Human Pathology Reports最新文献_第4页

Decoding lymph nodes: The crucial role of cytopathologists in diagnosing possible lymphoma 解码淋巴结：细胞病理学家在诊断可能的淋巴瘤中的关键作用

Human Pathology Reports Pub Date : 2024-04-17 DOI: 10.1016/j.hpr.2024.300740

Udit K Naik, Y. Helen Zhang

引用次数: 0

The utility of molecular studies on pancreatic cystic lesions: A comprehensive review 胰腺囊肿病变分子研究的实用性：全面回顾

Human Pathology Reports Pub Date : 2024-04-11 DOI: 10.1016/j.hpr.2024.300741

Rong Xia , Xiaoying Liu , Cristina H. Hajdu , Wenqing Cao , James N. Kaz , Tamas Gonda , Aylin Simsir

{"title":"The utility of molecular studies on pancreatic cystic lesions: A comprehensive review","authors":"Rong Xia , Xiaoying Liu , Cristina H. Hajdu , Wenqing Cao , James N. Kaz , Tamas Gonda , Aylin Simsir","doi":"10.1016/j.hpr.2024.300741","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300741","url":null,"abstract":"<div><p>Pancreatic cystic lesions, frequently detected in abdominal imaging, pose diagnostic challenges due to their varying malignancy potential. This review article focuses on the crucial role of molecular diagnostics in differentiating these lesions, with an emphasis on the significance of <em>KRAS</em> and <em>GNAS</em> mutations identified through endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). The use of next-generation sequencing (NGS) is highlighted for its precision in detecting genetic changes, crucial for accurate diagnosis and guiding management decisions.</p><p>Integration of molecular studies into standardized reporting for pancreaticobiliary cytopathology is also discussed, enhancing diagnostic accuracy. The potential of precision oncology, informed by molecular insights, is explored for targeted treatments of pancreatic cystic lesions.</p><p>Commercial platforms like PancreaSeq® Genomic Classifier and PancraGEN® are assessed for their effectiveness in analyzing pancreatic cystic fluid, proving beneficial in cases where traditional methods fall short.</p><p>In summary, molecular studies are indispensable in evaluating pancreatic cystic lesions, offering a pathway to more personalized treatment and management strategies in patient-centered care.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300741"},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000136/pdfft?md5=d9247f2a17e6528a0255145a63cf2ac4&pid=1-s2.0-S2772736X24000136-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates and challenges in serous fluid cytopathology 浆液细胞病理学的更新与挑战

Human Pathology Reports Pub Date : 2024-03-25 DOI: 10.1016/j.hpr.2024.300738

Hannah H. Chen , Xiaoying Liu , Qun Wang

{"title":"Updates and challenges in serous fluid cytopathology","authors":"Hannah H. Chen , Xiaoying Liu , Qun Wang","doi":"10.1016/j.hpr.2024.300738","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300738","url":null,"abstract":"<div><p>Serous fluids, encompassing pleural, pericardial, and peritoneal fluids, exhibit a wide spectrum of neoplastic and non-neoplastic conditions. Malignant effusions commonly result from metastasis, particularly from adenocarcinomas, and less frequently from primary malignant mesothelioma. Cytologic assessment of serous effusions remains an invaluable tool, especially with the expanding role of ancillary techniques available to resolve diagnostically challenging cases. The recently introduced International System for Reporting Serous Fluid Cytopathology (TIS) establishes a standardized reporting system with five distinct diagnostic categories: nondiagnostic (ND), negative for malignancy (NFM), atypia of undetermined significance (AUS), suspicious for malignancy (SFM), and malignant (MAL). Understanding the distribution of malignancy in serous fluids by site of origin in effusion cytology is important, especially in patients with an unknown primary. Immunohistochemistry (IHC) combined with clinical and radiologic data plays a crucial role in confirming malignancy, establishing the primary site, determining the stage, predicting prognosis, monitoring recurrence, and influencing medical management. This review aims to provide an overview of TIS reporting system, emphasizing its malignant category. It provides updates on the distribution of malignancies in serous fluids and discusses valuable IHC panels based on differential diagnosis, addressing challenging cases within this context.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300738"},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000100/pdfft?md5=d443fce159aed6e6b1613f9f5c399145&pid=1-s2.0-S2772736X24000100-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140209043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the horizon: The world health organization reporting system for liver cytopathology 在地平线上航行：世界卫生组织肝脏细胞病理学报告系统

Human Pathology Reports Pub Date : 2024-03-23 DOI: 10.1016/j.hpr.2024.300737

Yan Gao, Y. Helen Zhang

{"title":"Navigating the horizon: The world health organization reporting system for liver cytopathology","authors":"Yan Gao, Y. Helen Zhang","doi":"10.1016/j.hpr.2024.300737","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300737","url":null,"abstract":"<div><p>The upcoming World Health Organization (WHO) Reporting System in Liver Cytopathology marks the first internationally applicable system for diverse medical infrastructure settings. This system categorizes cases into five groups: Insufficient/Inadequate/Nondiagnostic, Benign, Atypical, Suspicious for Malignancy, and Malignant. Each category is associated with a risk of malignancy (ROM), guiding recommendations for further diagnostic testing to achieve specific diagnoses or refine differential diagnoses and follow-up management. The primary goal is to enhance and standardize cytopathology reporting, improve communication between cytopathologists and clinicians, and ultimately elevate patient care. The online WHO System provides direct access to the WHO Classification for Tumours 5th Edition. This review delves into the latest classification guidelines, addresses terminology standardization, navigates diagnostic complexities, and aligns patient management options with cytopathological interpretations, contributing to an overall enhancement of patient care.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300737"},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000094/pdfft?md5=6b2e0d3133feee7deebc5220b7c295fc&pid=1-s2.0-S2772736X24000094-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant Brenner tumor of the ovary: Pathologic evaluation, molecular insights and clinical management 卵巢恶性布伦纳瘤：病理评估、分子研究和临床治疗

Human Pathology Reports Pub Date : 2024-03-23 DOI: 10.1016/j.hpr.2024.300739

Tiannan Wang , Wei Huang , Brian S Finkelman , Huina Zhang

引用次数: 0

Updates and challenges in pancreatic cytopathology 胰腺细胞病理学的更新与挑战

Human Pathology Reports Pub Date : 2024-03-22 DOI: 10.1016/j.hpr.2024.300736

Patrick Yang , Liying Han , Zhongren Zhou

{"title":"Updates and challenges in pancreatic cytopathology","authors":"Patrick Yang , Liying Han , Zhongren Zhou","doi":"10.1016/j.hpr.2024.300736","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300736","url":null,"abstract":"<div><p>The World Health Organization (WHO) has recently introduced an international approach to standardize reporting of pancreaticobiliary cytopathology. The WHO Reporting system for Pancreaticobiliary Cytopathology (WHO system) introduces two distinct categories for non-invasive premalignant lesions of the ductal system, based on cytomorphological grading: “pancreatic neoplasm of low risk/grade” (PaN-low) and “pancreatic neoplasm of high risk/grade” (PaN-high). This reclassification aims to provide a more precise assessment of risks of malignancy (ROM) for different neoplastic categories. The WHO system focuses on the diagnostic categories, their associated ROM, and recommended management per category.</p><p>Pancreatic neoplasms comprise various histological types, each displaying distinct background features that can assist in the diagnostic process. Recognizing background features like mucin background, necrotic background, desmoplastic stroma, cancer-associated fibroblasts, and stromal fragments presents notable challenges. Certain background features may overlap across histological types.</p><p>In this review, we present a summary of the key updates in the WHO system and highlight diagnostic challenges associated with background features.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300736"},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000082/pdfft?md5=9ae5a9ecdaa95b3111706cea9a316c0f&pid=1-s2.0-S2772736X24000082-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic mesenchymal neoplasms diagnosed by endoscopic ultrasound-guided fine needle aspiration/biopsy: A concise review 通过内镜超声引导下细针穿刺/活组织检查诊断出的胰腺间质肿瘤：简明综述

Human Pathology Reports Pub Date : 2024-03-20 DOI: 10.1016/j.hpr.2024.300734

Qun Wang , Xiaoying Liu , Min Cui , Xiaoqin Zhu , Hannah H. Chen

{"title":"Pancreatic mesenchymal neoplasms diagnosed by endoscopic ultrasound-guided fine needle aspiration/biopsy: A concise review","authors":"Qun Wang , Xiaoying Liu , Min Cui , Xiaoqin Zhu , Hannah H. Chen","doi":"10.1016/j.hpr.2024.300734","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300734","url":null,"abstract":"<div><p>The mesenchymal tumors of the pancreas account for approximately 1–2% of all pancreatic neoplasms and they are not commonly encountered in our daily practice. When these rare entities are seen during endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) with rapid onsite evaluation (ROSE) or EUS-guided fine-needle biopsy (FNB) specimens sampled from the pancreas, it is usually difficult to establish a diagnosis solely based on cytohistology due to the significant overlapping cytomorphological features among these neoplasms. Ancillary studies including immunohistochemical stains and molecular testing are critical to reach the correct final diagnosis. Here, we reviewed the pancreatic mesenchymal neoplasms diagnosed with EUS-FNA cytology specimens or EUS-FNB small biopsy specimens. Gastrointestinal stromal tumors (GIST), solitary fibrous tumors (SFT), paraganglioma, perivascular epithelioid cell tumor (PEComa), and Granular cell tumor were discussed in detail each with a representative case from our practice collections. The characteristic cytohistological features and immunostaining markers for each entity are highlighted for differential diagnosis. In summary, cytopathologists need to be vigilant for these rare entities and perform necessary immunostaining to establish an accurate diagnosis.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300734"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000069/pdfft?md5=62bfaa5f7761d47b9c14e5e88129ab29&pid=1-s2.0-S2772736X24000069-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common practice issues in pulmonary cytology/small biopsy: Diagnostic pitfalls and appropriate use of immunohistochemical stains 肺细胞学/小活检的常见实践问题：诊断陷阱和免疫组化染色的适当使用

Human Pathology Reports Pub Date : 2024-03-13 DOI: 10.1016/j.hpr.2024.300735

Jessie Xiong , Erik Polsdofer , Jian Jing

{"title":"Common practice issues in pulmonary cytology/small biopsy: Diagnostic pitfalls and appropriate use of immunohistochemical stains","authors":"Jessie Xiong , Erik Polsdofer , Jian Jing","doi":"10.1016/j.hpr.2024.300735","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300735","url":null,"abstract":"<div><p>With the increasing emphasis on early detection of lung carcinoma in clinical practice, the utilization of small biopsies including cytology specimens has become more prevalent and an integral part of the diagnostic process. While holding immense significance for patient care and decision-making, the accurate identification of lung carcinoma from these small biopsies poses challenges. There is a significant overlap in the characteristics among benign, reactive, and malignant processes. This is aggravated by the absence of distinguishing biomarkers. Preserving specimen material for additional cytogenetic and molecular testing has also gained prominence to enable targeted precision medicine.</p><p>The focus of our review is directed towards understanding the morphologic attributes and potential diagnostic mimickers associated with the most frequent types of lung carcinoma observed in small biopsies. Additionally, we emphasize the importance of proper immunohistochemical staining practices to preserve tissue for further molecular testing.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"36 ","pages":"Article 300735"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000070/pdfft?md5=4c4c979490d68c686f279c96efdf9d59&pid=1-s2.0-S2772736X24000070-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140123179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urine cytology: Updates and challenges in reporting systems, ancillary studies, and artificial intelligence 尿液细胞学：报告系统、辅助研究和人工智能的更新与挑战

Human Pathology Reports Pub Date : 2024-02-28 DOI: 10.1016/j.hpr.2024.300733

Juan Xing , Jordan P. Reynolds , Xiaoying Liu , Liron Pantanowitz

{"title":"Urine cytology: Updates and challenges in reporting systems, ancillary studies, and artificial intelligence","authors":"Juan Xing , Jordan P. Reynolds , Xiaoying Liu , Liron Pantanowitz","doi":"10.1016/j.hpr.2024.300733","DOIUrl":"https://doi.org/10.1016/j.hpr.2024.300733","url":null,"abstract":"<div><p>Several urine cytology classifications have been published in the literature. However, global acceptance in the field of urine cytology was only gained in 2016 after The Paris System for reporting urinary cytology was published. Despite this Paris System and its shifted focus toward the detection of high-grade urothelial carcinoma, the perceived weakness of low sensitivity and indeterminate diagnoses when screening with urine cytology remains unresolved. To overcome these shortcomings, investigators have studied a variety of emerging ancillary tests to augment urine cytology (UroVysion, ImmunoCyt/uCyte+, BTA-stat/TRAK, NMP22, SCD-A7, URO17, CellDetect, UroMark, UroSEEK). Furthermore, with the advent of digital cytology, the creation of artificial intelligence tools has created innovative opportunities to aid with urine cytology. This review article discusses the lessons learned in the evolution of reporting systems, explores the merit and challenges of ancillary tests, and calls attention to potential utility of applying artificial intelligence in urine cytology.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"35 ","pages":"Article 300733"},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000057/pdfft?md5=47d0e37442379d106c973709c84ef298&pid=1-s2.0-S2772736X24000057-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139986115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Head and neck Cytopathology: Options for high-risk HPV testing in head and neck FNA specimens, a concise review 头颈部细胞病理学：头颈部 FNA 标本中的高危 HPV 检测选择，简明综述

Human Pathology Reports Pub Date : 2024-02-13 DOI: 10.1016/j.hpr.2024.300731

Tieying Hou, Hector Mesa, Shaoxiong Chen, Mohamed Hamdi Fouad Bikhet, Omer Saeed, Sheila Segura, Harvey Cramer

引用次数: 0