Biomedicine & Aging Pathology最新文献_第5页

Application of chitosan and herbal nanocomposites to develop antibacterial medical textile 壳聚糖与草药纳米复合材料在抗菌医用纺织品中的应用

Biomedicine & Aging Pathology Pub Date : 2014-02-27 DOI: 10.1016/J.BIOMAG.2013.10.007

S. Chandrasekar, S. Vijayakumar, R. Rajendran

引用次数: 36

Camel urine inhibits inflammatory angiogenesis in murine sponge implant angiogenesis model 骆驼尿对小鼠海绵植入血管生成模型炎性血管生成的抑制作用

Biomedicine & Aging Pathology Pub Date : 2014-01-01 DOI: 10.1016/j.biomag.2013.10.003

Abdulqader A. Alhaider , Abdel Galil M. Abdel Gader , Nawaf Almeshal , Sarita Saraswati

{"title":"Camel urine inhibits inflammatory angiogenesis in murine sponge implant angiogenesis model","authors":"Abdulqader A. Alhaider , Abdel Galil M. Abdel Gader , Nawaf Almeshal , Sarita Saraswati","doi":"10.1016/j.biomag.2013.10.003","DOIUrl":"https://doi.org/10.1016/j.biomag.2013.10.003","url":null,"abstract":"<div>Camel urine has traditionally been used to treat cancer, but this practice awaits scientific scrutiny, in particular its role in tumor angiogenesis, the key step involved in tumor growth and metastasis. We aimed to investigate the effects of camel urine on key components of inflammatory angiogenesis in the murine cannulated sponge implant angiogenesis model. Polyester-polyurethane sponges, used as a framework for fibrovascular tissue growth, were implanted in Swiss albino mice and camel urine (25, 50 and 100  days through installed cannula. The implants, collected at day 14 post-implantation, were processed for the assessment of hemoglobin (Hb), myeloperoxidase (MPO), N-acetylglucosaminidase (NAG) and collagen, which were used as indices for angiogenesis, neutrophil and macrophage accumulation and extracellular matrix deposition, respectively. Relevant inﬂammatory, angiogenic and ﬁbrogenic cytokines were also determined. Camel urine treatment attenuated the main components of the ﬁbrovascular tissue, wet weight, vascularization (Hb content), macrophage recruitment (NAG activity), collagen deposition and the levels of vascular endothelial growth factor (VEGF), interleukin (IL)-1β, IL-6, IL-17, tumor necrosis factor (TNF)-α and transforming growth factor (TGF-β). A regulatory function of camel urine on multiple parameters of the main components of inflammatory angiogenesis has been revealed giving insight into the potential therapeutic benefit underlying the anti-cancer actions of camel urine.</div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 1","pages":"Pages 9-16"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91654584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Contraceptive activity of 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2,7-diol via inhibiting ovulation in Gonadotropin-primed immature rat model 促性腺激素诱导的未成熟大鼠模型中，4-(4-羟基-3-甲基-己-5-烯基)-铬-2,7-二醇通过抑制排卵的避孕活性

Biomedicine & Aging Pathology Pub Date : 2014-01-01 DOI: 10.1016/J.BIOMAG.2013.12.001

Ashoke Kumar, S. Gullaiya, V. Dubey, A. Nagar, V. Singh, S. Agrawal

引用次数: 2

Hepato-ameliorative effect of hesperidin and ellagic acid on mercuric chloride intoxicated rats 橙皮苷和鞣花酸对氯化汞中毒大鼠肝脏的改善作用

Biomedicine & Aging Pathology Pub Date : 2014-01-01 DOI: 10.1016/j.biomag.2013.10.002

Erusan Bharathi, Ganesan Jagadeesan, Murugan Vijayakumar

{"title":"Hepato-ameliorative effect of hesperidin and ellagic acid on mercuric chloride intoxicated rats","authors":"Erusan Bharathi, Ganesan Jagadeesan, Murugan Vijayakumar","doi":"10.1016/j.biomag.2013.10.002","DOIUrl":"10.1016/j.biomag.2013.10.002","url":null,"abstract":"<div>Protective efficacy of Hesperidin and Ellagic acid on hepatotoxicity induced by mercuric chloride for 7 days in rats, Rattus norvegicus, were carried out in the present study. At sub-lethal dose of mercuric chloride (1.23 mg/kg body weight) treatment on mercury-intoxicated rats were restoring these oxidant and antioxidant activities near to normal level when compared to mercuric chloride intoxicated groups. These results suggested that the protective efficacy of hesperidin and ellagic acid on mercuric chloride induced hepatotoxicity in rats have been proven.</div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 1","pages":"Pages 17-21"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90679755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Protective activity profile of herbomineral medicine in early diabetic nephropathy rats: Restoration of kidney antioxidants, hemodynamics and suppression of proinflammatory mediators 草药药物对早期糖尿病肾病大鼠的保护作用:恢复肾脏抗氧化剂、血流动力学和抑制促炎介质

Biomedicine & Aging Pathology Pub Date : 2014-01-01 DOI: 10.1016/j.biomag.2013.10.001

Suresh Ramnath Naik , Nazneen Shaikh , Rajesh R. Patil , Rahul S. Somani , Abhijit S. Mali

{"title":"Protective activity profile of herbomineral medicine in early diabetic nephropathy rats: Restoration of kidney antioxidants, hemodynamics and suppression of proinflammatory mediators","authors":"Suresh Ramnath Naik , Nazneen Shaikh , Rajesh R. Patil , Rahul S. Somani , Abhijit S. Mali","doi":"10.1016/j.biomag.2013.10.001","DOIUrl":"https://doi.org/10.1016/j.biomag.2013.10.001","url":null,"abstract":"<div>The effect of Shakrino, a herbomineral medicine (HMM)) on early diabetic nephropathy in rats was evaluated. The occurrence of early diabetic nephropathy (DN) in rats treated with streptozotocin was revealed by hyperglycemia, depleted liver glycogen, decreased glucose uptake by peripheral tissue, impaired renal function, increased lipid peroxidation and decreased antioxidants in kidney. These changes were associated with increased total urine output, urinary albumin excretion rate, urinary albumin to creatinine ratio, increased relative kidney weight, increased arterial blood pressure, decreased glomerular filtration rate and urinary creatinine in DN rat. HMM treatment (200 and 400 mg/kg, p.o., 4 weeks) lowered blood glucose, glycosylated haemoglobin, creatinine, blood urea nitrogen, lipid profiles, serum albumin and total urine output, urinary albumin excretion rate, urinary albumin to creatinine ratio, relative kidney weight, increased urinary creatinine and GFR, and also restored depleted antioxidants, decreased malonolaldehyde formation in kidney of DN rats. Histoarchitecture study showed dense mesangial matrix in glomeruli of DN rats, which were improved by HMM treatment. The protective effect of HMM may be due to the presence of antioxidants like gallic acid, quercetin, β-sitosterol, Jamboline, ellagic acid, gymnemic acid B, α-amyrin and polyphenols.</div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 1","pages":"Pages 33-41"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90007949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Pyrethroid deltamethrin-induced developmental neurodegenerative cerebral injury and ameliorating effect of dietary glycoside naringin in male wistar rats 拟除虫菊酯溴氰菊酯诱导雄性wistar大鼠发育性神经退行性脑损伤及膳食糖苷柚皮苷的改善作用

Biomedicine & Aging Pathology Pub Date : 2014-01-01 DOI: 10.1016/J.BIOMAG.2013.11.001

V. Mani, S. Asha, A. Sadiq

引用次数: 19

Anticonvulsant activity of Morusin isolated from Morus alba: Modulation of GABA receptor 桑叶中分离的桑素抗惊厥活性:GABA受体的调节

Biomedicine & Aging Pathology Pub Date : 2014-01-01 DOI: 10.1016/j.biomag.2013.10.005

Gaurav Gupta , Kamal Dua , Imran Kazmi , Firoz Anwar

{"title":"Anticonvulsant activity of Morusin isolated from Morus alba: Modulation of GABA receptor","authors":"Gaurav Gupta , Kamal Dua , Imran Kazmi , Firoz Anwar","doi":"10.1016/j.biomag.2013.10.005","DOIUrl":"https://doi.org/10.1016/j.biomag.2013.10.005","url":null,"abstract":"<div><h3>Aim of the study</h3>Epilepsy is a complex neurological disorder affecting 50 million of world's total population. Number of medicinal plants has been used to treat the convulsion. In ancient time Morus alba was used to treat epilepsy and mental illness. In Chinese medicine also M. alba is used as neuroprotective herbs. The present study was designed to explore the effect of Morusin, a flavonoid glycoside isolated from M. alba as anticonvulsant activity along with biochemical mechanism.</div><div><h3>Materials and methods</h3>Morusin was isolated from M. alba and acute toxicity study was determined. Anticonvulsant activity of Morusin (5 and 10 mg/kg, i.p.) was studied by using isoniazid (INH) and maximal electroshock (MES)-induced convulsion models; diazepam (5 mg/kg) and phenytoin (20 mg/kg) were used as standards, respectively. Biochemical mechanism was investigated by estimating the GABA level in brain.</div><div><h3>Results</h3>The median lethal dose (LD50) of Morusin was found up to 20mg/kg) significantly increased level of brain GABA at both doses.</div><div><h3>Conclusion</h3>The findings of current study provide pharmacological credibility to anticonvulsant activity of Morusin. The protection against the convulsions and restoration of GABA level give a suggestion to its probable mechanism of action.</div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 1","pages":"Pages 29-32"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91654583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

The effect of pretreatment with different doses of Lavandula officinalis ethanolic extract on memory, learning and nociception 不同剂量薰衣草醇提物预处理对大鼠记忆、学习和伤害感受的影响

Biomedicine & Aging Pathology Pub Date : 2014-01-01 DOI: 10.1016/J.BIOMAG.2013.10.006

Z. Rabiei, M. Rafieian-kopaei, S. Mokhtari, Z. Alibabaei, M. Shahrani

引用次数: 75

Anticonvulsant activity of Morusin isolated from Morus alba: Modulation of GABA receptor 桑叶中分离的桑素抗惊厥活性:GABA受体的调节

Biomedicine & Aging Pathology Pub Date : 2014-01-01 DOI: 10.1016/J.BIOMAG.2013.10.005

G. Gupta, K. Dua, Imran Kazmi, F. Anwar

引用次数: 30

Camel urine inhibits inflammatory angiogenesis in murine sponge implant angiogenesis model 骆驼尿对小鼠海绵植入血管生成模型炎性血管生成的抑制作用

Biomedicine & Aging Pathology Pub Date : 2014-01-01 DOI: 10.1016/J.BIOMAG.2013.10.003

A. Alhaider, A. Gader, N. Almeshal, S. Saraswati

引用次数: 11