Environmental Chemistry and Ecotoxicology最新文献

{"title":"Molecularly imprinted poly(vinylidene fluoride) electrospinning membrane for enhancive endocrine disruptor adsorption and efficient dye removal by photodegradation","authors":"Xing-han Wang ,&nbsp;Luo-lin Deng ,&nbsp;Ke-yu Long ,&nbsp;Tian-mi Wang ,&nbsp;Ling-ling Yan ,&nbsp;De-yu Tang ,&nbsp;Qing-han Zhou","doi":"10.1016/j.enceco.2025.05.002","DOIUrl":"10.1016/j.enceco.2025.05.002","url":null,"abstract":"<div><div>Various water pollutants, such as endocrine disruptors, dyes, and microorganisms pose significant threats to the ecosystem and human health. However, integrated treatment methods for these pollutants are still scarcely investigated, which greatly impedes the advancement of water treatment technology. In this regard, there is an urgent need for novel combined processing techniques capable of simultaneously removing different types of pollutants from wastewater. Herein, we synthesized a molecularly imprinted MOF/PVDF electrospinning nanofibrous membrane, which is designed for selective adsorption of bisphenol A (BPA), photocatalytic degradation of methylene blue (MB), and efficient inhibition against bacteria in treating wastewater. Firstly, the as-prepared MOF/PVDF molecularly imprinted polymer membrane (MOF/PVDF-MIM) exhibits a higher affinity for BPA compared to other model pollutants attributing to the molecular imprinting effect. The adsorption mechanism was also investigated, indicating that the pseudo-second-order kinetics and Langmuir isotherm model closely match the adsorption process of the MOF/PVDF-MIM on BPA. In addition, the MOF/PVDF-MIM demonstrates excellent photocatalytic performance towards MB, achieving a degradation rate of up to 95.2 % under simulated sunlight irradiation. Moreover, the as-prepared membrane shows enhanced structural stability after several rounds of adsorption-desorption or degradation cycle, with a high adsorption rate of 53.1 % for BPA and a photocatalytic efficiency of 66.6 % for dye pollutants. Finally, it is observed that the as-prepared membrane exhibits excellent bacterial inhibition rates (&gt;99 %) against both Gram-negative and Gram-positive bacteria. In summary, the MOF/PVDF-MIM with outstanding performance in selective adsorption, photocatalytic degradation, and bacterial inhibition, can be potentially applied as an ideal filtration membrane for the combined treatments of water processing.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 882-900"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycyclic aromatic hydrocarbons in paddy soils: Distribution, source apportionment, and risk assessment in major rice-growing regions of China","authors":"Daoyu Liu ,&nbsp;Lili Niu ,&nbsp;Zili Guo ,&nbsp;Shuduan Mao ,&nbsp;Shuren Liu ,&nbsp;Dongmei Xu ,&nbsp;Chao Xu ,&nbsp;Xiaohui Sun ,&nbsp;Haiying Yu ,&nbsp;Weiping Liu","doi":"10.1016/j.enceco.2025.04.013","DOIUrl":"10.1016/j.enceco.2025.04.013","url":null,"abstract":"<div><div>Polycyclic aromatic hydrocarbons (PAHs) in agricultural environments and their potential health impacts have raised significant concern, particularly due to their substantial emissions from biomass and coal combustion. However, the environmental fate and human exposure risks of PAHs in flooded paddy soils, which are characterized by unique anaerobic conditions, remain poorly understood. To address this, we analyzed PAHs in flooded soils from three typical rice-growing regions in China, including Taihu Plain (TP), Hani Terrace (HT), and Sanjiang Plain (SP), covering a 4000 km transect with varying climatic and soil conditions. The concentrations of 16 U.S. Environmental Protection Agency priority PAHs ranged from 87.5 to 5820 ng/g in the TP, 56.6 to 707 ng/g in the HT, and 98.6 to 1480 ng/g in the SP. Notably, we found that 4–6-ring PAHs dominated in the TP, whereas 3- and 4-ring compounds were more prevalent in the HT and SP. Molecular diagnostic ratios, positive matrix factorization, and principal component analysis identified biomass combustion as the primary source of PAHs. Although 7 carcinogenic PAHs represented less than one-third of the total PAH concentrations, their toxic effects accounted for over 90 % of the overall toxicity, with cancer risks from daily rice consumption exceeding 60 %. Most samples showed PAH intake levels below permissible limits, and no samples posed unacceptable non-carcinogenic risk. These findings highlight the urgent need for a deeper understanding of PAH risks in paddy fields, providing multi-regional insights into the environmental and health impacts of rice cultivation and contributing to sustainable agricultural practices.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 935-943"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and source apportionment of methylated polycyclic aromatic hydrocarbons in sediments of reservoirs from the Qiantangjiang River, Wujiang River, and Pearl River","authors":"Tong Li ,&nbsp;Xiao-Ying Li ,&nbsp;Jun-Kang Ni ,&nbsp;Fu-Shun Wang ,&nbsp;Xue-Ping Chen ,&nbsp;Jing Ma ,&nbsp;Zi-Feng Zhang","doi":"10.1016/j.enceco.2025.02.008","DOIUrl":"10.1016/j.enceco.2025.02.008","url":null,"abstract":"<div><div>Methylated polycyclic aromatic hydrocarbons (MePAHs) pose more toxicity and persistence than their parent compounds, yet their contamination levels in reservoir sediments remain poorly understood. We analyzed 44 MePAHs in 72 surface and 199 core sediment samples from three watersheds in China: Qiantangjiang River (QTJ), Wujiang River (WJ), and Pearl River (PR). Total MePAH concentrations (ΣMePAHs) ranged from 19.7 to 1270 ng/g, with methylnaphthalenes and methyl phenanthrenes dominating. Temporally, the ΣMePAHs of surface sediments showed a pattern of dry season (340 ± 250 ng/g) &gt; wet season (303 ± 189 ng/g). Spatially, the ΣMePAHs of surface sediments showed a pattern of WJ (444 ± 235 ng/g) &gt; QTJ (253 ± 133 ng/g) &gt; PR (199 ± 161 ng/g). ΣMePAHs were higher in the surface sediments, and sediment cores of the reservoirs upstream than downstream (383 ± 261 ng/g &gt; 233 ± 113 ng/g, 340 ± 114 ng/g &gt; 105 ± 43.5 ng/g, respectively), and ΣMePAHs varied with the depth of the sediment cores. Notable disparities in component profiles were evident between QTJ and PR sites at various locations, whereas WJ exhibited homogeneity in its component distribution. Spatial and temporal variations revealed unique patterns influenced by diverse sources and environmental factors. TOC was the main factor affecting MePAH concentrations. The influence of hydrological factors on MePAHs pollution in sediments outweighed that of social factors. MePAH isomers that replace methyl groups at specific positions (1,2 or 4-position) were present in much higher concentrations than other isomers in sediment. These findings deepen our understanding of MePAHs pollution in reservoir sediments and are instrumental in crafting effective pollution control strategies.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 445-452"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidential-bio-inspired algorithms for modeling groundwater total hardness: A pioneering implementation of evidential neural network for feature selection in water resources management","authors":"Abdullahi G. Usman ,&nbsp;Abdulhayat M. Jibrin ,&nbsp;Sagiru Mati ,&nbsp;Sani I. Abba","doi":"10.1016/j.enceco.2025.02.012","DOIUrl":"10.1016/j.enceco.2025.02.012","url":null,"abstract":"<div><div>Accurate prediction of total hardness (TH) in groundwater is essential for ensuring its suitability for domestic, industrial, and agricultural use. Traditional methods often fail to capture the complex non-linear relationships that characterize water quality data, necessitating more advanced modeling techniques. In this study, three modeling schema batches were developed based on sensitivity analysis results using Evidential Neural Network (EVNN); Batch 1 (B1) include all the parameters, Batch 2 (B2) comprised of electrical conductivity (EC), residual sodium carbonate (RSC), calcium (Ca), chloride (Cl), magnesium (Mg), and nitrate (NO3), while Batch 3 (B3) composed of sulfate (SO4), sodium (Na), bicarbonate (HCO3), sodium adsorption ratio (SAR), potassium (K), groundwater level (GWL), Fluoride (F), pH, and carbonate (CO3) for modeling TH. The dataset was split into a 70:30 ratio for calibration and validation phases, respectively. The sensitivity analysis was subsequently enhanced by bio-inspired algorithms, to predict TH in groundwater, with a specific focus on optimizing feature selection. Sensitivity analysis identified key input features such as EC, RSC, Ca, and Mg as the most influential parameters. The EVNN, coupled with bio-inspired optimization algorithms, specifically the Firefly Algorithm (FA), Invasive Weed Optimization (IWO), and Anti-Bee Colony Optimization (ABC), achieved superior predictive accuracy compared to COVID optimization algorithm (COA). The EVNN-FA-ANN-B2 combination, particularly when using a refined set of features, demonstrated exceptional performance, with a coefficient of determination (R²) of 1.000 and RMSE close to zero. On the other hand, the EVNN-COA-ANN-B1 model exhibited the lowest accuracy, with an R² of 0.028 and an RMSE of 309.117. This research presents a novel, efficient, and reliable framework for predicting TH in groundwater, offering practical implications for water quality management, especially in regions where high TH levels pose significant challenges.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 494-505"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of low molecular weight organic acids on adsorption of Cd(II) by Auricularia auricula spent substrate-derived biochar: Types and reaction sequence","authors":"Xuesheng Liu ,&nbsp;Yue Jiang ,&nbsp;Wei Yang ,&nbsp;Sha Li ,&nbsp;Yu Jin ,&nbsp;Juanjuan Qu ,&nbsp;Wei Wang","doi":"10.1016/j.enceco.2024.09.001","DOIUrl":"10.1016/j.enceco.2024.09.001","url":null,"abstract":"<div><div>Cadmium (Cd) is one of the most mobile and toxic heavy metals that seriously deteriorates crop quality and threatens human health. It is considered an effective means to stabilize Cd in soil and reduce plant uptake by the application of biochar. However, the interactions and mechanisms between biochar and Cd in the rhizospheric soil are blurred due to the involvement of low molecular weight organic acids (LMWOAs). In this study, four different reaction sequences were established to simulate the chemical interactions between LMWOAs and cadmium (Cd) in the rhizospheric soil with biochar. In terms of adsorption patterns, the results show that, LMWOAs not only slow down the adsorption of Cd ions onto biochar, but also desorb the adsorbed Cd ions from biochar. Tartaric acid (TA) makes adsorption easier, while citric acid (CA) and malic acid (MA) make it more difficult. In terms of adsorption mechanism, the functional groups of MA and CA on biochar the vary wtih reaction sequence, thereby affecting the Cd adsorption onto biochar. The functional groups of TA participate in the adsorption to the greatest extent, and its impact on adsorption is rarely influenced by the reaction sequence. The reaction sequence does not affect the types of Cd-crystals, but affects dissolvement or attachment to the surface of biochar. This study provides chemical insights for further understanding the impact of LMWOAs on the interaction between biochar and heavy metals in soil.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 154-163"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the pervasive influence of brominated flame retardants on reproductive and developmental outcomes: A systematic review","authors":"Jiahua Meng ,&nbsp;Zitong Zhang ,&nbsp;Jiaqi Tian ,&nbsp;Ning Li ,&nbsp;Zhen Chen ,&nbsp;Xiang Yun ,&nbsp;Dandan Song ,&nbsp;Fei Li ,&nbsp;Lin Zhang","doi":"10.1016/j.enceco.2025.01.006","DOIUrl":"10.1016/j.enceco.2025.01.006","url":null,"abstract":"<div><div>Brominated flame retardants are a class of chemical flame retardants containing bromine elements. Widely used in various consumer products to reduce fire hazards. However, the ubiquitous presence of BFRs in the environment and their potential to bioaccumulate in human tissues have raised concerns about their reproductive and developmental toxicity. This comprehensive review synthesizes the current epidemiological, in vivo, and in vitro evidence regarding the effects of both traditional and novel BFRs on reproductive and developmental health outcomes, where epidemiological studies have linked BFRs exposure to adverse neurodevelopmental, perinatal, and reproductive health consequences, while animal studies provide further insights into the impact of BFRs on parental and offspring health across mammalian and non-mammalian species. Cellular and molecular investigations have unraveled the mechanisms underlying BFRs-induced toxicity, including germ cell and zygote vulnerability, testicular toxicity, sperm quality alterations, and placental dysfunction. Furthermore, the interactive effects of BFRs with other environmental contaminants such as heavy metals, Polychlorinated Biphenyls, methylmercury, and Polyfluoroalkyl Substances have also been explored, which highlights the importance of mixture toxicology in assessing the risks associated with BFRs exposure. Despite the growing body of evidence, limitations in current research and challenges in extrapolating findings to human health risk assessment are discussed, along with recommendations for future research directions and risk management strategies. Based on which this review provides a comprehensive foundation for understanding the reproductive and developmental toxicity of BFRs and underscores the need for proactive measures to mitigate their adverse health effects and protect vulnerable populations.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 319-338"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Still there: Persistent Organic Pollutants in fish from two Italian high-mountain lakes","authors":"Aina Queral-Beltran ,&nbsp;Paolo Pastorino ,&nbsp;Marino Prearo ,&nbsp;Romà Tauler ,&nbsp;Silvia Lacorte","doi":"10.1016/j.enceco.2025.03.011","DOIUrl":"10.1016/j.enceco.2025.03.011","url":null,"abstract":"<div><div>Persistent Organic Pollutants (POPs) can accumulate in high-mountain lake fish due to long-range transport. The aim of this study was to determine the presence of 41 POPs included in the Stockholm Convention in muscle and livers of <em>Salvelinus fontinalis</em> collected from two high-altitude lakes in the Cottian Alps (Italy) (Upper Balma Lake and Lower Balma Lake) and to assess differences among lakes and across years (2017–2021). Thirty-nine fish muscle samples and 28 liver samples were extracted using an ultrasonic bath, and analyses were conducted using a Gas Chromatograph coupled to an Orbitrap mass spectrometer (GC–MS-Orbitrap). This procedure was first optimized and validated using spiked cod fish samples, with quality control parameters and method uncertainty provided. The collected fish from both lakes revealed the presence of p,p'-DDE, hexachlorobutadiene, hexachlorobenzene, pentachlorobenzene, and various polychlorinated biphenyls (PCBs) at concentrations ranging from 0.005 to 1.8 ng/g wet weight (w.w.). Principal component analysis (PCA) showed no significant differences over the four years of monitoring or between the two lakes, although older fish exhibited higher contamination levels. These findings confirm that, even more than 30 years after their prohibition, legacy contaminants persist in theoretically pristine remote areas, highlighting the need for continued environmental monitoring. Future research should integrate passive sampling methods and assess the bioavailability and ecological impacts of these pollutants. Additionally, further investigation is required to understand the influence of climate change on the remobilization and transport of POPs in high-mountain aquatic ecosystems.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 686-695"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical leachates from car tyre granulates and PET bottles induce toxic effects on Mytilus edulis haemocytes","authors":"M. Elisabetta Michelangeli ,&nbsp;Sicco H. Brandsma ,&nbsp;Maria Margalef ,&nbsp;Emelie Forsman ,&nbsp;Sebastian Kuehr ,&nbsp;Davide Spanu ,&nbsp;Tânia Gomes","doi":"10.1016/j.enceco.2025.03.010","DOIUrl":"10.1016/j.enceco.2025.03.010","url":null,"abstract":"<div><div>Plastic materials contain hazardous chemicals, including additives like flame retardants, antioxidants, stabilizers, and metals, which can leach into the environment and impact aquatic life. This study is the first to evaluate the toxicity of leachates derived from car tyre granulates (CTG) and PET bottles (PET) on haemocytes of the mussel <em>Mytilus edulis</em> using a flow cytometry approach close to in vitro conditions. Following 24 h exposure, CTG leachates, characterized by a complex chemical profile (13,520 features) and high metal load, reduced cell viability, metabolic activity, mitochondrial reactive oxygen species (ROS) formation, lipid peroxidation (LPO) and lysosomal content. These leachates also impaired cytoplasmatic and mitochondrial membrane potentials, increased neutral lipids and altered DNA content. PET leachates, although with fewer chemical features (5631) and metal levels, also reduced cell viability, metabolic activity, LPO, and lysosome content, while increasing cytoplasmic membrane potential, ROS levels, NL, and altering MMP and DNA content. These findings indicated that leachates from CTG and PET can impair haemocytes functions in bivalves through mechanisms such as oxidative stress, membrane depolarization, and disrupted metabolic processes, underscoring their toxic potential. This study highlighted the toxicity pathways of plastic leachates in marine organisms, linking their complex chemical composition of organic and inorganic compounds to high ecotoxicological risks in environmental conditions.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 776-790"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weakened serum albumin binding-to-activated EGFR internalization in cellular accumulation for the synergistic toxicity of tetrabromobisphenol A and perfluorooctanoic acid","authors":"Chuxuan Chen ,&nbsp;Xijuan Chao ,&nbsp;Mingjiang Zuo ,&nbsp;Guoqiang Shan ,&nbsp;Yongmei Qi ,&nbsp;Dejun Huang ,&nbsp;Zhiguo Sheng ,&nbsp;Benzhan Zhu","doi":"10.1016/j.enceco.2025.03.004","DOIUrl":"10.1016/j.enceco.2025.03.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Brominated flame retardants (BFRs) and per-fluoroalkyl substances (PFAS), are globally concerned persistent toxic substances (PTS) with high co-exposure risks due to their coexistence in the environment matrices and even in humans. However, their combined toxicity hasn't been explored yet. The respective representatives tetrabromobisphenol A (TBBPA) and perfluorooctanoic acid (PFOA) share similar exposure routes and properties of substantial bioaccumulation and environmental persistence.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;To investigate the combined toxicity of BFRs and PFAS with TBBPA and PFOA as the research subjects, and elucidate the mechanisms responsible for the combined toxicity.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Combined toxicity were evaluated after co-exposure with TBBPA and PFOA at non-toxic and even environmentally relevant low doses in vitro. Cellular accumulation of TBBPA/PFOA was detected by UPLC-MS/MS. Serum albumin binding constant of TBBPA or PFOA under single and co-existence was detected by fluorescence spectrometric titration, and the effects of varied albumin binding affinity on cellular accumulation were evaluated. Then, combined methods of transcriptomics, Q-PCR, Western blot, immunofluorescence imaging, gene knockdown and molecular docking were employed to detect epidermal growth factor receptor (EGFR) expression, internalization and its role in contributing to the cellular uptake of the pollutants.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Cell viability under co-exposure with 100 μM TBBPA/250 μM PFOA at non-toxic concentration alone reduced to 65.55 %, while the ratio of apoptotic and necrotic cells enhanced to 63.93 %. The combined toxicity was demonstrated to be synergism. Increased cellular accumulation of each pollutant was responsible for the synergistic toxicity. We next found TBBPA/PFOA co-existence can weaken each other's serum albumin binding ability, leading to higher free TBBPA and PFOA levels in medium that were easier for cellular uptake than albumin-bounded ones, thereby resulting in the enhanced cellular levels of both compounds. Endocytosis was then demonstrated to contribute to the cellular uptake of free TBBPA/PFOA molecules. Thereafter, a non-canonical EGFR internalization was activated and upregulated due to the cellular oxidative stress, which further mediated more cellular uptake of TBBPA/PFOA.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Taken together, the effects of weakened serum albumin binding-to-activated EGFR internalization contributed to the enhanced cellular accumulation of each pollutant in a cascade mode, thereby resulting in the combined cytotoxicity. Our findings represent the first experimental study on BFRs and PFAS co-exposure risks with TBBPA/PFOA, and propose a new mechanism for the combined toxicity, which may have broad environmental, chemical, and biomedical significance for future research on the other environmental pollutants and their analogs.&lt;/d","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 623-634"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive analytical approach to monitoring selected emerging contaminant classes in sewage sludge and e-waste from Norway","authors":"Daniel Gutiérrez-Martín ,&nbsp;Gabriela Castro ,&nbsp;Susana V. González ,&nbsp;Hans Peter H. Arp ,&nbsp;Rebeca López-Serna ,&nbsp;Alexandros G. Asimakopoulos","doi":"10.1016/j.enceco.2025.05.004","DOIUrl":"10.1016/j.enceco.2025.05.004","url":null,"abstract":"<div><div>Sewage sludge and waste from electrical and electronic equipment (WEEE) constitute the most challenging materials to manage within a circular economy framework due to their complex composition and the presence of hazardous substances. Their increasing generation results in a wide variety of contaminants, highlighting the need for new strategies to ensure their proper management. Herein, an analytical procedure was developed for the analysis of 75 contaminants belonging to 7 contaminant classes in sewage sludge and WEEE: benzothiazoles, benzotriazoles, poly- and perfluorinated alkyl substances (PFAS), bisphenols, benzophenones, parabens, and monoester phthalate analogues and phthalic acid (mPHTs). The proposed methodology involved liquid-solid extraction (LSE) assisted by ultrasonication, followed by solid phase extraction (SPE) as a clean-up step, tailored to liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The methodology was successfully applied, obtaining method limits of quantification (mLOQs) ranging from 0.06 to 21.7 ng g⁻¹ in WEEE and from 0.26 to 43.6 ng g⁻¹ d.w. in sewage sludge. Median total concentrations of the target contaminants ranged from 22.5 to 257 ng g⁻¹ d.w. in sludge, and from 3.50 to 1025 ng g⁻¹ in WEEE. Removal efficiencies during the treatment of sludge were also assessed, demonstrating 89 % removal of the total concentrations during anaerobic digestion of sludge. Regarding WEEE, mPHTs demonstrated the highest detection rates, while PFAS were the least detected. This work improves the understanding of environmental contamination caused by emerging contaminants present in both sludge and WEEE and emphasizes the critical need for effective management.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 901-909"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}