Progress in the treatment of severe asthma with dupilumab

Abstract

Bronchial asthma (asthma) is such a chronic airway inflammatory disease which mediated by T helper cell type 2 (Th2). The Th2 cells secret interleukin-4 (IL-4) and IL-13, which activate the downstream signal transduction through the co-receptor interleukin-4 receptor α(IL-4Rα). Dupilumab is a fully human anti-IL-4 Rα monoclonal antibody that competitive inhibits the combination between IL-4Rα and IL-4 or IL-13, which can reduce severe exacerbation and increased lung function in patients with severe asthma.The update of the efficacy and safety of dupilumab for treating severe asthma is reviewed in this article. Key words: Asthma; Antibodies, monoclonal; Dupilumab