Nornicotine-typed insecticides: The potential insecticides with strong activity against Diaphorina citri

Advanced Agrochem Pub Date : 2023-06-01 DOI:10.1016/j.aac.2023.05.003

Pengfei Hu , Xiaoping Ye , Xiaoping Song , Mingxin Yang , Yunsheng Zhong , Yijing Cen , Yanxin Zhang , Yiming Song , Qingchao Liu

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引用次数: 0

Abstract

Nicotine and nornicotine-typed compounds are well-known for its potential as insecticide. Some researches have shown that nicotine was highly toxic to Diaphorina citri Kuwayama, an invasive and fast spreading pest. Here we report the effects of nornicotine-typed insecticide against D. citri. Novel compounds A1-A8, B1–B28, C1–C18 and D1-D12 were synthesized by reported procedure. And bioassays indicated that some of these compounds exhibited good effects against D. citri. Compounds B2, B3, B8, B12, B13, B22, C5, C7, D5, and D9 exhibited the mortality up to 100% within 120 h in 50 mg/L. And further data shows that A2-5, A7, B1, B8, B20 and B22 showed rapid insecticidal activities against D. citri in 24 h with the low LC₅₀ (LC₅₀ < 50 mg/L in 24 h, and LC₅₀ < 30 mg/L in 72 h). Nornicotine-typed derivatives exhibited activity against D. citri, and B8 and B22 exhibited the best insecticidal activity with an LC₅₀ of 18.0 ± 1.0, 18.2 ± 0.9 mg/L in 24 h, which had the lower cost than nicotine and showed the potential as powerful insecticides.

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nor烟碱型杀虫剂:对柑橘蚜具有较强活性的潜在杀虫剂

尼古丁和去烟碱类化合物以其作为杀虫剂的潜力而闻名。一些研究表明，尼古丁对入侵性强、传播速度快的香茅具有很强的毒性。本文报道了去甲烟碱类杀虫剂对柠檬D.citri的作用。采用报道的方法合成了新的化合物A1-A8、B1-B28、C1-C18和D1-D12。生物测定结果表明，这些化合物中的一些化合物对柠檬D.citri有很好的抑制作用。化合物B2、B3、B8、B12、B13、B22、C5、C7、D5和D9在50mg/L下120 h内的死亡率高达100%。进一步的数据表明，A2-5、A7、B1、B8、B20和B22在24小时内表现出快速的杀虫活性，LC50较低（24小时LC50＜50mg/L，72小时LC50＞30mg/L）。去烟碱类衍生物对柠檬黄曲霉表现出活性，B8和B22表现出最佳的杀虫活性，在24小时内的LC50分别为18.0±1.0、18.2±0.9mg/L，其成本低于烟碱，显示出作为强效杀虫剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Agrochem

CiteScore

3.50

自引率

0.00%

发文量