Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects最新文献_第3页

Spaltung von löslicher ribonucleinsäure und serin-spezifischen transfer-ribonucleinsäure-fraktionen mit pankreas-ribonuclease 微量蓖麻毒素，有微量附着蓖麻毒素的微量蓖麻毒素

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90003-9

F. Melchers, H.G. Zachau

引用次数: 15

The incorporation of 5-fluorouracil by Staphylococcus aureus (strain Duncan). II 金黄色葡萄球菌(Duncan菌株)对5-氟尿嘧啶的掺入。2

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90005-2

R.C. Hignett

{"title":"The incorporation of 5-fluorouracil by Staphylococcus aureus (strain Duncan). II","authors":"R.C. Hignett","doi":"10.1016/0926-6550(64)90005-2","DOIUrl":"10.1016/0926-6550(64)90005-2","url":null,"abstract":"<div><ul><li>1.1. The effects of 5-fluorouracil, not reversible in the presence of uracil, on Staphylococcus aureus (strain Duncan) were studied.</li><li>2.2. The logarithmic growth of S. aureus (strain Duncan) in the presence of 5-fluorouracil (100 μg/ml) and uracil (200 μg/ml) was retarded by 90% after 60-min incubation.</li><li>3.3. Up to 4% of the UMP in the ribosomal RNA was replaced during 60-min growth, by 5-fluorouracil ribotide: 14% of UMP in the soluble RNA was replaced during this period.</li><li>4.4. The proportions of cell wall, hexose and polysaccharide were unaffected, but the lipid content fell slightly.</li><li>5.5. Total nucleic acid fell by 45% but the total nitrogen (less nucleic acids) remained constant.</li><li>6.6. Continued incorporation of the analogue into soluble RNA was in contrast to its uptake into particulate RNA.</li><li>7.7. Acid-soluble protein from the cell sap showed marked changes in its electrophoretic characteristics.</li><li>8.8. It was concluded that protein synthesis was unabated, with the production of abnormal proteins caused by unnatural nucleic acids; and that ribosome synthesis was halted, although pre-existing ribosomes remained active.</li></ul></div>","PeriodicalId":100173,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1964-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6550(64)90005-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23813907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Chromatography of nucleoside mono- and polyphosphates on hydroxyapatite 羟基磷灰石上核苷单磷酸盐和多磷酸盐的色谱分析

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90030-1

Giorgio Bernardi

引用次数: 26

Further evidence for the biosynthesis of cordycepin and proof of the structure of 3-deoxyribose 虫草素生物合成的进一步证据和3-脱氧核糖结构的证明

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90021-0

R.J. Suhadolnik, Joseph G. Cory

引用次数: 23

Fluorinated pyrimidines. XXII. Effects of various compounds on the incorporation of [14C]formate into DNA thymine in suspensions of Ehrlich ascites cells 氟嘧啶。第二十二。不同化合物对埃利希腹水细胞混悬液中[14C]甲酸盐与DNA胸腺嘧啶结合的影响

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90012-X

Charles Heidelberger, Judith Boohar, G.D. Birnie

引用次数: 1

On the stability of aminoacyl-s-RNA to nucleophilic catalysis 氨基酰基-s- rna亲核催化稳定性研究

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90018-0

P.S. Sarin, P.C. Zamecnik

引用次数: 121

Histone synthesis after inhibition of deoxyribonucleic acid replication 抑制脱氧核糖核酸复制后的组蛋白合成

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90020-9

Joseph A. Ontko, Wells R. Moorehead

引用次数: 16

The distribution and properties of cytoplasmic deoxyribonucleic acid-like ribonucleic acid (messenger ribonucleic acid) 细胞质脱氧核糖核酸样核糖核酸(信使核糖核酸)的分布和性质

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90031-3

O.P. Samarina

引用次数: 21

Characteristics of ribosomes isolated from roots of Zea mays 玉米根核糖体的特性研究

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90007-6

Theodore C. Hsiao

{"title":"Characteristics of ribosomes isolated from roots of Zea mays","authors":"Theodore C. Hsiao","doi":"10.1016/0926-6550(64)90007-6","DOIUrl":"10.1016/0926-6550(64)90007-6","url":null,"abstract":"<div>Ribosomes were isolated from root tips of corn (Zea mays) and their properties studied. Five ribosomal components (40 S, 60 S, 80 S, 120 S, and 150 S), with the 80-S component predominating, were present in the cytoplasmic extract. Sedimentation coefficients at infinite dilution were determined for all except the 150-S component.Purified ribosomes contained 43% RNA which was characterized by a high guanine and relatively high cytosine content. The 80-S component dissociated into 60-S and 40-S particles when pH of the medium was increased from 6.5 to 8.0 or higher. Magnesium (0.5–2 mM) prevented the dissociation.In marked contrast to the 70-S ribosome of Escherichia coli, the 80-S ribosome of corn did not require added magnesium to maintain its integrity in a solution of nearly neutral pH and low ionic strength. In fact, 5 mM magnesium in such a solution caused the association of corn ribosomes into large random aggregates. Ribosomes of different organisms differ in the level of magnesium required to preserve their 70–80-S component and may be divided accordingly into three broad groups exemplified by E. coli, yeast, and corn ribosomes.</div>","PeriodicalId":100173,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1964-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6550(64)90007-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23813909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Fluorinated pyrimidines. XXIII. Further studies on nucleoside phosphorylase 氟嘧啶。二十三。核苷磷酸化酶的进一步研究

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-12-16 DOI: 10.1016/0926-6550(64)90013-1

Charles Heidelberger, Judith Boohar

引用次数: 7