Antidiabetic and antihyperlipidemic effect of p-hydroxycinnamic acid on streptozotocin-induced diabetic Wistar rats

Biomedicine & Aging Pathology Pub Date : 2013-10-01 DOI:10.1016/j.biomag.2013.09.004

Sagadevan Ambika , Ramalingam Saravanan , Kumarasamy Thirumavalavan

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引用次数: 29

Abstract

The objective of this study was to examine the hypothesis that intake of p-hydroxycinnamic acid (p-HCA) regulates blood glucose levels and hypolipidemic responses in rats with diabetes mellitus induced by injection of streptozotocin (STZ). The diabetic rats exhibited lower levels of body weight, insulin, hemoglobin (Hb), high-density lipoprotein (HDL) and higher levels of glucose, lipid profiles, lipid peroxidation markers in blood hepatic and renal tissues as compared with normal rats. In addition, diabetic rats showed decreased levels of superoxide dismutase (SOD) and catalase (CAT). Oral administration of p-HCA at the doses of 10, 20 and 40 mg/kg BW. was given once daily started after the rise of blood glucose for 45 days. Our result demonstrated that p-HCA administration could be lowered blood glucose, glycosylated hemoglobin, lipid profiles and significant increase in plasma insulin, hemogloblin, and HDL. In addition exert protective action against oxidative markers, TBARS and lipid hydroperoxides and improves antioxidant. The overall results suggest that p-HCA possesses potential hyperglycemic, hyperlipidemic and antioxidant activity in STZ-induced diabetic rats.

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对羟基肉桂酸对链脲佐菌素诱导的糖尿病Wistar大鼠的降糖降脂作用

本研究旨在探讨对羟基肉桂酸(p-HCA)对注射链脲佐菌素(STZ)诱导的糖尿病大鼠血糖水平和低血脂反应的调节作用。与正常大鼠相比，糖尿病大鼠表现出较低的体重、胰岛素、血红蛋白(Hb)、高密度脂蛋白(HDL)水平和较高的葡萄糖、脂质谱、血液中肝脏和肾脏组织中的脂质过氧化标志物水平。此外，糖尿病大鼠超氧化物歧化酶(SOD)和过氧化氢酶(CAT)水平降低。口服10、20、40 mg/kg BW的p-HCA。每日1次，血糖升高后开始服用，持续45天。我们的研究结果表明，p-HCA可以降低血糖、糖化血红蛋白、血脂，并显著增加血浆胰岛素、血红蛋白和高密度脂蛋白。对氧化标志物、TBARS和脂质氢过氧化物均有保护作用，提高抗氧化能力。综上所述，p-HCA对stz诱导的糖尿病大鼠具有潜在的高血糖、高血脂和抗氧化活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedicine & Aging Pathology

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