establish a diagnosis solely based on cytohistology due to the significant overlapping cytomorphological features among these neoplasms. Ancillary studies including immunohistochemical stains and molecular testing are critical to reach the correct final diagnosis. Here, we reviewed the pancreatic mesenchymal neoplasms diagnosed with EUS-FNA cytology specimens or EUS-FNB small biopsy specimens. Gastrointestinal stromal tumors (GIST), solitary fibrous tumors (SFT), paraganglioma, perivascular epithelioid cell tumor (PEComa), and Granular cell tumor were discussed in detail each with a representative case from our practice collections. The characteristic cytohistological features and immunostaining markers for each entity are highlighted for differential diagnosis. In summary, cytopathologists need to be vigilant for these rare entities and perform necessary immunostaining to establish an accurate diagnosis.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300734"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000069/pdfft?md5=62bfaa5f7761d47b9c14e5e88129ab29&pid=1-s2.0-S2772736X24000069-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0