{"title":"类器官技术的进展、前景与局限性","authors":"Jin Hee Park, Do Gyeung Byeun, Jung Kyu Choi","doi":"10.51335/organoid.2022.2.e9","DOIUrl":null,"url":null,"abstract":"Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs. In recent research, various organoids have been derived from pluripotent stem cells or multipotent organ-specific adult stem cells in vitro and have been used in regenerative medicine, disease modeling, precision medicine, toxicology studies, and drug discovery. However, research on reproduction-related organoids has not been comprehensive, and some limitations need to be addressed for culturing these organoids. In this review, we discuss the historical advances, major recent developments, limitations, and potential of organoid culture, including human reproductive organoids.","PeriodicalId":100198,"journal":{"name":"Brain Organoid and Systems Neuroscience Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Progress, prospects, and limitations of organoid technology\",\"authors\":\"Jin Hee Park, Do Gyeung Byeun, Jung Kyu Choi\",\"doi\":\"10.51335/organoid.2022.2.e9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs. In recent research, various organoids have been derived from pluripotent stem cells or multipotent organ-specific adult stem cells in vitro and have been used in regenerative medicine, disease modeling, precision medicine, toxicology studies, and drug discovery. However, research on reproduction-related organoids has not been comprehensive, and some limitations need to be addressed for culturing these organoids. In this review, we discuss the historical advances, major recent developments, limitations, and potential of organoid culture, including human reproductive organoids.\",\"PeriodicalId\":100198,\"journal\":{\"name\":\"Brain Organoid and Systems Neuroscience Journal\",\"volume\":\"15 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain Organoid and Systems Neuroscience Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.51335/organoid.2022.2.e9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Organoid and Systems Neuroscience Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.51335/organoid.2022.2.e9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Progress, prospects, and limitations of organoid technology
Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs. In recent research, various organoids have been derived from pluripotent stem cells or multipotent organ-specific adult stem cells in vitro and have been used in regenerative medicine, disease modeling, precision medicine, toxicology studies, and drug discovery. However, research on reproduction-related organoids has not been comprehensive, and some limitations need to be addressed for culturing these organoids. In this review, we discuss the historical advances, major recent developments, limitations, and potential of organoid culture, including human reproductive organoids.
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