Chinese Journal of Asthma最新文献

{"title":"Research progress of neutrophil-lymphocyte ratio in common lung diseases","authors":"Hui Nong, Yuxian Zhou, Yang Li, Mengli Li, W. Lei","doi":"10.3760/CMA.J.CN131368-20190721-01039","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190721-01039","url":null,"abstract":"Neutrophil-to-lymphocyte ratio (NLR) refers to the ratio of neutrophil to lymphocyte in peripheral blood.NLR is a new inflammation index which has attracted more and more attention in recent years.It reflects the dynamic balance between neutrophil and lymphocyte in peripheral blood and has been applied to the diagnosis, severity and prognosis of many diseases.This article reviews the research progress of NLR in common pulmonary diseases in order to improve clinicians′understanding of NLR. \u0000 \u0000Key words: \u0000Lung diseases; Neutrophil-to-lymphocyte ratio","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87924907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indications of bronchoscopic thermal vapor ablation","authors":"Jingyu Shi, Hui Zhu, Sai Yang, Wenjun Zhu, F. Luo","doi":"10.3760/CMA.J.CN131368-20190602-00814","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190602-00814","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a kind of progressive and irreversible chronic pulmonary disease characterized by limited airflow.Emphysema is a common clinic pathophysiological type of COPD.For COPD patients with emphysema, especially for severe or extremely severe emphysema, the effect of medical treatment is very limited.Therefore, the exploration of non-drug treatment has become a hot topic in recent years.Data from national emphysema treatment trial which have been finished in several countries and regiens indicated the effective of lung volume reduction surgery for emphysema.This paper is to summarize the indications of bronchoscopic thermal vapor ablation. \u0000 \u0000Key words: \u0000Pulmonary Emphysema; Endobronchial lung volume reduction; Indication","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87977047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between NADPH oxidase 4 and epithelial mesenchymal transformation in non-small cell lung cancer","authors":"Yan Li, Jin-chen Hu, Jieda Cui, B. Hao, Yongfa Hao, Hong Zhang, Juan Chen","doi":"10.3760/CMA.J.CN131368-20190712-01001","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190712-01001","url":null,"abstract":"Objective \u0000To explore the relationship between the expression of nicotinamide adenine dinucleotide oxidase 4 (NOX4) and epithelial mesenchymal transformation (EMT) in non-small cell lung cancer. \u0000 \u0000 \u0000Methods \u0000Collected from 2015 to 2018 in ningxia medical university general hospital by pathological diagnosis of non-small cell lung cancer patients with surgical specimens and paraffin embedding or fiber bronchoscope based tissue samples as lung cancer group (29 cases), select the same lobectomy or lung resection and admission or fiber bronchoscope lung benign lesions of organization as the control group (20 cases), immunohistochemical method is used respectively to detect lung cancer groups and control group in the lung tissue specimens NOX4, E-cadherin (E-Ca) and Vimentin expression.To analyze the relationship between NOX4 expression, tumor staging, distant metastasis and other tumor biological behaviors. \u0000 \u0000 \u0000Results \u0000The EMT-related marker protein Vimentin was mainly expressed in the cytoplasm, and the average optical density of the lung tissue in the lung cancer group and the control group was (26.42±8.40) and (11.66±8.30), respectively.The expression of Vimentin was higher than that in the control group, and the difference was statistically significant (t=6.078, P<0.001). E-Ca expression was mainly expressed in the cell membrane, and the average optical density of E-Ca expression in the lung cancer group and the control group was (5.15±6.67) and (14.97±7.68), respectively.E-Ca expression was lower than that in the control group, and the difference was statistically significant (t=-4.819, P<0.001). The main expression sites of NOX4 were cytoplasm and nucleus of cells.The average optical density of NOX4 expression in lung tissues of lung cancer group and control group was (29.36±11.60) and (11.27±7.36), respectively.The expression of NOX4 in lung cancer group was significantly higher than that in control group, and the difference was statistically significant (t=6.160, P<0.001). NOX4 protein expression in lung cancer group was negatively correlated with E-Ca expression (r=-0.612, P=0.001), and NOX4 expression was positively correlated with Vimentin expression (r=0.593, P=0.001). In the control group, NOX4 protein expression was not correlated with E-Ca expression (r=0.101, P=0.671), and NOX4 protein expression was not correlated with Vimentin expression (r=0.109, P=0.649). \u0000 \u0000 \u0000Conclusions \u0000High expression of NOX4 and EMT-related markers Vimentin and low expression of E-Ca were found in tumor tissues of NSCLC.NOX4 expression was negatively correlated with E-Ca expression, and positively with Vimentin expression.There is obvious EMT in lung cancer tissues, and NOX4 may participate in the EMT process through the oxidation-antioxidant signaling pathway. \u0000 \u0000 \u0000Key words: \u0000Carcinoma, non-small-cell lung; Oxidative stress; Nicotinamide adenine dinucleotide phosphate oxidase 4; Epithelial mesenchymal transformation","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82744736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the clinical effect of Anlotinib hydrochloride capsules in the treatment of advanced non-small cell lung cancer patients","authors":"Yitan Zou, Fang Ning, Jingxi Zhang, Yi Huang, Yiping Han, Li-jun Zhao, Yuchao Dong, C. Bai","doi":"10.3760/CMA.J.CN131368-20190621-00932","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190621-00932","url":null,"abstract":"Objective \u0000To observe the curative effects and toxic side effects of Anlotinib hydrochloride capsules in the treatment of advanced non-small cell lung cancer (NSCLC). \u0000 \u0000 \u0000Methods \u0000Clinical data was collected from 35 patients who were diagnosed of phase ⅢB to Ⅳ advanced NSCLC and were treated with Anlotinib hydrochloride capsules during June 2018 to March 2019 in Changhai Hospital Affiliated to Naval Medical University.All these patients had been treated with one or two lines of standard prior treatments and the follow-up time was cut off until March 31st, 2019. \u0000 \u0000 \u0000Results \u0000No case achieved complete response or partial response, 19 cases (54.3%)achieved stable disease and 16(45.7%) achieved progressive disease in 35 cases.The ORR was 0% and the DCR was 54.3%.The clinical effect was not related with the following factors including the mutation of EGFR and ROS1, the expression status of PD1, PDL1, p53 and KI67, gender, pathology type, stage, age and PS score.The median PFS of non-smoking group was higher than that of the smoking group [M(QR): 3.3(2.0) months vs 2.0(1.5) months] and the difference was statistically significant (Z=1.23, P<0.05). The median PFS of group with brain metastasis was lower than that of group without brain metastasis [M(QR): 3.7(2.9) months vs 6.5(2.0) months] and the difference was statistically significant (Z=-2.21, P<0.05). The median PFS of group with adverse reactions was higher than that of group without adverse reactions [M(QR): 3.6(1.9) months vs 2.3(1.7) months] and the difference was statistically significant (Z=-2.07, P<0.05). Adverse reactions included 4 cases of hypertension (11.42%), 6 case of hand-foot syndrome (17.14%), 5 case of gastrointestinal reaction (14.28%), 1 case of renal deficiency (2.85%), 1 case of pneumothorax (2.85%), 3 cases of oral ulcer (8.57%) and 4 cases of hoarseness (11.42%). \u0000 \u0000 \u0000Conclusions \u0000Anlotinib hydrochloride in the treatment of advanced NSCLC has certain therapeutic effect, which is superior in non-smoking patients, group without brain metastasis and patients suffering adverse reactions.The adverse reactions can be tolerated after symptomatic treatment.Anlotinib hydrochloride has special clinical application value in patients with advanced NSCLC. \u0000 \u0000 \u0000Key words: \u0000Carcinoma, non-small-cell lung; Treatment outcome; Anlotinib hydrochloride; Vascular endothelial growth factor-kinase inhibitor; Adverse reaction","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91046911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic predictive value of simplified Geneva score combined with age-adjusted D-dimer for pulmonary thromboembolism","authors":"Hua Yuan, Fangfang Fan, Qing Dong, Wei Zhang, Bowen Ran, Xiaoyun Hu","doi":"10.3760/CMA.J.CN131368-20191030-01499","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20191030-01499","url":null,"abstract":"Objective \u0000To investigate the diagnostic predictive value of simplified Geneva score (SGS), age-adjusted D-dimer (AADD) and their combination for pulmonary thromboembolism (PTE). \u0000 \u0000 \u0000Methods \u0000The study subjects were 102 hospitalized patients with suspected PTE from December 2016 to December 2017 in the First Affiliated Hospital of Shanxi Medical University.SGS was performed in all included patients and AADD was collected, with computed tomography and/or ventilation/perfusion positive results as the gold standard for the diagnosis of PTE.The sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and Yoden index of SGS, AADD and SGS combined with AADD were calculated and the diagnostic value of PTE was analyzed. \u0000 \u0000 \u0000Results \u0000Of the 102 patients with suspected PTE, 31 cases (30.4%) were diagnosed with PTE, and 71 cases (69.6%) were excluded from PTE.The sensitivity of SGS in diagnosing PTE was 80.6%, specificity was 76.1%, positive predictive value was 59.5%, negative predictive value was 90.0%, positive likelihood ratio was 3.37, negative likelihood ratio was 0.25, and Youden index was 0.567.The sensitivity of AADD in diagnosing PTE was 93.5%, specificity was 63.4%, positive predictive value was 52.7%, negative predictive value was 95.7%, positive likelihood ratio was 2.55, negative likelihood ratio was 0.10, and Youden index was 0.569.The sensitivity of SGS combined with AADD in diagnosing PTE was 92.0%, specificity was 90.4%, positive predictive value was 82.1%, negative predictive value was 95.9%, positive likelihood ratio was 9.58, negative likelihood ratio was 0.09, and Youden index was 0.824. \u0000 \u0000 \u0000Conclusions \u0000The combination of SGS and AADD can significantly improve the diagnostic efficacy of PTE, and its negative predictive value and positive predictive value are higher than when used alone. \u0000 \u0000 \u0000Key words: \u0000Pulmonary thromboembolism; Simplified Geneva score; Age-adjusted D-dimer; Forecasting","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73657494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value analysis of IgG antibody detection in diagnosis of chronic pulmonary aspergillosis","authors":"Luoman Yang, Qingtao Zhou, B. He","doi":"10.3760/CMA.J.CN131368-20191013-01402","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20191013-01402","url":null,"abstract":"Objective \u0000To evaluate the clinical value of aspergillus-specific immunoglobulin G (IgG) antibody in diagnosis of chronic pulmonary aspergillosis. \u0000 \u0000 \u0000Methods \u000047 patients who were admitted to Peking University Third Hospital from April 2018 to April 2019 and suspected to have chronic pulmonary aspergillosis infection were studied.The serum 1, 3-β-glucan test (G test), galactomannan (GM) test and aspergillus-specific IgG test were performed on these patients to evaluate the results of the three test methods. \u0000 \u0000 \u0000Results \u0000According to the clinical classification criteria, there were 26 patients in aspergillosis group, 21 patients in the non-aspergillosis group.The result of serum G test was 36 (10, 160) ng/L, GM test was 0.23(0.15, 0.30) and aspergillus-specific IgG detection was 151.43 (84.61, 322.63) AU/ml in aspergillosis group.In non-aspergillosis group, the result of serum G test was 10 (10, 45) ng/L, GM test was 0.26(0.15, 0.54) and aspergillus-specific IgG detection was 57.90 (42.79, 137.42) AU/ml.The sensitivity of aspergillus-specific IgG detection was 65.4%.The area under receiver operator characteristic curve of aspergillus-specific IgG detection method was 0.785 3. \u0000 \u0000 \u0000Conclusions \u0000In the clinical diagnosis and treatment of patients with chronic pulmonary aspergillosis, aspergillus-specific IgG antibody detection has a higher detection rate for aspergillus, which can make up for the defects of GM detection, and is beneficial for early diagnosis and timely effective treatment. \u0000 \u0000 \u0000Key words: \u0000Pulmonary aspergillosis; Early diagnosis; Aspergillus-specific immunoglobulin G detection","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79064695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of monocyte and large platelet for pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease","authors":"Jun Yang, Kaifen Yuan, Lijiao Cao","doi":"10.3760/CMA.J.CN131368-20190510-00722","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190510-00722","url":null,"abstract":"Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) can lead to a sharp deterioration of respiratory function, and the most chronic obstructive pulmonary disease (COPD)-associated death occurs in AECOPD.The prevalence of pulmonary embolism is high in COPD patients, especially in AECOPD patients.Pulmonary embolism and AECOPD have similar clinical symptoms.And it is difficult to distinguish them by symptoms, signs and simple laboratory tests, which leads to the excessive use of computer tomography pulmonary angiography.In recent years, many researchers have found that monocyte, platelet, especially large platelet, are evidently related to intravascular and extravascular inflammatory reaction and thrombogenesis. \u0000 \u0000Key words: \u0000Acute exacerbation of chronic obstructive pulmonary disease; Pulmonary embolism; Monocyte; Large platelet","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78155172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of salvia miltiorrhiza and ligustrazine injection on P-selectin and tissue factor in rats of pulmonary embolism","authors":"Yue Yang, Lu Liu, Shihuan Yu, Daping Fan, Tianyou Hu","doi":"10.3760/CMA.J.CN131368-20190602-00812","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190602-00812","url":null,"abstract":"Objective \u0000To study the effects of salvia miltiorrhiza and ligustrazine injection, low molecular weight heparin and their combination on pulmonary embolism rats by observing the changes of P-selectin (CD62P) and tissue factor (TF) in the blood of rats of pulmonary embolism. \u0000 \u0000 \u0000Methods \u000080 healthy male Wistar rats were randomly divided into 7 h and 7 d groups.Each group was divided into control group, embolism group, salviae miltiorrhiza and ligustrazine group, low molecular weight heparin group, and combined drug group, each group with eight rats.The rats were separated from the right jugular vein, the control group was injected with saline, and the remaining groups were injected with homemade emboli (n=25±3, d=0.5 mm). Each group collected blood at the 7th hour and the 7th day, TF and CD62P concentrations were detected, and lung tissue was observed. \u0000 \u0000 \u0000Results \u0000After embolization, rats had panting, cyanosis, accelerated heart rate, etc.The surface of lung tissue was rugged, uneven expansion, scattered in gray-white infarction areas.Compared with the control group, the concentrations of TF and CD62P in plasma of the embolism group increased significantly (all P<0.05). Compared with the embolism group, the concentrations of TF and CD62P of the therapy groups decreased to different degrees, and the combined group after therapy for one week was most significant. \u0000 \u0000 \u0000Conclusions \u0000The ideal model of pulmonary embolism can be prepared by jugular vein injection allothrombosis.The levels of TF and CD62P in pulmonary embolism rats could be significantly reduced by the combination of salvia miltiorrhiza and ligustrazine and low molecular weight heparin. \u0000 \u0000 \u0000Key words: \u0000Pulmonary embolism; Salvia miltiorrhiza and ligustrazine; Thromboplastin; P-selectin","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84833980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research advances on phenotypes of acute respiratory distress syndrome","authors":"Long Zheng, Liqiang Song","doi":"10.3760/CMA.J.CN131368-20190615-00879","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190615-00879","url":null,"abstract":"The clinical phenotypes of acute respiratory distress syndrome have been the focus of the academic community, but there is not an effective solution.Summarizing the research advances in this area will help to clarify the ideas and push the goal of personalized treatment further.This article reviews the clinical phenotypes of acute respiratory distress syndrome based on etiology, disease severity, onset time and inflammation level. \u0000 \u0000Key words: \u0000Respiratory distress syndrome, adult; Phenotype; Personalized treatment","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85440423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of alveolar macrophages in pulmonary homeostasis and infections","authors":"Yang Shen, Ganzhu Feng","doi":"10.3760/CMA.J.CN131368-20190924-01325","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190924-01325","url":null,"abstract":"Alveolar macrophages (AMs) are important immune cells in the lung.Different sources and polarization states make AMs play diverse functions in varying environment.Under physiological conditions, AMs are responsible for keeping lower levels of inflammation and maintaining homeostasis in the lung, promoting optimal gas exchange.They also mediate an immune response to invade microbes during infection and adjust their immune state in the later stage to reduce tissue damage and restore homeostasis, but may drive pathogen persistence.This review discusses the origin, polarization and functions of AMs in pulmonary homeostasis and infection, so as to provide new ideas for therapeutic strategy targeting at AMs. \u0000 \u0000Key words: \u0000Macrophages, alveolar; Origin; Polarization; Pulmonary homeostasis; Pulmonary infection","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83700188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}