发布求助
文献互助 智能选刊 最新文献

Chemical record最新文献

筛选
英文 中文
31P Nuclear Magnetic Resonance Spectroscopy for Monitoring Organic Reactions and Organic Compounds. 用于监测有机反应和有机化合物的 31P 核磁共振波谱。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-05 DOI: 10.1002/tcr.202400132
João Marcos Anghinoni, Irum, Haroon Ur Rashid, Eder João Lenardão, Márcio Santos Silva
{"title":"<sup>31</sup>P Nuclear Magnetic Resonance Spectroscopy for Monitoring Organic Reactions and Organic Compounds.","authors":"João Marcos Anghinoni, Irum, Haroon Ur Rashid, Eder João Lenardão, Márcio Santos Silva","doi":"10.1002/tcr.202400132","DOIUrl":"https://doi.org/10.1002/tcr.202400132","url":null,"abstract":"<p><p><sup>31</sup>P NMR spectroscopy is a consolidated tool for the characterization of organophosphorus compounds and, more recently, for reaction monitoring. The evolution of organic synthesis, mainly due to the combination of elaborated building blocks with enabling technologies, generated great challenges to understand and to optimize the synthetic methodologies. In this sense, <sup>31</sup>P NMR experiments also became a routine technique for reaction monitoring, accessing products and side products yields, chiral recognition, kinetic data, intermediates, as well as basic organic parameters, such as acid-base and hydrogen-bonding. This review deals with these aspects demonstrating the essential role of the <sup>31</sup>P NMR spectroscopy. The recent publications (the last ten years) will be explored, discussing the experiments of <sup>31</sup>P NMR and the strategies accomplished to detect and/or quantify distinct organophosphorus molecules, approaching reaction mechanism, stability, stereochemistry, and the utility as a probe.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400132"},"PeriodicalIF":7.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Data Science Guiding Analysis of Organic Reaction Mechanism and Prediction. 数据科学指导有机反应机理分析和预测。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-05 DOI: 10.1002/tcr.202400148
Giovanna Scalli Tâmega, Mateus Oliveira Costa, Ariel de Araujo Pereira, Marco Antonio Barbosa Ferreira
{"title":"Data Science Guiding Analysis of Organic Reaction Mechanism and Prediction.","authors":"Giovanna Scalli Tâmega, Mateus Oliveira Costa, Ariel de Araujo Pereira, Marco Antonio Barbosa Ferreira","doi":"10.1002/tcr.202400148","DOIUrl":"https://doi.org/10.1002/tcr.202400148","url":null,"abstract":"<p><p>Advancements in synthetic organic chemistry are closely related to understanding substrate and catalyst reactivities through detailed mechanistic studies. Traditional mechanistic investigations are labor-intensive and rely on experimental kinetic, thermodynamic, and spectroscopic data. Linear free energy relationships (LFERs), exemplified by Hammett relationships, have long facilitated reactivity prediction despite their inherent limitations when using experimental constants or incorporating comprehensive experimental data. Data-driven modeling, which integrates cheminformatics with machine learning, offers powerful tools for predicting and interpreting mechanisms and effectively handling complex reactivities through multiparameter strategies. This review explores selected examples of data-driven strategies for investigating organic reaction mechanisms. It highlights the evolution and application of computational descriptors for mechanistic inference.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400148"},"PeriodicalIF":7.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomotors as Therapeutic Agents: Advancing Treatment Strategies for Inflammation-Related Diseases. 纳米马达作为治疗剂：推进炎症相关疾病的治疗策略。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-05 DOI: 10.1002/tcr.202400162
Min Luo, Fu-Kun Zhao, Yuan-Min Wang, Yong Luo
{"title":"Nanomotors as Therapeutic Agents: Advancing Treatment Strategies for Inflammation-Related Diseases.","authors":"Min Luo, Fu-Kun Zhao, Yuan-Min Wang, Yong Luo","doi":"10.1002/tcr.202400162","DOIUrl":"https://doi.org/10.1002/tcr.202400162","url":null,"abstract":"<p><p>Inflammation is a physiological response of the body to harmful stimuli such as pathogens, damaged cells, or irritants, involving a series of cellular and molecular events. It is associated with various diseases including neurodegenerative disorders, cancer, and atherosclerosis, and is a leading cause of global mortality. Key inflammatory factors, such as Tumor Necrosis Factor-alpha (TNF-α), Interleukin-1 (IL-1), Interleukin-6 (IL-6), Monocyte Chemoattractant Protein-1 (MCP-1/CCL2), RANTES (CCL5), and prostaglandins, play central roles in inflammation and disease progression. Traditional treatments such as NSAIDs, steroids, biologic agents, and antioxidants have limitations. Recent advancements in nanomaterials present promising solutions for treating inflammation-related diseases. Unlike nanomaterials that rely on passive targeting and face challenges in precise drug delivery, nanomotors, driven by chemical or optical stimuli, offer a more dynamic approach by actively navigating to inflammation sites, thereby enhancing drug delivery efficiency and therapeutic outcomes. Nanomotors allow for controlled drug release in response to specific environmental changes, such as pH and inflammatory factors, ensuring effective drug concentrations at disease sites. This active targeting capability enables the use of smaller drug doses, which reduces overall drug usage, costs, and potential side effects compared to traditional treatments. By improving precision and efficiency, nanomotors address the limitations of conventional therapies and represent a significant advancement in the treatment of inflammation-related diseases. This review summarizes the latest research on nanomotor-mediated treatment of inflammation-related diseases and discusses the challenges and future directions for optimizing their clinical translation.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400162"},"PeriodicalIF":7.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rubizhne Institute - a Birthplace of Photochromic Molecules. 鲁比日内研究所--光致变色分子的诞生地。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-03 DOI: 10.1002/tcr.202400143
Andrey G Lvov, Daria V Berdnikova
{"title":"Rubizhne Institute - a Birthplace of Photochromic Molecules.","authors":"Andrey G Lvov, Daria V Berdnikova","doi":"10.1002/tcr.202400143","DOIUrl":"https://doi.org/10.1002/tcr.202400143","url":null,"abstract":"<p><p>We introduce the community to the remarkable fact that two significant discoveries in the field of organic photoswitches are associated to the Rubizhne (Rubezhnoe) branch of the Research Institute of Organic Intermediates and Dyes during the last century. The institute in Rubizhne was a place where researchers of various nationalities carried out studies of organic dyes for printing and textiles. These efforts resulted in the discoveries of photoswitchable hemithioindigos by M. A. Mostoslavskii and peri-aryloxyquinones by Yu. E. Gerasimenko. Herein, based on the available literature, we reconstruct the circumstances surrounding these outstanding findings and highlight the unique role of the Rubizhne institute as a research center. Furthermore, we demonstrate the impact of the results of the Rubizhne researchers on the field of photoswitchable molecules.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400143"},"PeriodicalIF":7.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Review on the Synthesis of [1,2,3]Triazolo[1,5-a]Quinolines. 1,2,3]三唑并[1,5-a]喹啉类化合物合成综述》。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-01 Epub Date: 2024-10-16 DOI: 10.1002/tcr.202400107
Gabriel P Da Costa, Manoela Sacramento, Angelita M Barcellos, Diego Alves
{"title":"Comprehensive Review on the Synthesis of [1,2,3]Triazolo[1,5-a]Quinolines.","authors":"Gabriel P Da Costa, Manoela Sacramento, Angelita M Barcellos, Diego Alves","doi":"10.1002/tcr.202400107","DOIUrl":"10.1002/tcr.202400107","url":null,"abstract":"<p><p>This report outlines the evolution and recent progress about the different protocols to synthesize the N-heterocycles fused hybrids, specifically [1,2,3]triazolo[1,5-a]quinoline. This review encompasses a broad range of approaches, describing several reactions for obtaining this since, such as dehydrogenative cyclization, oxidative N-N coupling, Dieckmann condensation, intramolecular Heck, (3+2)-cycloaddition, Ullman-type coupling and direct intramolecular arylation reactions. We divided this review in three section based in the starting materials to synthesize the target [1,2,3]triazolo[1,5-a]quinolines. Starting materials containing quinoline or triazole units previously formed, as well as starting materials which both quinoline and triazole units are formed in situ. Different methods of obtaining are described, such as metal-free or catalyzed conditions, azide-free, using conventional heating or alternative energy sources, such as electrochemical and photochemical methods. Mechanistic insights underlying the reported reactions were also described in this comprehensive review.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400107"},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Graphene-Based Catalysts: Emerging Applications and Potential Impact. 石墨烯基催化剂：新兴应用与潜在影响》。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1002/tcr.202400096
Mir Waqas Alam, Nassiba Allag, Mir Naveed-Ur-Rehman, Shahidul Islam Bhat
{"title":"Graphene-Based Catalysts: Emerging Applications and Potential Impact.","authors":"Mir Waqas Alam, Nassiba Allag, Mir Naveed-Ur-Rehman, Shahidul Islam Bhat","doi":"10.1002/tcr.202400096","DOIUrl":"10.1002/tcr.202400096","url":null,"abstract":"<p><p>Carbon nanofillers in general and graphene in particular are considered as promising potential candidates in catalysis due to their two-dimensional (2D) nature, zero bandwidth, single atom thickness with a promising high surface area: volume ratio. Additionally, graphene oxide via result of tunable electrical properties has also been developed as a catalytic support for metal and metal oxide nanofillers. Moreover, the possession of higher chemical stability followed by ultrahigh thermal conductivity plays a prominent role in promoting higher reinforcement of catalytically active sites. In this review we have started with an overview of carbon nanofillers as catalyst support, their main characteristics and applications for their use in heterogeneous catalysis. The review article also critically focusses on the catalytic properties originating from both functional groups as well as doping. An in-depth literature on the various reaction catalysed by metal oxide based nanoparticles supported on GO/rGO has also been incorporated with a special focus on the overall catalytic efficiency with respect to graphene contribution. The future research prospective in the aforementioned field has also been discussed.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400096"},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Developments in Copper-Catalyzed Annulations for Synthesis of Spirooxindoles. 铜催化环化合成螺吲哚的最新进展。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-01 Epub Date: 2024-10-22 DOI: 10.1002/tcr.202400126
Jinzan Feng, Yue Wang, Er-Qing Li, Teck-Peng Loh
{"title":"Recent Developments in Copper-Catalyzed Annulations for Synthesis of Spirooxindoles.","authors":"Jinzan Feng, Yue Wang, Er-Qing Li, Teck-Peng Loh","doi":"10.1002/tcr.202400126","DOIUrl":"10.1002/tcr.202400126","url":null,"abstract":"<p><p>Spirooxindoles represent a special scaffold for pharmaceuticals and natural products, and significant advancements have been achieved in their synthesis in recent years. Among these, transition metal catalysis, particularly copper catalysis, has emerged as an efficient and reliable method for the synthesis of spirooxindoles. Based on different reaction types, two distinct substrate types have been summarized and classified by us for constructing spirooxindole scaffolds via intramolecular and intermolecular annulations. This review outlines the latest advancements in copper-catalyzed cyclization reactions for synthesizing spirooxindoles and provides detailed insights into the types of annulation reactions and their possible reaction mechanisms.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400126"},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in Desilylation Reactions for the Synthesis of Valuable Organic Molecules. 脱硅反应在合成有价值有机分子方面的进展。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI: 10.1002/tcr.202400120
Chuang Liu, Le Zhang, Qingqing You, Huangdi Feng, Junhai Huang
{"title":"Advancements in Desilylation Reactions for the Synthesis of Valuable Organic Molecules.","authors":"Chuang Liu, Le Zhang, Qingqing You, Huangdi Feng, Junhai Huang","doi":"10.1002/tcr.202400120","DOIUrl":"10.1002/tcr.202400120","url":null,"abstract":"<p><p>Silicon, due to its abundance, non-toxicity, and cost-effectiveness, is a critical element in the earth's crust with significant industrial applications. In organic chemistry, main group elements, and in particular silicon, are extensively utilized as versatile synthetic intermediates. Despite the current challenges associated with harsh reaction conditions and unsustainable practices in synthesizing crucial organic structural molecules, desilylation reactions have emerged as a facilitative method, offering milder conditions and operational simplicity. This review provides a comprehensive analysis of recent advancements in the synthesis of valuable organic molecules through two distinct desilylation reactions. It systematically presents the synthesis of a variety of derivatives, such as furan, alcohol, N-heterocyclic, and ketone, highlighting the broad substrate tolerance of these reactions. This broad functional group compatibility suggests a promising future for the synthesis of a wide range of bioactive molecules, underscoring the significant potential of desilylation in contemporary organic synthesis.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400120"},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Progress on NHC-Catalyzed 1,6-Conjugate Addition Reactions. NHC催化1,6-共轭物加成反应的最新进展。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI: 10.1002/tcr.202400125
Jun Sun, Shichun Jiang, Yonggui Liu, Ling Pan, Ying-Guo Liu, Bing Zeng
{"title":"Recent Progress on NHC-Catalyzed 1,6-Conjugate Addition Reactions.","authors":"Jun Sun, Shichun Jiang, Yonggui Liu, Ling Pan, Ying-Guo Liu, Bing Zeng","doi":"10.1002/tcr.202400125","DOIUrl":"10.1002/tcr.202400125","url":null,"abstract":"<p><p>As a significant variant of the Michael reaction, the 1,6-addition reaction has undergone considerable development over the past decade. This effective strategy enables the synthesis of a variety of novel and potentially bioactive functional molecules. In this review, we summarize the recent progress in NHC-catalyzed 1,6-addition reactions, highlighting their efficiency in the rapid synthesis of complex functional molecules. We also provide our perspectives on the future development of this dynamic and highly active research area.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400125"},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transition Metal-Catalyzed C-H Activation/Functionalization of 8-Methylquinolines. 过渡金属催化的 8-甲基喹啉的 C-H 活化/官能化。
IF 7 2区 化学
Chemical record Pub Date : 2024-11-01 Epub Date: 2024-10-18 DOI: 10.1002/tcr.202400116
Fatemeh Doraghi, Mohammad Mahdi Aghanour Ashtiani, Mahmoud Ameli, Bagher Larijani, Mohammad Mahdavi
{"title":"Transition Metal-Catalyzed C-H Activation/Functionalization of 8-Methylquinolines.","authors":"Fatemeh Doraghi, Mohammad Mahdi Aghanour Ashtiani, Mahmoud Ameli, Bagher Larijani, Mohammad Mahdavi","doi":"10.1002/tcr.202400116","DOIUrl":"10.1002/tcr.202400116","url":null,"abstract":"<p><p>8-Methylquinoline is regarded as an ideal substrate to participate in diversely C(sp<sup>3</sup>)-H functionalization reactions. The presence of the chelating nitrogen atom enables 8-methylquinoline to easily form cyclometallated complexes with various transition metals, leading to the selective synthesis of functionalized quinolines. Considering the great importance of quinoline cores in medicinal chemistry, in this review article, we have covered the publications related to the C-H activation and functionalization of 8-methylquinoline under transition metal catalysis during the last decade.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202400116"},"PeriodicalIF":7.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信