Kelcilene B.R. Teodoro , Tamires S. Pereira , Ana Laura M.M. Alves , Francisco V. dos Santos , Fabrício A. dos Santos , Daniel S. Correa
{"title":"3D-printed microneedles for sensing applications: Emerging topics and future trends","authors":"Kelcilene B.R. Teodoro , Tamires S. Pereira , Ana Laura M.M. Alves , Francisco V. dos Santos , Fabrício A. dos Santos , Daniel S. Correa","doi":"10.1016/j.asems.2025.100139","DOIUrl":"10.1016/j.asems.2025.100139","url":null,"abstract":"<div><div>3D-printed microneedles (MNs) have revolutionized the biomedical sector, enabling applications in aesthetic treatments, vaccine delivery, diagnostics, and real-time biomarker analysis. These minimally invasive structures advance the development of sensors and biosensors for diverse applications, including human, veterinary, agricultural, and environmental domains. Recent trends favor MNs made from polymers and nanomaterials over traditional metals, addressing challenges related to cost, biocompatibility, and scalability. In this context, this review explores recent advancements on different MNs-based sensors, fabricated by 3D printing, highlighting innovations, shortcomings and also pointing future opportunities to expand their applications in medical, agricultural and environmental domains. Initially, we discuss the general aspects of planning an efficient MN's design (encompassing possible types and required properties), as well as the choice of materials and manufacturing techniques for 3D printing polymeric MNs. Next, we examine the relationship between printing techniques, the manufactured MNs, and their integration with sensors, followed by examples of studies that explore this connection. Key innovations include the use of biodegradable resins, nanocomposites, artificial intelligence, and machine learning for design optimization. While biomedical applications dominate, we highlight significant opportunities for MNs in agriculture and environmental monitoring through tailored manufacturing approaches.</div></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"4 2","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaokang Ren , Lei Ren , Biancheng Wei , Yubo Liu , Jianzhong Yang , Jiang Li , Lihua Wang
{"title":"DNA-templated fabrication of metal nanostructures with special shapes","authors":"Shaokang Ren , Lei Ren , Biancheng Wei , Yubo Liu , Jianzhong Yang , Jiang Li , Lihua Wang","doi":"10.1016/j.asems.2024.100133","DOIUrl":"10.1016/j.asems.2024.100133","url":null,"abstract":"<div><div>Metal structures with special shapes at the length scales of electromagnetic waves, particularly visible light (∼10<sup>–</sup><sup>7</sup> m), hold great promise in the development of next-generation electronic/optical devices. However, downscaling the metal structure features to the sub-10 nm scale remains a challenge due to the resolution limitations inherent in conventional top-down microfabrication techniques. In recent years, DNA nanotechnology has garnered significant attention due to its capability to construct nanostructures with programmable shapes at the nanometer scale, which can serve as templates for the fabrication of metal nanostructures. Here, we review the development of DNA-templated metal nanostructures with unique shapes, focusing on their electronic and optical properties and applications. We discuss the advantages and limitations of these strategies and provide an outlook for this research area.</div></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"4 1","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulla Alsaad, Iftikhar Ahmad, Adel Aawan, Ahmed M. Abdelrhman, Wajid Khan
{"title":"Design, development and testing of a wearable hybrid energy harvester for sustainable gadgets","authors":"Abdulla Alsaad, Iftikhar Ahmad, Adel Aawan, Ahmed M. Abdelrhman, Wajid Khan","doi":"10.1016/j.asems.2025.100137","DOIUrl":"10.1016/j.asems.2025.100137","url":null,"abstract":"<div><div>This research paper presents the design, development and testing of a novel wearable hybrid energy harvester (WH-EH) aimed at powering sustainable gadgets. By harnessing energy using both electromagnetic and piezoelectric transduction mechanisms to capture ambient mechanical energy from human body motion, this device offers a versatile solution to the growing demand for portable and renewable energy. The paper details the integration of both mechanisms into a single device that fits in human shoes and the practical implications of deploying such technology in everyday gadgets. The WH-EH comprised of 3D printed frame, a cantilever beam made up of stainless steel, two permanent neodymium magnets residing at the tip of the cantilever beam, two printed circuit board-based micro planar coils that were fixed to the top and bottom of the 3D printed frame. Through rigorous testing, the WH-EH has demonstrated significant potential of producing maximum a power of 577 μW which can help in reducing the reliance on traditional power sources and advancing the frontier of wearable technology. Energy harvesters like WH-EH are pivotal in advancing the sustainability of wearable gadgets, diminishing the dependence on traditional battery sources. These innovations not only strengthen the longevity and eco-friendliness of personal electronics but also align with global sustainable development goals, particularly in the energy and environmental sectors. The progression of such energy harvesters marks a crucial milestone in the ongoing integration of renewable energy practices into daily electrical applications.</div></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"4 1","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ingemar Petermann , Magnus Lindblom , Carola Sterner , Greger Gregard , Stefan Karlsson
{"title":"Optical fiber sensor solutions for in-situ transmittance control of electrochromic glazing","authors":"Ingemar Petermann , Magnus Lindblom , Carola Sterner , Greger Gregard , Stefan Karlsson","doi":"10.1016/j.asems.2025.100134","DOIUrl":"10.1016/j.asems.2025.100134","url":null,"abstract":"<div><div>Windows are essential to let natural daylight into our buildings. Smart and dynamic glazing is an important technology for achieving sustainable and energy-efficient buildings with good indoor environment by reducing the need for air-conditioning. Electrochromic glazing is the commercial state-of-the-art for smart and dynamic glazing. In principle electrochromic glazing works like a thin film battery, whose lifetime is enhanced if the combination of elevated temperature and a high state-of-charge, or low light transmittance, are avoided. Therefore, a direct transmittance measurement is desirable. In this study, we have evaluated four different methods using optical fibers, whereof two methods were found to work well, both in initial testing and when compared to reference transmittance cycling measurements. Both methods relied on light from a light emitting diode, at 810 nm wavelength, that was propagated either through the electrochromic foil or along it. The latter shows most potential to be implemented in a manufacturing process of smart glazing.</div></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"4 1","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yitian Tang , Qunmei Zhang , Hongchang Yuan , Xiaoyin Wang , Liuyang Xu , Guoqiang Wang , Min Zhang , Ping Lu , Hua Zhong , Yihan Wang
{"title":"Recent applications and challenges of inorganic nanomaterial-based biosensing devices for detecting nucleic acid biomarkers","authors":"Yitian Tang , Qunmei Zhang , Hongchang Yuan , Xiaoyin Wang , Liuyang Xu , Guoqiang Wang , Min Zhang , Ping Lu , Hua Zhong , Yihan Wang","doi":"10.1016/j.asems.2025.100136","DOIUrl":"10.1016/j.asems.2025.100136","url":null,"abstract":"<div><div>Nucleic acids are specific biomolecules for clinically relevant diseases. Highly sensitive detection of these low-abundance biomolecules is essential for understanding their functions in disease diagnosis, prognosis, and predicting treatment effects. As a traditional detection method, polymerase chain reaction (PCR) has high sensitivity. However, it is time-consuming and requires complex experimental equipment, which limits its application in on-site rapid detection. To address these issues, biosensing devices based on inorganic nanomaterials (INMs) have been widely used to detect nucleic acid biomarkers in recent years. Compared with organic or polymer nanomaterials, INMs have unique physical and chemical properties that produce synergistic effects regarding biocompatibility, electrical conductivity, and high specific surface area. It can also amplify the signal by increasing the signal tag loading, making it ideal for biosensing devices. This article reviews the latest progress of INMs (metal nanoparticles, metal oxide nanomaterials, carbon-based nanomaterials, quantum dots, magnetic nanomaterials) in nucleic acid detection and introduces the definition, specific effects, and synthesis of INMs. Subsequently, the applications of INMs integrated into various sensing platforms were discussed, including electrochemical biosensors, electrochemiluminescence (ECL) biosensors, photoelectrochemical (PEC) biosensors, and self-powered biosensor and point-of-care testing (POCT) to achieve highly sensitive and specific detection of nucleic acid molecules such as DNA and RNA. Finally, the opportunities and challenges faced by biosensing devices based on INMs in the future development of nucleic acid detection are discussed and prospected.</div></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"4 1","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xin Wang , Stefen Stangherlin , Nan Cheng , Juewen Liu
{"title":"Non-thiolated spherical nucleic acids for biosensors and assembly of nanomaterials","authors":"Xin Wang , Stefen Stangherlin , Nan Cheng , Juewen Liu","doi":"10.1016/j.asems.2024.100132","DOIUrl":"10.1016/j.asems.2024.100132","url":null,"abstract":"<div><div>Spherical nucleic acids (SNAs) refer to a nanoparticle core decorated with a high density of single-stranded DNA or RNA. SNAs have garnered significant attention for their unique physicochemical properties and advantages in biomedical, nanotechnology and biosensing applications. The preparation of traditional SNAs typically relies on the strong bonding between thiolated DNA and gold nanoparticles (AuNPs) to ensure a high-density and stable DNA attachment. Interestingly, non-thiolated DNA also strongly interacts with gold surfaces through the coordination of its nucleobases, enabling the preparation of cost-effective non-thiolated SNAs. In this review, we introduce the adsorption properties of DNA on AuNPs, followed by a review of the current methods for the synthesis of non-thiolated SNAs and a discussion of their stability based on existing data. The reviewed methods include salt-aging, low-pH, freezing, microwaving, and thermal drying. Most methods rely on a poly-adenine block to anchor onto the surface of AuNPs. Furthermore, two types of non-thiolated SNA products are discussed, which are characterized by their DNA density as a function of the length of the poly-adenine block. Finally, we briefly outline the current applications of SNAs, including biosensing and DNA-directed assembly, and discuss potential future developments.</div></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"4 1","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huang Dai , Huilin Hu , Zhiyong Gong , Jing Shu , Jiahua Wang , Xiaodan Liu , Fuwei Pi , Qiao Wang , Shuo Duan , Yingli Wang
{"title":"Needle−tip effect promoted flexible electrochemical sensor for detecting chloride ions in food by in−situ deposited silver dendrimers","authors":"Huang Dai , Huilin Hu , Zhiyong Gong , Jing Shu , Jiahua Wang , Xiaodan Liu , Fuwei Pi , Qiao Wang , Shuo Duan , Yingli Wang","doi":"10.1016/j.asems.2024.100100","DOIUrl":"10.1016/j.asems.2024.100100","url":null,"abstract":"<div><p>Salt plays a crucial role in food processing and consumption, and the rapid detection of chloride ions in food and feed has great significance for practical applications. In this work, Ag−based nanomaterials were deposited on the surface of a flexible integrated electrochemical sensor for the detection of Cl<sup>−</sup> in food. In order to enhance the detection performance, a unique needle−tip structure was formed by manipulating the electro−engraving process during the electrodeposition growth. Theoretical calculations and electrochemical investigations have demonstrated that the dendrimer’s rich tip structure significantly enhanced its electrochemical performance. A sensitive and flexible integrated electrochemical sensor was creatively developed for the detection of Cl<sup>−</sup> using needle−tip effect−promoted Ag micro dendrimers. The sensor achieved quantitative detection of Cl<sup>−</sup> over a dynamic range of 10.0 μM–100.0 mM, with a low limit of detection of 0.148 μM. The flexible electrochemical sensor proposed in this work exhibited good repeatability, selectivity and recoveries in real food samples.</p></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"3 4","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773045X24000116/pdfft?md5=7f1732a8a93054fff68eb3a6c33e9d2c&pid=1-s2.0-S2773045X24000116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Functionalized MXene fiber electrode for the electrochemical sensing of urinary ammonia","authors":"","doi":"10.1016/j.asems.2024.100091","DOIUrl":"10.1016/j.asems.2024.100091","url":null,"abstract":"<div><p>The development of technologically advanced fiber-based flexible microelectrodes has been of extensive research interest in healthcare systems because of their unique construction and synergistic effect on multifunctional properties. In this work, we constructed functional MXene fiber (MXF) by a simple and versatile wet spinning method, and then, a well-aligned ZIF-67 nanoarray was grown in situ on the surface. Using the chemical vapor deposition (CVD) method, carbon nanotubes (CNTs) were produced on MXF via the pyrolysis of ZIF-67 and melamine. Finally, Pt nanoparticles were electrodeposited on the CNTs forest, and a Pt@CNTs/MXF electrode was obtained. Owing to the plethora of surface active sites and the synergistic effects between MXene, CNTs, and Pt nanoparticles, the as-fabricated fiber electrode enabled the precise detection of ammonia under alkaline conditions via differential pulse voltammetry (DPV), which exhibited a linear range of 0.1 μM–10 mM and a detection limit of 73.2 nM. Due to their good performance in ammonia detection, Pt@CNTs/MXF electrodes could be adopted to determine the ammonia concentration in urine for clinical estimation, which provides a practical approach for the diagnosis of urinary ammonia-associated diseases.</p></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"3 4","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773045X24000025/pdfft?md5=178ff2e2268690d230f9d5db61430805&pid=1-s2.0-S2773045X24000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139685771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chunxin Xia , Hemei Cheng , Xinwei Hou , Yu Zhang , Xinchi Zhou , Qinglong Yan , Shuting Cao
{"title":"Spherical nucleic acids for biomedical applications","authors":"Chunxin Xia , Hemei Cheng , Xinwei Hou , Yu Zhang , Xinchi Zhou , Qinglong Yan , Shuting Cao","doi":"10.1016/j.asems.2024.100117","DOIUrl":"10.1016/j.asems.2024.100117","url":null,"abstract":"<div><p>Spherical nucleic acids (SNAs) are a 3D spherical nanostructure composed of highly oriented, dense layers of oligonucleotides conjugated to a hollow or solid core. This structure allows SNAs to show resistance to nuclease degradation, enter into nearly all cells without transfection agents and enable precise interactions with target molecules. Based on superior biological properties, SNAs can be tailored for diverse biological applications, rendering them a flexible and biosafe tool for biological applications as well as an enabling platform for therapy. In this review, we mainly discuss the structure and conjugation mode of SNAs and focus on recent advances in their applications, such as biomedical detection, imaging, and drug delivery. Finally, the remaining challenges and future directions of SNAs are also discussed and proposed.</p></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"3 4","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773045X24000281/pdfft?md5=922efe7325a759155f5fd01b2b6e8d27&pid=1-s2.0-S2773045X24000281-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liandi Guan , Fang Liu , Cun Zhang , Wei Wang , Jianwei Zhang , Qionglin Liang
{"title":"Porphyrin-based metal-organic frameworks for cancer theranostics","authors":"Liandi Guan , Fang Liu , Cun Zhang , Wei Wang , Jianwei Zhang , Qionglin Liang","doi":"10.1016/j.asems.2024.100123","DOIUrl":"10.1016/j.asems.2024.100123","url":null,"abstract":"<div><div>Theranostics, integrating diagnostic and therapeutic functionalities, have emerged as advanced systems for timely cancer diagnosis and effective treatment. The development of versatile materials suitable for cancer theranostics is intensifying. Porphyrin-based metal-organic frameworks (MOFs) leverage the structural diversity and designability inherent in MOFs, alongside the robust photophysical, catalytic, and biological properties of porphyrins. These materials enhance the solubility and stability of porphyrins and facilitate their stable functionalized assemblies, conferring the potential for multimodal imaging diagnostics and precision therapeutics. In this review, we summarized the potential of porphyrin-based MOFs as cancer theranostics platforms, focusing on recent advancements in porphyrin-based MOFs, and highlighting their functionalized strategies and developments in diagnostic imaging and synergistic therapies. Finally, we proposed the challenges and prospects of these emerging materials in cancer theranostics.</div></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"3 4","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773045X24000347/pdfft?md5=a7f73b22591dd7ae6783fa296693b3ef&pid=1-s2.0-S2773045X24000347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}