ChemistryEurope最新文献_第3页

Front Cover: Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame. (ChemistryEurope 3-4/2024) 封面：通过反应挤压合成肽。应用于阿斯巴甜的连续无溶剂制备。(欧洲化学》3-4/2024）。

ChemistryEurope Pub Date : 2024-07-08 DOI: 10.1002/ceur.202400043

Dr. Tharwat Mohy El-Dine, Matthieu Lavayssiere, Dr. Hélène Adihou, Prof. Gilles Subra, Dr. Thomas-Xavier Métro, Dr. Olivier Ludemann-Hombourger, Dr. Frédéric Lamaty

{"title":"Front Cover: Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame. (ChemistryEurope 3-4/2024)","authors":"Dr. Tharwat Mohy El-Dine, Matthieu Lavayssiere, Dr. Hélène Adihou, Prof. Gilles Subra, Dr. Thomas-Xavier Métro, Dr. Olivier Ludemann-Hombourger, Dr. Frédéric Lamaty","doi":"10.1002/ceur.202400043","DOIUrl":"https://doi.org/10.1002/ceur.202400043","url":null,"abstract":"Front Cover picture illustrates the merging of mechanics and chemistry to produce molecules of interest. The synthesis of peptides by flow mechanochemistry was performed in a twin-screw extruder (TSE) used as a chemical reactor. In their Research Article, T. M. El-Dine, T.-X. Métro, F. Lamaty, and co-workers describe how applications of screw-generated mechanical forces to a mixture of amino acids and coupling agents delivered to the top of a TSE barrel promoting the synthesis of the corresponding peptide—in this case, aspartame—recovered from the die of the TSE. Various peptides were synthesized by this method. The artwork was designed my by Marcelin Lamaty.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>\u0000 ","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"2 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.202400043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Feature: Introducing Weakly Ligated Tris(trifluoromethyl)copper(III) (ChemistryEurope 3-4/2024) 封面专题：弱连接三(三氟甲基)铜(III)介绍（欧洲化学 3-4/2024）

ChemistryEurope Pub Date : 2024-07-08 DOI: 10.1002/ceur.202400049

Dr. Vladimir Motornov, Martin Procházka, Nora Alpuente, Dr. Pedro Salvador, Prof. Petr Slavíček, Dr. Blanka Klepetářová, Prof. Xavi Ribas, Dr. Petr Beier

引用次数: 0

Activation of σ-Bonds by Group 13/Ylide-Based Ambiphiles: Understanding and Design 第 13 组/基于 Ylide 的 Ambiphiles 对 σ 键的活化：理解与设计

ChemistryEurope Pub Date : 2024-06-17 DOI: 10.1002/ceur.202400020

Daniel González-Pinardo, Dr. Felix Krämer, Prof. Dr. Frank Breher, Prof. Dr. Israel Fernández

引用次数: 0

Sulfoxide-Mediated Cys-Trp-Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization 氧化硫介导的 Cys-Trp 选择性生物共轭，可实现蛋白质标记和肽异源二聚化

ChemistryEurope Pub Date : 2024-06-17 DOI: 10.1002/ceur.202400014

Dr. Daishiro Kobayashi, Dr. Masaya Denda, Junya Hayashi, Kota Hidaka, Yutaka Kohmura, Dr. Takaaki Tsunematsu, Dr. Kohei Nishino, Dr. Harunori Yoshikawa, Dr. Kento Ohkawachi, Dr. Kiyomi Nigorikawa, Dr. Tetsuro Yoshimaru, Prof. Naozumi Ishimaru, Prof. Wataru Nomura, Prof. Toyomasa Katagiri, Prof. Hidetaka Kosako, Prof. Akira Otaka

{"title":"Sulfoxide-Mediated Cys-Trp-Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization","authors":"Dr. Daishiro Kobayashi, Dr. Masaya Denda, Junya Hayashi, Kota Hidaka, Yutaka Kohmura, Dr. Takaaki Tsunematsu, Dr. Kohei Nishino, Dr. Harunori Yoshikawa, Dr. Kento Ohkawachi, Dr. Kiyomi Nigorikawa, Dr. Tetsuro Yoshimaru, Prof. Naozumi Ishimaru, Prof. Wataru Nomura, Prof. Toyomasa Katagiri, Prof. Hidetaka Kosako, Prof. Akira Otaka","doi":"10.1002/ceur.202400014","DOIUrl":"https://doi.org/10.1002/ceur.202400014","url":null,"abstract":"A method was developed that enables the magnesium chloride (MgCl2)-activated S-acetamidomethyl cysteine sulfoxide (Cys(Acm)(O)) to induce the sp2(C−H) sulfenylation of the indole of Trp residues. The reaction operates under mild acidic conditions using acetic acid or an ionic liquid to give the Trp-sulfenylated products. Other than Trp, all other proteinogenic amino acids are unreactive to the sulfenylation conditions. We demonstrated the successful application of this reaction to various peptides, including lysozyme. Furthermore, we achieved the Trp-modification of a monoclonal antibody by a MgCl2-mediated reaction in an acidic ionic liquid. The resulting antibody exhibited antibody performance comparable to the parent protein. The amide moiety in the Acm group contributes to the difference in chemical behaviors between S-Acm and S-p-methoxybenzyl (MBzl)-protected cysteine sulfoxides. This is because the S-Acm sulfoxide is converted to S-chlorocysteine responsible for Trp-sulfenylation under less acidic conditions than those required for the reaction of S-MBzl sulfoxide. Based on this rationale, we prepared a linker possessing S-Acm and S-MBzl oxide moieties and subjected the linker to heterodimerization of DNA-binding MYC and MAX peptides containing a Trp handle. The one-pot/stepwise Cys-Trp conjugation between the linker and DNA-binding peptides allowed the generation of a heterodimeric MYC/MAX DNA binder.","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"2 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.202400014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent Paracyclophanes: Unveiling Ultra-Strong Binding with Cucurbit[8]uril in Aqueous Environments 荧光副环烷：揭示葫芦[8]脲在水环境中的超强结合力

ChemistryEurope Pub Date : 2024-06-03 DOI: 10.1002/ceur.202400003

Laura Marie Grimm, Yichuan Wang, Amrutha Prabodh, Emma Barilli, Sebastian Spicher, Zahid Hassan, Stefan Grimme, Stefan Bräse, Frank Biedermann

{"title":"Fluorescent Paracyclophanes: Unveiling Ultra-Strong Binding with Cucurbit[8]uril in Aqueous Environments","authors":"Laura Marie Grimm, Yichuan Wang, Amrutha Prabodh, Emma Barilli, Sebastian Spicher, Zahid Hassan, Stefan Grimme, Stefan Bräse, Frank Biedermann","doi":"10.1002/ceur.202400003","DOIUrl":"10.1002/ceur.202400003","url":null,"abstract":"In supramolecular chemistry, the pursuit of highly efficient molecular recognition systems holds paramount significance. This study introduces new [2.2]paracyclophanes (PCP) as exceptional guest molecules for cucurbit[8]uril (CB8). This well-matched host-guest interaction is marked by ultra-high binding affinities (Ka up to 1015 M−1 in water) accompanied by unprecedented exothermic contributions (ΔH up to −20.6 kcal mol−1) observed in CB8 binding, rivaling the exceptional affinities of cucurbit[7]uril (CB7), which has until now been recognized as the gold standard for high-affinity binding in water. The PCPs demonstrate an excellent fit within the CB8 cavity without structural deformation of the host. Our research methodology incorporates organic synthesis, NMR, fluorescence titration, and isothermal titration calorimetry (ITC) experiments, as well as quantum mechanical simulations, to systematically examine the binding characteristics of fluorescent mono- and dicationic PCP guests within the CB8 cavity. This study not only corroborates but also critically reevaluates certain aspects of the “high-energy water release model” for cucurbit[n]uril systems. Furthermore, the ease of modifying PCP compounds, combined with their superior water solubility compared to di- and triamantanes, and their characteristic fluorescent response in forming and disassembling host-guest complexes, elevates PCPs as promising candidates for the creation of advanced supramolecular CB8-functional materials and sensing assays.","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"2 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.202400003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141271296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of a Stable Cr2O3/Cu/TiO2 Plasmonic Photocatalyst for Selective Alcohol Oxidation under Visible Light Irradiation (λ>600 nm) 制备稳定的 Cr2O3/Cu/TiO2 等离子体光催化剂，用于在可见光照射下（λ>600 纳米）选择性氧化酒精

ChemistryEurope Pub Date : 2024-03-26 DOI: 10.1002/ceur.202400008

Dr. Atsuhiro Tanaka, Kohki Okabayashi, Ryosuke Yagi, Prof. Dr. Hiroshi Kominami

{"title":"Preparation of a Stable Cr2O3/Cu/TiO2 Plasmonic Photocatalyst for Selective Alcohol Oxidation under Visible Light Irradiation (λ>600 nm)","authors":"Dr. Atsuhiro Tanaka, Kohki Okabayashi, Ryosuke Yagi, Prof. Dr. Hiroshi Kominami","doi":"10.1002/ceur.202400008","DOIUrl":"10.1002/ceur.202400008","url":null,"abstract":"Copper (Cu) nanoparticles (NPs) loaded on titanium(IV) oxide (TiO2) exhibit an extinction at about λ=580 nm because of surface plasmon resonance (SPR); however, they rapidly lose their its SPR when exposed to air. In order to stabilize the Cu NPs, a multi-step photodeposition method was used to introduce chromium, which resulted in successful synthesis of a Cr2O3/Cu/TiO2 sample that exhibited extinction even when exposed to air. Transmission electron microscopy, scanning transmission electron microscopy, X-ray photoelectron spectroscopy and UV-vis spectroscopy were utilized to analyze the Cu/TiO2 and Cr2O3/Cu/TiO2 samples with a focus on SPR of the nanoparticles and state of the Cu species. The prepared Cr2O3/Cu/TiO2 samples acted as plasmonic photocatalysts in oxidation of 2-propanol under aerated conditions and visible light irradiation. Expandability of the Cr2O3/Cu/TiO2 plasmonic photocatalyst was also investigated, and the results suggested the potential of a Cu-based plasmonic photocatalyst working under irradiation of visible light.","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"2 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.202400008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame. 通过反应挤压合成肽。应用于阿斯巴甜的连续无溶剂制备。

ChemistryEurope Pub Date : 2024-03-25 DOI: 10.1002/ceur.202400007

Dr. Tharwat Mohy El-Dine, Matthieu Lavayssiere, Dr. Hélène Adihou, Prof. Gilles Subra, Dr. Thomas-Xavier Métro, Dr. Olivier Ludemann-Hombourger, Dr. Frédéric Lamaty

引用次数: 0

Single-Carbon Atom Doping Reactions Using Atomic Carbon and Its Equivalents 使用原子碳及其等价物的单碳原子掺杂反应

ChemistryEurope Pub Date : 2024-03-07 DOI: 10.1002/ceur.202400005

Dr. Hayato Fujimoto, Prof. Dr. Mamoru Tobisu

引用次数: 0

Introducing Weakly Ligated Tris(trifluoromethyl)copper(III) 引入弱配位三(三氟甲基)铜(III)

ChemistryEurope Pub Date : 2024-03-01 DOI: 10.1002/ceur.202400004

Dr. Vladimir Motornov, Martin Procházka, Nora Alpuente, Dr. Pedro Salvador, Prof. Petr Slavíček, Dr. Blanka Klepetářová, Prof. Xavi Ribas, Dr. Petr Beier

{"title":"Introducing Weakly Ligated Tris(trifluoromethyl)copper(III)","authors":"Dr. Vladimir Motornov, Martin Procházka, Nora Alpuente, Dr. Pedro Salvador, Prof. Petr Slavíček, Dr. Blanka Klepetářová, Prof. Xavi Ribas, Dr. Petr Beier","doi":"10.1002/ceur.202400004","DOIUrl":"10.1002/ceur.202400004","url":null,"abstract":"Tris(trifluoromethyl)copper(III), Cu(CF3)3, was prepared for the first time and fully characterized in the form of weakly coordinated highly reactive solvent neutral adducts (DMF)2Cu(CF3)3 and (MeCN)Cu(CF3)3. Free Cu(CF3)3 is an elusive molecule of distorted T-shaped geometry with Lewis acid properties, which is stabilized by solvation. Substitution of solvent molecules with monoanionic ligands in mild conditions afforded the first Cu(III)(CF3)3 carboxylates [Cu(CF3)3(OAc)]− and [Cu(CF3)3(OBz)]− and Cu(III) nitrito complex [Cu(CF3)3(ONO)]−. An improved synthesis of valuable Grushin's trifluoromethylation reagents via the intermediacy of (MeCN)Cu(CF3)3 was developed. (DMF)2Cu(CF3)3 demonstrated promising properties in photoinduced radical C-H trifluoromethylation. Oxidation state theoretical studies showed the Cu(CF3)3 compounds to be borderline between classical Cu(III) and inverted ligand field Cu(I) assignment.","PeriodicalId":100234,"journal":{"name":"ChemistryEurope","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ceur.202400004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140091339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Switching Product Selectivity in Immobilized Tungstate Catalysts by Control of Hydrophobicity of Mesoporous Silicate Supports (ChemistryEurope 2/2024) 封面：通过控制介孔硅酸盐载体的疏水性来改变固定化钨酸盐催化剂的产品选择性（欧洲化学 2/2024 期）

ChemistryEurope Pub Date : 2024-02-29 DOI: 10.1002/ceur.202400009

Ko Kuwamoto, Dr. Masaya Okamura, Prof. Dr. Shiro Hikichi

引用次数: 0