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Current Preventive Therapy: What We Know About Mechanism(s) of Action? 当前的预防治疗:我们对其作用机制了解多少?
Headache Currents Pub Date : 2009-05-12 DOI: 10.1111/j.1743-5013.2006.00041.x-i1
Julio Pascual M.D., Ph.D.
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引用次数: 0
Current Preventive Therapy: Preventive Treatment Mechanisms 当前预防治疗:预防治疗机制
Headache Currents Pub Date : 2009-05-12 DOI: 10.1111/j.1743-5013.2006.00042.x-i1
Stephen D. Silberstein M.D., F.A.C.P.
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引用次数: 4
Future Preventive Therapy: Are There Promising Drug Targets? 未来的预防治疗:有希望的药物靶点吗?
Headache Currents Pub Date : 2009-05-12 DOI: 10.1111/j.1526-4610.2005.05063.x-i1
Lars Edvinsson M.D., Ph. D.
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引用次数: 3
Future Preventive Therapy: Are There Promising Drug Targets? 未来的预防治疗:有希望的药物靶点吗?
Headache Currents Pub Date : 2009-05-12 DOI: 10.1111/j.1743-5013.2006.00040.x-i1
Jean Schoenen M.D., Ph.D.
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引用次数: 0
Future Preventive Therapy: Are There Promising Drug Targets? 未来的预防治疗:有希望的药物靶点吗?
Headache Currents Pub Date : 2006-09-01 DOI: 10.1111/J.1526-4610.2005.05063.X-I1
L. Edvinsson
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引用次数: 3
Current Preventive Therapy: Preventive Treatment Mechanisms 当前预防治疗:预防治疗机制
Headache Currents Pub Date : 2006-09-01 DOI: 10.1111/J.1743-5013.2006.00042.X-I1
F. Silberstein
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引用次数: 4
Future Preventive Therapy: Are There Promising Drug Targets? 未来的预防治疗:有希望的药物靶点吗?
Headache Currents Pub Date : 2006-09-01 DOI: 10.1111/J.1743-5013.2006.00042.X
J. Schoenen
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引用次数: 1
Hemiplegic and Basilar-type Migraine: Current and Future Treatment 偏瘫和基底型偏头痛:目前和未来的治疗
Headache Currents Pub Date : 2006-08-14 DOI: 10.1111/j.1743-5013.2006.00039.x
Gisela M. Terwindt M.D., Ph.D. , Joost Haan M.D., Ph.D. , Michel D. Ferrari M.D., Ph.D.
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引用次数: 1
Hemiplegic and Basilar-type Migraine: Epidemiology, Genetics, and Mechanisms 偏瘫和基底型偏头痛:流行病学、遗传学和机制
Headache Currents Pub Date : 2006-08-14 DOI: 10.1111/j.1743-5013.2006.00036.x
Esther De Theije-Kors M.D., Ph.D., Joost Haan M.D., Ph.D.
{"title":"Hemiplegic and Basilar-type Migraine: Epidemiology, Genetics, and Mechanisms","authors":"Esther De Theije-Kors M.D., Ph.D.,&nbsp;Joost Haan M.D., Ph.D.","doi":"10.1111/j.1743-5013.2006.00036.x","DOIUrl":"https://doi.org/10.1111/j.1743-5013.2006.00036.x","url":null,"abstract":"<p> <i>Migraine is a frequent primary paroxysmal headache disorder. Within the migraine spectrum, rare variants can be recognized, such as hemiplegic migraine and basilar-type migraine. Hemiplegic migraine can occur sporadically or run in families with an autosomal dominant inheritance pattern. Genetic research in familial hemiplegic migraine has led to the identification of three genes so far. The CACNA1A gene is associated with the FHM1 phenotype, the ATP1A2 gene with FHM2, and the SCN1A gene with FHM3. A large phenotypic variety is seen, without a clear genotype-phenotype relation. While additional cerebellar ataxia predominantly is associated with the FHM1 phenotype, all three are associated with epileptic phenomena. Mutated genes in all three types of FHM are important in ion transport, defining FHM—and probably migraine in general—as an “ionopathy.” Functional studies of FHM1, FHM2, and FHM3 link the effects to the initiation of cortical spreading depression. With the identification of the three genetic subtypes of FHM, confirmation of a migraine diagnosis by molecular tests has become available.</i> </p>","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 4","pages":"73-81"},"PeriodicalIF":0.0,"publicationDate":"2006-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00036.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91833651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Hemiplegic and Basilar-type Migraine: Epidemiology, Genetics, and Mechanism(s) 偏瘫和基底型偏头痛:流行病学、遗传学和机制
Headache Currents Pub Date : 2006-08-14 DOI: 10.1111/j.1743-5013.2006.00038.x
Martin Dichgans M.D.
{"title":"Hemiplegic and Basilar-type Migraine: Epidemiology, Genetics, and Mechanism(s)","authors":"Martin Dichgans \u0000 M.D.","doi":"10.1111/j.1743-5013.2006.00038.x","DOIUrl":"https://doi.org/10.1111/j.1743-5013.2006.00038.x","url":null,"abstract":"","PeriodicalId":100600,"journal":{"name":"Headache Currents","volume":"3 4","pages":"82-85"},"PeriodicalIF":0.0,"publicationDate":"2006-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1743-5013.2006.00038.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91833649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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