Brain Organoid and Systems Neuroscience Journal最新文献_第7页

Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids 全球类器官技术和产业的趋势:从培养皿中的器官生成到类器官的商业化

Brain Organoid and Systems Neuroscience Journal Pub Date : 2021-07-10 DOI: 10.51335/organoid.2021.1.e11

Hanbyeol Lee, Jeong Suk Im, Daejin Choi, Dong-Hun Woo

{"title":"Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids","authors":"Hanbyeol Lee, Jeong Suk Im, Daejin Choi, Dong-Hun Woo","doi":"10.51335/organoid.2021.1.e11","DOIUrl":"https://doi.org/10.51335/organoid.2021.1.e11","url":null,"abstract":"Animal models have been standard methods for non-clinical research in drug development for decades. However, many drugs that have shown satisfactory results in non-clinical studies have failed in the clinical stage, presumably because animal data are not fully convertible to human data. Human organoid technology has recently been considered as an alternative to existing non-clinical testing methods, and it could potentially serve a role as a bridge from non-clinical to clinical trials, compensating for the current limitations arising from non-clinical animal models. For this reason, organoid technology is being utilized in various fields of research including academic studies, disease modeling, drug screening, biobanks, and regenerative medicine. In addition, as organoid technology progressively develops, it has been combined with bioengineering to develop applications from manufacturing to drug evaluation platforms, which is leading to a demand for commercialization of organoids for researchers. In accordance with this global trend, the organoid industry continues to grow throughout the world, and organoid research and the market for organoids have been boosted by the demand for efficient and rapid drug development in response to the coronavirus disease 2019 pandemic. In this review, we discuss recent global trends in organoid research, based on tissue types and applications, as well as the organoid market and its prospects.","PeriodicalId":100198,"journal":{"name":"Brain Organoid and Systems Neuroscience Journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82224679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Engineered models for studying blood-brain-barrier-associated brain physiology and pathology 用于研究血脑屏障相关的脑生理学和病理学的工程模型

Brain Organoid and Systems Neuroscience Journal Pub Date : 2021-06-19 DOI: 10.51335/ORGANOID.2021.1.E10

H. Kim

引用次数: 2

Optimizing a three-dimensional spheroid clearing method for the imaging-based evaluation of cardiotoxicity 优化一种三维球体清除方法，用于基于成像的心脏毒性评估

Brain Organoid and Systems Neuroscience Journal Pub Date : 2021-05-30 DOI: 10.51335/organoid.2021.1.e7

Ji Hye Park, Jaemeun Lee, Sun-Hyun Park, Ki-Suk Kim

{"title":"Optimizing a three-dimensional spheroid clearing method for the imaging-based evaluation of cardiotoxicity","authors":"Ji Hye Park, Jaemeun Lee, Sun-Hyun Park, Ki-Suk Kim","doi":"10.51335/organoid.2021.1.e7","DOIUrl":"https://doi.org/10.51335/organoid.2021.1.e7","url":null,"abstract":"Toxicity evaluation based on two-dimensional cell culture shows differences from clinical results and has the disadvantage of not accurately reflecting cell-to-cell cross-signaling. Since almost all cells in the human body are arranged in a three-dimensional structure and constitute a tissue, the in vitro reproduction of three-dimensional tissues composed of human cells can be used as effective models for drug development and toxicity evaluation. The clearing technique improves image resolution and can be used to generate three-dimensional bio-images throughout the organized structure, improving the efficiency of toxicity evaluation for disease models using spheroids. Herein, we report the first optical spheroid clearing protocol for an image-based toxicity prediction model. In our results, spheroid clearing significantly increased fluorescence intensity and enabled image-based toxicity prediction. We propose that this spheroid clearing method can be utilized for image-based cardiotoxicity evaluation. Furthermore, we also present the possibility that our protocol can be utilized for patient-tailored toxicity prediction.","PeriodicalId":100198,"journal":{"name":"Brain Organoid and Systems Neuroscience Journal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81953895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disease modeling and drug screening using human airway organoids: a systematic review 人类气道类器官的疾病建模和药物筛选:系统综述

Brain Organoid and Systems Neuroscience Journal Pub Date : 2021-05-30 DOI: 10.51335/ORGANOID.2021.1.E8

D. Kim, S. Kim

引用次数: 1

Therapeutic applications of three-dimensional organoid models in lung cancer 三维类器官模型在肺癌治疗中的应用

Brain Organoid and Systems Neuroscience Journal Pub Date : 2021-04-10 DOI: 10.51335/organoid.2021.1.e6

C. Yeo, Y. Yun, Dong Hyuck Ahn, Y. Hwang, Seung Hee Yang, Hyobin Won, Hyeong Jun Cho, Chan Kwon Park, S. Kim, Jong Y. Park

{"title":"Therapeutic applications of three-dimensional organoid models in lung cancer","authors":"C. Yeo, Y. Yun, Dong Hyuck Ahn, Y. Hwang, Seung Hee Yang, Hyobin Won, Hyeong Jun Cho, Chan Kwon Park, S. Kim, Jong Y. Park","doi":"10.51335/organoid.2021.1.e6","DOIUrl":"https://doi.org/10.51335/organoid.2021.1.e6","url":null,"abstract":"Lung cancer, which remains a major cause of mortality worldwide, is a histologically diverse condition and demonstrates substantial phenotypic and genomic diversity among individual patients, manifesting as both intertumoral and intratumoral heterogeneity. This heterogeneity has made it difficult to develop lung cancer models. Two-dimensional (2D) cancer cell lines have been used to study genetic and molecular alterations in lung cancer. However, cancer cell lines have several disadvantages, including random genetic drift caused by long-term culture, a lack of annotated clinical data, and most importantly, the fact that only a subset of tumors shows 2D growth on plastic. Three-dimensional models of cancer have the potential to improve cancer research and drug development because they are more representative of cancer biology and its diverse pathophysiology. Herein, we present an integrated review of current information on preclinical lung cancer models and their limitations, including cancer cell line models, patient-derived xenografts, and lung cancer organoids, and discuss their possible therapeutic applications for drug discovery and screening to guide precision medicine in lung cancer research. Altogether, the success rate of generating lung cancer organoids must be improved, and a lung cancer organoid culture system is necessary to achieve the goal of designing an individualized therapeutic strategy for each lung cancer patient.","PeriodicalId":100198,"journal":{"name":"Brain Organoid and Systems Neuroscience Journal","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87055180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presidential message 总统的消息

Brain Organoid and Systems Neuroscience Journal Pub Date : 2021-01-20 DOI: 10.51335/organoid.2021.1.e1

Hyung-Ryong Kim

引用次数: 0