hLife Pub Date : 2025-09-01 Epub Date: 2025-06-05 DOI: 10.1016/j.hlife.2025.05.012

David Musoke, Paineto Masengere, Allan Ssembuusi, Keneth Sebukeera, Filimin Niyongabo, Carol Nabbanja, Shafik Senkubuge, Grace B. Lubega, Rhoda K. Wanyenze

引用次数: 0

Mucosal adenovirus vaccine Ad5-XBB.1.5 boosting elicits nasal IgA and transiently prevents JN.1 wave infection for less than 6 months in real-world settings 在现实环境中，黏膜腺病毒疫苗Ad5-XBB.1.5增强可诱导鼻腔IgA，并在不到6个月的时间内短暂预防JN.1波感染

hLife Pub Date : 2025-09-01 Epub Date: 2025-05-12 DOI: 10.1016/j.hlife.2025.05.001

Yanqun Wang , Peilan Wei , Jingjun Zhang , Tian Tang , Ruoxi Cai , Aiping You , Zhaoyong Zhang , Jiantao Chen , Yuanyuan Zhang , Bin Qu , Lei Chen , Qier Zhong , Xindan Xing , Zhiwei Lin , Jingxian Zhao , Xingui Tian , Airu Zhu , Lu Zhang , Jincun Zhao

{"title":"Mucosal adenovirus vaccine Ad5-XBB.1.5 boosting elicits nasal IgA and transiently prevents JN.1 wave infection for less than 6 months in real-world settings","authors":"Yanqun Wang , Peilan Wei , Jingjun Zhang , Tian Tang , Ruoxi Cai , Aiping You , Zhaoyong Zhang , Jiantao Chen , Yuanyuan Zhang , Bin Qu , Lei Chen , Qier Zhong , Xindan Xing , Zhiwei Lin , Jingxian Zhao , Xingui Tian , Airu Zhu , Lu Zhang , Jincun Zhao","doi":"10.1016/j.hlife.2025.05.001","DOIUrl":"10.1016/j.hlife.2025.05.001","url":null,"abstract":"<div><div>Mucosal antibodies are critical for protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by limiting viral replication and transmission. While systemic immunity to SARS-CoV-2 is well-characterized, the durability and protective efficacy of mucosal vaccines, especially during the recent JN.1 wave, are less understood. In this study, we conducted a longitudinal assessment of systemic and nasal immune responses in 34 individuals who had received the inhaled Ad5-XBB.1.5 vaccination at days 0, 7, 14, 28, 90, and 180 post-vaccination, using neutralization assays, immunoglobulin A/G (IgA/IgG) enzyme-linked immunosorbent assay (ELISA), T-cell staining, and Fc-effector function assays. Our results showed that mucosal vaccination preferentially induces IgA responses in both nasal mucosa and systemic circulation, with nasal IgA showing stronger correlation with neutralizing titers than IgG. However, nasal antibody responses declined significantly by 6 months post-vaccination, with most participants experiencing breakthrough infections during the JN.1 wave. Individuals with high pre-existing anti-Ad5 antibodies exhibited reduced vaccine-induced neutralizing responses. The Ad5-XBB.1.5 mucosal vaccine enhanced antigen-specific CD8<sup>+</sup> T cell responses with a slight increase in Fc-mediated antibody-dependent cellular phagocytosis (ADCP), but failed to induce detectable CD4<sup>+</sup> T cell responses. Collectively, our findings elucidate the limited durability of mucosal immunity post-vaccination and highlight the need for improved mucosal vaccine strategies that sustain and optimize nasal IgA responses.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 9","pages":"Pages 433-447"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crucial functions of gut microbiota on gut–liver repair 肠道菌群在肠肝修复中的关键功能

hLife Pub Date : 2025-08-01 Epub Date: 2025-01-24 DOI: 10.1016/j.hlife.2025.01.001

Yamei Wang , Huining Yan , Qianqian Zheng , Xun Sun

引用次数: 0

Histoplasmosis misdiagnosed as malignancies in immunocompetent and immunocompromised patients 免疫功能正常和免疫功能低下患者中被误诊为恶性肿瘤的组织胞浆菌病：临床表现、放射学和病理学发现的全球视角

hLife Pub Date : 2025-08-01 Epub Date: 2024-07-05 DOI: 10.1016/j.hlife.2024.07.001

Ofonime E. Benjamin , Thelma E. Bassey , Chimaobi I. Nwagboso , Asukwo Onukak , Anthony C. Nlemadim , Bernard B. Akpu , David Elem , Bassey E. Ekeng

引用次数: 0

Candida albicans overgrowth impairs anti-PD-1 immunotherapy in oral tumor-bearing mice 白色念珠菌过度生长损害口腔荷瘤小鼠抗pd -1免疫治疗

hLife Pub Date : 2025-08-01 Epub Date: 2025-01-16 DOI: 10.1016/j.hlife.2024.12.004

Xu Wang , Xinming Zhang , Shuangshuang Wu , Zhimin Yan

引用次数: 0

Dissection of intratumor microbiome–host interactions at the single-cell level in lung cancer 肺癌单细胞水平肿瘤内微生物-宿主相互作用的解剖

hLife Pub Date : 2025-08-01 Epub Date: 2024-09-13 DOI: 10.1016/j.hlife.2024.09.001

Yong-Jing Ma , Yuan-Chen Sun , Lu Wang , Wan-Xing Xu , Xiao-Dan Fan , Jun Ding , Christopher Heeschen , Wen-Juan Wu , Xiao-Qi Zheng , Ning-Ning Liu

{"title":"Dissection of intratumor microbiome–host interactions at the single-cell level in lung cancer","authors":"Yong-Jing Ma , Yuan-Chen Sun , Lu Wang , Wan-Xing Xu , Xiao-Dan Fan , Jun Ding , Christopher Heeschen , Wen-Juan Wu , Xiao-Qi Zheng , Ning-Ning Liu","doi":"10.1016/j.hlife.2024.09.001","DOIUrl":"10.1016/j.hlife.2024.09.001","url":null,"abstract":"<div><div>The intratumor microbiome, one of the hallmarks of cancer, plays a crucial role in cancer progression through its interaction with the host. However, the underlying mechanisms remain poorly understood. In this study, six publicly available single-cell transcriptomic lung cancer datasets (comprising 178 samples) from multiple centers (Shanghai, New York, Seoul) were integrated to investigate the heterogeneity of host–microbiome interactions at the single-cell level using single-cell analysis of host–microbiome interactions (SAHMI). The results indicate that primary tumor tissues have a high proportion of fungi-associated cells, whereas metastatic brain tissues predominantly contain bacteria-associated cells. There are also distinct microbial distributions across cell types. Notably, the presence of specific bacteria significantly influences the transcriptome of resident host cells, including T cells and macrophages, by modulating pathways related to ribosomal RNA (rRNA) processing, cellular responses to stress and stimuli, and RNA and protein metabolism. Finally, specific cell-associated bacteria are significantly correlated with clinical features, such as lung cancer stages and smoking frequency. These single-cell insights into microbiome–host interactions improve current understanding about lung cancer development and progression and offer potential micro-ecological and diagnostic insights.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 8","pages":"Pages 391-406"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin microbiome dysbiosis in Prototheca wickerhamii infection wickerhamii原鞘感染的皮肤微生物群失调

hLife Pub Date : 2025-08-01 Epub Date: 2025-03-11 DOI: 10.1016/j.hlife.2025.03.001

Yan Zhang , Jian Guo , Runze Zhu , Liang Hu , Teng Li , Xiaoli Cao , Han Shen , Wenjuan Wu

引用次数: 0

778th Xiangshan Science Conference convenes experts to explore breakthroughs in lung and respiratory mucosal immunity 第778届香山科学大会汇聚专家，探讨肺与呼吸粘膜免疫的新突破

hLife Pub Date : 2025-08-01 Epub Date: 2025-04-17 DOI: 10.1016/j.hlife.2025.04.006

Qun Yan , Shuo Wang , Yi Shi

引用次数: 0

Advancing global antifungal development to combat invasive fungal infection 推进全球抗真菌药物研发，对抗侵袭性真菌感染

hLife Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI: 10.1016/j.hlife.2025.06.001

Xiu-Li Wang , Jun Ding , Koon Ho Wong , Chen Ding , Chang-Bin Chen , Wen-Juan Wu , Ning-Ning Liu

引用次数: 0

Ferritin-NP-preS1 vaccine synergizes with siRNA for sustained seroconversion against chronic hepatitis B in mice 铁蛋白np - pres1疫苗与siRNA协同作用，在小鼠体内持续进行血清转化，对抗慢性乙型肝炎

hLife Pub Date : 2025-07-01 Epub Date: 2025-02-18 DOI: 10.1016/j.hlife.2025.02.004

Wenjun Wang , Xiaoxiao Zhou , Tingting Guo , Qian Chai , Hongjun Wang , Mingzhao Zhu

引用次数: 0

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