Thuc Anh Ngo, Tanju Yildirim, Meng-Qun Feng, Kosuke Minami, Kota Shiba, Genki Yoshikawa
{"title":"Empirical Modification of Force Fields for the Development of Peptide-Based Gas Sensors (Adv. Sensor Res. 4/2025)","authors":"Thuc Anh Ngo, Tanju Yildirim, Meng-Qun Feng, Kosuke Minami, Kota Shiba, Genki Yoshikawa","doi":"10.1002/adsr.202570008","DOIUrl":"10.1002/adsr.202570008","url":null,"abstract":"<p><b>Empirical Force Fields Optimization for Gas Dynamics</b></p><p>In article 2400122, Thuc Anh Ngo, Genki Yoshikawa, and co-workers introduce an innovative artificial nose concept using peptide-based sensors for selective gas molecule detection. Optimized molecular modeling targets gas-phase interactions, enhancing detection accuracy. This approach offers potential applications in medical diagnostics, blending biology with advanced technology.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202570008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annelot Nijkoops, Manuela Ciocca, Martina Aurora Costa Angeli, Silvia Pogliaghi, Soufiane Krik, Enrico Avancini, Niko Münzenrieder, Paolo Lugli, Luisa Petti
{"title":"Ammonia Dynamics in the Human Body: Insights in Biomedical Sensing Technologies","authors":"Annelot Nijkoops, Manuela Ciocca, Martina Aurora Costa Angeli, Silvia Pogliaghi, Soufiane Krik, Enrico Avancini, Niko Münzenrieder, Paolo Lugli, Luisa Petti","doi":"10.1002/adsr.202400179","DOIUrl":"10.1002/adsr.202400179","url":null,"abstract":"<p>Advancements in sensor technologies capable of measuring key biomarkers can greatly enhance medical diagnostics and health monitoring, facilitating more effective diagnosis, treatment, and prevention. While there are numerous biomarkers of interest, gaseous ammonia (NH<sub>3</sub>) stands out due to its significance as an indicator of organ function (e.g., liver and kidney failure) or bacterial infections (e.g., <i>Helicobacter pylori</i>, <i>Proteus mirabilis</i>) in the body. This review discusses the metabolism and presence of NH<sub>3</sub> in body organs, as well as clinical conditions associated with the regulation of NH<sub>3</sub> concentrations. This paper reviews various sensing materials and parameters, along with current state-of-the-art gas sensors capable of detecting NH<sub>3</sub> for biomedical applications. Additionally, it addresses the challenges faced by biomedical sensing technologies already in use in medical applications. This review highlights that while NH<sub>3</sub> sensing applications for breath analysis are already well-developed, in vivo NH<sub>3</sub> sensing remains in its early stages and faces significant challenges. Finally, promising future research directions for NH<sub>3</sub> sensing are discussed, including the integration of NH<sub>3</sub> sensors in catheters or in the Simulator of Human Intestinal Microbial Ecosystem, as well as the early detection of antibiotic-resistant bacteria to enhance medical diagnostics.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Force Myography (FMG) Armband Based on Micro-Structured Textile-Pressure Sensors for Human-Machine Interface (HMI)","authors":"Rayane Tchantchane, Hao Zhou, Shen Zhang, Gursel Alici","doi":"10.1002/adsr.202500012","DOIUrl":"10.1002/adsr.202500012","url":null,"abstract":"<p>Wearable pressure sensors for specific applications are in growing demand due to their flexibility, sensitivity, low power consumption, and portability. Flexible capacitive pressure sensors with micro-structured dielectric layers have shown promise in meeting these demands by tuning the dielectric geometry and material properties. Finite Element Analysis (FEA) based on Finite Element Method (FEM) predicts the response of a sensor under various inputs and parameters and hence facilitates the design and development of sensors. By employing FEA, the performance pressure sensors can be predicted based on microstructures. A textile-based capacitive pressure sensor is presented, enhanced with a triangular prism micro-structure in the dielectric layer, improving sensitivity by up to four orders higher than its non-structured counterparts. The sensor demonstrates a remarkable sensitivity of 5.52% kPa<sup>−</sup>¹(0.24–50 kPa), with linearity (R<sup>2</sup> = 0.981), a wide sensing range (0.24–330 kPa), and mechanical stability >1000 cycles. Its use is demonstrated in a 4-channel force myography (FMG) armband, validated across five subjects with an average gesture recognition accuracy of 92% for common hand gestures. The applications of the device are further demonstrated to control a prosthetic hand and operate a game, paving the way for advancements in smart wearable technologies within HMI applications.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Virulent Factor-Targeted Point-of-Care Biosensor for Detection of Staphylococcus Aureus Infections","authors":"Zahra Marvi, Yara Raphael, Dario Job, Graziele Cruzado, Geraldine Merle","doi":"10.1002/adsr.202400153","DOIUrl":"10.1002/adsr.202400153","url":null,"abstract":"<p>Rapid detection of pathogenic bacteria like <i>Staphylococcus aureus</i> (<i>S. aureus</i>) is crucial for timely diagnosis and infection control. Aureolysin (Aur), an extracellular metalloprotease involved in <i>S. aureus</i> pathogenesis, is a promising biomarker. This study presents a rapid, low-cost, label-free electrochemical immunosensor for aureolysin detection using antibody-gold (Ab-Au) bioconjugates. Anti-aureolysin antibodies are immobilized on gold nanospikes via 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide / N-Hydroxysuccinimide (EDC/NHS) chemistry and screen-printed gold electrodes (SPGEs). The detection relied on changes in peak current from antigen-antibody complex formation, measured through differential pulse voltammetry (DPV). Selectivity tests confirmed the sensor's specificity for <i>S. aureus</i>, with no cross-reactivity against <i>Escherichia coli</i> or <i>Pseudomonas aeruginosa</i>. A strong linear correlation (R<sup>2</sup> = 0.9739) between peak current and logarithmic <i>S. aureus</i> concentrations is observed, with a detection limit of 5 pg·mL⁻¹ in buffer and 2 Colony-forming unit (CFU) mL⁻¹ in bacterial cultures. The sensor also detected <i>S. aureus</i> in biofilms, highlighting its potential for real-world use. Offering rapid detection within 1h, high sensitivity, and specificity, this immunosensor is a promising point-of-care tool for <i>S. aureus</i> detection in clinical settings. This approach greatly enhances the sensor's effectiveness in real-world clinical applications, where biofilm formation often complicates diagnosis and treatment.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksander Ejsmont, Klaudia Bucoń, Teresa Łuczak, Joanna Goscianska
{"title":"High-Sensitivity Dopamine Detection with Copper Terephthalate-Modified Carbon Electrode","authors":"Aleksander Ejsmont, Klaudia Bucoń, Teresa Łuczak, Joanna Goscianska","doi":"10.1002/adsr.202400183","DOIUrl":"10.1002/adsr.202400183","url":null,"abstract":"<p>The development of sensitive and simple materials for dopamine detection is crucial for advancing diagnostic and therapeutic approaches. Copper-based metal–organic frameworks (Cu-MOFs) have emerged as competitive candidates for sensor design, owing to their tunable electronic properties, structural flexibility, and cost-effective preparation. In this study, four MOFs with copper nodes and terephthalate or trimesate linkers are synthesized, both with and without modulators, to investigate the influence of synthetic strategies and morphological characteristics on sensor performance. Among the materials, a non-modulated, Cu(OH)<sub>2</sub>-derived copper-terephthalate MOF demonstrates exceptional sensitivity for dopamine detection. Its unique flake-like morphology and mesoporosity significantly enhance charge transfer and substrate accessibility, achieving a linear detection range of 5 × 10⁻<sup>5</sup>–0.75 mmol L<sup>−1</sup> and a limit of detection of 1.26 nmol L<sup>−1</sup>—outperforming most reported MOF-based sensors. These results highlight the critical role of precise morphological control and synthetic optimization in tailoring Cu-MOFs for electrochemical applications. This work positions Cu-MOFs as scalable, efficient, and competitive alternatives to complex, multicomponent sensors for neurotransmitter detection.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shah Zayed Riam, Md. Najmul Islam, Ali Reza Galib, Mohammad Solaiman, AKM Sarwar Inam, Brian D. Ott, Shawana Tabassum
{"title":"AQUA-FINS: Advanced Quantitative Underwater Analysis by a Flexible Integrated Nitrate Sensor","authors":"Shah Zayed Riam, Md. Najmul Islam, Ali Reza Galib, Mohammad Solaiman, AKM Sarwar Inam, Brian D. Ott, Shawana Tabassum","doi":"10.1002/adsr.202500010","DOIUrl":"10.1002/adsr.202500010","url":null,"abstract":"<p>This work presents a novel, integrated sensor array for real-time monitoring of key water quality parameters in aquaculture: nitrate, pH, and temperature. The array, fabricated on a flexible substrate, comprises potentiometric nitrate and pH sensors, and a resistive temperature sensor. The nitrate sensor, utilizing a polymer nanocomposite and ion-selective membrane, exhibited a near-Nernstian response with high selectivity, a low detection limit of 0.44 mg L<sup>−1</sup>, and a sensitivity of −50 mV dec<sup>−1</sup>. The polyaniline-based pH sensor demonstrated a sensitivity of −56.959 mV dec<sup>−1</sup> in recirculating aquaculture water samples, along with a high repeatability. The temperature sensor showed a linear response to changes in temperature (R<sup>2</sup> = 0.921). While testing in recirculating aquaculture tanks with catfish, the nitrate sensor initially showed a root mean square error of 4.779 mg L<sup>−1</sup> due to pH fluctuations, but a multiple linear regression model effectively corrected this error, and significantly improved accuracy (with a root mean square error of 3.090 mg L<sup>−1</sup>). The pH sensor measurements also closely matched commercial meter readings (with root mean square error of 0.072). This integrated sensor array offers a promising solution for real-time, in situ monitoring of critical water quality parameters in aquaculture.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Sazid Bin Sadeque, Mahmudur Rahman, Md Mehdi Hasan, Mustafa Ordu
{"title":"Thermal Drawing of MoS2 Integrated PVDF Triboelectric Fiber for Continuous Respiration Monitoring (Adv. Sensor Res. 3/2025)","authors":"Md Sazid Bin Sadeque, Mahmudur Rahman, Md Mehdi Hasan, Mustafa Ordu","doi":"10.1002/adsr.202570006","DOIUrl":"10.1002/adsr.202570006","url":null,"abstract":"<p><b>Triboelectric Based Face Mask</b></p><p>In article 2400114, Mustafa Ordu and co-workers report a smart triboelectric face mask for real-time monitoring of human breathing rate and breathing conditions. A triboelectric fiber is integrated with the smart mask. The superior sensitivity of the face mask is achieved by the enhancement of triboelectric properties of thermally drawn polyvinylidene fluoride (PVDF) with the addition of molybdenum disulfide which modulates the electroactive phase behaviors of PVDF.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 3","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202570006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical Microfiber Biomedical Sensors: Classification, Applications, and Future Perspectives","authors":"Lili Liang, Fei Xie, Li Jin, Bowen Yang, Li-Peng Sun, Bai-Ou Guan","doi":"10.1002/adsr.202400185","DOIUrl":"10.1002/adsr.202400185","url":null,"abstract":"<p>Optical microfiber biosensors have emerged as a revolutionary technology in the biomedical field, offering exceptional sensitivity, specificity, and versatility for biomarkers detection, health monitoring, and disease treatment. This comprehensive review explores the diverse types of optical microfiber biosensors based on their fundamental principles and underscores their pivotal roles in biomedical advancements. Furthermore, the latest advancements and challenges faced by optical microfiber biosensors in their applications are scrutinized, offering insights into the future directions, potential breakthroughs, and hurdles that need to be addressed in the biomedical arena.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}