Chem & Bio Engineering最新文献

{"title":"Advances in Antibacterial Polymer Coatings Synthesized via Chemical Vapor Deposition","authors":"Haonian Shu,&nbsp;Pengyu Chen and Rong Yang*,&nbsp;","doi":"10.1021/cbe.4c0004310.1021/cbe.4c00043","DOIUrl":"https://doi.org/10.1021/cbe.4c00043https://doi.org/10.1021/cbe.4c00043","url":null,"abstract":"<p >Biofouling is a major issue across various industries ranging from healthcare to the production of food and water and transportation. Biofouling is often induced or mediated by environmental microbes, such as bacteria. Therefore, developing antibacterial coatings has been an essential focus of recent research on functional polymer thin films. To achieve high film quality, vapor-phase techniques represent promising alternatives to traditional solution-based methods, especially for the design and synthesis of antibacterial polymer coatings, as they enable highly uniform, chemically precise, and substrate-independent coatings. This Perspective examines the potential of vapor-phase polymerization techniques to create novel antibacterial polymer coatings. Current advancements in the design of antifouling, bactericidal, antibiofilm, and multifunctional coatings via vapor-phase techniques are organized based on their action mechanisms and design principles. The opportunities and challenges associated with implementing vapor-phase polymerization for developing antibacterial coatings are highlighted.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 6","pages":"516–534 516–534"},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141959193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering Interphasial Chemistry for Zn Anodes in Aqueous Zinc Ion Batteries","authors":"Boyuan Zhu,&nbsp;Jiahao Tang,&nbsp;Zhenjie Yao,&nbsp;Junjie Cui,&nbsp;Yangrui Hou,&nbsp;Jiarong Chen,&nbsp;Li Tang,&nbsp;Yongsheng Fu,&nbsp;Wenyao Zhang* and Junwu Zhu*,&nbsp;","doi":"10.1021/cbe.4c00053","DOIUrl":"10.1021/cbe.4c00053","url":null,"abstract":"<p >Aqueous zinc ion batteries (AZIBs) have emerged as promising candidates for large-scale energy storage systems during post lithium-ion era, drawing attention for their environmental-friendliness, cost-effectiveness, high safety, and minimal manufacturing constraints. However, the long-standing roadblock to their commercialization lies in the dendrite growth and parasitic reactions (hydrogen evolution reaction and water-induced corrosion) of the metallic zinc anode, which strongly depends on the complicated interphasial chemistries. This review, with a focus on optimizing the zinc anode/electrolyte interphase, begins by elucidating the intrinsic factor of zinc ions’ migration, diffusion, nucleation, electro-crystallization, and growth of the zinc nucleus in AZIBs, along with the underlying scientific principles. Then the electrochemical theories pertinent to the plating behavior of the interphase is systematically clarified, thereby enriching the understanding of how anode structure and electrolyte design principles relate to the electrode interphase. Accordingly, the rational strategies emphasizing structural engineering of the zinc anode and electrolyte have been summarized and discussed in detail. The mechanisms, advances, drawbacks, and future outlook of these strategies are analyzed for the purpose of fabricating a chemically and electrochemically stable interphase. Finally, the challenging perspectives and major directions of zinc anode are proposed. This review is expected to shed light on developing high-performance Zn anodes for use in sustainable AZIBs.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 5","pages":"381–413"},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141349700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Metal-Free Peptide Stapling Strategies","authors":"Wanglin Zhan,&nbsp;Hongliang Duan and Chengxi Li*,&nbsp;","doi":"10.1021/cbe.3c0012310.1021/cbe.3c00123","DOIUrl":"https://doi.org/10.1021/cbe.3c00123https://doi.org/10.1021/cbe.3c00123","url":null,"abstract":"<p >Protein–protein interactions (PPIs) pose challenges for intervention through small molecule drugs, protein drugs, and linear peptides due to inherent limitations such as inappropriate size, poor stability, and limited membrane penetrance. The emergence of stapled α-helical peptides presents a promising avenue as potential competitors for inhibiting PPIs, demonstrating enhanced structural stability and increased tolerance to proteolytic enzymes. This review aims to provide an overview of metal-free stapling strategies involving two identical natural amino acids, two different natural amino acids, non-natural amino acids, and multicomponent reactions. The primary objective is to delineate comprehensive peptide stapling approaches and foster innovative ideation among readers by accentuating methodologies published within the past five years and elucidating evolving trends in stapled peptides.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 7","pages":"593–605 593–605"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.3c00123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable Poly(amino acid)–Bismuth Nanotheranostic Agents for CT/MR Imaging and Photothermal–Chemodynamic Synergistic Therapy","authors":"Fengfeng Xiao,&nbsp;Yongkang Liu,&nbsp;Yanhong Su,&nbsp;Xu He,&nbsp;Ligong Lu,&nbsp;Meixiao Zhan,&nbsp;Liewei Wen*,&nbsp;Yunlu Dai* and Bing Liu*,&nbsp;","doi":"10.1021/cbe.4c00078","DOIUrl":"10.1021/cbe.4c00078","url":null,"abstract":"<p >Clearly delineating the tumor foci based on multimodal imaging techniques and precisely guiding the minimally invasive therapy are pivotal to completely remove tumors, especially for early micro-tumor lesions. Nevertheless, single-mode imaging techniques are difficult to accurately visualize the tumor region, and the mono-therapeutic strategy is hardly a complete removal of the tumor. In this study, we prepare a biodegradable amphiphilic polymer containing poly(aspartic acid). It is further self-assembled with Bi³⁺ and ultrasmall Fe₃O₄ to form a multifunctional nanocomplex (Bi/Fe₃O₄@P3), which served as a CT/MRI dual-imaging contrast agent and enhanced the photothermal/chemodynamic synergistic therapy. In addition, to enhance the photothermal efficiency, the thermal stress also elevated the level of intracellular H₂O₂, which would facilitate the Fenton reaction between Bi³⁺/Fe²⁺ and H₂O₂ and improve the chemodynamic therapy (CDT) efficacy. Particularly, Bi/Fe₃O₄@P3 would concurrently deplete the abundant intracellular GSH through the coordination of Bi³⁺ with GSH to further potentiate the PTT/CDT synergistic tumoricidal efficacy. Therefore, our study was expected to provide a promising theranostic nano-agent and potential comprehensive therapeutic strategy for microtumors.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 5","pages":"448–460"},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Electrosynthesis of Biomass Derived Furanic Compounds via Nitroxyl Radical Redox Mediation","authors":"Emily Carroll,&nbsp;Sarah L. Parker,&nbsp;Anna Fukushima,&nbsp;Sophie Downey,&nbsp;Delaney Miller,&nbsp;Zachary A. Nguyen,&nbsp;Dylan G. Boucher* and Shelley D. Minteer*,&nbsp;","doi":"10.1021/cbe.4c00034","DOIUrl":"10.1021/cbe.4c00034","url":null,"abstract":"<p >Biomass is an abundantly available, underutilized feedstock for the production of bulk and fine chemicals, polymers, and sustainable and biodegradable plastics that are traditionally sourced from petrochemicals. Among potential feedstocks, 2,5-furan dicarboxylic acid (FDCA) stands out for its potential to be converted to higher-value polymeric materials such as polyethylene furandicarboxylate (PEF), a bio-based plastic alternative. In this study, the sustainable, electrocatalytic oxidation of stable furan molecule 2,5-bis(hydroxymethyl)furan (BHMF) to FDCA is investigated using a variety of TEMPO derivative electrocatalysts in a mediated electrosynthetic reaction. Three TEMPO catalysts (acetamido-TEMPO, methoxy-TEMPO, and TEMPO) facilitate full conversion to FDCA in basic conditions with &gt;90% yield and &gt;100% Faradaic efficiency. The remaining three TEMPO catalysts (hydroxy-TEMPO, oxo-TEMPO, and amino-TEMPO) all perform intermediate oxidation of BHMF in basic conditions but do not facilitate full conversion to FDCA. On the basis of pH studies completed on all TEMPO derivatives to assess their electrochemical reversibility and response to substrate, pH and reversibility play significant roles in the catalytic ability of each catalyst, which directly influences catalyst turnover and product formation. More broadly, this study also highlights the importance of an effective and rapid electroanalytical workflow in mediated electrosynthetic reactions, demonstrating how voltammetric catalyst screening can serve as a useful tool for predicting the reactivity and efficacy of a catalyst–substrate electrochemical system.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 5","pages":"427–438"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance Study of Catalysts for Dehydrochlorination Reaction of 1,1,2-TCE Using In Situ FTIR-MS","authors":"Xiang Ge,&nbsp;Yu Jiang,&nbsp;Yu Chen,&nbsp;Shiyong Wu,&nbsp;Mei Cong and Jigang Zhao*,&nbsp;","doi":"10.1021/cbe.4c0007410.1021/cbe.4c00074","DOIUrl":"https://doi.org/10.1021/cbe.4c00074https://doi.org/10.1021/cbe.4c00074","url":null,"abstract":"<p >Dichloroethylene is mainly used to prepare high polymer compounds such as vinyl chloride fibers and polyvinylidene chloride. It is also an important raw material for producing lithium-ion battery adhesives. The industrial method for producing dichloroethylene involves a saponification reaction between trichloroethane and sodium hydroxide, which can lead to high environmental pollution. The 1,1,2-TCE (1,1,2-trichloroethane) catalytic cracking method has been widely studied due to its environmentally friendly potential to replace the saponification method. However, the low performance and stability of the catalysts have hindered the further development. The main reason is the lack of research on the intermediate processes of catalytic cracking. In this paper, in situ FTIR (Fourier transform infrared spectroscopy) and mass spectrometry combined technology was innovatively adopted to study the intermediate process of catalytic cracking of 1,1,2-TCE. In situ FTIR was used to analyze the generation of intermediate products, and online mass spectrometry was used to analyze the composition of exhaust gas. The formation of saturated steam from inert gas bubbling reactants in an in situ reaction pool could be used to investigate the microscopic reaction behavior of reactants on the catalyst surface in a macroscopic time system. The results indicated that 1,1,2-TCE produced residual products such as chloroacetylene and vinyl chloride during the dehydrochloride process. When 0.6 Cs/Al₂O₃ (activated alumina loaded with cesium chloride) was used as the catalyst, the dehydrochlorination of 1,1,2-TCE produced more chloroacetylene, reaching 4.62% at 533 K. When 0.6 Ba/Al₂O₃ (activated alumina loaded with barium chloride) was used as the catalyst, the dehydrochlorination of 1,1,2-TCE produced more vinyl chloride, reaching 6.54% at 533 K. Under the catalysis of 0.6 Cs/Al₂O₃, the initial cracking temperature of 1,1,2-TCE was 405 K, while under the catalysis of 0.6 Ba/Al₂O₃, the initial cracking temperature of 1,1,2-TCE was 450 K. The results revealed real-time changes in reactants and products during the reaction process, which was of great significance for catalyst screening, process condition selection, and research on the reaction mechanism.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 11","pages":"934–939 934–939"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Bioprinting of Microbial-based Living Materials for Advanced Energy and Environmental Applications","authors":"Xingqun Pu,&nbsp;Yuqi Wu,&nbsp;Junqiu Liu* and Baiheng Wu*,&nbsp;","doi":"10.1021/cbe.4c0002410.1021/cbe.4c00024","DOIUrl":"https://doi.org/10.1021/cbe.4c00024https://doi.org/10.1021/cbe.4c00024","url":null,"abstract":"<p >Microorganisms, serving as super biological factories, play a crucial role in the production of desired substances and the remediation of environments. The emergence of 3D bioprinting provides a powerful tool for engineering microorganisms and polymers into living materials with delicate structures, paving the way for expanding functionalities and realizing extraordinary performance. Here, the current advancements in microbial-based 3D-printed living materials are comprehensively discussed from material perspectives, covering various 3D bioprinting techniques, types of microorganisms used, and the key parameters and selection criteria for polymer bioinks. Endeavors on the applications of 3D printed living materials in the fields of energy and environment are then emphasized. Finally, the remaining challenges and future trends in this burgeoning field are highlighted. We hope our perspective will inspire some interesting ideas and accelerate the exploration within this field to reach superior solutions for energy and environment challenges.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 7","pages":"568–592 568–592"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust Two-Dimensional Hydrogen-Bonded Organic Framework for Efficient Separation of C1–C3 Alkanes","authors":"Yunzhe Zhou,&nbsp;Yongqin Zhu,&nbsp;Danhua Song,&nbsp;Zhenyu Ji,&nbsp;Cheng Chen and Mingyan Wu*,&nbsp;","doi":"10.1021/cbe.4c0005710.1021/cbe.4c00057","DOIUrl":"https://doi.org/10.1021/cbe.4c00057https://doi.org/10.1021/cbe.4c00057","url":null,"abstract":"<p >Separating natural gas to obtain high-quality C1–C3 alkanes is an imperative process for supplying clean energy sources and high valued petrochemical feedstocks. However, developing adsorbents which can efficiently distinguish CH₄, C₂H₆, and C₃H₈ molecules remains challenging. We herein report an ultra-stable layered hydrogen-bonded framework (HOF-NBDA), which features differential affinities and adsorption capacities for CH₄, C₂H₆, and C₃H₈ molecules, respectively. Breakthrough experiments on ternary component gas mixture show that HOF-NBDA can achieve efficient separation of CH₄/C₂H₆/C₃H₈ (v/v/v, 85/7.5/7.5). More importantly, HOF-NBDA can realize efficient C₃H₈ recovery from ternary CH₄/C₂H₆/C₃H₈ gas mixture. After one cycle of breakthrough, 70.9 L·kg^–1 of high-purity (≥ 99.95%) CH₄ and 54.2 L·kg^–1 of C₃H₈ (purity ≥99.5%) could be obtained. Furthermore, excellent separation performance under different flow rates, temperatures, and humidities could endow HOF-NBDA an ideal adsorbent for the future natural gas purification.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 10","pages":"846–854 846–854"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142736461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable, Recyclable, and Bench-Stable Catalytic System for Synthesis of Poly(ester-b-carbonate)","authors":"Yifan Jia,&nbsp;Bokun Li,&nbsp;Yifei Sun,&nbsp;Chenyang Hu,&nbsp;Xiang Li,&nbsp;Shunjie Liu,&nbsp;Xianhong Wang,&nbsp;Xuan Pang* and Xuesi Chen*,&nbsp;","doi":"10.1021/cbe.4c0006410.1021/cbe.4c00064","DOIUrl":"https://doi.org/10.1021/cbe.4c00064https://doi.org/10.1021/cbe.4c00064","url":null,"abstract":"<p >Transferring abundant, inexpensive, and nontoxic carbon dioxide (CO₂) into biodegradable polymers is one of the ideal ways to promote sustainable development. Although a great deal of preeminent researches has been reported in the last decade, including well-designed organometallic complexes, Lewis pairs, etc. The moisture- and air-sensitive nature of these extensively used catalysts preclude their use in industrial applications. Herein, we report a novel stable catalyst system of commercial zinc glutarate (ZnGA) with a supported metal for the synthesis of poly(ester-<i>b</i>-carbonate). The special supported microstructure facilitates efficient polymerizations via a plausible heterometal coordination mechanism. Notably, the resulted biodegradable CO₂-based copolymer showed strong tensile strength (&gt;40 MPa), improved elongation (45% versus 7%), excellent transmittance, and low water vapor permeability (WVP) (1.7 × 10^–11 g m^–1 s^–1 Pa^–1). Moreover, the supported ZnGA catalyst is recyclable, and its simple and low-cost preparation process is compatible with the manufacturing and processing methods of the existing infrastructure.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 6","pages":"559–567 559–567"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141959259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4D Printing of Shape-Morphing Liquid Crystal Elastomers","authors":"Tongzhi Zang,&nbsp;Shuang Fu,&nbsp;Junpeng Cheng,&nbsp;Chun Zhang,&nbsp;Xili Lu*,&nbsp;Jianshe Hu*,&nbsp;Hesheng Xia* and Yue Zhao*,&nbsp;","doi":"10.1021/cbe.4c0002710.1021/cbe.4c00027","DOIUrl":"https://doi.org/10.1021/cbe.4c00027https://doi.org/10.1021/cbe.4c00027","url":null,"abstract":"<p >In nature, biological systems can sense environmental changes and alter their performance parameters in real time to adapt to environmental changes. Inspired by these, scientists have developed a range of novel shape-morphing materials. Shape-morphing materials are a kind of “intelligent” materials that exhibit responses to external stimuli in a predetermined way and then display a preset function. Liquid crystal elastomer (LCE) is a typical representative example of shape-morphing materials. The emergence of 4D printing technology can effectively simplify the preparation process of shape-morphing LCEs, by changing the printing material compositions and printing conditions, enabling precise control and macroscopic design of the shape-morphing modes. At the same time, the layer-by-layer stacking method can also endow the shape-morphing LCEs with complex, hierarchical orientation structures, which gives researchers a great degree of design freedom. 4D printing has greatly expanded the application scope of shape-morphing LCEs as soft intelligent materials. This review systematically reports the recent progress of 3D/4D printing of shape-morphing LCEs, discusses various 4D printing technologies, synthesis methods and actuation modes of 3D/4D printed LCEs, and summarizes the opportunities and challenges of 3D/4D printing technologies in preparing shape-morphing LCEs.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 6","pages":"488–515 488–515"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141959258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}