Biomedicine & Aging Pathology最新文献

{"title":"Contraceptive activity of 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2,7-diol via inhibiting ovulation in Gonadotropin-primed immature rat model","authors":"Ashok Kumar ,&nbsp;Sumeet Gullaiya ,&nbsp;Vishal Dubey ,&nbsp;Ashish Nagar ,&nbsp;Varun Singh ,&nbsp;Shyam S. Agrawal","doi":"10.1016/j.biomag.2013.12.001","DOIUrl":"https://doi.org/10.1016/j.biomag.2013.12.001","url":null,"abstract":"<div><p>Gonadotropin-primed immature rats (GPIR) were used to study the anti-ovulatory effect of 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2,7-diol (chroman derivative) isolated from seeds of <em>Ensete superbum</em><span> on ovulation<span>. Present results depicted dose-related anti-ovulatory effect of the chroman derivative at 2</span></span> <!-->mg/kg bw and 4<!--> <span>mg/kg bw. Chroman derivative showed dose-dependent anti-estrogenic activity on MCF-7 cell line. Attenuation of ovulation was associated with a lowered ovarian estrogen and progesterone<span> levels along with reduced levels of some major cytokines, i.e. TNFα, VEGF, IL-6 and IL-1β, indicating the disrupted cytokinine signaling. Unruptured preovulatory follicles were found in all the ovaries extracted from animals treated with chroman derivative. Our findings demonstrated that chroman derivative has potential contraceptive activity through its anti-estrogenic activity which leads to inhibition in ovulation and attenuated ovarian cytokinine signaling.</span></span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 1","pages":"Pages 43-47"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91654586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of chitosan and herbal nanocomposites to develop antibacterial medical textile","authors":"S. Chandrasekar ,&nbsp;S. Vijayakumar ,&nbsp;R. Rajendran","doi":"10.1016/j.biomag.2013.10.007","DOIUrl":"https://doi.org/10.1016/j.biomag.2013.10.007","url":null,"abstract":"<div><h3>Aim</h3><p>To enhance the efficiency of biological, chemical and physical properties like antibacterial activity<span>, wash durability, air-permeability and biocompatibility, cotton fabric materials were finished with chitosan and herbal nanocomposites.</span></p></div><div><h3>Methodology</h3><p>Extracts of <span><em>Senna auriculata</em></span> and <span><em>Achyranthes aspera</em></span> with chitosan solution was bulk finished on 40 cotton fabrics. To increase the functional properties, chitosan and herbal extract nanocomposites were finished on to another set of fabrics (nanocomposite finishing). Different functional properties were carried out for both the sets of fabrics and comparatively analyzed. Antibacterial activity was carried out using standard EN ISO 20645 method and durability of finished fabrics was done using a standard AATCC–124 test method. Physical properties like tensile strength, abrasion resistance and air-permeability were analyzed using the standards, ASTM D 5035-2006, AATCC 119-2004 and ASTM D 737-1996 respectively. Biocompatible properties of the finished fabric were determined by HET-CAM to ensure that material do not cause irritation points on skin surface.</p></div><div><h3>Results</h3><p>Antibacterial activity of nanocomposite finished fabrics showed more inhibitory zones of 31<!--> <!-->mm for <em>E.</em> <em>coli</em> and 29<!--> <!-->mm for <em>S.</em> <em>aureus</em> when compared to bulk finished fabrics. Nanocomposite finished fabrics showed good durable properties and physical properties than bulk finished fabrics. Bulk and nanocomposite finished fabrics showed good biocompatible properties when analyzed using a standard HET-CAM test.</p></div><div><h3>Conclusion</h3><p>The study concludes that, nanocomposites could provide better functional properties than the bulk finished fabrics. The nano-sized particles in the composites was considered significant for its functional applications in hospital based fabrics to prevent the transmission of nosocomial infections.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 1","pages":"Pages 59-64"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.10.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91654956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poly lactic acid (PLA) nanoparticles sustain the cytotoxic action of temozolomide in C6 Glioma cells","authors":"Darshana S. Jain ,&nbsp;Rajani B. Athawale ,&nbsp;Amrita N. Bajaj ,&nbsp;Shruti S. Shrikhande ,&nbsp;Peeyush N. Goel ,&nbsp;Yuvraj Nikam ,&nbsp;Rajiv P. Gude","doi":"10.1016/j.biomag.2013.08.003","DOIUrl":"10.1016/j.biomag.2013.08.003","url":null,"abstract":"<div><p><span>Targeting brain tumor largely depends on the chemotherapeutic agent uptake by the cancerous cells. The uptake further depends on its dosage form, route of administration<span><span><span><span> and surface modifications. In the present study, temozolomide<span><span> (TMZ) loaded into poly lactic acid (PLA) </span>nanoparticles was employed to evaluate the efficacy against C6 </span></span>glioma cells. Solvent evaporation method was used to fabricate PLA nanoparticles. Particle size determination, </span>zeta potential and diffusion studies were performed for the plain </span>drug<span> and drug-loaded nanoparticulate delivery system. The functional assessment was performed using in vitro studies, such as MTT, clonogenic and wound scratch assays respectively. The cellular uptake of formulated nanoparticles was investigated using flow cytometry and confocal microscopy<span>. The results indicate that the action of TMZ against C6 glioma is sustained when loaded into nanoparticles. This observation is of </span></span></span></span>clinical significance<span>, as it would avoid repeated administration of the drug as well as minimising the side effects and toxicity.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 4","pages":"Pages 201-208"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79942312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antinociceptive effect of Phyllanthus fraternus extract in complete Freund's adjuvant induced chronic pain in mice","authors":"Atul R. Chopade,&nbsp;F.J. Sayyad","doi":"10.1016/j.biomag.2013.09.001","DOIUrl":"10.1016/j.biomag.2013.09.001","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the effects <span><em>of </em><em>Phyllanthus</em><em> fraternus</em></span><span> (PF) extract on chronic inflammatory pain.</span></p></div><div><h3>Method</h3><p>Complete Freund's adjuvant<span><span><span> (CFA) induced inflammatory pain model was used to investigate the effects of (PF) extract on chronic inflammatory </span>hypersensitivity<span> in adult Swiss albino mice. Twenty-four hours after CFA injection, we used Von Frey filaments and acetone-evoked cooling to evaluate tactile and thermal hypersensitivity, respectively. The </span></span>paw edema was measured with the help of a digital plethysmometer.</span></p></div><div><h3>Results</h3><p><span>Single intraperitoneal injections of PF extract (200 &amp; 400</span> <!-->mg/kg) administered 30<!--> <!-->minutes before testing reduced CFA-induced mechanical hypersensitivity. Similarly, PF reduced acetone-evoked hypersensitivity up to 4<!--> <span>hours after treatment. Compared with vehicle, PF produced a marked reduction in CFA-induced paw edema. Multiple treatments with PF extracts given chronically (twice a day from 1st to 5th day and from 9th to 10th day) significantly reduced mechanical hypersensitivity induced by CFA. This multi-dose strategy did not cause tolerance.</span></p></div><div><h3>Conclusion</h3><p>The present study reveals the antinociceptive activity<span> of PF in chronic inflammatory hyperalgesia and also indicates that it might be potentially effective in management of the persistent pain.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 4","pages":"Pages 235-240"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90209191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of insulin transport by D-glucose in alveolar epithelial cells","authors":"Keisuke Oda ,&nbsp;Ryoko Yumoto ,&nbsp;Junya Nagai ,&nbsp;Mikihisa Takano","doi":"10.1016/j.biomag.2013.09.003","DOIUrl":"10.1016/j.biomag.2013.09.003","url":null,"abstract":"<div><p><span>D-glucose concentration in alveolar lining fluid is maintained much lower than that in the plasma, but is elevated by hyperglycemia<span>. In the present study, we examined insulin uptake in A549 human alveolar epithelial cells; especially focusing on the effect of D-glucose on the uptake. Time- and temperature-dependence were observed in FITC-insulin uptake in A549 cells in the presence of D-glucose. Confocal laser scanning microscopic analysis showed the punctate localization of FITC-insulin in the cells. These results indicated that FITC-insulin was taken up by the cells through an endocytotic pathway. FITC-insulin uptake was increased 2–4 fold by extracellular D-glucose, but glucose analogs such as 3-</span></span><em>O</em><span>-methyl-D-glucose and 2-deoxy-D-glucose did not show any enhancement effect. Moreover, FITC-albumin and FD-4 uptake were not affected by D-glucose. Intracellular ATP amount was not affected by D-glucose during the incubation. Phloretin, a facilitative glucose transporter inhibitor, significantly inhibited D-glucose uptake as well as D-glucose-stimulated FITC-insulin uptake. Taken together, D-glucose may regulate the insulin uptake after being taken up by A549 cells, through the mechanism that is not directly related to ATP production. The effect of D-glucose on insulin absorption was also examined in </span><em>in-vivo</em><span> pulmonary administration study in rats, and co-administration of D-glucose potentiated the hypoglycemic action of insulin. These findings suggest that endocytosis is involved in insulin uptake, and D-glucose specifically enhances the endocytosis of insulin in alveolar epithelial cells. D-glucose concentration in alveolar lining fluid may play an important role in the absorption of insulin from the lung.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 4","pages":"Pages 247-252"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87259859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemopreventive and therapeutic efficacy of Salsola inermis extract against N-nitrosodiethylamine-initiated and phenobarbital-promoted hepatocellular carcinogenesis in Wistar rats","authors":"Samir F. Zohny ,&nbsp;Ahlam H. Mahmoud ,&nbsp;Ibrahim H. Borai ,&nbsp;Faten S. Bayoumi ,&nbsp;Eman Eissa","doi":"10.1016/j.biomag.2013.08.002","DOIUrl":"10.1016/j.biomag.2013.08.002","url":null,"abstract":"<div><p><span>Hepatocellular carcinoma is one of the most common cancers worldwide and is known to be resistant to conventional chemotherapy. Therefore, we aimed to assess the </span><span><em>Salsola</em><em> inermis</em></span> extract as a novel chemopreventive and/or therapeutic agent against <em>N</em><span><span>-nitrosodiethylamine (DNE)/phenobarbital (PB)-induced hepatocarcinogenesis in rats. Adult male </span>Wistar albino rats were divided into five groups: group 1 rats were served as normal controls; group 2 rats were injected intraperitoneally with </span><em>S.</em> <em>inermis</em> extract (100<!--> <!-->mg/kg body weight/day) for 20<!--> <span>weeks; group 3 rats were subjected to two-phase hepatocarcinogenic regimen (initiation of hepatocarcinogenesis was performed by a single intraperitoneal injection of DEN at a dose of 200</span> <!-->mg/kg body weight, 2<!--> <!-->weeks later, the carcinogenic effect was promoted by supplementation of rats with 0.05% PB for 16<!--> <!-->weeks); group 4 rats were injected intraperitoneally with <em>S.</em> <em>inermis</em> extract 2<!--> <!-->weeks prior to the injection of DEN, the daily injection of <em>S.</em> <em>inermis</em> extract was then continued for 18<!--> <!-->weeks along with two-phase hepatocarcinogenic regimen (chemoprevention group); and group 5 rats were subjected to the two-phase hepatocarcinogenic regimen, and then, the animals were injected intraperitoneally with <em>S.</em> <em>inermis</em> extract for 4<!--> <span>weeks (treatment group). The activities of serum liver enzymes<span><span> and levels of total bilirubin, </span>conjugated bilirubin, α-fetoprotein, vascular endothelial growth factor (VEGF) and soluble intercellular adhesion molecule-1 (sICAM-1) in serum were decreased in chemopreventive and treated rats compared with DEN/PB-administered rats. Interestingly, the serum levels of total protein and albumin were normalized in chemopreventive and treated rats. Moreover, the majority of chemopreventive and treated rats showed an almost normal histological pattern of liver. In conclusion, </span></span><em>S.</em> <em>inermis</em> extract possessed chemopreventive and therapeutic activities against hepatocarcinogenesis in rats partially through the inhibition of VEGF and sICAM-1.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 4","pages":"Pages 229-234"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73481379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic and antihyperlipidemic effect of p-hydroxycinnamic acid on streptozotocin-induced diabetic Wistar rats","authors":"Sagadevan Ambika ,&nbsp;Ramalingam Saravanan ,&nbsp;Kumarasamy Thirumavalavan","doi":"10.1016/j.biomag.2013.09.004","DOIUrl":"10.1016/j.biomag.2013.09.004","url":null,"abstract":"<div><p>The objective of this study was to examine the hypothesis that intake of <em>p</em>-hydroxycinnamic acid (<em>p</em><span><span>-HCA) regulates blood glucose<span> levels and hypolipidemic responses in rats with diabetes mellitus induced by injection of </span></span>streptozotocin<span> (STZ). The diabetic rats exhibited lower levels of body weight, insulin, hemoglobin (Hb), high-density lipoprotein (HDL) and higher levels of glucose, lipid profiles, lipid peroxidation<span><span> markers in blood hepatic and renal tissues as compared with normal rats. In addition, diabetic rats showed decreased levels of superoxide dismutase (SOD) and </span>catalase<span> (CAT). Oral administration of </span></span></span></span><em>p</em>-HCA at the doses of 10, 20 and 40<!--> <!-->mg/kg BW. was given once daily started after the rise of blood glucose for 45<!--> <!-->days. Our result demonstrated that <em>p</em><span><span>-HCA administration could be lowered blood glucose, glycosylated hemoglobin, lipid profiles and significant increase in plasma insulin, hemogloblin, and HDL. In addition exert protective action against oxidative markers, </span>TBARS<span> and lipid hydroperoxides and improves antioxidant. The overall results suggest that </span></span><em>p</em><span><span>-HCA possesses potential hyperglycemic, hyperlipidemic and </span>antioxidant activity in STZ-induced diabetic rats.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 4","pages":"Pages 253-257"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79098859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioration of cardiac hypertrophy induced by abdominal aortic banding in ferulic acid treated rats","authors":"Urmila Aswar,&nbsp;Umesh Mahajan,&nbsp;Geetanjali Nerurkar,&nbsp;Manoj Aswar","doi":"10.1016/j.biomag.2013.08.001","DOIUrl":"10.1016/j.biomag.2013.08.001","url":null,"abstract":"<div><p><span><span><span>The objective of the present study was to investigate the beneficial effects of treatment of the abundant </span>phytochemical </span>Ferulic acid<span><span> (FA), alone or in combination with angiotensin II receptor antagonist </span>telmisartan<span><span> on pressure overload–induced cardiac hypertrophy in rats. </span>Albino Wistar rats<span> were divided into 6 groups: Sham, abdominal aorta constriction (AAB) and three FA (20</span></span></span></span> <!-->mg/kg) treatment groups given as a pretreatment or post-treatment or in combination with telmisartan (Tel; 10<!--> <span>mg/kg). The standard drug used was Tel (10</span> <span>mg/kg). The pretreatment was given for 35 days while the other treatments were started from the 29th day of surgery<span> for a period of 7 days orally. After recording the exercise testing and hemodynamic parameters, animals were sacrificed for biochemical and histopathological studies. The AAB group had a significant increase in left ventricular weight (LVW) (</span></span><em>p</em> <!-->&lt;<!--> <span>0.001), elevated blood pressure (</span><em>p</em> <!-->&lt;<!--> <span>0.001), a significant increase in reactive oxygen species (ROS) (</span><em>p</em> <!-->&lt;<!--> <!-->0.001) and serum creatinine kinase-MB (CK-MB) (<em>p</em> <!-->&lt;<!--> <span>0.001), significantly lowered glutathione<span> concentration and superoxide dismutase (SOD) (</span></span><em>p</em> <!-->&lt;<!--> <!-->0.001). Pretreatment with FA alone or post-treatment of FA in combination with telmisartan attenuated the rise in LVW and blood pressure (<em>p</em> <!-->&lt;<!--> <!-->0.001). It eliminated the ROS significantly (<em>p</em> <!-->&lt;<!--> <!-->0.01), reduced CK-MB, raised the glutathione and SOD (<em>p</em> <!-->&lt;<!--> <!-->0.001). These findings confirm the protective role of pretreatment of FA and post-treatment of FA with telmisartan in pressure overload–induced cardiac hypertrophy mediated through its integrated effect of potent antioxidative, anti-hypertensive and anti-inflammatory activity.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 4","pages":"Pages 209-217"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87255147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Cyperus rotundus tubers ethanolic extract on learning and memory in animal model of Alzheimer","authors":"Zahra Rabiei ,&nbsp;Mohammadreza Hojjati ,&nbsp;Mahmoud Rafieian-Kopaeia ,&nbsp;Zahra Alibabaei","doi":"10.1016/j.biomag.2013.08.006","DOIUrl":"10.1016/j.biomag.2013.08.006","url":null,"abstract":"<div><p><span><span>Alzheimer's disease (AD) is a degenerative disorder that leads to progressive cognitive decline. The memory dysfunction of AD has been associated with a cortical </span>cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert (NBM). This study investigated the effect of </span><span><em>Cyperus rotundus</em></span><span> tubers ethanolic extract on learning and memory in the rat model of Alzheimer's and intact rats. In this experimental study, 49 male Wistar rats were divided randomly into seven groups. Wistar rats received bilateral electric lesions of the NBM. The NBM-lesioned rats received </span><em>Cyperus rotundus</em> tubers ethanolic extract (100 and 200<!--> <span>mg/kg; ip) for 15 days while the control and sham groups received distilled water. Intact rats received extract without any surgery. Passive avoidance<span> learning and memory performance was assessed using passive avoidance paradigm, and Morris water maze test used for spatial learning and memory evaluation. In shuttle box test, the initial latency significantly decreased in Alzh+ CRT (NBM-lesioned rats that received extract) groups. Step through latency significantly increased in Alzh+ CRT groups. In Morris water maze task, in the probe trial, Alzh+ CRT groups demonstrated a significant preference for the quadrant in which the platform was located on the preceding day. The decrease in the escape latency improved significantly in Alzh+ CRT groups when compared with Alzh (NBM-lesioned rats) group. The results suggest that </span></span><em>Cyperus rotundus</em> tubers ethanolic extract has some repairing effects on the memory and behavioral disorders produced by lesioning of the NBM in rats.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 4","pages":"Pages 185-191"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.08.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77001880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protection against aluminium neurotoxicity: A repertoire of lettuce antioxidants","authors":"S.N. Harsha,&nbsp;K.R. Anilakumar","doi":"10.1016/j.biomag.2013.08.004","DOIUrl":"10.1016/j.biomag.2013.08.004","url":null,"abstract":"<div><p><span>Exposure to aluminium, though toxic in various ways is unavoidable owing to the abundant presence and use of aluminium in everyday living. Also, the fact that aluminium toxicity can lead to serious, life-threatening complications provides compelling reasons to find novel and effective therapeutic interventions. A distinct feature of aluminium toxicity is its ability to create pro-oxidant environment. The present study investigates the effectiveness of the anti-oxidant property of </span><span><em>Lactuca</em><em> sativa</em></span><span><span> as a neuroprotective agent against aluminium induced </span>neurotoxicity. The lyophilized hydro-ethanol extract of </span><em>Lactuca sativa</em> (LS) was reconstituted in water and administered orally at doses of 200 and 400<!--> <span>mg/kg body weight to mice for a period of 30 days. Aluminium chloride was injected intraperitonially at a conc. of 10</span> <span><span><span><span>mg/kg body weight. Behavioral tests viz., novel object recognition and open field test were performed to assess the exploratory behavior of mice. Biochemical parameters including lipid peroxidation, nitrite levels, </span>ROS<span>, LDH, </span></span>glutathione<span><span>, catalase and </span>acetylcholinesterase activity was assayed in the plasma and </span></span>brain homogenates<span>. Administration of the plant extract significantly improved the exploratory behavior of mice and also attenuated oxidative stress<span> and decreased the acetylcholinesterase activity. Hence, we report a significant recoupment in the blood and biochemical parameters with the treatment of </span></span></span><em>Lactuca sativa</em> extract against aluminium chloride induced neurotoxicity.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"3 4","pages":"Pages 179-184"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76118313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}