老化的心血管连续体

中华老年医学杂志 Pub Date : 2019-10-14 DOI:10.3760/CMA.J.ISSN.0254-9026.2019.10.029

Caiqing Zhang, Huashan Hong

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引用次数: 2

摘要

动脉粥样硬化心血管连续体或传统心血管连续体（CCC）由Dzau于2006年首次描述，描述了心血管疾病经历的一系列步骤，从开始的风险因素到终末期心脏病（以心室扩张、心力衰竭和死亡为特征）。CCC的基本特征是心肌缺血和冠状动脉狭窄引起的心肌梗死，冠状动脉狭窄源于冠状动脉粥样硬化。O’Rourke在2010年提出了衰老-心血管连续体（ACC），以解释衰老，尤其是血管衰老在心血管疾病发展中的作用。该连续体包括随着动脉硬度和扩张的增加，近端主动脉特性的逐渐恶化，从而对心脏、大脑和肾脏等重要器官产生不利影响。这两个连续体既有区别又有联系，相辅相成，充分说明了心血管连续体的发生和发展。关键词：血管；衰老；动脉粥样硬化

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The aging cardiovascular continuum

The atherosclerotic cardiovascular continuum or the conventional cardiovascular continuum(CCC)was first described by Dzau in 2006, describing a series of steps cardiovascular disease undergoes, from risk factors at the beginning to end-stage heart disease(characterized by ventricular dilation, heart failure, and death). The essential features of CCC are myocardial ischemia and myocardial infarction due to coronary artery stenosis, which originates from coronary atherosclerosis.O'Rourke proposed the aging cardiovascular continuum(ACC)in 2010 to explained the role of aging, especially vascular aging, in the development of cardiovascular disease.The continuum encompasses progressive deterioration of the proximal aorta properties with increasing arterial stiffness and dilation, resulting in adverse effects on important organs such as the heart, brain, and kidneys.The two continuums are both distinct and related, complement each other and fully illustrate the occurrence and progression of the cardiovascular continuum. Key words: Blood vessels; Aging; Atherosclerosis

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中华老年医学杂志

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