Porphyrin-based metal-organic frameworks for cancer theranostics

Advanced Sensor and Energy Materials Pub Date : 2024-08-28 DOI:10.1016/j.asems.2024.100123

Liandi Guan , Fang Liu , Cun Zhang , Wei Wang , Jianwei Zhang , Qionglin Liang

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Abstract

Theranostics, integrating diagnostic and therapeutic functionalities, have emerged as advanced systems for timely cancer diagnosis and effective treatment. The development of versatile materials suitable for cancer theranostics is intensifying. Porphyrin-based metal-organic frameworks (MOFs) leverage the structural diversity and designability inherent in MOFs, alongside the robust photophysical, catalytic, and biological properties of porphyrins. These materials enhance the solubility and stability of porphyrins and facilitate their stable functionalized assemblies, conferring the potential for multimodal imaging diagnostics and precision therapeutics. In this review, we summarized the potential of porphyrin-based MOFs as cancer theranostics platforms, focusing on recent advancements in porphyrin-based MOFs, and highlighting their functionalized strategies and developments in diagnostic imaging and synergistic therapies. Finally, we proposed the challenges and prospects of these emerging materials in cancer theranostics.

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用于癌症治疗的卟啉基金属有机框架

集诊断和治疗功能于一体的疗法已成为及时诊断和有效治疗癌症的先进系统。适用于癌症治疗的多功能材料的开发正在不断加强。基于卟啉的金属有机框架（MOFs）利用了 MOFs 固有的结构多样性和可设计性，以及卟啉强大的光物理、催化和生物特性。这些材料提高了卟啉的溶解性和稳定性，促进了卟啉稳定的功能化组装，为多模式成像诊断和精准治疗带来了潜力。在这篇综述中，我们总结了卟啉基 MOFs 作为癌症治疗平台的潜力，重点介绍了卟啉基 MOFs 的最新进展，并强调了其在诊断成像和协同治疗方面的功能化策略和发展。最后，我们提出了这些新兴材料在癌症治疗学中面临的挑战和前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Sensor and Energy Materials

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