中华老年医学杂志最新文献

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Prognostic value of pretreatment albumin to globulin ratio in prostate cancer patients treated with maximal androgen blockade 最大雄激素阻断治疗前列腺癌患者前处理白蛋白/球蛋白比值的预后价值
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.022
Huafeng Zhang, Jia Zhao, Daoming Xu, L. Xia
{"title":"Prognostic value of pretreatment albumin to globulin ratio in prostate cancer patients treated with maximal androgen blockade","authors":"Huafeng Zhang, Jia Zhao, Daoming Xu, L. Xia","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.022","url":null,"abstract":"Objective \u0000To investigate the prognostic value of pretreatment albumin to globulin ratio(AGR)in prostate cancer(Pca)patients treated with maximal androgen blockade(MAB). \u0000 \u0000 \u0000Methods \u0000Clinical and pathological data of 210 Pca patients who underwent MAB as first-line therapy between January 2013 and June 2018 were retrospectively analyzed.The ages of patients in our cohort ranged from 61 to 90 years, with a mean of(77.0±6.5)years.According to the cut-off point for AGR calculated by the receiver-operating curve analysis, patients were categorized into two groups: the high-AGR group and the low-AGR group.Clinical and pathological features were compared between the groups.Independent factors affecting prognosis were analyzed by using univariate and multivariate analysis. \u0000 \u0000 \u0000Results \u0000The median follow-up duration was 44.0 months.Of the 210 patients, 99 cases had castration resistance, 100 patients(47.6%)had disease progression and 67 patients(31.8%)died.The cut-off point for AGR calculated by the receiver-operating curve analysis was 1.56.There were 103 cases in the low-AGR group(AGR<1.56)and 107 cases in the high-AGR group(AGR≥1.56). Univariate analysis revealed that the progression-free survival(PFS), cancer-specific survival(CSS)and overall survival(OS)were lower in the low-AGR group than in the high-AGR group[1.773(1.298~2.442), 1.948(1.220~3.213), 1.965(1.217~2.996), all P<0.05]. Multivariate Cox regression analysis showed that Gleason score, regional lymph nodes and bone metastases and AGR were independent prognostic factors for PFS(P=0.007, 0.040 and 0.022, P=0.031), CSS(P=0.003, 0.035 and 0.041, P=0.009)and OS(P=0.003, 0.026 and 0.023, P=0.002). \u0000 \u0000 \u0000Conclusions \u0000Pretreatment AGR<1.56 is an independent predictor for poor prognosis in Pca patients treated with MAB. \u0000 \u0000 \u0000Key words: \u0000Prostatic neoplasms; Androgen antagonists; Albumins; Prognosis","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1153-1157"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44458181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disability and rehabilitation in the elderly 老年人的残疾和康复
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.011
B. Zeng, G. Liang
{"title":"Disability and rehabilitation in the elderly","authors":"B. Zeng, G. Liang","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.011","url":null,"abstract":"失能是老年人的常见问题,并给老年人带来一系列不良影响。以运动训练、认知训练为代表的康复治疗手段可有效地延缓老年人的肌肉萎缩、体能下降、日常活动量减少、记忆力减退、执行能力下降等功能障碍,并能预防跌倒等二次损伤,从而改善其生存质量、延长生命。","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1101-1103"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47276675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The aging cardiovascular continuum 老化的心血管连续体
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.029
Caiqing Zhang, Huashan Hong
{"title":"The aging cardiovascular continuum","authors":"Caiqing Zhang, Huashan Hong","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.029","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.029","url":null,"abstract":"The atherosclerotic cardiovascular continuum or the conventional cardiovascular continuum(CCC)was first described by Dzau in 2006, describing a series of steps cardiovascular disease undergoes, from risk factors at the beginning to end-stage heart disease(characterized by ventricular dilation, heart failure, and death). The essential features of CCC are myocardial ischemia and myocardial infarction due to coronary artery stenosis, which originates from coronary atherosclerosis.O'Rourke proposed the aging cardiovascular continuum(ACC)in 2010 to explained the role of aging, especially vascular aging, in the development of cardiovascular disease.The continuum encompasses progressive deterioration of the proximal aorta properties with increasing arterial stiffness and dilation, resulting in adverse effects on important organs such as the heart, brain, and kidneys.The two continuums are both distinct and related, complement each other and fully illustrate the occurrence and progression of the cardiovascular continuum. \u0000 \u0000 \u0000Key words: \u0000Blood vessels; Aging; Atherosclerosis","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1180-1184"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45787795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Perforation of sigmoid colon caused by an eel in the elderly: a rare case report 老年人鳗鱼致乙状结肠穿孔1例
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.027
Guogang Wu, Zhaorun Liu, Minghui Wang, Jisheng Liu, M. Leng
{"title":"Perforation of sigmoid colon caused by an eel in the elderly: a rare case report","authors":"Guogang Wu, Zhaorun Liu, Minghui Wang, Jisheng Liu, M. Leng","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.027","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.027","url":null,"abstract":"患者,男,80岁,入院2 h前为寻求性快感将鳝鱼置入肛门,自觉下腹部撕裂样疼痛,难以忍受,伴有心慌、胸闷、呼吸急促、四肢冰冷等症,多次试取,均未成功,急来我院就诊。腹部CT重建:(1)考虑乙状结肠穿孔;(2)盆腔内异物,结合病史考虑为鳝鱼。心电图及各项抽血化验未见明显异常。入院诊断:(1)急性腹膜炎、乙状结肠穿孔?(2)盆腔内异物。急诊在全麻下行腹腔镜下腹腔探查+鳝鱼取出+乙状结肠穿孔修补术,术后5 d逐步恢复饮食,间断排便,术后7 d拔出引流管,术后9 d切口拆线,病愈出院。","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1173-1174"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45029638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of obstructive sleep apnoea-hypoapnoea syndrome on retinopathy processes in elderly patients with type 2 diabetes mellitus 阻塞性睡眠呼吸暂停-低呼吸暂停综合征对老年2型糖尿病视网膜病变进程的影响
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.017
Xie Xiang-rong, Liu Huilin, W. Qing, Tao Tianchang, Hao Shaofeng
{"title":"Effects of obstructive sleep apnoea-hypoapnoea syndrome on retinopathy processes in elderly patients with type 2 diabetes mellitus","authors":"Xie Xiang-rong, Liu Huilin, W. Qing, Tao Tianchang, Hao Shaofeng","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.017","url":null,"abstract":"Objective \u0000To investigate the effect of obstructive sleep apnoea-hypoapnoea syndrome(OSAHS)on diabetic retinopathy(DR)in elderly patients with type 2 diabetes mellitus(T2DM)and analyze risk factors for DR process. \u0000 \u0000 \u0000Methods \u0000Data of elderly diabetic patients without DR admitted into our hospital from January 2012 to December 2014 were retrospectively analyzed.Based on whether or not to combine OSAHS, patients were divided into the OSAHS group(n=42)and the control group(n=85). After 36 months' follow-up, the incidence and progression of DR were compared, and the effect of different degree of OSAHS on DR was analyzed.Multivariate logistic regression analysis was used to analyze the risk factors for DR. \u0000 \u0000 \u0000Results \u0000The systolic pressure, diastolic pressure and Epworth sleepiness scores were higher in the OSAHS group than in the control group(P<0.05). At the(34.5±6.7)months of follow-up versus baseline, body mass index, renal function and cardiac function were markedly decreased in both groups(P<0.05). The systolic pressure, diastolic pressure, 2-h postprandial blood glucose and Epworth sleepiness scores were higher in the OSAHS group than in the control group; and the glomerular filtration rate(GFR)and left ventricular ejection fraction were lower in the OSAHS group than in the control group(P<0.05). The incidences of mild, moderate and severe non-proliferative DR were higher in the OSAHS group than in the control group(P<0.05). The results of subgroup analysis showed that the incidence of DR was higher in patients with moderate to severe OSAHS than in controls(OR=4.57, 95%CI: 1.24~13.78, P=0.002), while the incidence of DR in patients with mild OSAHS was similar to that in the controls(OR=2.33, 95%CI: 0.66~12.56, P=0.29). Multivariate logistic regression analysis showed that T2DM duration ≥7 years(OR=3.24, 95%CI: 1.80-9.59, P<0.05), haemoglobin A1c(HbA1c)≥7.5%(OR=2.07, 95%CI: 1.41-8.52, P<0.05), GFR<60 ml/min(OR=4.52, 95%CI: 1.75-14.26, P<0.05)and apnea/hyponea index ≥15/h(OR=2.03, 95%CI: 1.37-11.24, P<0.05)were independent risk factors for DR. \u0000 \u0000 \u0000Conclusions \u0000OSAHS patients tend to have hypertension and high glucose level, and are more prone to cardiac and renal dysfunction and DR.T2DM duration ≥7 years, HbA1c ≥7.5%, GFR<60 ml/min and AHI ≥15/h are independent risk factors for DR progression.And more studies are needed to confirm the independent risk factors. \u0000 \u0000 \u0000Key words: \u0000Diabetic retinopathy; Sleep hypoapnea, obstructive","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1126-1130"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46993092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chinese expert consensus on core information for disability prevention in the elderly 中国专家就老年人残疾预防核心信息达成共识
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.001
Pulin Yu, Chao Gao, Ping Lei, Xiaohong Liu, Cun-yuan Zhang, Jianye Wang
{"title":"Chinese expert consensus on core information for disability prevention in the elderly","authors":"Pulin Yu, Chao Gao, Ping Lei, Xiaohong Liu, Cun-yuan Zhang, Jianye Wang","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.001","url":null,"abstract":"失能是包括功能受损、活动受限及社会功能受限在内的总括性术语,涵盖身体结构和功能、活动、社会参与3个方面。失能是老年人体力与脑力的下降和外在环境综合作用的结果。失能这一概念最早由社会学家Saad Nagi于1965年提出,在中国,失能这个概念被广泛应用的时间仅20年。目前我国尚无针对性的老年人失能预防指南,因此有必要结合我国老年人失能现状制订适合中国人的失能预防核心信息,以便指导我国老年人失能的预防。","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1073-1074"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47345401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The current situation and relevant risk factors for disability and dementia in the elderly in urban areas of Jiangsu Province 江苏省城市老年人残疾和痴呆现状及相关危险因素分析
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.015
Shuo Lu, Sha Liu, Jing Tang, Yue Gu, Yumu Wang, Wenhai Wang, Zhao-hui Qin
{"title":"The current situation and relevant risk factors for disability and dementia in the elderly in urban areas of Jiangsu Province","authors":"Shuo Lu, Sha Liu, Jing Tang, Yue Gu, Yumu Wang, Wenhai Wang, Zhao-hui Qin","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.015","url":null,"abstract":"Objective \u0000To study the current situation and relevant risk factors for disability and dementia among the elderly in urban areas of Jiangsu province. \u0000 \u0000 \u0000Methods \u0000A stratified cluster sampling method was used to select representative elderly people aged 60 years and over in urban areas in Jiangsu Province, and a face-to-face questionnaire survey was conducted.The activities of daily living(ADL)scale and mini-mental state examination(MMSE)were used to assess the status of disability and dementia.And the relevant risk factors for disability and dementia were analyzed by univariate and multivariate Logistic regression methods. \u0000 \u0000 \u0000Results \u0000A total of 1 600 elderly people were investigated and 1 514 valid questionnaires were recovered.The effective recovery rate was 94.6%.The rates of disability and dementia were 17.9%(271/1 514)and 8.5%(129/1 514)respectively in the elderly in Jiangsu urban areas.Univariate analysis showed that age, marital status, education level, empty-nest, whether or not to suffer from chronic diseases, health status, medication, and whether or not to have dementia were significantly related with the disability in the elderly(P<0.01). And age, gender, marital status, education level, whether or not to suffer from chronic diseases, health status, medication, and whether or not to have disability were significantly related with the dementia in the elderly(P<0.01). Multivariate analysis showed that the risk factors associating with increasing disability in the elderly were advanced age(OR=16.371), non-marriage(OR=1.917), chronic disease(OR=2.256), poor health condition(OR=23.214), dementia(OR=4.067)and insufficient income(OR=1.607)(P<0.05). And the factors associating with increasing risks for dementia in the elderly were advanced age(OR=2.864), female(OR=1.610), poor health condition(OR=3.097), empty nest(OR=1.607)and disability(OR=4.026)(P<0.05). Therefore, comprehensive measures should be taken for intervention of disability and dementia in the elderly. \u0000 \u0000 \u0000Conclusions \u0000The incidence of disability and dementia is high among the elderly in urban areas of Jiangsu Province.Disability and dementia are the results of the interaction effect of health, family and social factors.Therefore, comprehensive measures against risk factors should be taken for intervention of disability and dementia in the elderly. \u0000 \u0000 \u0000Key words: \u0000Activities of daily living; Cognition disorders; Risk factors","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1116-1120"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42898840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elderly hypertension patients with obstructive sleep apnea syndrome and heart rate and blood pressure variability and the intervention effects of home-based continuous positive airway pressure therapy 老年高血压患者伴阻塞性睡眠呼吸暂停综合征的心率、血压变异性及基于家庭的持续气道正压治疗的干预效果
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.016
Shao-jun Xu, B. Zhou, Xiangyang Ban, Feifei Liu, Hai-lin Zhou, Q. Xu
{"title":"Elderly hypertension patients with obstructive sleep apnea syndrome and heart rate and blood pressure variability and the intervention effects of home-based continuous positive airway pressure therapy","authors":"Shao-jun Xu, B. Zhou, Xiangyang Ban, Feifei Liu, Hai-lin Zhou, Q. Xu","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.016","url":null,"abstract":"Objective \u0000To study the correlation of the degree of sleep apnea with arrhythmia, heart rate variability(HRV)and blood pressure variability(BPV)in elderly patients with obstructive sleep apnea hypopnea syndrome(OSAHS), and to investigate the intervention effects of home-based continuous positive airway pressure(CPAP)treatment. \u0000 \u0000 \u0000Methods \u0000A total of 122 elderly hypertension patients with OSAHS were recruited in the prospective study.Patients were divided into three groups according to the sleep apnea hypopnea index(apnea hypopnea index, AHI): the mild OSAHS group(5 times/h≤AHI≤15 times/h, n=42), moderate OSAHS group(15 times/h 30 times/h, n=40). All patients took ambulatory electrocardiogram and ambulatory blood pressure examinations before and after three months of CPAP treatment.The incidences of arrhythmia, HRV and BPV indexes of each group before and after CPAP treatment were compared between the groups. \u0000 \u0000 \u0000Results \u0000The incidences of premature atrial contraction, atrial tachycardia and premature ventricular beats were higher in the moderate and severe OSAHS groups than in the mild OSAHS group(P<0.01). Compared with the mild OSAHS group, the RR interval standard deviation(SDNN), root mean square of successive differences(rMSSD), proportion of patients with consecutive RR-interval differences greater than 50 ms(PNN5), standard deviation of the averaged normal RR intervals for all 5 min segments and deceleration capacity of rate increased in the moderate and severe OSAHS groups(P<0.05), and the increases were more obvious in the severe group.Compared with the mild OSAHS group, the standard deviation of 24-h systolic blood pressure, standard deviation of 24-h diastolic blood pressure, standard deviation of daytime systolic blood pressure, standard deviation of nighttime systolic blood pressure and incidence of non-dipper hypertension increased in the moderate and severe OSAHS groups(P<0.05), with the increases were more obvious in the severe group, and the differences was significant between the moderate and severe OSAHS groups(P<0.05). HRV and BPV indicators improved except for high frequency(HF)/low frequency(LF)in all groups(P<0.05)after home treatment of CPAP, and the improvement was more obvious in the severe group.The incidence of non-dipper circadian rhythm of blood pressure improved more significantly in the severe OSAHS group than in the moderate OSAHS group. \u0000 \u0000 \u0000Conclusions \u0000With aggravated sleep apnea, the incidences of arrhythmias such as premature atrial contraction, atrial tachycardia, and premature ventricular contraction are increased and the HRV and BPV are enlarged in elderly hypertension patients complicated with OSAHS.The home treatment of CPAP can improve the above indicators, and it is an effective way to treat OSAHS complicated by hypertension in elderly patients. \u0000 \u0000 \u0000Key words: \u0000Hypertension; Sleep apnea, obstructive; Intermittent pressure ventilation","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1121-1125"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43033972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpretation of the international clinical practice guidelines for sarcopenia and the significance of sarcopenia management in preventing disability among the elderly 国际少肌症临床实践指南解读以及少肌症管理在预防老年人残疾中的意义
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.013
S. Jia
{"title":"Interpretation of the international clinical practice guidelines for sarcopenia and the significance of sarcopenia management in preventing disability among the elderly","authors":"S. Jia","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.013","url":null,"abstract":"肌少症是与增龄相关的骨骼肌质量与力量的下降,其与跌倒、骨折、失能、死亡率增加相关;老年人失能在当今老龄化社会是一个比较突出的问题,严重阻碍了健康老龄化,肌少症是失能的一大危险因素,本文主要解读2018国际肌少症临床实践指南,旨在为临床医务人员提供肌少症诊断和管理的参考标准,并简要分析肌少症的识别与干预对预防老年人失能的意义。","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1107-1110"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45678774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Major adverse events and prognostic factors in elderly patients with cervical cancer undergoing intensive-modulated radiotherapy combined with intravaginal brachytherapy 老年宫颈癌患者行调强放疗联合阴道内近距离放疗的主要不良事件及预后因素分析
中华老年医学杂志 Pub Date : 2019-10-14 DOI: 10.3760/CMA.J.ISSN.0254-9026.2019.10.021
Jian Wang, Lijun Hu, Boyu Yu, Lili Wang, Jingping Yu, Q. Meng, Zhiqiang Sun, Jianlin Wang
{"title":"Major adverse events and prognostic factors in elderly patients with cervical cancer undergoing intensive-modulated radiotherapy combined with intravaginal brachytherapy","authors":"Jian Wang, Lijun Hu, Boyu Yu, Lili Wang, Jingping Yu, Q. Meng, Zhiqiang Sun, Jianlin Wang","doi":"10.3760/CMA.J.ISSN.0254-9026.2019.10.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-9026.2019.10.021","url":null,"abstract":"Objective \u0000To investigate the adverse effects and clinical efficacy of the intensive modulated radiotherapy(IMRT)and intravaginal brachytherapy combined with versus without chemotherapy in elderly patients with cervical cancer, and to analyze its prognostic factors. \u0000 \u0000 \u0000Methods \u0000Clinical data and follow-up results of 214 patients with cervical cancer aged ≥60 years undergoing IMRT and intravaginal brachytherapy combined with or without chemotherapy were retrospectively analyzed.The overall survival(OS)rate was calculated by using the Kaplan-Meier method.Prognostic factors were analyzed by Log-rank single factor test and Cox multivariate analysis. \u0000 \u0000 \u0000Results \u0000The rates of myelosuppression(≥grade 3)was higher in the concurrent chemo-radiotherapy group than in simple radiotherapy group(48.6% vs.15.8%, χ2=27.372, P<0.05). The complete response(CR)rate was higher in the concurrent chemo-radiotherapy group than in the simple radiotherapy group(83.0% vs.68.3%, χ2=5.993, P=0.014). The 1-, 3- and 5-year OS rate were 92.2%, 79.3% and 65.6%, respectively in all patients.Univariate analysis showed that the staging, lymph node metastasis status, pathological type and short-term efficacy of cervical cancer(based on FIGO guideline)were influencing factors for the prognosis(χ2=4.321-30.316, all P<0.05). Multivariate analysis showed that the FIGO staging, lymph node metastasis status and short-term efficacy were independent influencing factors for the prognosis(χ2=5.284-14.261, all P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The intensive modulated radiotherapy and intravaginal brachytherapy combined with chemotherapy have a good efficacy and favorable long-term survival rate for the treatment of cervical cancer in elderly patients, and its major adverse effects can be tolerated.The FIGO staging, lymph node metastasis status and short-term efficacy are independent influencing factors for the prognosis in elderly patients with cervical cancer. \u0000 \u0000 \u0000Key words: \u0000Uterine cervical neoplasms; Radiotherapy; Prognosis","PeriodicalId":9997,"journal":{"name":"中华老年医学杂志","volume":"38 1","pages":"1148-1152"},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41958797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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