Advanced Agrochem最新文献_第9页

Research progress of DNA aptamer-based silver ions detection 基于DNA适配体的银离子检测研究进展

Advanced Agrochem Pub Date : 2023-09-01 DOI: 10.1016/j.aac.2023.06.006

Yushi Xie , Min Yang , Longjiao Zhu , Xiaoyu Yue , Baiqiang Zhai , Wentao Xu

引用次数: 1

Application of photopharmacology in agrochemicals 光药理学在农药中的应用

Advanced Agrochem Pub Date : 2023-06-01 DOI: 10.1016/j.aac.2023.04.002

Wen Fu , Zhong Li , Xusheng Shao

{"title":"Application of photopharmacology in agrochemicals","authors":"Wen Fu , Zhong Li , Xusheng Shao","doi":"10.1016/j.aac.2023.04.002","DOIUrl":"https://doi.org/10.1016/j.aac.2023.04.002","url":null,"abstract":"<div>Photopharmacology is a novel technology in drug design that aims at solving poor drug selectivity. This technology is currently in the proof-of-concept phase and relies on the photoactivation or inactivation of photochromic ligands (PCLs) to regulate biological functions and living organisms. As potential molecular tools in future agriculture 4.0, the photochromic pesticides are effective in optical control of receptors, ion channels, living behaviors, and enzymes, which displays an innovative way of pesticide discovery. In this review, we highlight the progresses of the photoisomerized insecticides and fungicides. By integrating photoswitches, such as azobenzenes and diarylethenes, into pesticide molecules, several PCLs were developed for optical regulation of important insect or fungi targets in vivo, including GABARs, RyRs, nAChRs, SURs, sodium channels, GluCls, and SDH. The results are highly significant in revealing interactions of agrochemicals with their targets, biological functions, and living behaviors, and provide powerful toolkits in understanding ligand-receptor interactions. Moreover, there is a growing demand for a diverse range of PCLs, particularly those that are sensitive to red and NIR light or sunlight, for actual field use in agriculture. We envision that this particular mode of pesticide discovery is of great promise for overcoming the challenges posed by the improper use of agrochemicals.</div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"2 2","pages":"Pages 142-153"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49712334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Discovery of tetrazolium nicotinamide derivatives as novel 4-Hydroxyphenylpyruvate dioxygenase inhibiting-based herbicides 新型4-羟基苯基丙酮酸双加氧酶抑制剂四氮唑烟酰胺衍生物的发现

Advanced Agrochem Pub Date : 2023-06-01 DOI: 10.1016/j.aac.2023.05.001

Li-Jun Chen , Guang-Yi Huang , Jin Dong, Zhuo-Mei Cai, Bao-Qing Ye, Qiong Chen, Hong-Yan Lin

{"title":"Discovery of tetrazolium nicotinamide derivatives as novel 4-Hydroxyphenylpyruvate dioxygenase inhibiting-based herbicides","authors":"Li-Jun Chen , Guang-Yi Huang , Jin Dong, Zhuo-Mei Cai, Bao-Qing Ye, Qiong Chen, Hong-Yan Lin","doi":"10.1016/j.aac.2023.05.001","DOIUrl":"https://doi.org/10.1016/j.aac.2023.05.001","url":null,"abstract":"<div>4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is currently one of the popular targets of herbicide research, and herbicides targeting it have shown promising results in treating resistant weeds. However, the long-term application of HPPD inhibitors with in their classical scaffolds inevitably leads to the development of drug resistance. To further delay the underlying development of weed resistance to HPPD inhibitors, we successfully screened HPPD inhibitor pharmacophore with novel chelate structures using computer-aided drug molecular design and obtained 2-trifluoromethyltetrazolium nicotinamide derivatives through active fragment splicing. Among these derivatives, 6-(3,3-diethyl-1-methylureido)-N-(1-methyl-1H-tetrazol-5-yl)-2-(trifluoromethyl)nicotinamide (compound 31), exhibited the most promising in vitro enzyme inhibitory activity, with IC50 value of 0.072 μM, which was approximately five times better than that of the control agent mesotrione (IC50 = 0.363 μM). The crystal structure of the AtHPPD complexed with compound 31 (2.0 Å) and the binding energy calculations of the representative compounds revealed several important interactions of the ligand binding to the target protein, which explained the superior enzyme inhibitory activity of the compounds at the molecular level. In addition, compounds 7 and 31 possessed 100% inhibition against the five target weeds at the tested dosage and both were more effective against Setaria viridis than mesotrione. In general, it is promising to design novel HPPD inhibitors by developing novel chelating structures, and compounds 7 or 31 could be used as the leads for further development of valuable HPPD inhibitors.</div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"2 2","pages":"Pages 163-172"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49726958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis and biological evaluation of thiazole and imidazo[1,2-a]pyridine derivatives containing a hydrazone substructure as potential agrochemicals 含腙亚结构的噻唑和咪唑[1,2-a]吡啶衍生物的设计、合成和生物学评价

Advanced Agrochem Pub Date : 2023-06-01 DOI: 10.1016/j.aac.2023.04.001

Xiaofang Yao , Rongrong Zhang , Bo Lv , Wei-Wei Wang , Zhigang Liu , Zhaonong Hu , Ding Li

{"title":"Design, synthesis and biological evaluation of thiazole and imidazo[1,2-a]pyridine derivatives containing a hydrazone substructure as potential agrochemicals","authors":"Xiaofang Yao , Rongrong Zhang , Bo Lv , Wei-Wei Wang , Zhigang Liu , Zhaonong Hu , Ding Li","doi":"10.1016/j.aac.2023.04.001","DOIUrl":"https://doi.org/10.1016/j.aac.2023.04.001","url":null,"abstract":"<div>Agricultural chemicals with multifunctional applications in crop protection have attracted increasing attention. Herein, two new series of thiazole and imidazo[1,2-a]pyridine derivatives containing a hydrazone substructure were designed and synthesized via a concise synthesis route. Bioassay results showed that most of the thiazole derivatives exhibited broad-spectrum fungistatic activities, which were exemplified by compounds 1c, 1e, 1g, 1h and 1j. In particular, compound 1e displayed excellent in vitro inhibitory effects with the EC50 values of 5.00, 18.24, 6.94, and 3.03 μg/mL against the fungi Botrytis cinerea, Cytospora sp, Fusarium graminearum, and Fusarium solani, respectively. Detached fruit experiments against tomato gray mold (caused by B. cinerea) in vivo revealed that the control efficiency of compound 1e at 10, 20 and 40 μg/mL for 5 days was 35.05%, 54.14% and 81.83%, respectively, which was comparable and even superior to that of the fungicide carbendazim. Additionally, the title compounds also showed remarkable larvicidal activity against M. separata and some compounds exhibited good aphicidal activity. In a word, the bioassay indicated that a certain number of title compounds had multiple biological activities. Given their excellent antifungal and larvicidal characteristics, these interesting derivatives based on the title compounds could be served as new scaffolds for the development of pesticide with multifunctional applications.</div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"2 2","pages":"Pages 154-162"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fluorescent probes for the detection of biogenic amines, nitrite and sulfite in food: Progress, challenges and perspective 荧光探针检测食品中生物胺、亚硝酸盐和亚硫酸盐:进展、挑战和展望

Advanced Agrochem Pub Date : 2023-06-01 DOI: 10.1016/j.aac.2023.03.001

Jin Zhang , Chenyang Yue , Yingjun Ke , Hemi Qu , Lintao Zeng

{"title":"Fluorescent probes for the detection of biogenic amines, nitrite and sulfite in food: Progress, challenges and perspective","authors":"Jin Zhang , Chenyang Yue , Yingjun Ke , Hemi Qu , Lintao Zeng","doi":"10.1016/j.aac.2023.03.001","DOIUrl":"https://doi.org/10.1016/j.aac.2023.03.001","url":null,"abstract":"<div>Foodborne contaminants such as biogenic amines (BAs), nitrite and sulfite are harmful to human health. To safeguard food safety, the content of BAs, nitrite and sulfite should be strictly controlled. Small-molecule fluorescent probes are a promising analytical tool for monitoring BAs, nitrite and sulfite because they are highly sensitive and selective, offer simplicity of operation, and can enable optical signal visualization of the analyte. In this review, we summarize the most recent progress on the development of fluorescent probes for selectively detecting BAs, nitrite, and sulfite. In particular, we discuss the working mechanisms, sensing performance, and practical applications of various fluorescent probes that have been developed in recent years for detecting BAs, nitrite, and sulfite, with a particular emphasis on the utilization of these probes in food. Lastly, we discuss the research directions, trends, and prospects of molecular fluorescent probes in food applications in the future. We hope this review can offer conceptual and design guidance for researchers and practitioners to develop novel fluorescent probes for food safety.</div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"2 2","pages":"Pages 127-141"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Preparation of oximoether derivatives of osthole and their pesticidal properties 蛇床子素氧醚衍生物的制备及其杀虫性能

Advanced Agrochem Pub Date : 2023-06-01 DOI: 10.1016/j.aac.2023.05.002

Zili Ren, Min Lv, Yuling Zhang, Jiawei Du, Hui Xu

引用次数: 1

Nornicotine-typed insecticides: The potential insecticides with strong activity against Diaphorina citri nor烟碱型杀虫剂:对柑橘蚜具有较强活性的潜在杀虫剂

Advanced Agrochem Pub Date : 2023-06-01 DOI: 10.1016/j.aac.2023.05.003

Pengfei Hu , Xiaoping Ye , Xiaoping Song , Mingxin Yang , Yunsheng Zhong , Yijing Cen , Yanxin Zhang , Yiming Song , Qingchao Liu

{"title":"Nornicotine-typed insecticides: The potential insecticides with strong activity against Diaphorina citri","authors":"Pengfei Hu , Xiaoping Ye , Xiaoping Song , Mingxin Yang , Yunsheng Zhong , Yijing Cen , Yanxin Zhang , Yiming Song , Qingchao Liu","doi":"10.1016/j.aac.2023.05.003","DOIUrl":"https://doi.org/10.1016/j.aac.2023.05.003","url":null,"abstract":"<div>Nicotine and nornicotine-typed compounds are well-known for its potential as insecticide. Some researches have shown that nicotine was highly toxic to Diaphorina citri Kuwayama, an invasive and fast spreading pest. Here we report the effects of nornicotine-typed insecticide against D. citri. Novel compounds A1-A8, B1–B28, C1–C18 and D1-D12 were synthesized by reported procedure. And bioassays indicated that some of these compounds exhibited good effects against D. citri. Compounds B2, B3, B8, B12, B13, B22, C5, C7, D5, and D9 exhibited the mortality up to 100% within 120 h in 50 mg/L. And further data shows that A2-5, A7, B1, B8, B20 and B22 showed rapid insecticidal activities against D. citri in 24 h with the low LC50 (LC50 < 50 mg/L in 24 h, and LC50 < 30 mg/L in 72 h). Nornicotine-typed derivatives exhibited activity against D. citri, and B8 and B22 exhibited the best insecticidal activity with an LC50 of 18.0 ± 1.0, 18.2 ± 0.9 mg/L in 24 h, which had the lower cost than nicotine and showed the potential as powerful insecticides.</div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"2 2","pages":"Pages 180-184"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, fungicidal activity and molecular docking studies of tavaborole derivatives 他瓦波罗衍生物的合成、杀真菌活性及分子对接研究

Advanced Agrochem Pub Date : 2023-06-01 DOI: 10.1016/j.aac.2023.05.004

Zhuo He , Dai-Chuan Huang , Dale Guo , Fang Deng , Qiang Sha , Ming-Zhi Zhang , Wei-Hua Zhang , Yu-Cheng Gu

引用次数: 0

A balanced mechanism between plant growth and stress response 植物生长与胁迫反应之间的平衡机制

Advanced Agrochem Pub Date : 2023-06-01 DOI: 10.1016/j.aac.2023.01.002

Zi-Bo Lin , Yan-Xiang Zhao , Wen-Chao Yang

引用次数: 0

Research process in application of fluorescent sensor for pesticide detection 荧光传感器在农药检测中的应用研究进展

Advanced Agrochem Pub Date : 2023-06-01 DOI: 10.1016/j.aac.2023.02.003

Zongyan Quan, Hongjuan Li, Shiguo Sun, Yongqian Xu

引用次数: 0