Chinese Journal of Asthma最新文献

{"title":"Changes of myocardial oxidative stress injury and intervention of edaravone in intermittent hypoxic rat model","authors":"Y. Duan, Jizu Ling, Xinhui Yuan, Lifang Li, Qin Yu","doi":"10.3760/CMA.J.CN131368-20190312-00334","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190312-00334","url":null,"abstract":"Objective \u0000To investigate the effect of intermittent hypoxia (IH) on myocardial oxidative stress injury and its possible mechanism by establishing IH rat model, and to further understand the intervention effect of edaravone, provide new ideas for the research and prevention of obstructive sleep apnea-hypopnea syndrome and related cardiovascular complications. \u0000 \u0000 \u0000Methods \u0000Eighty healthy male Wistar rats were randomly divided into normal control (NC) group, IH group, IH+ edaravone group, and IH+ normal saline (NS) group, 20 rats in each group.The IH rat model was established by using a gas control device to fill the closed simulation chamber with nitrogen, oxygen and compressed air.After four weeks of modeling, the serum levels of lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase-MB (CK-MB) and malondialdehyde (MDA), superoxide dismutase (SOD) and hydroxyl radicals were measured.The mitochondrial adenosine triphosphate (ATP) level in cardiomyocytes was measured.Myocardial morphology and ultrastructure were observed by light microscopy and transmission electron microscopy.Transcription-polymerase chain reaction technique was used to detect the expressions of Bcl-2, Bax and Caspase-3 mRNA in myocardial tissue. \u0000 \u0000 \u0000Results \u0000(1)Compared with the NC group, the levels of LDH, CK, CK-MB, MDA and hydroxyl radicals, the expressions of Bax and Caspase-3 mRNA were significantly increased, while the SOD activity, ATP content, and the expression of Bcl-2 mRNA were significantly decreased in the IH group and the IH+ NS group (all P<0.05). (2)Under light microscope and transmission electron microscope, no obvious damage was found in myocardial tissue of NC group, but the morphology and ultrastructure of myocardial tissue in IH group and IH+ NS group were damaged.(3)After intervention with edaravone, serum LDH, CK, CK-MB and myocardial tissue MDA, hydroxyl radicals, Bax and Caspase-3 mRNA expressions decreased, SOD activity and ATP content increased, Bcl-2 mRNA expression level was elevated (all P<0.05), and the degree of myocardial tissue damage under light and electron microscopy was alleviated.(4)Caspase-3 mRNA expression in cardiomyocytes was positively related with CK (r=0.575), CK-MB (r=0.460), MDA (r=0.643), hydroxyl radical (r=0.454), and Bax mRNA (r=0.741), negatively related with ATP (r=-0.525) and Bcl-2 mRNA (r=-0.578). \u0000 \u0000 \u0000Conclusions \u0000(1)IH can induce myocardial oxidative stress damage in rats by increasing oxidants, reducing antioxidants and activating Bcl-2, Bax and Caspase-3.(2)The myocardial oxidation stress injury induced by IH may be achieved by mitochondria-mediated apoptosis.(3)Edaravone has an intervention effect on myocardial injury induced by IH. \u0000 \u0000 \u0000Key words: \u0000Intermittent hypoxia; Oxidative stress; Myocardial injury; Adenosine triphosphate; Edaravone; Apoptosis","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75129769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences of cardiopulmonary exercise testing parameters in cardiac output prediction for patients with chronic thromboembolic pulmonary hypertension","authors":"Zuogang Wang, Zi-Long Zhao, Y. Huang, Liang Yu, Qinhua Zhao, S. Gong, P. Yuan, Jinming Liu","doi":"10.3760/CMA.J.CN131368-20190327-00438","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190327-00438","url":null,"abstract":"Objective \u0000To evaluate the sex differences of cardiopulmonary exercise testing (CPET) parameters in cardiac output (CO) prediction for patients with chronic thromboembolic pulmonary hypertension (CTEPH). \u0000 \u0000 \u0000Methods \u0000From May 2010 to February 2016, 73 cases (32 males and 41 females) with CTEPH were enrolled from Shanghai Pulmonary Hospital, all of whom underwent both right-heart catheterization and CPET.Multivariate regression analysis was applied to assess the prognostic value of CPET parameters. \u0000 \u0000 \u0000Results \u0000Sex differences were of no significance in both demographic and hemodynamic parameters in total patients, but younger in female patients.Male patients had higher O2 pulse at anaerobic threshold (AT), peak minute ventilation (VE), end-tidal partial pressure of oxygen output (PETO2) at AT, peak O2 pulse, VE at AT and nadir VE/carbon dioxide (VCO2), but lower oxygen uptake efficiency slope compared with female patients (all P<0.05). There was no significant difference in CPET parameters between male event group and male event-free group, but peak oxygen uptake(VO2)in female event group was lower than that in female event-free group (P<0.05). Female event group had lower peak VO2, VE at AT and peak VE compared to the male event group (all P<0.05). Nadir VE/VCO2 and peak PETO2 were independent predictors of CO for male and female CTEPH patients, respectively. \u0000 \u0000 \u0000Conclusions \u0000The independent predictors of CPET parameters are different in the assessment of CO in male and female CTEPH patients, which suggests that sex differences of CPET should be considered to be the better clinical assessment of CTEPH patients. \u0000 \u0000 \u0000Key words: \u0000Chronic thromboembolic pulmonary hypertension; Cardiopulmonary exercise testing; Sex characteristic; Cardiac output","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89251621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on mechanical prevention of venous thromboembolism","authors":"Yue Zhao, Yuan-yuan Liu, Zhaozhong Cheng","doi":"10.3760/CMA.J.CN131368-20191011-01395","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20191011-01395","url":null,"abstract":"With the increasement of the morbidity and mortality of venous thromboembolism (VTE), and the increasement of social burden, medical staff pay more attention to VTE and improve their awareness of it.As a preventable disease, the prevention of VTE is especially important.VTE prevention mainly includes drug prevention and mechanical prevention.However, drug prevention may cause the risk of bleeding, which limits the application of drug prevention.Mechanical prevention has extensive applications due to non-invasiveness, high patient compliance, fewer complications, simpleness and convenience, and excellent effectiveness.This article mainly summarizes the methods, advantages and disadvantages of mechanical prevention. \u0000 \u0000Key words: \u0000Venous thromboembolism; Mechanical prophylaxis; Epidemiology","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80108589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of probiotics on prevention of ventilator-associated pneumonia and intestinal function in critically ill patients","authors":"Ying Xu, Rui-Xiang Chen, Jun Jin","doi":"10.3760/CMA.J.CN131368-20190906-01252","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190906-01252","url":null,"abstract":"Objective \u0000To observe the effect of probiotics on prevention of ventilator-associated pneumonia (VAP) and intestinal function in critically ill patients. \u0000 \u0000 \u0000Methods \u0000In this prospective, randomized, controlled study, 155 patients who met the conditions for enrollment were randomly divided into control group and test group.The same treatment was given to all patients, in addition, the patients in test group were given probiotics (Bifidobacterium, Lactobacillus mixture) for three weeks.The incidence of VAP, changes in gut microbiota and incidence of gastrointestinal symptoms were compared between the two groups. \u0000 \u0000 \u0000Results \u0000120 patients finished the study, including 58 cases in the control group and 62 cases in the test group.The incidence of VAP in the test group was lower than that in the control group (38.7% vs 62.1%, χ2=6.541, P<0.05). The total detection rate of microbial colonization in the oropharynx and stomach of the test group was significantly lower than that of the control group (51.6% vs 89.7%, χ2=20.052, P<0.05). The incidences of increased intra-abdominal pressure, diarrhea, and weakened or disappeared bowel sounds were significantly reduced in the test group (χ2=8.439, 10.849, 13.327, all P<0.05). The proportion of lactobacillus in the intestinal tract of the test group was significantly increased.The time of mechanical ventilation and length of stay in intensive care unit in the test group were also significantly shortened compared with the control group (t=8.051, 6.538, all P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Probiotics preparation can significantly increase the proportion of lactobacillus in the intestinal tract, reduce the incidence of VAP in critically ill patients, reduce the incidence of gastrointestinal symptoms, reduce the time of mechanical ventilation and the length of stay in intensive care unit, then have the value of clinical promotion. \u0000 \u0000 \u0000Key words: \u0000Probiotics; Pneumonia, ventilator-associated; Gut microbiota; Lactobacillus","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89890959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New progress in diagnosis and treatment of community-acquired pneumonia","authors":"Xiao-yu Li, Jian-ping Bo","doi":"10.3760/CMA.J.CN131368-20191018-01433","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20191018-01433","url":null,"abstract":"In recent years, the morbidity and mortality of community-acquired pneumonia have increased gradually, with more severe cases.However, in clinical diagnosis and treatment, there are some phenomena such as unclear etiology diagnosis, insufficient understanding of the significance of serological detection, inaccurate severity evaluation and unreasonable use of antibiotics.This paper refers to a large number of the latest literatures on community-acquired pneumonia published at home and abroad in recent years, and reviews in serology, etiology, rational use of antibiotics, whether glucocorticoids should be used, adjuvant therapy and the latest advances of diagnosis and treatment. \u0000 \u0000Key words: \u0000Community-acquired pneumonia; Severity score; Treatment; New progress","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77621504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of modified Padua risk assessment model in identifying high venous thromboembolism risk among hospitalized medical patients","authors":"Heng Liu, Jing Wang, Yuhong Pi, Sun Zhang, S. Qing, Chunli Liu, Nuofu Zhang","doi":"10.3760/CMA.J.CN131368-20171204-01476","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20171204-01476","url":null,"abstract":"Objective \u0000To retrospectively test the validity of modified Padua risk assessment model in identifying high venous thromboembolism (VTE) risk among hospitalized medical patients. \u0000 \u0000 \u0000Methods \u0000A retrospective case-control study was performed among hospitalized medical patients admitted into the First Affiliated Hospital of Guangzhou Medical University from January 2013 to December 2016.A total of 432 patients with definite VTE during hospitalization were recruited and a tota1 of 864 controls were randomly selected from the patients without VTE admitted into the same department within the same period.The medical history, laboratory examination results and other clinical data of two groups was retrospectively collected.The risks of both groups were retrospectively assessed with the Padua risk assessment model and modified Padua risk assessment model and the two risk assessment models were compared. \u0000 \u0000 \u0000Results \u0000The score of the two risk assessment models in VTE group was significant higher than that in control group (Padua: 2.92±0.18 vs 1.25±0.10, t=16.241, P<0.05; modified Padua: 3.27±0.19 vs 1.64±0.11, t=14.245, P<0.05). With the increase in risk score, the occurrence of VTE increased accordingly.By Padua risk assessment model and modified Padua risk assessment model, the risk of VTE of high-risk patients was 12.27 times (95% CI: 9.00-17.98, P<0.05) and 8.17 times (95% CI: 6.00-11.12, P<0.05) as high as that of low-risk patients.The proportion of high-risk patients judged by modified Padua risk assessment model was significant higher than that by Padua risk assessment model (48.61% vs 39.12%, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Modified Padua risk assessment model can effectively and quantitatively assess the risk of VTE among medical patients based on their individual VTE risk factors. \u0000 \u0000 \u0000Key words: \u0000Modified Padua risk assessment model; Medical patients; Venous thromboembolism; Case-control study","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90895943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaesthetic management of montgomery T-tube insertion for subglottic stenosis","authors":"Hongli Yue, Juan Wang, Y. Pei, Chen-yang Zhang, Min Xu","doi":"10.3760/CMA.J.CN131368-20190811-01139","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190811-01139","url":null,"abstract":"Objective \u0000To discuss the anaesthetic management of Montgomery T-tube insertion for subglottic stenosis. \u0000 \u0000 \u0000Methods \u0000The data including characteristics, clinical features, anaesthetic methods, operation procedures and postoperative recovery of 20 patients with subglottic stenosis underwent Montgomery T-tube insertion were reviewed and analyzed. \u0000 \u0000 \u0000Results \u0000The causes of stenosis were tracheal intubation (12 cases), tracheal trauma (four cases), internal and external tracheal tumors (three cases). On the degree of stenosis, there was one case of Myer-Cotton grade Ⅰ, three cases of grade Ⅱ, nine cases of grade Ⅲ, seven cases of grade Ⅳ.Bronchoscopic examination showed tracheal collapse in nine cases.All patients were tracheotomized before operation and used a rigid bronchoscope as working channel during operation.All patients were anaesthetized with total intravenous anaesthesia.The anaesthesia of all patients was stable, and ventilation modes were alternated smoothly.Postoperative complications such as cough (80%), sore throat (45%), fever (45%), difficulty in sputum evacuation (40%), difficulty breathing (25%), infection (10%), airway obstruction (5%), aspiration (5%) were cured after active treatment. \u0000 \u0000 \u0000Conclusions \u0000During montgomery T-tube insertion for subglottic stenosis, total intravenous anaesthesia can ensure depth of anaesthesia and stability of circulatory parameters.Controlled ventilation or high frequency ventilation by tracheotomy tube, T-tube, and laryngeal mask on demand can ensure oxygen supply.Communication closely during perioperation and active treatment of postoperative complications are beneficial for the safety and the recovery of patients. \u0000 \u0000 \u0000Key words: \u0000Acquired subglottic stenosis; Tracheal T-tube; Anesthesia","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75135832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of clinical features and related risks of prognosis in 68 non-human immunodeficiency virus immunosuppressed patients with cytomegalovirus pneumonia","authors":"Wensen Pan, Ranran Xiao, Xin Liu, X. Gong, J. Zhao, Jing Yu","doi":"10.3760/CMA.J.CN131368-20190923-01323","DOIUrl":"https://doi.org/10.3760/CMA.J.CN131368-20190923-01323","url":null,"abstract":"Objective \u0000To analyze the clinical characteristics of 68 non-human immunodeficiency virus immunosuppressed patients with cytomegalovirus pneumonia, and the risk factors related to death, so as to provide reference for clinical diagnosis and treatment. \u0000 \u0000 \u0000Methods \u0000A retrospective case analysis study was used.The clinical data of 68 patients with cytomegalovirus pneumonia admitted to the Second Department of Respiratory Medicine of the Second Hospital of Hebei Medical University were collected.According to the patient′s 28d outcome, the patients were divided into the survival group and the death group.The general conditions and clinical data of the two groups were compared, and risk factors were analyzed. \u0000 \u0000 \u0000Results \u0000The top three underlying diseases were kidney disease, rheumatic disease, and blood system disease.In the death group, the acute physiology and chronic health evaluation Ⅱ scores, hypersensitive C-reactive protein, the smallest absolute counts of white blood cells, neutrophil percentage were higher than those in the survival group (all P<0.05), and the absolute counts of lymphocyte, CD3+ lymphocyte, CD4+ lymphocyte were lower (all P<0.05). Long-term (more than three months) application of glucocorticoids or combination with immunosuppressive agents were significantly more in the death group (all P<0.05). The immunosuppressed patients who suffered from dermatological disease, had gram-positive coccal pneumonia or bloodstream infections, needed mechanical ventilation had a poor prognosis (all P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Cytomegalovirus pneumonia patients who received long-term (more than three months) application of glucocorticoids or combination with immunosuppressive agents, had gram-positive coccal pneumonia or bloodstream infections, and needed mechanical ventilation have a poor prognosis. \u0000 \u0000 \u0000Key words: \u0000Cytomegalovirus pneumonia; Respiratory insufficiency; T lymphocyte subsets; Prognosis","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88630373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological characteristics of digestive tract in rats with chronic obstructive pulmonary disease induced by tobacco smoke","authors":"Difei Li, Defu Li, Zeguang Zheng, Wenju Lu, Jieying Hu, Rongchang Chen","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.001","url":null,"abstract":"Objective \u0000To observe the pathological changes of the digestive tract of rats with chronic obstructive pulmonary disease (COPD), as well as to provide a theoretical basis for exploring the mechanism of COPD dystrophy. \u0000 \u0000 \u0000Methods \u0000The COPD rat model was established by cigarette smoke (CS) exposure.Lung functions were measured using Buxco lung function measurement system.Arterial blood gas parameters were examined with GEM3000 blood gas analyzer.The inflammatory cells were counted and the level of interlukin-6 (IL-6), monocyte chemo-attractant protein-1 (MCP-1) and IL-10 in bronchoalveolar lavage fluid (BALF) were assayed with enzyme-linked immunosorbent assay.Pathological changes of lung tissue, liver, spleen, stomach, small intestine were observed. \u0000 \u0000 \u0000Results \u0000At the end of modeling, the weight of the model group rats were significantly lower than those of the control group.Compared with control rats, the CS exposed rats presented typical COPD-like lung function decline indicated by increases in functional residual volume (FRC), total lung capacity (TLC), Chord compliance (Cchord), as well as a decrease in the FEV50/FVC ratio.Damaged alveolar walls and pulmonary bullae were observed in rats′ lungs exposed to CS.In alveolar lavage fluid, the total number of inflammatory cells and the categorical counts (neutrophils, macrophages, and lymphocytes) were higher than those of the control group, as well as the levels of IL-6 and MCP-1 as proinflammatory mediators.The anti-inflammatory cytokine IL-10 was lower than that of the control group.Moreover, the histological staining showed that a little congestion in the central hepatic lobule with inflammatory cell infiltration and mild hepatic edema, a small amount of congestion in the spleen, mild erosion in the stomach, small intestine mucosal atrophy with a small amount of inflammatory cell infiltration. \u0000 \u0000 \u0000Conclusions \u0000In COPD, gastrointestinal pathological changes including hyperemia, edema, congestion, erosion, and inflammatory cell infiltration are observed in the digestive tract tissues including liver, spleen, gastric mucosa, and small intestinal mucosa. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Inflammation; Pathological changes in the digestive tract","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74925387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on accurate treatment of bronchial asthma","authors":"Wang Luo, Y. Qiao, C. Ye, S. Cai, H. Dong","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.011","url":null,"abstract":"Bronchial asthma (asthma) is a heterogeneous disease characterized by chronic airway inflammation.It is one of the most common chronic diseases in the world which causes huge medical burden.Although the symptoms of most asthma patients can be effectively controlled by inhaled glucocorticoids and bronchodilators, some patients with severe asthma are still unable to achieve ideal control under conventional treatment.Therefore, more and more attention has been paid to targeted drugs at the molecular level.The purpose of this review is to discuss the current research progress in accurate treatment of asthma and to explore the application value of targeted therapy drugs in the treatment of severe asthma. \u0000 \u0000 \u0000Key words: \u0000Asthma; Precise treatment; Targeted therapy","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86844192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}