Chinese Journal of Asthma最新文献

{"title":"A comparative study of the expectoration effect by breath training device and pursed lip breathing in patients with AECOPD","authors":"Ping Zhang, Feng Yang, Yin-huan Li, Ni Liu, Jieying Hu, Wenshuai Duan, Yanfei Cao, Huiyin Xu, C. Duan, Rongchang Chen, N. Zhong, Zeguang Zheng","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.005","url":null,"abstract":"Objective \u0000To observe and compare the expectoration effect of breath training device and the pursed lip breathing in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). \u0000 \u0000 \u0000Methods \u0000Forty patients hospitalized because of AECOPD were consecutively observed from March 2018 to May 2018.The patients were randomly divided into two groups in which sputum inducted respectively by breath training device or pursed lip breathing for observing the expectoration effect of the breath training device and the pursed lip breathing. \u0000 \u0000 \u0000Results \u0000During the intervention period of both breath training device and pursed lip breathing, the total volumes expelled and their pure sputum volumes of the two groups were significantly higher than those before the intervention (breath training device group: all P<0.01; pursed lip breathing group: all P<0.05), and the increase of sputum volume by breath training device was more significant than that by pursed lip breathing (P< 0.05); the ratio of sputum water component volume to total sputum volume in the breath training device group was also significantly increased than that before the intervention (P<0.01). The cough difficulty and sputum properties in the breath training device group were significantly improved compared with those before intervention (all P<0.05), and the viscosity of sputum in the trainer group was higher than that before intervention (P<0.05), but all of cough difficulty, sputum properties and viscosity of sputum did not in the pursed lip breathing group.After finishing of the intervention, the total sputum volume and pure sputum volume in the two groups were lower than those before the intervention.Although the viscosity of sputum in the two groups were higher than those before intervention, and the viscosity of sputum in the breath training device group was much higher than that in the pursed lip breathing group, the cough difficulty and sputum properties were significantly improved than those before and during the intervention. \u0000 \u0000 \u0000Conclusions \u0000Both breath training device and the pursed lip breathing can help patients with AECOPD to expel phlegm.Breath training device can promote the hydration of phlegm, improve the characteristics of phlegm and speed up the discharge of phlegm. \u0000 \u0000 \u0000Key words: \u0000Respiratory rehabilitation; Acute exacerbation of chronic obstructive pulmonary disease; Expectoration; Pursed lip breathing","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81494648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application value of FeNO in cough variant asthma","authors":"Yanqi Wang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.012","url":null,"abstract":"Cough variant asthma (CVA) is one of the common causes of chronic cough.Due to its high incidence rate and wide age of onset, it is easy to be misdiagnosed as chronic bronchitis and delay treatment, and then develop into typical asthma.In recent years, fraction exhaled nitric oxide, as a non-invasive, simple, timely and highly repeatable inflammatory marker, has been widely used in clinical practice, which is of great significance for the diagnosis, treatment, monitoring and management of CVA.Therefore, this paper reviews the application of fraction exhaled nitric oxide in CVA. \u0000 \u0000 \u0000Key words: \u0000Asthma; Cough; Fraction exhaled nitric oxide","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87940310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of impulse oscillometry system in patients with asthma-chronic obstructive pulmonary disease","authors":"Ling Wen, Pengbo Sun, Lihua Zhu, Na Wang, Luotong Fu, Li Zhao","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.004","url":null,"abstract":"Objective \u0000To evaluate the diagnostic value of impulse oscillometry system (IOS) pulmonary function test-related indicators for the diagnosis of asthma-chronic obstructive pulmonary disease overlap (ACO) and to obtain the cut-off values of relevant parameters. \u0000 \u0000 \u0000Methods \u0000A total of 56 patients were enrolled, including 46 patients with chronic obstructive pulmonary disease (COPD) and 10 patients with ACO.General spirometry and IOS were performed before and after bronchodilation. \u0000 \u0000 \u0000Results \u0000The ROC curve shows that, at the baseline state, the area under the curve (AUC) of the predicted value of the impedance at 20 Hz (R20%pred) and the impedance difference at 5 Hz and 20 Hz (R5-R20) is higher.The optimal threshold values are 117.33% and 0.27, respectively, and the sensitivity is 0.80 and 0.70, the specificity is 0.74 and 0.72 respectively.After the bronchodilation test, the threshold value, sensitivity, and specificity of R20%pred-post were 102.78%, 0.80, and 0.70, respectively.From the changes before and after the bronchialdilation test, when Δ(R5-R20)>0.06 and the area under the reactance ΔAX>0.98, satisfactory composite sensitivity (0.80 and 0.90, respectively) and specificity (0.78 and 0.72, respectively) were obtained.In addition, the variables of inspiratory phase impedance and reactance at 5 Hz before and after the bronchial dilation test, ΔR5in>0.12, ΔX5in>0.06 are the breakpoints, with moderate diagnostic value. \u0000 \u0000 \u0000Conclusions \u0000As an auxiliary examination method of ACO, IOS has certain clinical application value, which is helpful for the differentiation of ACO patients and patients with simple COPD. \u0000 \u0000 \u0000Key words: \u0000Chronic obstructive pulmonary disease; Asthma-COPD overlap; Impulse oscillometry system","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79282916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between sputum eosinophils and lung function, fractional exhaled nitric oxide concentration in children with bronchial asthma","authors":"Shouye Wu, Yu-zhen Zhang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.006","url":null,"abstract":"Objective \u0000To explore the relationship between sputum eosinophils count (EOS) and lung function, fractional exhaled nitric oxide (FeNO) concentration in children with bronchial asthma (asthma). \u0000 \u0000 \u0000Methods \u0000A total of 113 children with asthma in Hainan Women and Children′s Medical Center from October 2016 to December 2018 was retrospectively enrolled in the observation group.Meanwhile, 50 healthy children who had physical examination in Hainan Women and Children′s Medical Center in the same period were assigned into the control group.The induced sputum EOS, forced expiratory volume in one second as a percentage of expected value (FEV1%pred) and FeNO levels of two groups were detected and analyzed. \u0000 \u0000 \u0000Results \u0000The level of induced sputum EOS and FeNO in the observation group was significantly higher than that of in the control group (t=11.921, 17.081, both P<0.05). And the FEV1%pred of the observation group was much lower than that of in the control group (t=18.673, P<0.05). To further analyze the data of children with asthma, a positive correlation between FeNO and sputum EOS was observed (r=0.265, P=0.005), but there was no correlation between FEV1%pred and sputum EOS (r=0.158, P=0.093). \u0000 \u0000 \u0000Conclusions \u0000In children with asthma, there is a positive correlation between FeNO and sputum EOS, but no correlation between FEV1%pred and sputum EOS. \u0000 \u0000 \u0000Key words: \u0000Asthma; Child; Induced sputum eosinophils; Lung function; Fractional exhaled nitric oxide concentration","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90364066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of fractional exhaled nitric oxide test in corticosteroid responsive cough patients in China: a meta-analysis","authors":"Zhijing Wang, Miao Wang, Shengyuan Wang, Li Yu","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.007","url":null,"abstract":"Objective \u0000To evaluate diagnostic value of fractional exhaled nitric oxide (FeNO) test in corticosteroid responsive cough (CRC) patients in China, and provide evidences for clinical treatment. \u0000 \u0000 \u0000Methods \u0000We searched China Biology Medicine disc (CBMdisc, in Chinese), Chinese National Knowledge Infrastructure (CNKI, in Chinese), China Science and Technology Journal Database (VIP, in Chinese), Wanfang date (in Chinese), Cochrane library, PubMed, Web of science and Embase databases and selected articles according to the inclusion and exclusion criteria.The outcome indicators included the value of FeNO, sensitivity, specificity and so on.We used Statistical analysis software RevMan5.3 and stata12.0 for meta analysis. \u0000 \u0000 \u0000Results \u0000There were 13 studies selected finally.The results showed that the value of FeNO in CRC patients was significantly higher than that of in non-corticosteroids responsive cough (NCRC) patients [MD=20.44, 95%CI: (15.29-25.59), P<0.05]. In subgroup analysis, we found that the value of FeNO in cough variant asthma (CVA) patients was obviously higher than that of in other patients with chronic cough [MD=30.03, 95%CI: (21.43-38.63), P<0.05]. Similarly, the level of FeNO in eosinophilic bronchitis (EB) patients was also higher than that of in other patients with chronic cough [MD=12.32, 95%CI: (9.02-15.61), P<0.05]. And it was showed that in patients of CRC, the pooled sensitivity was 0.74(95%CI: 0.67-0.80), the pooled specificity was 0.87(95%CI: 0.83-0.91), positive likelihood ratio was 5.8(95%CI: 4.3-7.8), negative likelihood ratio was 0.30(95%CI: 0.23-0.38), diagnostic odds ratio was 20(95%CI: 12-31), and area under SROC curve was 0.89(95%CI: 0.86-0.91). Of that, the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under the SROC curve of CVA were 0.80(95%CI: 0.74-0.84), 0.85(95%CI: 0.80-0.90), 5.5(95%CI: 3.8-7.9), 0.24(95%CI: 0.18-0.32), 23(95%CI: 13-42), and 0.89(95%CI: 0.86-0.92). And we could not do diagnostic analysis in EB and AC patients, for there were only 3 and 1 studies included. \u0000 \u0000 \u0000Conclusions \u0000At present, we have showed that the value of FeNO in CRC patients is significantly higher than that of in chronic cough patients with other causes, and FeNO has important clinical significance in the diagnosis of CRC patients in China.It can provide an experiential treatment strategy for chronic cough patients with high FeNO.However, there still needs large-scale studies in the analysis, due to the limitations of the research quality and the sample size. \u0000 \u0000 \u0000Key words: \u0000Nitric oxide; Cough; Glucocorticoids; Diagnosis","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82657181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of YKL-40 related to respiratory diseases","authors":"Ling Wang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.013","url":null,"abstract":"YKL-40 is a newly discovered mammalian chitinase-like protein.Recent studies have shown that YKL-40 is closely relate to the pathogenesis of respiratory diseases.This article reviews the recent development of YKL-40 and its involvement in respiratory diseases. \u0000 \u0000 \u0000Key words: \u0000YKL-40; Chitinase 3 like 1; Respiratory diseases","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75951169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of RT-PCR in children with acute respiratory viruses in Urumqi","authors":"Tuyihong Yihepaer, Aishan Bilali, M. Jiang, Hong-ping Zhang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.009","url":null,"abstract":"Objective To analyze four viruses [human adenovirus (HADV), human bocavirus (HBoV), human metapneumovirus (HMPV), human respiratory syncytial virus (HRSV) ] infection situation in children with acute lower respiratory tract infection by multiplex fluorescent reverse transcription polymerase chain reaction (RT-PCR). Methods A total of 1 045 hospitalized children with acute respiratory infections were enrolled in the specimens of deep nasopharyngeal secretions.Multiple fluorescent RT-PCR was used to detect four markers of respiratory virus, and the clinical epidemiological characteristics were analyzed in terms of virus distribution and seasonal factors. Results Of the 1 045 patients, 281 were positive for 4 respiratory viruses, and the total positive rate was 26.89%.Among them, 194(69.04%) were infected with a single virus, 87(30.96%) were infected with mixed virus, and the highest was HMPV, 120 cases (42.70%), followed by HRSV infection in 119 cases (42.35%); 229 cases (36.06%) were positive in ≤3 years old group, 114 cases (42.22%) were positive in 4-7 years old group, ≥8 years old group in each age group positive in 63 cases (45.00%). From the perspective of seasonal distribution, the detection rates of spring, summer, autumn and winter were 25.68%, 28.24%, 49.34%, and 65.57%, respectively. Conclusions Multiplex fluorescent RT-PCR can rapidly detect acute respiratory virus in children in Urumqi.The main infections of respiratory virus are HMPV and HRSV infection.The highest age of respiratory virus infection is ≥8 years old.The incidence of respiratory virus infection is high in autumn and winter period. Key words: Respiratory tract infection; Respiratory syncytial viruses; Influenza virus; Boka virus; Metapneumovirus","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88216218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotine induces the secretion of TGF-β1 and FGF-2 via HMGB1/RAGE in human airway epithelial cells","authors":"W. Zou, Xiaoqian Wang, Qing Sheng, Xiaoting Zhou","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.008","url":null,"abstract":"Objective \u0000To test whether nicotine induces the secretion of transforming growth factor-β1 (TGF-β1)and fibroblast growth factor 2 (FGF-2) in HBECs in vitro via the high mobility group protein B1 (HMGB1)/receptor for advanced glycation end products (RAGE) signaling pathway. \u0000 \u0000 \u0000Methods \u0000Cultured HBECs were exposed to nicotine (6×10-6 mol/L) for 24 h. The secretion of HMGB1, TGF-β1 and FGF-2 was assessed by ELISA, the expression of RAGE was assessed by Western blotting.HBECs were either transfected with a small interfering RNA (siRNA) targeting HMGB1 for 48 h or incubated with anti-RAGE antibodies for 1 h and subsequently stimulated with nicotine for 24 h, then the secretion of HMGB1, TGF-β1 and FGF-2 was assessed by ELISA, the expression of RAGE was assessed by Western blotting. \u0000 \u0000 \u0000Results \u0000We showed that cells exposed to nicotine for 24 h exhibited significantly increased HMGB1, TGF-β1 and FGF-2 secretion and RAGE expression.The HMGB1 siRNA prevented these effects.Furthermore, anti-RAGE antibodies significantly decreased the secretion of TGF-β1 and FGF-2 from HBECs. \u0000 \u0000 \u0000Conclusions \u0000These results suggest that nicotine induces the secretion of TGF-β1 and FGF-2 in HBECs via the HMGB1/RAGE signaling pathway. \u0000 \u0000 \u0000Key words: \u0000Nicotine; Transforming growth factor beta1; Fibroblast growth factor 2; Human bronchial epithelial cells; High mobility group protein B1/Receptor for advanced glycation end products","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75095681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum biomarkers in silicosis: current perspectives","authors":"Yi Zhang, Fang Yang, Zhongqiu Wei","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.014","url":null,"abstract":"Silicosis is still one of the main occupational diseases in China.Early diagnosis or prediction may be very useful to control the disease, yet only relatively late stage patients with silicosis could be diagnosed based on radiological and lung function abnormalities.Seeking for biomarkers in blood serum that change their values with deposition of silica dust in the lung and onset of lung fibrosis has been one of the hot areas in the study of silicosis.This particular review focusses on the recent advances in the study of serum biomarkers for silicosis including inflammatory cytokines(tumor necrosis factor-α, interleukin-17, transforming growth factor-β1 and IL-12p40-containing cytokines, etc), miRNAs (miR-21, miR-200c, etc), serum enzymes (proline peptidase, heme oxygenase-1, superoxide dismutase, glutathione peroxidase and angiotensin-converting enzyme), immunoglobins and nephronectin, Clara cell protein 16, etc.There have been quite a lot of biomarkers being studied and some showed potential usefulness in the early detection and diagnosis of silicosis.Further improvement in the sensitivity and specificity of biomarkers and large scale multicenter validation are needed for the application in the future. \u0000 \u0000 \u0000Key words: \u0000Silicosis; MicroRNAs; Biomarker cytokines; Inflammatory cytokines; Enzyme","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74232993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in the treatment of severe asthma with dupilumab","authors":"Jia Li, Lun Li","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.05.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.05.010","url":null,"abstract":"Bronchial asthma (asthma) is such a chronic airway inflammatory disease which mediated by T helper cell type 2 (Th2). The Th2 cells secret interleukin-4 (IL-4) and IL-13, which activate the downstream signal transduction through the co-receptor interleukin-4 receptor α(IL-4Rα). Dupilumab is a fully human anti-IL-4 Rα monoclonal antibody that competitive inhibits the combination between IL-4Rα and IL-4 or IL-13, which can reduce severe exacerbation and increased lung function in patients with severe asthma.The update of the efficacy and safety of dupilumab for treating severe asthma is reviewed in this article. \u0000 \u0000 \u0000Key words: \u0000Asthma; Antibodies, monoclonal; Dupilumab","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89618285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}