Headache Currents最新文献

{"title":"Hemiplegic Migraine: Clinical Features, Links with Basilar-type Migraine, Current and Future Treatment","authors":"Anne Ducros M.D., Ph.D.","doi":"10.1111/j.1743-5013.2006.00037.x","DOIUrl":"10.1111/j.1743-5013.2006.00037.x","url":null,"abstract":"<p> <i>Hemiplegic migraine (HM) is a rare variety of migraine with aura characterized by the presence of a motor weakness during the aura. The HM has two main forms according to the familial history: cases where at least one first- or second-degree relative has aura including motor weakness have familial hemiplegic migraine (FHM), and cases without such familial history have sporadic hemiplegic migraine (SHM). FHM is the only variety of autosomal dominant migraine and all three known genes encode ion-transporters. Typical HM attacks include a motor weakness that is always associated to other aura symptoms, the most frequent being sensory, visual, and speech disturbances. In addition, basilar-type symptoms occur in up to 70% of the patients. Severe attacks may occur in FHM as well as in SHM with prolonged hemiplegia, confusion, coma, fever, and seizures. The clinical spectrum also includes permanent cerebellar signs (nystagmus, ataxia, dysarthria) and less frequently various types of seizures and mental retardation. A genetic diagnosis is now possible by screening the two major genes involved in FHM (CACNA1A and ATP1A2). Treatment of FHM and SHM is based on what is done in other varieties of migraine with aura. According to the new physiopathologic insights, preventive treatments by various antiepileptic agents seem promising.</i> </p>","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 4","pages":"86-96"},"PeriodicalIF":0.0,"publicationDate":"2006-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00037.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89692246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemiplegic and Basilar‐type Migraine: Epidemiology, Genetics, and Mechanisms","authors":"Esther de Theije-Kors, J. Haan","doi":"10.1111/J.1743-5013.2006.00036.X","DOIUrl":"https://doi.org/10.1111/J.1743-5013.2006.00036.X","url":null,"abstract":"Migraine is a frequent primary paroxysmal headache disorder. Within the migraine spectrum, rare variants can be recognized, such as hemiplegic migraine and basilar-type migraine. Hemiplegic migraine can occur sporadically or run in families with an autosomal dominant inheritance pattern. Genetic research in familial hemiplegic migraine has led to the identification of three genes so far. The CACNA1A gene is associated with the FHM1 phenotype, the ATP1A2 gene with FHM2, and the SCN1A gene with FHM3. A large phenotypic variety is seen, without a clear genotype-phenotype relation. While additional cerebellar ataxia predominantly is associated with the FHM1 phenotype, all three are associated with epileptic phenomena. Mutated genes in all three types of FHM are important in ion transport, defining FHM - and probably migraine in general - as an \"ionopathy.\"Functional studies of FHM1, FHM2, and FHM3 link the effects to the initiation of cortical spreading depression. With the identification of the three genetic subtypes of FHM, confirmation of a migraine diagnosis by molecular tests has become available.","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"116 1","pages":"73-81"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76148785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemiplegic and Basilar-type Migraine: Epidemiology, Genetics, and Mechanism(s)","authors":"M. Dichgans","doi":"10.1111/J.1743-5013.2006.00038.X","DOIUrl":"https://doi.org/10.1111/J.1743-5013.2006.00038.X","url":null,"abstract":"","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"46 1","pages":"82-85"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84809041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained Opioid Therapy Should Rarely Be Administered to Headache Patients: Clinical Observations, Literature Review, and Proposed Guidelines","authors":"Joel R. Saper M.D., F.A.C.P., F.A.A.N.,&nbsp;Alvin E. Lake III Ph.D.","doi":"10.1111/j.1743-5013.2006.00034.x","DOIUrl":"10.1111/j.1743-5013.2006.00034.x","url":null,"abstract":"","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 3","pages":"67-70"},"PeriodicalIF":0.0,"publicationDate":"2006-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00034.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90043082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioids in the Treatment of Headache: Perspective from the Bench","authors":"Michael H. Ossipov Ph.D.","doi":"10.1111/j.1743-5013.2006.00032.x","DOIUrl":"10.1111/j.1743-5013.2006.00032.x","url":null,"abstract":"<p> <i>It is well appreciated that excessive use of medication in the treatment of severe headaches may result in a paradoxical increase in intensity and frequency of the headaches, along with changes in the subjective qualities of the headaches themselves. A parallel development is found in the increasing appreciation for the observations that development of paradoxic abnormal pain can occur in response to prolonged exposure to opioids. In both of these situations, no clear mechanisms have yet been established. The increase in opioid use for clinical management of chronic, nonmalignant pain, including recurrent headache syndromes, over the past two decades has resulted in increased interest in the study of this phenomenon. Recent studies have indicated that prolonged opioid exposure results in several neuroplastic changes that ultimately lead to the establishment of descending facilitation arising from the RVM and in spinal sensitization. These changes have been associated with increased activity of CCK in the RVM that likely results in increased expression of spinal dynorphin, which itself promotes increased afferent inputs. Activation of a descending pain facilitatory system along with increased spinal dynorphin promote the release of excitatory neurotransmitters from primary afferent neurons. Together with increased release of PGE₂ from spinal neurons, the increased outflow of neurotransmitters from the primary afferent fibers sensitizes projection neurons that in turn activate descending pain facilitatory systems. Ultimately, knowledge of the mechanisms of possible deleterious actions of opiates may allow the development of new chemical approaches that can prevent these effects. Importantly, evidence is emerging that medication-induced enhanced pain is not unique to opioids, but may be generalized to other analgesic classes acting through G-protein coupled receptor systems. An understanding of these mechanisms would lead to improved therapeutic management of long-term painful conditions, including recurrent headache.</i> </p>","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 3","pages":"53-62"},"PeriodicalIF":0.0,"publicationDate":"2006-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00032.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83237127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioids in the Treatment of Headache: Scientific Abstract and Commentary","authors":"Andrew H. Ahn \u0000 M.D., Ph.D.","doi":"10.1111/j.1743-5013.2006.00033.x","DOIUrl":"10.1111/j.1743-5013.2006.00033.x","url":null,"abstract":"","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 3","pages":"63-66"},"PeriodicalIF":0.0,"publicationDate":"2006-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00033.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90509359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Opioid Therapy for Intractable Headache: Great Expectations or Dangerous Liaison?","authors":"Marwan Shuayto \u0000 M.D.\u0000 ,&nbsp;\u0000 John F. Rothrock \u0000 M.D.","doi":"10.1111/j.1743-5013.2006.00035.x","DOIUrl":"10.1111/j.1743-5013.2006.00035.x","url":null,"abstract":"","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 3","pages":"71-72"},"PeriodicalIF":0.0,"publicationDate":"2006-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00035.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88123030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Foramen Ovale and Migraine: Evidence for a Link?","authors":"Marie-Germaine Bousser M.D., Ph.D.","doi":"10.1111/j.1743-5013.2006.00030.x","DOIUrl":"10.1111/j.1743-5013.2006.00030.x","url":null,"abstract":"<p> <i>Recent epidemiological data suggest a bidirectional link between patent foramen ovale (PFO) and migraine with aura (MA) with a relative risk of 2 for PFO in subjects with MA and for MA in subjects with PFO. There is no evidence for a link between PFO and migraine without aura (MoA). This link is not systematic and applies only to subsets of PFO, mostly large ones, and to subsets of patients with MA. Although comorbidity cannot be ruled out, it is likely that this link is partly causal and that some large PFOs may favor MA attacks in genetically predisposed subjects, by allowing vasoactive substances, platelet emboli, or paradoxical emboli to bypass the lung filter and trigger cortical spreading depression. Even if ongoing randomized trials of PFO closure confirm the apparent benefit observed in the available retrospective studies, it would be dangerous to extrapolate from the improvement or even the cessation of symptomatic MA attacks to the treatment of migraine as a primary headache disorder.</i> </p>","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 2","pages":"44-51"},"PeriodicalIF":0.0,"publicationDate":"2006-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00030.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79264895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Foramen Ovale and Migraine—Where Do We Go From Here? Review of Selected Abstracts and Commentary","authors":"Todd J. Schwedt \u0000 M.D.\u0000 ,&nbsp;David W. Dodick \u0000 M.D.","doi":"10.1111/j.1743-5013.2006.00031.x","DOIUrl":"10.1111/j.1743-5013.2006.00031.x","url":null,"abstract":"","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 2","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2006-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00031.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90881935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Foramen Ovale: A Primer for Headache Physicians","authors":"Robert J. Sommer M.D.","doi":"10.1111/j.1743-5013.2006.00029.x","DOIUrl":"10.1111/j.1743-5013.2006.00029.x","url":null,"abstract":"<p> <i>Evidence continues to mount relating the patent foramen ovale (PFO), a small flap-valve in the wall separating the right and left atria of the heart, and number of neurologic syndromes including thromboembolic stroke, migraine headache, and decompression illness in divers. With increasing focus on the migraine relationship, both industry and patients are looking to neurologists for additional information about this cardiac defect. This review will examine the PFO in detail: its role in the fetal circulation, the formation of the atrial septum, the disease processes felt to be associated with it and their probable mechanisms, current closure techniques, and upcoming trials of these techniques.</i> </p>","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 2","pages":"23-36"},"PeriodicalIF":0.0,"publicationDate":"2006-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00029.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91467735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}