Human Pathology Reports最新文献_第4页

Navigating the horizon: The world health organization reporting system for liver cytopathology 在地平线上航行：世界卫生组织肝脏细胞病理学报告系统

Human Pathology Reports Pub Date : 2024-03-23 DOI: 10.1016/j.hpr.2024.300737

Yan Gao, Y. Helen Zhang

{"title":"Navigating the horizon: The world health organization reporting system for liver cytopathology","authors":"Yan Gao, Y. Helen Zhang","doi":"10.1016/j.hpr.2024.300737","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300737","url":null,"abstract":"<div><p>The upcoming World Health Organization (WHO) Reporting System in Liver Cytopathology marks the first internationally applicable system for diverse medical infrastructure settings. This system categorizes cases into five groups: Insufficient/Inadequate/Nondiagnostic, Benign, Atypical, Suspicious for Malignancy, and Malignant. Each category is associated with a risk of malignancy (ROM), guiding recommendations for further diagnostic testing to achieve specific diagnoses or refine differential diagnoses and follow-up management. The primary goal is to enhance and standardize cytopathology reporting, improve communication between cytopathologists and clinicians, and ultimately elevate patient care. The online WHO System provides direct access to the WHO Classification for Tumours 5th Edition. This review delves into the latest classification guidelines, addresses terminology standardization, navigates diagnostic complexities, and aligns patient management options with cytopathological interpretations, contributing to an overall enhancement of patient care.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300737"},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000094/pdfft?md5=6b2e0d3133feee7deebc5220b7c295fc&pid=1-s2.0-S2772736X24000094-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant Brenner tumor of the ovary: Pathologic evaluation, molecular insights and clinical management 卵巢恶性布伦纳瘤：病理评估、分子研究和临床治疗

Human Pathology Reports Pub Date : 2024-03-23 DOI: 10.1016/j.hpr.2024.300739

Tiannan Wang , Wei Huang , Brian S Finkelman , Huina Zhang

引用次数: 0

Updates and challenges in pancreatic cytopathology 胰腺细胞病理学的更新与挑战

Human Pathology Reports Pub Date : 2024-03-22 DOI: 10.1016/j.hpr.2024.300736

Patrick Yang , Liying Han , Zhongren Zhou

{"title":"Updates and challenges in pancreatic cytopathology","authors":"Patrick Yang , Liying Han , Zhongren Zhou","doi":"10.1016/j.hpr.2024.300736","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300736","url":null,"abstract":"<div><p>The World Health Organization (WHO) has recently introduced an international approach to standardize reporting of pancreaticobiliary cytopathology. The WHO Reporting system for Pancreaticobiliary Cytopathology (WHO system) introduces two distinct categories for non-invasive premalignant lesions of the ductal system, based on cytomorphological grading: “pancreatic neoplasm of low risk/grade” (PaN-low) and “pancreatic neoplasm of high risk/grade” (PaN-high). This reclassification aims to provide a more precise assessment of risks of malignancy (ROM) for different neoplastic categories. The WHO system focuses on the diagnostic categories, their associated ROM, and recommended management per category.</p><p>Pancreatic neoplasms comprise various histological types, each displaying distinct background features that can assist in the diagnostic process. Recognizing background features like mucin background, necrotic background, desmoplastic stroma, cancer-associated fibroblasts, and stromal fragments presents notable challenges. Certain background features may overlap across histological types.</p><p>In this review, we present a summary of the key updates in the WHO system and highlight diagnostic challenges associated with background features.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300736"},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000082/pdfft?md5=9ae5a9ecdaa95b3111706cea9a316c0f&pid=1-s2.0-S2772736X24000082-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic mesenchymal neoplasms diagnosed by endoscopic ultrasound-guided fine needle aspiration/biopsy: A concise review 通过内镜超声引导下细针穿刺/活组织检查诊断出的胰腺间质肿瘤：简明综述

Human Pathology Reports Pub Date : 2024-03-20 DOI: 10.1016/j.hpr.2024.300734

Qun Wang , Xiaoying Liu , Min Cui , Xiaoqin Zhu , Hannah H. Chen

{"title":"Pancreatic mesenchymal neoplasms diagnosed by endoscopic ultrasound-guided fine needle aspiration/biopsy: A concise review","authors":"Qun Wang , Xiaoying Liu , Min Cui , Xiaoqin Zhu , Hannah H. Chen","doi":"10.1016/j.hpr.2024.300734","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300734","url":null,"abstract":"<div><p>The mesenchymal tumors of the pancreas account for approximately 1–2% of all pancreatic neoplasms and they are not commonly encountered in our daily practice. When these rare entities are seen during endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) with rapid onsite evaluation (ROSE) or EUS-guided fine-needle biopsy (FNB) specimens sampled from the pancreas, it is usually difficult to establish a diagnosis solely based on cytohistology due to the significant overlapping cytomorphological features among these neoplasms. Ancillary studies including immunohistochemical stains and molecular testing are critical to reach the correct final diagnosis. Here, we reviewed the pancreatic mesenchymal neoplasms diagnosed with EUS-FNA cytology specimens or EUS-FNB small biopsy specimens. Gastrointestinal stromal tumors (GIST), solitary fibrous tumors (SFT), paraganglioma, perivascular epithelioid cell tumor (PEComa), and Granular cell tumor were discussed in detail each with a representative case from our practice collections. The characteristic cytohistological features and immunostaining markers for each entity are highlighted for differential diagnosis. In summary, cytopathologists need to be vigilant for these rare entities and perform necessary immunostaining to establish an accurate diagnosis.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300734"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000069/pdfft?md5=62bfaa5f7761d47b9c14e5e88129ab29&pid=1-s2.0-S2772736X24000069-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common practice issues in pulmonary cytology/small biopsy: Diagnostic pitfalls and appropriate use of immunohistochemical stains 肺细胞学/小活检的常见实践问题：诊断陷阱和免疫组化染色的适当使用

Human Pathology Reports Pub Date : 2024-03-13 DOI: 10.1016/j.hpr.2024.300735

Jessie Xiong , Erik Polsdofer , Jian Jing

{"title":"Common practice issues in pulmonary cytology/small biopsy: Diagnostic pitfalls and appropriate use of immunohistochemical stains","authors":"Jessie Xiong , Erik Polsdofer , Jian Jing","doi":"10.1016/j.hpr.2024.300735","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300735","url":null,"abstract":"<div><p>With the increasing emphasis on early detection of lung carcinoma in clinical practice, the utilization of small biopsies including cytology specimens has become more prevalent and an integral part of the diagnostic process. While holding immense significance for patient care and decision-making, the accurate identification of lung carcinoma from these small biopsies poses challenges. There is a significant overlap in the characteristics among benign, reactive, and malignant processes. This is aggravated by the absence of distinguishing biomarkers. Preserving specimen material for additional cytogenetic and molecular testing has also gained prominence to enable targeted precision medicine.</p><p>The focus of our review is directed towards understanding the morphologic attributes and potential diagnostic mimickers associated with the most frequent types of lung carcinoma observed in small biopsies. Additionally, we emphasize the importance of proper immunohistochemical staining practices to preserve tissue for further molecular testing.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300735"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000070/pdfft?md5=4c4c979490d68c686f279c96efdf9d59&pid=1-s2.0-S2772736X24000070-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140123179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urine cytology: Updates and challenges in reporting systems, ancillary studies, and artificial intelligence 尿液细胞学：报告系统、辅助研究和人工智能的更新与挑战

Human Pathology Reports Pub Date : 2024-02-28 DOI: 10.1016/j.hpr.2024.300733

Juan Xing , Jordan P. Reynolds , Xiaoying Liu , Liron Pantanowitz

{"title":"Urine cytology: Updates and challenges in reporting systems, ancillary studies, and artificial intelligence","authors":"Juan Xing , Jordan P. Reynolds , Xiaoying Liu , Liron Pantanowitz","doi":"10.1016/j.hpr.2024.300733","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300733","url":null,"abstract":"<div><p>Several urine cytology classifications have been published in the literature. However, global acceptance in the field of urine cytology was only gained in 2016 after The Paris System for reporting urinary cytology was published. Despite this Paris System and its shifted focus toward the detection of high-grade urothelial carcinoma, the perceived weakness of low sensitivity and indeterminate diagnoses when screening with urine cytology remains unresolved. To overcome these shortcomings, investigators have studied a variety of emerging ancillary tests to augment urine cytology (UroVysion, ImmunoCyt/uCyte+, BTA-stat/TRAK, NMP22, SCD-A7, URO17, CellDetect, UroMark, UroSEEK). Furthermore, with the advent of digital cytology, the creation of artificial intelligence tools has created innovative opportunities to aid with urine cytology. This review article discusses the lessons learned in the evolution of reporting systems, explores the merit and challenges of ancillary tests, and calls attention to potential utility of applying artificial intelligence in urine cytology.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"35 ","pages":"Article 300733"},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000057/pdfft?md5=47d0e37442379d106c973709c84ef298&pid=1-s2.0-S2772736X24000057-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139986115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Head and neck Cytopathology: Options for high-risk HPV testing in head and neck FNA specimens, a concise review 头颈部细胞病理学：头颈部 FNA 标本中的高危 HPV 检测选择，简明综述

Human Pathology Reports Pub Date : 2024-02-13 DOI: 10.1016/j.hpr.2024.300731

Tieying Hou, Hector Mesa, Shaoxiong Chen, Mohamed Hamdi Fouad Bikhet, Omer Saeed, Sheila Segura, Harvey Cramer

引用次数: 0

Adult-onset autoimmune enterocolopathy initially presenting with lower gastrointestinal histologic findings: A case report and review of literature 成人发病的自身免疫性肠结肠病最初表现为下消化道组织学发现：病例报告和文献综述

Human Pathology Reports Pub Date : 2024-02-13 DOI: 10.1016/j.hpr.2024.300732

Jennifer Pfeiffer , John M. Kennedy

{"title":"Adult-onset autoimmune enterocolopathy initially presenting with lower gastrointestinal histologic findings: A case report and review of literature","authors":"Jennifer Pfeiffer , John M. Kennedy","doi":"10.1016/j.hpr.2024.300732","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300732","url":null,"abstract":"<div><p>Autoimmune enterocolopathy (AIE) is an immune-mediated disease effecting the gastrointestinal tract that has been increasingly recognized in adults. Prior reports of adult-onset AIE, as well as published diagnostic criteria, emphasize the histopathologic findings in the small bowel to support the diagnosis. However, AIE is known to be a pan-enteric disease, and the initial histologic findings could be first encountered at non-small bowel sites. Here, we report a case of adult-onset AIE, where the initial histologic findings of AIE manifested in the colon as marked loss of goblet cells and prominent basal apoptoses. We review the differential diagnostic considerations, and discuss the subsequent clinical workup needed to evaluate for AIE if it is suspected on a colon biopsy. Additionally, a literature review was performed to determine the histopathologic characteristics of adult-onset AIE in the colon. Overall, the present case report, as well as findings from the literature review, suggest that AIE should enter the differential diagnosis in an adult patient with diarrhea when loss of goblet cells and prominent basal apoptoses are observed in a patient’s colon biopsy, especially when alternative etiologies are not supported by appropriate clinical context.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"35 ","pages":"Article 300732"},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000045/pdfft?md5=c6869c8c9a75a8f2f2e6ff7388c7bf1b&pid=1-s2.0-S2772736X24000045-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blau syndrome complicated by granulomatous tubulointerstitial nephritis and immune complex mediated glomerulonephritis: A case report and review of the literature 布劳综合征并发肉芽肿性肾小管间质性肾炎和免疫复合物介导的肾小球肾炎：病例报告和文献综述

Human Pathology Reports Pub Date : 2024-01-28 DOI: 10.1016/j.hpr.2024.300730

Kelly M. Garrity , Richard Chiu , Rachana Srivastava , Deborah K. McCurdy , Jonathan E. Zuckerman

{"title":"Blau syndrome complicated by granulomatous tubulointerstitial nephritis and immune complex mediated glomerulonephritis: A case report and review of the literature","authors":"Kelly M. Garrity , Richard Chiu , Rachana Srivastava , Deborah K. McCurdy , Jonathan E. Zuckerman","doi":"10.1016/j.hpr.2024.300730","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300730","url":null,"abstract":"<div><p>Blau syndrome is a rare, autosomal dominant or de novo mutation, granulomatous, auto-inflammatory disorder classically manifesting as a triad of polyarthritis, uveitis, and dermatitis. Rarely, this disease involves visceral sites such as the liver, lung, and kidney. In this report, we describe a case of a 13-year old female with Blau syndrome, with prior findings of polyarticular arthritis, uveitis, granulomatous sialadenitis of the right parotid gland, and positive NOD2 mutation testing, whose serum creatinine acutely rose despite being on anti-TNF-alpha therapy since age two. Kidney biopsy revealed granulomatous tubulointerstitial nephritis (TIN) and an immune complex (IC)-mediated glomerulonephritis attributed to Blau syndrome. We conducted a literature search to find all reported cases of Blau syndrome with biopsy findings of granulomatous renal involvement, finding ten other case reports. We assessed the likelihood of TIN and immune complex deposition, the drugs used to treat these patients, and the clinical outcomes. We found coexisting IC renal deposition rare, occurring in 2/11 patients including ours and renal involvement that was anti-TNF unresponsive was only present in our patient with a recorded renal treatment outcome.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"35 ","pages":"Article 300730"},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000021/pdfft?md5=700387b75208cc35b52a2b0adc843f45&pid=1-s2.0-S2772736X24000021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139653699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Submandibular basal cell adenoma – A rare presentation 颌下基底细胞腺瘤--一种罕见的表现形式

Human Pathology Reports Pub Date : 2024-01-13 DOI: 10.1016/j.hpr.2024.300729

Fahad Al Qooz , Mohammad Alanazi , Mohammad S. Al Olaimat , Tasneem Malahmeh , Zaid Rasheed Alzoubi

引用次数: 0