Chemical record最新文献_第2页

Green Synthesis and Biological Aspect of Seven-Membered Azepine Hybrids: A Recent Update". 七元氮杂化物的绿色合成与生物学研究进展”。

IF 7 2区化学

Chemical record Pub Date : 2025-01-13 DOI: 10.1002/tcr.202400156

Annu Bhardwaj, Shivangi Jaiswal, Kanika Verma, Khushboo Bhardwaj, Manali Sharma, Sonika Jain, Jaya Dwivedi, Swapnil Sharma

{"title":"Green Synthesis and Biological Aspect of Seven-Membered Azepine Hybrids: A Recent Update\".","authors":"Annu Bhardwaj, Shivangi Jaiswal, Kanika Verma, Khushboo Bhardwaj, Manali Sharma, Sonika Jain, Jaya Dwivedi, Swapnil Sharma","doi":"10.1002/tcr.202400156","DOIUrl":"https://doi.org/10.1002/tcr.202400156","url":null,"abstract":"Seven-membered nitrogen-containing heterocycles, particularly azepine-based compounds, represent an intriguing class of molecules with vast arrays of applications. These compounds have garnered considerable attention in synthetic and medicinal chemistry due to their non-planar, non-aromatic features, which offer structural flexibility and diversity to design new drugs with improved pharmacological properties. This review summarizes the recent advances in the synthesis of azepine derivatives, including eco-friendly methodologies that align with the principles of green chemistry, which emphasize atom economy, sustainability, and waste reduction. Besides, the present article highlights diverse biological activities, viz. anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, and neuroprotective effects of azepine derivatives. Additionally, the review discusses key aspects such as molecular docking studies, structure-activity relationships (SAR), and mode of action evident through preclinical and clinical trials. The information presented in the current review article would assist researchers in designing and developing novel azepine-based leads for varied therapeutic applications.","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400156"},"PeriodicalIF":7.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Current Collectors for Aqueous Zinc-ion Batteries. 锌离子电池集流器的研究进展。

IF 7 2区化学

Chemical record Pub Date : 2025-01-05 DOI: 10.1002/tcr.202400217

Hao Li, Le Li, Wanxin Liu, Shaofeng Jia, Shi Yue, Yuanyuan Yang, Conghui Wang, Chao Tan, Dan Zhang

引用次数: 0

Targeted Nanoprobes Enabled Precision Theranostics in Triple-Negative Breast Cancer. 靶向纳米探针用于三阴性乳腺癌的精确治疗。

IF 7 2区化学

Chemical record Pub Date : 2025-01-02 DOI: 10.1002/tcr.202400171

Ke Ma, Meng Yin, Ke-Zheng Chen, Sheng-Lin Qiao

{"title":"Targeted Nanoprobes Enabled Precision Theranostics in Triple-Negative Breast Cancer.","authors":"Ke Ma, Meng Yin, Ke-Zheng Chen, Sheng-Lin Qiao","doi":"10.1002/tcr.202400171","DOIUrl":"https://doi.org/10.1002/tcr.202400171","url":null,"abstract":"Triple-negative breast cancer (TNBC) represents a highly aggressive and prognostically unfavorable subtype of breast cancer, characterized by the absence of common hormone receptors, which renders conventional therapies largely ineffective. This review comprehensively examines the molecular and clinical characteristics of TNBC, underscoring the substantial challenges inherent in its treatment and the innovative potential of targeted nanoprobes in advancing both diagnostic and therapeutic paradigms. Through the modification of targeting molecules, nanoprobes can deliver therapeutic agents highly specific to TNBC cells, thus significantly improving the sensitivity of diagnostic modalities and the efficacy of therapeutic interventions. Our discussion systematically explores the application of various targeting molecules and their advantages and limitations. In addition, this review presents a series of multifunctional targeted nanoprobes that are designed to perform both diagnostic and therapeutic functions, thus providing a synergistic approach to the treatment of TNBC. These advanced nanoprobes enable precise tumor localization while monitoring the therapeutic response in real time, thus facilitating a more personalized and dynamic treatment regimen. The major obstacles encountered during clinical translation are discussed in detail. The use of targeted nanoprobes represents a major leap forward in personalized medicine for TNBC, and current research efforts will continue to refine these technologies to improve clinical applicability.","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400171"},"PeriodicalIF":7.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organometallic Photocatalyst-Promoted Synthesis and Modification of Carbohydrates under Photoirradiation 有机金属光催化剂促进碳水化合物在光照射下的合成和修饰。

IF 7 2区化学

Chemical record Pub Date : 2024-12-27 DOI: 10.1002/tcr.202400161

Jing Wang, Fan Zhou, Yuping Xu, Lei Zhang

引用次数: 0

Cover Picture: Reductive Transformation of CO2 to Organic Compounds (Chem. Rec. 12/2024)

IF 7 2区化学

Chemical record Pub Date : 2024-12-23 DOI: 10.1002/tcr.202481201

An-Guo Wu, Jie Ding, Lan Zhao, Prof. Dr. Hong-Ru Li, Prof. Dr. Liang-Nian He

引用次数: 0

Electrochemical Selective Nitrate Reduction: Pathways to Nitrogen and Ammonia Production. 电化学选择性硝酸盐还原：氮和氨生产途径。

IF 7 2区化学

Chemical record Pub Date : 2024-12-23 DOI: 10.1002/tcr.202400206

Md Monjorul Islam, S M Abu Nayem, Syed Shaheen Shah, Md Zahidul Islam, Md Abdul Aziz, A J Saleh Ahammad

{"title":"Electrochemical Selective Nitrate Reduction: Pathways to Nitrogen and Ammonia Production.","authors":"Md Monjorul Islam, S M Abu Nayem, Syed Shaheen Shah, Md Zahidul Islam, Md Abdul Aziz, A J Saleh Ahammad","doi":"10.1002/tcr.202400206","DOIUrl":"https://doi.org/10.1002/tcr.202400206","url":null,"abstract":"Nitrate (NO3 -) contamination from industrial, agricultural, and anthropogenic activities poses significant risks to human health and ecosystems. While traditional NO3 - remediation methods are effective, they often generate secondary pollutants and incur high costs. Electrochemical NO3 -reduction (ECNR) offers a sustainable alternative, converting NO3 - into environmentally benign nitrogen (N2) or valuable ammonia (NH3). This review explores recent advancements in selective ECNR pathways for NO3 --to-N2and NO3 --to-NH3 conversion, focusing on mechanistic insights, electrocatalyst development, and optimization strategies. Key factors influencing ECNR performance, such as electrode materials, electrolyte composition, and hydrogen evolution inhibition, are discussed. Additionally, the review highlights the role of single-atom, bimetallic, and nanostructured catalysts in enhancing faradaic efficiency, total N2 removal, and selectivity, with particular attention to Pd-Cu systems. Strategies to address challenges like low selectivity and catalyst degradation are also explored. This review underscores the potential of ECNR as a viable alternative to the energy-intensive Haber-Bosch process for NH3 production, aligning with global sustainability goals. Finally, we identify research gaps and propose future directions for improving the efficiency, stability, and scalability of ECNR technologies.","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400206"},"PeriodicalIF":7.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis and Application of 1,4-disubstituted 1,2,3-triazole Based Chemosensors: A Promising Avenue 1,4-二取代1,2,3-三唑类化学传感器的设计、合成与应用

IF 7 2区化学

Chemical record Pub Date : 2024-12-23 DOI: 10.1002/tcr.202400195

Poonam Malik, Mona Yadav, Ravi Bhushan

引用次数: 0

Recent Progress of Substituted Allylboron Compounds in Catalytic Asymmetric Allylation Reactions. 取代烯丙基硼化合物催化不对称烯丙基化反应的研究进展。

IF 7 2区化学

Chemical record Pub Date : 2024-12-20 DOI: 10.1002/tcr.202400208

Xiaoxue Tang, Yushuang Chen, Jingbin Huang

引用次数: 0

The Sweet Spirits of the Mineral Acids: Diethyl Ether, Ethyl Nitrite, and Chloroethane. Late Medieval-Early Modern Organic Chemistry. 无机酸的甜烈酒：乙醚、亚硝酸盐乙酯和氯乙烷。中世纪晚期-近代早期有机化学。