Biomedicine & Aging Pathology最新文献

{"title":"Antihyperglycemic activity of trigonelline and sitagliptin in nicotinamide-streptozotocin induced diabetes in Wistar rats","authors":"Hemant V. Kamble,&nbsp;Subhash L. Bodhankar","doi":"10.1016/j.biomag.2013.05.006","DOIUrl":"10.1016/j.biomag.2013.05.006","url":null,"abstract":"<div><p><span><span>The objective of the present study was to evaluate the protective effect of trigonelline (TRIG) and </span>sitagliptin<span><span> (SITA) combination in streptozotocin-nicotinamide induced diabetes in Wistar rats. Diabetes was induced by </span>streptozotocin (65</span></span> <!-->mg/kg i.p.) injected 15<!--> <span>min after nicotinamide (110</span> <!-->mg/kg, i.p.). The rats were divided into following groups: Group 1: non-diabetic control, Group 2: diabetic control (saline), Groups 3, 4, 5 received TRIG as 25, 50, 100<!--> <!-->mg/kg p.o., Groups 6, 7, 8 received SITA as 2.5, 5, 10<!--> <!-->mg/kg p.o. respectively. For acute study, serum glucose (SG) levels were measured at 0, 2nd, 4th, 6th and 24th hour after administration. To find out effective combination, acute study of TRIG<!--> <!-->+<!--> <!-->SITA combination was done. The doses used are in combination TRIG<!--> <!-->+<!--> <!-->SITA as Groups 9, 10, 11 as 70%<!--> <!-->+<!--> <!-->30%, 50%<!--> <!-->+<!--> <!-->50%, 30<!--> <!-->+<!--> <!-->70%. SG was measured as per above-mentioned pattern. A 28-day subacute study was performed by taking effective percentage combination of TRIG<!--> <!-->+<!--> <!-->SITA. For subacute study SG, body weight was measured on 7th, 14th, 21st, 28th day; while serum insulin, HbA_1c and pancreatic histopathological study were done on 28th day. In acute study, TRIG<!--> <!-->+<!--> <!-->SITA (50%<!--> <!-->+<!--> <!-->50%) were more effectively 43.08% reduction in SG level at 6<!--> <!-->h with onset at 2<!--> <!-->h and effect waned at 24<!--> <!-->h. Subacute study reveals that the TRIG<!--> <!-->+<!--> <!-->SITA (50%<!--> <!-->+<!--> <!-->50%) reduces SG by 54.72% than alone on 28th day. Serum insulin levels, body weight, pancreatic mass were increased with reduction in HbA_1c levels in animals receiving 50%<!--> <!-->+<!--> <!-->50% combination of TRIG<!--> <!-->+<!--> <!-->SITA. The concomitant administration of TRIG<!--> <!-->+<!--> <!-->SITA (50%<!--> <!-->+<!--> <!-->50%) contributes in the prevention to development diabetes and showed synergistic antihyperglycemic effect.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 3","pages":"Pages 125-130"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.05.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89601895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus","authors":"Hemant Kamble ,&nbsp;Amit D. Kandhare ,&nbsp;Subhash Bodhankar ,&nbsp;Viswanathan Mohan ,&nbsp;Prasad Thakurdesai","doi":"10.1016/j.biomag.2013.06.002","DOIUrl":"10.1016/j.biomag.2013.06.002","url":null,"abstract":"<div><h3>Background</h3><p><span>Plant-derived polysaccharides<span> such as galactomannans (GAL) have very interesting and useful applications in the biomedical and biopharmaceutical field. GAL from fenugreek (</span></span><em>Trigonella foenum graecum</em> L.) seeds has been shown to have promising but inconsistent anti-hyperglycemic activity due to variable composition.</p></div><div><h3>Aim</h3><p>We have isolated and characterized low molecular weight GAL fraction from fenugreek seeds (LMWGAL-TF) and evaluated its anti-hyperglycemic potential.</p></div><div><h3>Materials and methods</h3><p><span>LMWGAL-TF was isolated, well characterized (HPLC and LC-MS) and evaluated for anti-hyperglycemic activity after acute and subacute oral treatment in doses of 50, 100 and 200</span> <span>mg/kg in alloxan-induced hyperglycemia in mice.</span></p></div><div><h3>Results</h3><p>The isolated LMWGAL-TF was of 91.5% purity with low molecular weight. LMWGAL-TF showed dose-dependent anti-hyperglycemic activity against alloxan-induced hyperglycemia without body weight gain, and protected mice pancreas from alloxan-induced histological changes.</p></div><div><h3>Conclusions</h3><p>LMWGAL-TF showed promising and dose-dependent anti-hyperglycemic effects in animal model of DM.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 3","pages":"Pages 145-151"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87196582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular pathways and therapy strategies of sleep disorders and molecular processes of sleep","authors":"Xiaolong Zhu","doi":"10.1016/j.biomag.2013.05.005","DOIUrl":"10.1016/j.biomag.2013.05.005","url":null,"abstract":"<div><p>Sleep is a naturally complex dynamic state governed by nervous and signaling systems. Sleep disorders are prevalent and challenging in medicine and psychology, involved in genetic or inherited elements and environmental factors<span><span>. The determination of the molecular changes during sleep and in sleep disturbance is fundamental to the understanding, diagnosis and therapy as well as pharmaceutical development of sleep disorders. Genetic and environmental contributions to sleep timing and sleep structure by molecular processes provide important insights into sleep deprivation or disorders. In this review, molecular mechanisms during sleep and in sleep-wake transition are overviewed in immune systems, metabolic process and neuronal activity. Current research progress in genetics of sleep disorders is summarized and the therapy or </span>treatment approaches are presented in psychological-behavioural therapy, sleep-assistance devices and medications to introduce the strategy of addressing various sleep disorders. Although the correlation of environmental conditions and genetic changes is still not completely revealed, some advances are already achieved that environmental factors or medications have impacts on gene traits or genes controlling sleep and sleep deprivation by molecular pathways.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 3","pages":"Pages 171-177"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.05.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86755509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The reactivity of human serum natural autoantibodies with certain autoantigens increases along with aging","authors":"Mir Hadi Jazayeri ,&nbsp;Ali Akbar Pourfathollah ,&nbsp;Mohammad Javad Rasaee ,&nbsp;Mohammad Farhadi ,&nbsp;Narges Zarei ,&nbsp;Mohammad Ebrahim Jafari","doi":"10.1016/j.biomag.2013.06.001","DOIUrl":"10.1016/j.biomag.2013.06.001","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Natural autoantibodies (NAAs) that recognize </span>autoantigens<span><span><span> are mainly generated in the absence of any apparent immunization with foreign antigens (Ags). These antibodies maintain the body homeostasis through functions, such as inhibition of </span>tumor angiogenesis, detection of structural changes in autoantigens, and exertion of anti-inflammatory impacts. The human body is shown to go through immunological and physiological changes during aging. However, data regarding the potential variations in the </span>binding activity of NAAs is still scarce. Therefore, in this study, we were about to explore the trend through which the reactivity of serum NAAs with several autoantigens varies with advancing age.</span></p></div><div><h3>Materials and methods</h3><p>Serum samples were prepared from healthy individuals of seven age intervals: (0) cord blood, (1) infancy, (2) childhood, (3) adolescence, (4) early adulthood, (5) middle adulthood, and (6) late adulthood (the elderly). The mean immune reactivity<span> (MIR) of the sera with 24 human autoantigens that were obtained from Immunculus research center (Russia) was determined using ELISA and inter-group comparisons were also performed.</span></p></div><div><h3>Results</h3><p>In general, the MIR of serum natural antibodies with the autoantigens was shown to follow an upward trend with advancing age so that the lowest and highest MIRs were detected in the cord blood and late adulthood samples, respectively. Moreover, the results of the inter-group comparisons indicated that the MIRs of the first, second, fourth, and sixth groups were significantly higher than those of their previous groups, i.e. zero, first, third, and fifth groups, respectively.</p></div><div><h3>Conclusion</h3><p>This study showed that the reactivity of human tissue-specific and non-specific NAAs with autoantigens varied along with aging. Regarding the crucial roles NAAs play in maintaining the body homeostasis, the variation in their concentration at different age intervals might account for the immunological and pathological changes that occur in the elderly.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 3","pages":"Pages 115-118"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86706811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephro-protective significance of kaempferol on mercuric chloride induced toxicity in Wistar albino rats","authors":"Shanmugam Vijayaprakash ,&nbsp;Kulanthaivel Langeswaran ,&nbsp;Subbaraj Gowtham Kumar ,&nbsp;Rajendran Revathy ,&nbsp;Maruthaiveeran Periyasamy Balasubramanian","doi":"10.1016/j.biomag.2013.05.004","DOIUrl":"10.1016/j.biomag.2013.05.004","url":null,"abstract":"<div><p><span>The kidney is an imperative intention of the toxicity of drugs<span>, xenobiotics, and oxidative stress. The intend of the present investigation was to conclude nephro-protective efficiency over mercuric chloride (MgCl</span></span>₂<span><span>) induced oxidative stress and renal injury in rats. Mercuric chloride induced </span>nephrotoxicity (1</span> <!-->mg<!--> <span>kg bw; i.p.) as it induces noticeable and characteristic changes in proximal tubular cells in group II animals. These changes are conduit and accompanied by signs of renal dysfunctions. The levels of blood urea, serum creatinine, uric acid<span>, and lipid peroxidation were elevated (</span></span><em>P</em> <!-->&lt;<!--> <span><span>0.05) in heavy metal intoxicated group II animals. On the other hand there was a decline in the levels of serum protein, </span>nucleic acids<span>, enzymic and non-enzymic antioxidant enzymes<span> in group II toxicity induced rats. In group III, rats administration of kaempferol (100</span></span></span> <!-->mg<!--> <span>kg bw p.o.) brought back these elevated urinary constituents, lipid peroxidation (</span><em>P</em> <!-->&lt;<!--> <!-->0.05) and increase the levels of antioxidants and nucleic acids levels to near normal (<em>P</em> <!-->&lt;<!--> <!-->0.05) due to its therapeutic and scavenging properties. Histopathological results muscularly supports the nephro-protective activities of kaempferol by convalescing oxidative damage and morphological changes of kidneys induced by MgCl₂. Therefore, the present analysis evidently showed that kaempferol may be useful due to antioxidant possessions in fighting against free radical-induced oxidative stress and tissue injury resulted from mercuric chloride induced nephrotoxicity.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 3","pages":"Pages 119-124"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73765149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normobaric hyperoxia (HO) preconditioning induces durable and effective neuroprotection against cerebral ischemia and mGluRII expression","authors":"Samane Nasrniya,&nbsp;Mohammad Reza Bigdeli","doi":"10.1016/j.biomag.2013.05.002","DOIUrl":"10.1016/j.biomag.2013.05.002","url":null,"abstract":"<div><p><span><span>Preconditioning/ischemic tolerance of brain refers to a natural adaptive response induced by sublethal insults to increase brain resistance after stroke. Molecular studies can contribute to clarify precise mechanism(s) of this neuroprotective phenomenon. In this study, we attempted to determine durability of </span>neuroprotection<span> exerted by normobaric hyperoxia (HO) and its effects on mGluRII expression. Rats were divided into five groups (hyperoxia-intact, hyperoxia-MCAO, room air-intact, room air-MCAO and room air-sham). Hyperoxia groups consist of four subgroups (2HO, 5HO, 10HO and 15HO). It means that respectively 2, 5, 10 or 15 days after pretreatment (exposure to 95% inspired O</span></span>₂ for 4<!--> <span>h/day and 6 consecutive days) animals were subjected to MCAO surgery (hyperoxia-MCAO group) or that decapitated as intact (hyperoxia-intact). Room air groups were considered as control and exposed to 21% oxygen. MCAO groups after the time specified in each group were subjected to 60</span> <!-->minutes of right middle cerebral artery occlusion (MCAO). 24<!--> <span>hours after reperfusion, neurologic deficit score (NDS) and brain infarct<span><span> volume (IV) were evaluated in MCAO-operated groups. Sham operated and intact groups were used to assess expression of mGluR2/3 and glutathione (GSH) levels of core, penumbra and </span>subcortex regions. Preconditioning with HO transiently decreased NDS and IV, and increased expression of mGluR2/3 in core, penumbra, and subcortex. These effects of hyperoxia disappeared gradually during15 days after pretreatment. Although additional studies will be required to further elucidate precise mechanism(s) in ischemic tolerance, it seems that likely part of protective effect of intermittent HO is associated with upregulation of mGluR2/3.</span></span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 3","pages":"Pages 137-144"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90439510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiproliferative and apoptotic effects of naringin on diethylnitrosamine induced hepatocellular carcinoma in rats","authors":"P. Thangavel, M. Vaiyapuri","doi":"10.1016/J.BIOMAG.2013.01.006","DOIUrl":"https://doi.org/10.1016/J.BIOMAG.2013.01.006","url":null,"abstract":"","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"7 1","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88075581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of Phoenix dactylifera against oxidative stress and neuronal damage induced by global cerebral ischemia in rats","authors":"Rohini R. Pujari ,&nbsp;Neeraj S. Vyawahare ,&nbsp;Prasad A. Thakurdesai","doi":"10.1016/j.biomag.2013.04.003","DOIUrl":"10.1016/j.biomag.2013.04.003","url":null,"abstract":"<div><p><em>Phoenix dactylifera</em> (PD) has been claimed for its neuroprotective potential in the traditional system of medicine but has not yet been scientifically documented. Phytochemical reports of <em>Phoenix dactylifera</em> fruits have demonstrated the presence of polyphenols and flavonoids, which have already been documented to play major role in neuroprotection against various experimental models of cerebral ischemia/reperfusion. In the present study, we have investigated the neuroprotective as well as antioxidant properties of methanolic extract of <em>Phoenix dactylifera</em> fruits (MEPD) at 30, 100, 300<!--> <!-->mg/kg p.o against global cerebral ischemia-induced oxidative stress and neuronal death. The global cerebral ischemia was induced by occlusion of bilateral common carotid arteries for 5<!--> <!-->min followed by 24<!--> <!-->h of reperfusion. Varied biochemical/enzymatic alterations, produced subsequent to the application bilateral common carotid artery occlusion (BCCAO) followed by reperfusion viz. increase in lipid peroxidation and decrease in glutathione, glutathione reductase, catalase, glutathione-<em>S</em>-transferase, glutathione peroxidase and superoxide dismutase, were markedly reversed and restored to near normal levels in the groups pre-treated with 15<!--> <!-->days. The pretreatment also reversed the histopathological changes induced by global cerebral ischemia in CA1 hippocampal region. The protective action, exhibited by MEPD against global cerebral induced brain injury, suggests its therapeutic potential in cerebrovascular diseases (CVD) including stroke. These findings are important because the present treatment strategies for CVD are far from adequate and PD with wide usage is known to be a safe natural product.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 2","pages":"Pages 75-81"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77643313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal and lens protective effect of sitagliptin in streptozotocin induced type-I diabetic wistar rats","authors":"Rahul S. Pandit ,&nbsp;Aditya S. Kelkar ,&nbsp;Subhash L. Bodhankar","doi":"10.1016/j.biomag.2013.04.002","DOIUrl":"https://doi.org/10.1016/j.biomag.2013.04.002","url":null,"abstract":"<div><p><span>The objective of this study was to investigate effect of antidiabetic drug<span><span> sitagliptin against </span>diabetic retinopathy<span> in wistar rats (150–180</span></span></span> <span>gm). A non-diabetic group of animals received normal saline (group 1). Streptozotocin (65</span> <!-->mg/kg, i.p.) was administered in rats. After 15<!--> <!-->days, rats that showed serum glucose above 200<!--> <!-->mg/dL (diabetic) were randomly divided into following groups: group 2 (diabetic control), group 3 (sitagliptin 10<!--> <!-->mg/kg), group 4 (sitagliptin 20<!--> <!-->mg/kg), group 5 (sitagliptin 40<!--> <!-->mg/kg). Serum glucose was determined periodically over a period of 90<!--> <!-->days. Body weight and food intake of each rat was recorded during the study. Opthalmoscopic examination of the lens (slit microscopy) and retina (fundoscopy) was carried out every 7<!--> <span>days. Cataracted lens after the 60th day obscured the view of the retina and hence retinal damage was recorded till day 60 only. Lenticular opacities were scored under five categories (clear, stage 1, 2, 3 and 4 with stage 4 exhibiting maximum damage to the eye). On completion of 90</span> <span>days, blood sugar and glycated hemoglobin<span><span> was determined. Animals were then euthanized, eyes dissected and the advanced glycation end product (AGE) content of the lens was determined. </span>Histopathology<span> of the eye and pancreas was carried out. Animals of group 2 showed hyperglycemia, elevated glycated hemoglobin, cataract and retinal damage. Histopathology showed necrotic changes in lens. Sitagliptin showed dose dependent decrease in serum glucose, glycated hemoglobin, cataract development and retinal damage. It is concluded that, sitagliptin 40</span></span></span> <span><span>mg/kg prolonged but not prevented the development of cataract and retinopathy in diabetic rats. Sitagliptin is effective as an ancillary </span>drug for prolonging onset of diabetic retinopathy.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 2","pages":"Pages 65-73"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91725084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical estimations of multidrug resistance (ferulic acid and paclitaxel) in non-small cells lung carcinoma cells in vitro","authors":"J.P. Jose Merlin ,&nbsp;B. Venkadesh ,&nbsp;R. Hussain ,&nbsp;S.S. Rajan","doi":"10.1016/j.biomag.2013.03.002","DOIUrl":"10.1016/j.biomag.2013.03.002","url":null,"abstract":"<div><p><span>Ferulic acid<span><span> (FA) is a phenolic phytonutrient<span><span>, which possesses strong anticancer effect. However, its prominent application in cancer is limited due to poor bioavailability at the tumor site. Paclitaxel (PTX) is a semi synthetic drug which is used for cancer </span>treatment. The aim of the study was to investigate the </span></span>multidrug resistance of FA and PTX. It was noticed that anticancer potential of FA</span></span> <!-->+<!--> <!-->PTX was greater than that of FA and PTX treatment alone. Further, FA<!--> <!-->+<!--> <span>PTX exhibits increased TBARS<span><span>, Catalase<span> and SOD, altered GSH and </span></span>GPx in NCI-H460 cells when compared to bulk FA and PTX treatment alone. Our results indicate that FA</span></span> <!-->+<!--> <span>PTX demonstrated increased anticancer property in cancer cells than FA and PTX treatment alone.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 2","pages":"Pages 47-50"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90862886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}