Child's Nervous System最新文献

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Microsurgical management of a ruptured intracranial mycotic aneurysm in infancy. 婴儿颅内霉菌性动脉瘤破裂的显微手术治疗。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-06-27 DOI: 10.1007/s00381-024-06505-6
Orlando Sánchez-Orbegoso, Jhon E Bocanegra-Becerra, Rolando Rojas-Apaza, José Cenzano-Ramos
{"title":"Microsurgical management of a ruptured intracranial mycotic aneurysm in infancy.","authors":"Orlando Sánchez-Orbegoso, Jhon E Bocanegra-Becerra, Rolando Rojas-Apaza, José Cenzano-Ramos","doi":"10.1007/s00381-024-06505-6","DOIUrl":"10.1007/s00381-024-06505-6","url":null,"abstract":"<p><strong>Introduction: </strong>During infancy, infectious aneurysms are uncommon and potentially fatal lesions with an imminent risk of intracranial hemorrhage development.</p><p><strong>Case presentation: </strong>A 1-month-old infant presented with loss of consciousness and clonic movements of the right superior limb after a work-up for Hirschsprung's disease. His physical exam revealed stupor, miosis, anterior fontanelle swelling, and hyperreflexia of the right superior limb. Blood cultures were positive for Candida albicans. In addition, brain imaging revealed an intraparenchymal hematoma in the left temporal lobe and a saccular aneurysm at the M3 segment of the left middle cerebral artery. Upon careful discussion with the patient's family, he underwent evacuation of the hematoma and aneurysm repair. His postoperative clinical course was uneventful. At the 5-month follow-up, a brain MRI showed encephalomalacia in the area of prior hemorrhage. Furthermore, he had preserved motor function and adequate psychomotor development on subsequent pediatric evaluations.</p><p><strong>Conclusion: </strong>Microsurgical management of ruptured mycotic aneurysms demands a systematic work-up and nuanced appraisal of clinical and aneurysmal factors. Operating in a confined space and considering the fragile nature of aneurysms are of utmost relevance for effectively treating these lesions.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis. 新生儿脑室内出血发病率和死亡率的地区差异:国家数据库分析。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-03 DOI: 10.1007/s00381-024-06514-5
Sumaiya Sayeed, Brianna C Theriault, Astrid C Hengartner, Paul Serrato, Sina Sadeghzadeh, Selma Belkasim, Nabihah Ahsan, Emad A Elsamadicy, Michael DiLuna, Aladine A Elsamadicy
{"title":"Regional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis.","authors":"Sumaiya Sayeed, Brianna C Theriault, Astrid C Hengartner, Paul Serrato, Sina Sadeghzadeh, Selma Belkasim, Nabihah Ahsan, Emad A Elsamadicy, Michael DiLuna, Aladine A Elsamadicy","doi":"10.1007/s00381-024-06514-5","DOIUrl":"10.1007/s00381-024-06514-5","url":null,"abstract":"<p><strong>Background: </strong>Intraventricular hemorrhage (IVH) often affects newborns of low gestational age and low birth weight, requires critical care for neonates, and is linked to long-term neurodevelopmental outcomes. Assessing regional differences in the U.S. in care for neonatal IVH and subsequent outcomes can shed light on ways to mitigate socioeconomic disparities.</p><p><strong>Methods: </strong>Using the 2016-2019 National Inpatient Sample (NIS), patients with a primary diagnosis of IVH were identified using ICD-10-CM codes. A retrospective cohort study was conducted with patients stratified by hospital region. Demographics, comorbidities, presentation, intraoperative variables, and inpatient outcomes were assessed. Multivariate logistic regression analyses were used to identify the impact of insurance status on extended LOS (defined as > 75<sup>th</sup> percentile of LOS), exorbitant cost (defined as > 75<sup>th</sup> percentile of cost), and mortality.</p><p><strong>Results: </strong>Included in this study were 1630 newborns with IVH. A larger portion of patients in the South and Midwest were Black, compared to the Northeast and West (Northeast: 12.2% vs Midwest: 30.2% vs South: 22.8% vs West: 5.8%, p < 0.001), while a greater percentage of patients in the West and South were Hispanic (Northeast: 7.3% vs Midwest: 9.5% vs South: 22.8% vs West: 36.2%, p < 0.001). LOS was similar among all regions. Factors associated with prolonged LOS included hydrocephalus and CSF diversions. Median total cost of admission was highest in the West, while the South was associated with decreased odds of exorbitant cost. LOS was associated with exorbitant cost, and large bed-volume hospital, VLBW, and permanent CSF shunt were associated with mortality.</p><p><strong>Conclusions: </strong>Demographic variables, but not presenting or intraoperative variables, differed among regions, pointing to possible geographic health disparities. The West had the highest total cost of admission, while the South was associated with reduced odds of exorbitant admission costs.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing medically refractory elevated intracranial pressure in a pediatric patient on ECMO: illustrative case. 治疗使用 ECMO 的儿科患者药物难治性颅内压升高:示例病例。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-24 DOI: 10.1007/s00381-024-06549-8
Tirone Young, Bahie Ezzat, Noah Nichols, Scott Aydin, Peter Pastuszko, Peter F Morgenstern
{"title":"Managing medically refractory elevated intracranial pressure in a pediatric patient on ECMO: illustrative case.","authors":"Tirone Young, Bahie Ezzat, Noah Nichols, Scott Aydin, Peter Pastuszko, Peter F Morgenstern","doi":"10.1007/s00381-024-06549-8","DOIUrl":"10.1007/s00381-024-06549-8","url":null,"abstract":"<p><strong>Purpose: </strong>We demonstrate the complexities of managing pediatric patients on extracorporeal membrane oxygenation (ECMO) therapy requiring neurosurgery, focusing on systemic anticoagulation, cardiac function, and medically refractory intracranial pressure (ICP).</p><p><strong>Methods: </strong>A 3.5-year-old female with Tetralogy of Fallot developed severe ischemic cerebral edema following post-operative cardiac arrest and required ECMO. This case, along with four additional cases of children requiring neurosurgery while on ECMO, was examined.</p><p><strong>Results: </strong>Emergency neurosurgical intervention in the primary case led to significant improvement, highlighting the delicate balance between managing ECMO-induced anticoagulation and urgent neurosurgical needs. The additional cases had variable outcomes, emphasizing the challenges of caring for these critically ill patients.</p><p><strong>Conclusion: </strong>Successful management of children requiring ECMO support and neurosurgical intervention requires thoughtful multidisciplinary care. This report illustrates some of the nuances in such decision-making, and demonstrates one potential path to a good outcome.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of pathogenic TCF12 variants in children with coronal craniosynostosis-a systematic review with addition of two novel cases. TCF12致病变体在冠状颅畸形患儿中的作用--系统综述及两例新病例。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-27 DOI: 10.1007/s00381-024-06544-z
Jon Foss-Skiftesvik, Carl Christian Larsen, Ulrik Kristoffer Stoltze, Thomas Kofod, Hanne Hove, Lars Bøgeskov, Elsebet Østergaard
{"title":"The role of pathogenic TCF12 variants in children with coronal craniosynostosis-a systematic review with addition of two novel cases.","authors":"Jon Foss-Skiftesvik, Carl Christian Larsen, Ulrik Kristoffer Stoltze, Thomas Kofod, Hanne Hove, Lars Bøgeskov, Elsebet Østergaard","doi":"10.1007/s00381-024-06544-z","DOIUrl":"10.1007/s00381-024-06544-z","url":null,"abstract":"<p><p>Craniosynostosis constitutes one of the most common congenital cranial malformations, affecting approximately 6/10,0000 live births. A genetic etiology has long been known for several forms of syndromic craniosynostosis, including pathogenic variants in TWIST1 and FGFR3 in children with Saethre-Chotzen and Muenke syndrome. Over the last decade, reports of genetic aberrations in TCF12 in children with craniosynostosis have emerged, in particular in cases with premature closure of the coronal suture(s). In this study, we, therefore, systematically reviewed the rapidly growing knowledge of TCF12-related coronal craniosynostosis, clearly illustrating its high degree of genotype and phenotype variability. With the two novel cases presented, at least 113 cases of TCF12-related coronal craniosynostosis have currently been reported. By pooling data from several prospectively collected undifferentiated craniosynostosis cohorts (n<sub>total</sub> = 770), we estimate a prevalence of pathogenic TCF12 variants of at least 2%. Overall, pathogenic germline variants in TCF12 are relatively frequent in children with coronal craniosynostosis, accounting for ∼10-20% of TWIST1- and FGFR1/2/3-negative cases, with even higher rates for bicoronal and syndromic cases. Genetic counseling is recommended for all children with craniosynostosis, and involvement of the coronal suture(s) should precipitate TCF12 testing.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical epidermoid cyst of the fourth ventricle with minimal diffusion-restriction. 第四脑室非典型表皮样囊肿,弥散限制极小。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-29 DOI: 10.1007/s00381-024-06553-y
Rose Fluss, Rianna Lo Bu, Mandana Behbahani
{"title":"Atypical epidermoid cyst of the fourth ventricle with minimal diffusion-restriction.","authors":"Rose Fluss, Rianna Lo Bu, Mandana Behbahani","doi":"10.1007/s00381-024-06553-y","DOIUrl":"10.1007/s00381-024-06553-y","url":null,"abstract":"<p><strong>Background: </strong>Epidermoid cysts are benign, slow growing extra-axial lesions most commonly found in the cerebellopontine angle that have a characteristic imaging pattern of restricted diffusion on diffusion-weighted imaging (DWI).</p><p><strong>Methods: </strong>A 10-year-old male with a history of asthma and diabetes was found to have a lesion within the fourth ventricle on a magnetic resonance imaging (MRI) brain study. MRI showed a well-circumscribed vermian lesion without contrast enhancement or restricted diffusion with mild hydrocephalus. He was referred to the neurosurgical service once he acutely developed symptoms of dizziness. He underwent a gross-total resection of the lesion on which histopathology confirmed an epidermoid cyst.</p><p><strong>Results: </strong>Here, we report a case of an atypical epidermoid cysts found in the midline of the fourth ventricle without restricted diffusion on MRI.</p><p><strong>Conclusion: </strong>Avid restricted-diffusion on DWI is usually pathognomonic for an epidermoid cyst when evaluating an extra-axial lesion, yet we report the second case in the literature of an epidermoid cyst without this classical imaging characteristic.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term outcomes after surgical correction of anterior plagiocephaly secondary to isolated frontosphenoidal synostosis: a systematic review and two illustrative cases. 继发于孤立性额蝶骨突畸形的前额畸形手术矫正术后的长期疗效:系统综述和两个说明性病例。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI: 10.1007/s00381-024-06572-9
Felipe Gutierrez-Pineda, Juan Pablo Gutierrez Pineda, MMemet Özek
{"title":"Long-term outcomes after surgical correction of anterior plagiocephaly secondary to isolated frontosphenoidal synostosis: a systematic review and two illustrative cases.","authors":"Felipe Gutierrez-Pineda, Juan Pablo Gutierrez Pineda, MMemet Özek","doi":"10.1007/s00381-024-06572-9","DOIUrl":"10.1007/s00381-024-06572-9","url":null,"abstract":"<p><strong>Purpose: </strong>Anterior plagiocephaly ( AP), secondary to isolated frontosphenoidal synostosis (IFS), represents one of the rarest forms of craniosynostosis documented in medical literature. Therefore, there is a lack of comprehensive understanding regarding the long-term (> 2 years) postoperative outcomes of this minor suture synostosis.</p><p><strong>Methods: </strong>This study presents the long-term outcomes of two patients previously treated for IFS, detailing their clinical, imaging, and postoperative characteristics. Additionally, a systematic review was conducted following PRISMA criteria to summarize existing literature on the topic. The review specifically focuses on long-term aesthetic outcomes, reoperation rates, and complications following surgical intervention for IFS.</p><p><strong>Results: </strong>Four articles encompassing 12 patients were included in the systematic review. The review highlights clinical features, postoperative complications, reoperation rates, and long-term aesthetic outcomes. The mean age at surgery was 17.5 months (range 9.5-24 months), with an average age at diagnosis of 9.3 months (range 6-10 months). Fronto-orbital advancement was the predominant surgical approach described across all cases. The reoperation rate among patients was 16.6%, with only two cases reporting postoperative complications. In one of our cases, an intraoperative CT scan was utilized to illustrate real-time improvement in frontal bone alignment according to the surgical plan, which significantly contributed to positive long-term clinical outcomes observed during a follow-up period exceeding 24 months.</p><p><strong>Conclusion: </strong>IFS, is a rare minor suture synostosis, significantly affects the aesthetic appearance of the forehead and necessitates consideration in the management of AP cases. Surgical intervention has shown minimal reoperation rates and excellent long-term prognosis. These findings are reinforced by recent institutional data and a comprehensive systematic review of the current literature.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pott's puffy tumor with intracranial extension in a child with incontinentia pigmenti: case based review of the eponymous disease. 一名患有猪大小便失禁症的儿童颅内扩展的波特浮肿瘤:同名疾病的病例回顾。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-08-24 DOI: 10.1007/s00381-024-06577-4
Debajyoti Datta, Albert Tu
{"title":"Pott's puffy tumor with intracranial extension in a child with incontinentia pigmenti: case based review of the eponymous disease.","authors":"Debajyoti Datta, Albert Tu","doi":"10.1007/s00381-024-06577-4","DOIUrl":"10.1007/s00381-024-06577-4","url":null,"abstract":"<p><strong>Background: </strong>Pott's puffy tumor (PPT) is an uncommon infection involving the frontal bone, first described by Sir Percival Pott more than 250 years ago. It can present with intracranial extension and serious neurological morbidity. Incontinentia pigmenti (IP) is a rare inherited genodermatosis that is lethal prenatally in males and manifests clinically in females. IP is associated with recurrent infections and immune dysfunction/suppression.</p><p><strong>Methods: </strong>We report a case of Pott's puffy tumor presenting in a child with IP. We also performed a literature review of reported cases of PPT associated with immune dysfunction. We discuss the clinical presentation, diagnosis, and management of these lesions.</p><p><strong>Results: </strong>We identified 12 cases of PPT associated with immune dysfunction/suppression. Diabetes was the most commonly identified cause followed by iatrogenic immunosuppression. Surgery is the standard treatment for managing PPT and the management of PPT with and without intracranial involvement, particularly in the context of underlying immune dysfunction/suppression, is discussed.</p><p><strong>Conclusion: </strong>PPT remains a rare but not infrequent diagnosis, often requiring neurosurgical intervention. Immune dysfunction/suppression is an additional risk factor that may predispose to PPT. Early and aggressive management should be instituted for optimal outcome.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parental diagnosis of shunt malfunction in children. 家长对儿童分流器故障的诊断。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1007/s00381-024-06601-7
Katie Herbert, Alexander Lam, Aishik Mukherjee, Amy Drew, Fardad T Afshari
{"title":"Parental diagnosis of shunt malfunction in children.","authors":"Katie Herbert, Alexander Lam, Aishik Mukherjee, Amy Drew, Fardad T Afshari","doi":"10.1007/s00381-024-06601-7","DOIUrl":"10.1007/s00381-024-06601-7","url":null,"abstract":"<p><p>IntroductionEvaluation of shunt for malfunction and blockage is a common neurosurgical clinical scenario in day-to-day paediatric neurosurgery practice. Parental concern for shunt malfunction is normally considered a reliable indication for undertaking further assessment of a child with a shunt. Accuracy of parental diagnosis of shunt malfunction likely is dependent on combination of parental knowledge and patient symptomatology and familiarity of symptoms in relation to previous shunt malfunction symptoms. There are currently no UK studies on accuracy of parental diagnosis of shunt malfunction. We undertook this study to investigate sensitivity and specificity of parental diagnosis in our tertiary paediatric neurosurgical unit to identify any factors that can be used for further education and raising awareness in parents with children with shunts.MethodsWe undertook a review of all referrals with suspected shunt malfunction to our tertiary paediatric neurosurgical unit over a period of 10 months. All referrals and presentations were evaluated for parental concern for likelihood of shunt malfunction and marked as yes or no. Further information gathered included demographics, age, sex, symptoms at presentation, previous history of shunt revision, cases of shunt malfunction and part of the shunt revised. Sensitivity, specificity, positive and negative predictive values and accuracy were then calculated and factors associated with positive diagnosis of shunt malfunction analysed.ResultsOverall, 100 referrals with suspected shunt malfunction were made over 10 months period. Mean age for children at the time of referral was 6.3 years with an M/F ratio of 42M:58F. Twenty-one shunt malfunction cases were identified leading to overall revision rate of 21%. Parental evaluation of shunt function had sensitivity of 90.4%, specificity of 10.1%, positive predictive value of 21.1% and negative predictive value of 80%. Drowsiness and higher number of symptoms at presentation were associated with true positive diagnosis of shunt malfunction. No link was identified with true diagnosis of shunt malfunction with other symptoms of shunt malfunction or previous history of shunt revision and age of the patient.ConclusionParental diagnosis of shunt malfunction has high sensitivity and negative predictive value and low specificity and positive predictive value. Increased number of symptoms as well as drowsiness were associated with correct parental diagnosis of shunt malfunction. Educational programs and parental training can be valuable in increasing awareness about shunt malfunction signs.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robot-assisted insular stereoelectroencephalography in pediatric drug-resistant epilepsy: accuracy and diagnostic value. 机器人辅助岛叶立体脑电图在小儿耐药性癫痫中的应用:准确性和诊断价值。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-09-05 DOI: 10.1007/s00381-024-06571-w
A González-Crespo, F Brugada-Bellsolà, S Candela-Cantó, J Aparicio Calvo, J Rumià Arboix, J Hinojosa Bernal
{"title":"Robot-assisted insular stereoelectroencephalography in pediatric drug-resistant epilepsy: accuracy and diagnostic value.","authors":"A González-Crespo, F Brugada-Bellsolà, S Candela-Cantó, J Aparicio Calvo, J Rumià Arboix, J Hinojosa Bernal","doi":"10.1007/s00381-024-06571-w","DOIUrl":"10.1007/s00381-024-06571-w","url":null,"abstract":"<p><strong>Background: </strong>Insular epilepsy is a well-known cause of drug-resistant epilepsy (DRE) in the pediatric population. It can be a source of surgical epilepsy treatment failures when not ruled out pre-operatively. Non-invasive methods often provide limited information about its existence, being the invasive methods necessary to diagnose it in the vast majority of cases. The most used is stereoelectroencephalography (SEEG). We report a series of DRE pediatric patients in which insular SEEG was performed to rule out insular epilepsy.</p><p><strong>Method: </strong>We performed a retrospective review of pediatric DRE patients operated on SEEG including insular electrodes between April 2016 and September 2022. We described the different trajectories used (orthogonal or oblique) and surgical techniques. After implantation, we assessed electrodes' precision using three measures: entry point location error (EPLE), target point location error (TPLE), and target deviation (TD). We also reported complications that occurred with this technique as well as the diagnostic information provided.</p><p><strong>Results: </strong>Overall, 32 DRE patients were operated on SEEG including insular electrodes. Four hundred one electrodes were implanted, 148 (39.91%) of whom were directed to the insula. One hundred twelve followed an orthogonal trajectory, and 36 were oblique. The mean EPLE was 1.45 mm, TPLE was 1.88 mm and TD was 0.71 mm. Three patients suffered from frontal hematoma, two of them diagnosed on post-operative MRI and one who required surgery, with no sequelae. One patient suffered from meningitis treated with antibiotics with no permanent sequelae. Nine patients (28.13%) had the insula included in the epileptogenic zone.</p><p><strong>Conclusions: </strong>Insular epilepsy has to be ruled out in DRE patients when little suspicion is obtained after non-invasive testing. This is especially important in the pediatric population, in which seizure semiology is more difficult to characterize and failures to control epilepsy have devastating consequences in neurocognitive development and scholarship. Given its relative low rate of relevant complications and potential benefits, we should consider widening the inclusion criteria for insular SEEG monitoring.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A tale of two pediatric craniopharyngiomas exemplifying treatment strategies. 两个小儿颅咽管瘤治疗策略的故事。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-30 DOI: 10.1007/s00381-024-06540-3
Segev Gabay, Danil A Kozyrev, Jonathan Roth, Shlomi Constantini
{"title":"A tale of two pediatric craniopharyngiomas exemplifying treatment strategies.","authors":"Segev Gabay, Danil A Kozyrev, Jonathan Roth, Shlomi Constantini","doi":"10.1007/s00381-024-06540-3","DOIUrl":"10.1007/s00381-024-06540-3","url":null,"abstract":"","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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