AJO International最新文献

{"title":"Impact of recipient and donor factors on corneal graft clearance: insights from serial anterior segment optical coherence tomography","authors":"Stylianos Christodoulou ,&nbsp;Dimitris Kola ,&nbsp;Fedonas Herodotou ,&nbsp;Aikaterini Athanasiadou ,&nbsp;Chara Tzavara ,&nbsp;Neofytos Michael ,&nbsp;Anastasia Neokleous ,&nbsp;Georgina Hadjilouka ,&nbsp;Sotiria Palioura","doi":"10.1016/j.ajoint.2025.100147","DOIUrl":"10.1016/j.ajoint.2025.100147","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate how recipient and donor characteristics influence corneal graft clearance, using serial measurements of central corneal thickness (CCT) and central graft thickness (CGT) derived from anterior segment optical coherence tomography (AS-OCT).</div></div><div><h3>Design</h3><div>Prospective cohort study.</div></div><div><h3>Methods</h3><div>Seventy-one patients (76 eyes) who underwent corneal transplantation (October 2021–April 2024) were followed for at least six months. Serial AS-OCT scans were used to extract CCT and CGT measurements, which were analyzed using mixed linear regression models with time splines to assess changes over time. These thickness parameters served as surrogate markers of corneal and graft deturgescence, respectively.</div></div><div><h3>Results</h3><div>Both CCT and CGT (for DSAEK grafts only) decreased significantly up to 3 months post-surgery (β = -1.73 μm/day, SE = 0.12, p &lt; 0.001; β = -0.53 μm/day, SE = 0.05; p &lt; 0.001), stabilizing thereafter (β = 0.063 μm/day, SE = 0.045, p = 0.156; β = 0.02 μm/day, SE = 0.02; p = 0.228). Faster clearance was observed in grafts from younger donor age (&lt;56 years; β = 0.67 μm/day, SE = 0.23; p = 0.004) and those with higher endothelial cell density (ECD ≥3,021 cells/mm²; β = –1.14 μm/day, p = 0.001). Penetrating keratoplasty was associated with slower CCT reduction compared to Descemet stripping automated endothelial keratoplasty (β = 0.74 μm/day, SE = 0.32; p = 0.021). Other preoperative factors did not significantly influence clearance</div></div><div><h3>Conclusion</h3><div>CCT and CGT are useful quantitative markers of corneal graft clearance. Donor age, ECD and surgical technique significantly influence early postoperative dynamics. Serial AS-OCT imaging offers valuable, non-invasive insights into graft behavior that can inform clinical decision-making.</div></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 3","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal crosslinking for keratoconus in children with thin corneas: A multicentre registry study","authors":"Charles J. Proxenos ,&nbsp;Himal Kandel ,&nbsp;Aanchal Gupta ,&nbsp;Jern Yee Chen ,&nbsp;Adam Watson ,&nbsp;Nicholas Downie ,&nbsp;Stephanie L. Watson","doi":"10.1016/j.ajoint.2025.100145","DOIUrl":"10.1016/j.ajoint.2025.100145","url":null,"abstract":"<div><h3>Purpose</h3><div>This study reports the clinical outcomes of corneal crosslinking in children with thin corneas in the real-world setting.</div></div><div><h3>Design</h3><div>Retrospective, longitudinal study</div></div><div><h3>Subjects</h3><div>The subjects were extracted from the Save Sight Keratoconus Registry and 18 children (21 eyes) under the age of 18 with corneas of 400 µm or less were included in the study.</div></div><div><h3>Methods</h3><div>Using the Save Sight Keratoconus Registry data was collected from 10 practices across Australia and New Zealand. Outcomes were assessed at the final follow-up visit. The primary outcome measure was a change in corneal curvature. Secondary outcomes included a change in visual acuity, a change in corneal thickness, and adverse events.</div></div><div><h3>Results</h3><div>Eighteen patients (21 eyes), of which 12 (66.7 %) were male, with a median age of 16 years (IQR 4.0, Range 8 to 18) underwent CXL. Median follow-up was 10 months (IQR 8, range 3 -55). Median values in outcome measures changed from baseline to follow-up: Kmax from 70.5D (IQR 15.5) to 69.3D (IQR 20.7), K2 from 60.5D (IQR 11.3) to 58.6D (IQR 13.5), habitual visual acuity from 47 (IQR 44.0) to 50 (IQR 31.0) LogMAR letters, pinhole visual acuity from 55 (IQR 11.0) to 60 (IQR 11.0) LogMAR letters and minimum corneal thickness from 390 μm (IQR 29.0) to 370.5 μm (IQR 48.5). Three eyes experienced adverse events. Two developed corneal scarring and one developed microbial keratitis requiring corneal graft.</div></div><div><h3>Conclusions</h3><div>This real-world study shows that CXL in children with thin corneas can stabilise corneal parameters and vision. Adverse events occur and include scarring and microbial keratitis. The small sample size and short duration of follow-up are notable limitations, and further larger prospective studies are needed to determine the safety and efficacy of CXL in children.</div></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 3","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Danish ophthalmological society guidelines for treatment of diabetic retinopathy","authors":"Jakob Grauslund ,&nbsp;Sara Brandi ,&nbsp;Javad Nouri Hajari ,&nbsp;Caroline Schmidt Laugesen ,&nbsp;Majbrit Lind ,&nbsp;Mette Slot Nielsen ,&nbsp;Katja Christina Schielke ,&nbsp;Yousif Subhi","doi":"10.1016/j.ajoint.2025.100146","DOIUrl":"10.1016/j.ajoint.2025.100146","url":null,"abstract":"","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 3","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on eye care access and telemedicine-based glaucoma screening among Latine individuals with limited English proficiency","authors":"Norma E. Del Risco ,&nbsp;Mildred Silva Zuccaro ,&nbsp;Jade J. Livingston ,&nbsp;Michele Heisler ,&nbsp;Harry Levine ,&nbsp;Maria A. Woodward ,&nbsp;Amanda K. Bicket ,&nbsp;Angela R. Elam ,&nbsp;Denise A. John ,&nbsp;Paula Anne Newman-Casey","doi":"10.1016/j.ajoint.2025.100144","DOIUrl":"10.1016/j.ajoint.2025.100144","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine Program (MI-SIGHT) was developed to facilitate access to glaucoma and eye disease screening and improve attendance at recommended follow-up in underserved communities. MI-SIGHT offered free eye disease screenings, low-cost glasses and for those who screened positive for glaucoma, personalized education, and language-concordant coaching grounded in motivational interviewing. The primary aims of this study were 1) To explore barriers to eye care among Latine participants with limited English proficiency (LEP) who screened positive for glaucoma, 2) to understand whether and how the MI-SIGHT program facilitated access to care and 3) to understand participant experience in MI-SIGHT to inform the development of future interventions.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Qualitative study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Subjects&lt;/h3&gt;&lt;div&gt;21 participants who identified as Latine with low English proficiency (LEP) who screened positive for glaucoma during the MI-SIGHT program and received personalized health education about their screening results, motivational-interviewing based health coaching, and care navigation all in Spanish.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Participants were recruited from the two MI-SIGHT sites, a Federally Qualified Health Center (FQHC) and a free clinic. Semi-structured interviews were conducted in Spanish by a native Spanish speaker. Interviews were audio-recorded and transcribed verbatim in Spanish. Grounded theory was used to guide qualitative analysis. Thematic saturation was achieved after analyzing 16 interviews.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main outcome measures&lt;/h3&gt;&lt;div&gt;Themes regarding barriers to eye care access and facilitators to eye care access through MI-SIGHT.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Between 7/11/23–12/19/23, 154 MI-SIGHT participants identified as Latine and had LEP, 22 screened positive for glaucoma and 21 agreed to be interviewed. Interviews revealed that the primary obstacles to accessing eye care among Latine participants with LEP were language barriers, financial constraints due to lack of insurance, insufficient social support, and difficulty with transportation. Additional challenges included immigration-related fears and complexities in healthcare system navigation. Participants identified key facilitators of the MI-SIGHT program as language concordance with providers, availability of interpreters, affordable eye care and glasses, and transportation services. Personalized coaching in their native language further enhanced their understanding of their eye disease and participation. High satisfaction was evident, with nearly all participants willing to recommend the program to others.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Eye care access for Latine participants with LEP is shaped by interconnected structural, socioeconomic, and cultural barriers. Language-concordant interventions, like the MI-SIGHT p","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 3","pages":"Article 100144"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of nanoemulsion compared to conventional cyclosporine in dry eye disease: A systematic review and meta-analysis","authors":"Afaf Bachira Gouhiri ,&nbsp;Mohamed A. Aldemerdash ,&nbsp;Naila-Oulfet Zitouni ,&nbsp;Zina Otmani ,&nbsp;Omar F. Abbas ,&nbsp;Weam Aldiban ,&nbsp;Youssef Adel Youssef Ashmawi ,&nbsp;Abdelaziz A Awad ,&nbsp;Hashem Abu Serhan","doi":"10.1016/j.ajoint.2025.100143","DOIUrl":"10.1016/j.ajoint.2025.100143","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the efficacy and safety of nanoemulsion cyclosporine compared to conventional cyclosporine in reducing symptoms of dry eye disease (DED).</div></div><div><h3>Design</h3><div>A systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>We searched Scopus, Web of Science, PubMed, Embase, and Cochrane for relevant randomized clinical trials (RCTs) and pooled the mean differences (MD) for continuous efficacy outcomes, including the Schirmer test, ocular surface disease index (OSDI), and tear film break-up time (TBUT), and risk ratios (RR) for dichotomous safety outcomes, such as adverse drug reactions or ocular adverse events, with their corresponding 95% confidence intervals (CI) across different time points from baseline. We used R statistical software to run the meta-analysis and I² statistic to assess heterogeneity.</div></div><div><h3>Results</h3><div>Seven RCTs involving 545 patients were included. At 12 weeks, nanoemulsion cyclosporine significantly improved tear production as measured by the Schirmer test (MD = 0.77 mm, 95% CI, 0.22 to 1.31, p &lt; 0.01) and tear film stability assessed by TBUT (MD = 0.51 seconds, 95% CI, 0.32 to 0.70, p &lt; 0.01) compared to conventional cyclosporine. Safety analysis showed no significant difference in overall adverse events between groups (RR = 1.13, 95% CI, 0.81 to 1.56, p = 0.44). However, nanoemulsion cyclosporine was associated with a significantly higher risk of ocular adverse events (RR = 3.53, 95% CI, 1.18 to 10.54, p = 0.02).</div></div><div><h3>Conclusions</h3><div>Our meta-analysis demonstrates that nanoemulsion cyclosporine significantly improves tear production and tear film stability at the longest available follow-up. However, it is also associated with an increased risk of ocular adverse events. These findings highlight the need to balance efficacy and safety when considering nanoemulsion cyclosporine and could help inform clinical guidelines on optimal treatment duration and monitoring.</div></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 3","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cornea eye care coverage based on geographic distribution and population demographics in the United States","authors":"Riya H. Patel ,&nbsp;David Mothy ,&nbsp;Hassaam S. Choudhry ,&nbsp;Aliya Grinberg ,&nbsp;Jayant Bhasin ,&nbsp;Mohammad H. Dastjerdi","doi":"10.1016/j.ajoint.2025.100139","DOIUrl":"10.1016/j.ajoint.2025.100139","url":null,"abstract":"<div><h3>Purpose</h3><div>To correlate the geographic distribution of cornea-specializing ophthalmologists with United States population demographics and identify communities with gaps in cornea care access.</div></div><div><h3>Design</h3><div>Cross-sectional analysis</div></div><div><h3>Methods</h3><div>In June 2024, office addresses of cornea ophthalmologists obtained from the Academy of Ophthalmology (AAO) public database and Google searches were geocoded using Esri ArcGIS Pro. Geographic distribution of cornea ophthalmologists within the United States compared to US county-level population demographics, such as county median incomes, educational attainment rates, poverty rates, and health insurance coverage rates. Independent samples <em>t</em>-tests were used for statistical analysis.</div></div><div><h3>Results</h3><div>1665 cornea ophthalmologists’ office addresses were identified. 85.6 % (<em>n</em> = 2688) of US counties had no practicing cornea ophthalmologists whereas 14.3 % (<em>n</em> = 447) of US counties had at least one cornea ophthalmologist. There was an average of 5.02 cornea ophthalmologists per million people throughout the United States. When correlated with population demographics, counties with at least one cornea ophthalmologist had greater median income [$77,444], educational attainment rates [35.5 %], and health insurance coverage rates [98.6 %] compared to the median household annual income [$60,872], educational attainment rates [21.4 %], and health insurance coverage rates [97.5 %] of counties with no cornea ophthalmologists (<em>p</em> &lt; 0.001). Additionally, counties with at least one cornea ophthalmologist had lower poverty rates [12.0 %] compared to counties with no cornea ophthalmologists [14.2 %] (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Geographic disparities in cornea care access are pronounced in low socioeconomic counties. Addressing these issues is crucial for equitable eye care.</div></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 3","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Ocular neuropathic pain in a real-world patient cohort with dry eye disease: A save sight dry eye registry study” [AJO International (2024) Volume 1, Issue 4, 100068]","authors":"Damien Tuan-Man Le ,&nbsp;Himal Kandel ,&nbsp;Ngozi C Chidi-Egboka ,&nbsp;Gerd Geerling ,&nbsp;Saaeha Rauz ,&nbsp;Alberto Recchioni ,&nbsp;Chris HL Lim ,&nbsp;Stephanie L Watson","doi":"10.1016/j.ajoint.2025.100138","DOIUrl":"10.1016/j.ajoint.2025.100138","url":null,"abstract":"","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 2","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Danish Ophthalmological Society guidelines for screening of diabetic retinopathy","authors":"Jakob Grauslund ,&nbsp;Nis Andersen ,&nbsp;Jens Andresen ,&nbsp;Toke Bek ,&nbsp;Søren Tang Knudsen ,&nbsp;Yousif Subhi","doi":"10.1016/j.ajoint.2025.100141","DOIUrl":"10.1016/j.ajoint.2025.100141","url":null,"abstract":"<div><div>N/A as this is submitted as a Perspective.</div></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 3","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144196435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of antibiotic additives in irrigation fluid used during cataract surgery: A systematic review","authors":"Brian Edward Yu ,&nbsp;William Herspiegel ,&nbsp;Robert Khatib ,&nbsp;Jeffrey Thevaranjan ,&nbsp;Abbie Lai ,&nbsp;Amit X. Garg ,&nbsp;Cindy M.L. Hutnik ,&nbsp;Monali Malvankar-Mehta","doi":"10.1016/j.ajoint.2025.100134","DOIUrl":"10.1016/j.ajoint.2025.100134","url":null,"abstract":"<div><h3>Purpose</h3><div>To conduct a systematic review investigating the efficacy of antibiotics used in irrigation fluid during cataract surgery on the incidence of post-operative endophthalmitis.</div></div><div><h3>Design</h3><div>Systematic review of literature.</div></div><div><h3>Methods</h3><div>Literature was searched through MEDLINE, EMBASE, CINAHL, ClinicalTrials.gov, and ProQuest Dissertations and Theses until February 17, 2024. Conferences held through the Association for Research in Vision and Ophthalmology and American Academy of Ophthalmology were searched until March 22, 2024. A total of 5341 records were screened leaving 13. One author independently reviewed them for quality and extracted data. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines were followed. Data on the types of antibiotics used, as well as the incidence of post-operative endophthalmitis and complications, were extracted.</div></div><div><h3>Results</h3><div>A total of 608,064 eyes and 566,760 patients were included in the current study. Surgical procedures included phacoemulsification, manual small-incision, and extracapsular extraction. Results showed antibiotic additives reduced postoperative endophthalmitis and bacterial contamination. Vancomycin showed the lowest infection rates, with one study reporting 0 infections out of 220 patients using a concentration of 20 mg/L. Similarly, gentamicin, tobramycin, and cefuroxime also demonstrated reduced infection rates, with gentamicin achieving rates as low as 0.008 % at higher concentrations. Combination therapy with vancomycin and gentamicin further reduced bacterial contamination, with culture positivity rates as low as 2.73 %. In comparator groups without antibiotics, infection rates were significantly higher, ranging from 0.04 % to 0.07 %. No adverse events or complications were reported in those who received antibiotics in their irrigation fluid.</div></div><div><h3>Conclusions</h3><div>Antibiotic additives in irrigation fluid reduce postoperative endophthalmitis and bacterial contamination in cataract surgery. These findings support their inclusion in surgical practice to improve patient outcomes. Based on the current systematic review, the overall quality of evidence is moderate, as findings are supported by a mix of randomized controlled trials and observational studies with some heterogeneity. Further high-quality RCTs are needed to determine optimal antibiotic concentrations and establish standardized guidelines.</div></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 3","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A modified technique of compression sutures combined with intracameral sulfur hexafluoride (SF6) for acute corneal hydrops","authors":"Omar Kirat ,&nbsp;Nada K. Naaman ,&nbsp;Adhwa Alsadoon ,&nbsp;Halah Bin Helayel ,&nbsp;Rafah Fairaq","doi":"10.1016/j.ajoint.2025.100140","DOIUrl":"10.1016/j.ajoint.2025.100140","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to present cases of acute corneal hydrops managed using a modified compression suture technique and intracameral gas tamponade.</div></div><div><h3>Methods</h3><div>Eight cases presented to the emergency room with acute drop in vision, corneal opacity, and Descemet’s membrane defects. The primary diagnoses included keratoconus in six cases, pellucid marginal degeneration (PMD) in one, and post-refractive ectasia in one. They were managed using a modified compression suture technique and intracameral air/gas tamponade. The procedure included creating a small surgical inferior peripheral iridectomy, followed by intracameral injection of sulfur hexafluoride (SF6) 20 % , and suturing the Descemet’s membrane defect with 10–0 Prolene using a straight needle in a continuous crisscross, horizontal cruciate mattress full-thickness technique.</div></div><div><h3>Results</h3><div>A total of eight eyes from eight patients were included. The series consisted of four males (50 %) and four females (50 %), with a median age of 27 years (range: 12–58 years). The median duration of hydrops symptoms prior to presentation was 24 days (range: 16–60 days). Uncorrected visual acuity at presentation ranged from 20/200 to hand motion. The median time for corneal edema resolution postoperatively was 2 weeks (range: 1–3 weeks). Sutures were removed at two months with no documented recurrences. Final uncorrected visual acuity ranged from 20/50 to 20/200, with a median of 20/80, excluding one patient with a difficult-to-assess visual acuity.</div></div><div><h3>Conclusions</h3><div>The modified compression suturing technique appears to be an effective alternative with a double mattress effect for expediting corneal edema resolution and Descemet’s membrane defect closure. Advantages include facilitating contact lens fitting and reducing the risk of corneal neovascularization. This technique may be particularly beneficial for pediatric and high-risk patients, including those who are mentally challenged, when postponing keratoplasty is necessary.</div></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 2","pages":"Article 100140"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}