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The Evolving Landscape of Neuroscience Therapeutics: an Interplay of Multiple Modalities 不断发展的神经科学疗法：多种模式的相互作用
IF 1.2 4区 化学
Chimia Pub Date : 2024-02-28 DOI: 10.2533/chimia.2024.62
Hendrik Knoetgen, Torsten Schindler, Felix F. Schumacher, Antonia F. Stepan, Alain C. Tissot, Jaclyn I. Wamsteeker Cusulin
{"title":"The Evolving Landscape of Neuroscience Therapeutics: an Interplay of Multiple Modalities","authors":"Hendrik Knoetgen, Torsten Schindler, Felix F. Schumacher, Antonia F. Stepan, Alain C. Tissot, Jaclyn I. Wamsteeker Cusulin","doi":"10.2533/chimia.2024.62","DOIUrl":"https://doi.org/10.2533/chimia.2024.62","url":null,"abstract":"","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inspiring Students to Explore Science Topics Since 2011 自 2011 年起激励学生探索科学课题
IF 1.2 4区 化学
Chimia Pub Date : 2024-02-28 DOI: 10.2533/chimia.2024.67
Sabine Kastner, Thomas Flüeler
{"title":"Inspiring Students to Explore Science Topics Since 2011","authors":"Sabine Kastner, Thomas Flüeler","doi":"10.2533/chimia.2024.67","DOIUrl":"https://doi.org/10.2533/chimia.2024.67","url":null,"abstract":"To succeed in Science on the Move, the nationwide competition for Swiss high school classes, students are requested to work as a team on relevant research topics. The project shapes their notion of science as one of the foundations of our society and as a possible professional field for themselves.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Practical Approaches to Genetic Code Expansion with Aminoacyl-tRNA Synthetase/tRNA Pairs. 利用氨基酰-tRNA 合成酶/tRNA 对扩展遗传密码的实用方法。
IF 1.2 4区 化学
Chimia Pub Date : 2024-02-28 DOI: 10.2533/chimia.2024.22
Anton Natter Perdiguero, Alexandria Deliz Liang
{"title":"Practical Approaches to Genetic Code Expansion with Aminoacyl-tRNA Synthetase/tRNA Pairs.","authors":"Anton Natter Perdiguero, Alexandria Deliz Liang","doi":"10.2533/chimia.2024.22","DOIUrl":"10.2533/chimia.2024.22","url":null,"abstract":"<p><p>Genetic code expansion (GCE) can enable the site-selective incorporation of non-canonical amino acids (ncAAs) into proteins. GCE has advanced tremendously in the last decade and can be used to create biorthogonal handles, monitor and control proteins inside cells, study post-translational modifications, and engineer new protein functions. Since establishing our laboratory, our research has focused on applications of GCE in protein and enzyme engineering using aminoacyl-tRNA synthetase/tRNA (aaRS/tRNA) pairs. This topic has been reviewed extensively, leaving little doubt that GCE is a powerful tool for engineering proteins and enzymes. Therefore, for this young faculty issue, we wanted to provide a more technical look into the methods we use and the challenges we think about in our laboratory. Since starting the laboratory, we have successfully engineered over a dozen novel aaRS/tRNA pairs tailored for various GCE applications. However, we acknowledge that the field can pose challenges even for experts. Thus, herein, we provide a review of methodologies in ncAA incorporation with some practical commentary and a focus on challenges, emerging solutions, and exciting developments.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rotational-state-selected Carbon Astrochemistry. 旋转状态选择碳天体化学。
IF 1.2 4区 化学
Chimia Pub Date : 2024-02-28 DOI: 10.2533/chimia.2024.40
Jutta Toscano
{"title":"Rotational-state-selected Carbon Astrochemistry.","authors":"Jutta Toscano","doi":"10.2533/chimia.2024.40","DOIUrl":"https://doi.org/10.2533/chimia.2024.40","url":null,"abstract":"<p><p>The addition of individual quanta of rotational excitation to a molecule has been shown to markedly change its reactivity by significantly modifying the intermolecular interactions. So far, it has only been possible to observe these rotational effects in a very limited number of systems due to lack of rotational selectivity in chemical reaction experiments. The recent development of rotationally controlled molecular beams now makes such investigations possible for a wide range of systems. This is particularly crucial in order to understand the chemistry occurring in the interstellar medium, such as exploring the formation of carbon-based astrochemical molecules and the emergence of molecular complexity in interstellar space from the reaction of small atomic and molecular fragments.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simplifying Nitration Chemistry with Bench-stable Organic Nitrating Reagents. 使用台式稳定有机硝化试剂简化硝化化学。
IF 1.2 4区 化学
Chimia Pub Date : 2024-02-28 DOI: 10.2533/chimia.2024.32
Subrata Patra, Vasiliki Valsamidou, Dmitry Katayev
{"title":"Simplifying Nitration Chemistry with Bench-stable Organic Nitrating Reagents.","authors":"Subrata Patra, Vasiliki Valsamidou, Dmitry Katayev","doi":"10.2533/chimia.2024.32","DOIUrl":"https://doi.org/10.2533/chimia.2024.32","url":null,"abstract":"<p><p>Nitro compounds play a crucial role in academia and industries, serving as building blocks for the synthesis of drugs, agrochemicals, and materials. Nitration, a fundamental process in organic synthesis, has undergone significant evolution since the 19th century. While electrophilic nitration dominates historically, recent decades have seen a focus on new reagents and their reactivity modes for achieving mild and robust synthesis of nitro compounds. Our group has a longstanding interest in developing cost-effective, readily available, recyclable nitrating reagents derived from organic scaffolds. These reagents serve as a controllable source of nitryl radical and nitronium ion species, enabling mild and practical nitration of hydrocarbons with exceptional functional group tolerance. This account details the development of nitrating reagents and their diverse applications in catalytic nitration across various classes of organic molecules.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In situ/In vivo Optical Microspectroscopy to Probe the Emergence of Morphology. 利用原位/活体光学显微光谱探究形态的形成。
IF 1.2 4区 化学
Chimia Pub Date : 2024-02-28 DOI: 10.2533/chimia.2024.50
Natercia Barbosa, Oscar Urquidi, Johanna Brazard, Takuji B M Adachi
{"title":"In situ/In vivo Optical Microspectroscopy to Probe the Emergence of Morphology.","authors":"Natercia Barbosa, Oscar Urquidi, Johanna Brazard, Takuji B M Adachi","doi":"10.2533/chimia.2024.50","DOIUrl":"10.2533/chimia.2024.50","url":null,"abstract":"<p><p>Morphology governs function. Yet, understanding and controlling the emergence of morphology at the molecular level remains challenging. The difficulty in studying the early stage of morphology formation is due to its stochastic nature both spatially and temporally occurring at the nanoscale. This nature has been particularly detrimental for the application of optical spectroscopy. To overcome this problem, we have been developing new in situ/in vivo optical spectroscopy tools, which are label-free and non-invasive. This account highlights several examples of how optical spectroscopy can become an important tool in studying the birth of morphology.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable Materials: Production Methods and End-of-life Strategies. 可持续材料：生产方法和报废策略。
IF 1.2 4区 化学
Chimia Pub Date : 2023-12-20 DOI: 10.2533/chimia.2023.848
Arpa Ghosh, Remy Buser, Florent Héroguel, Jeremy Luterbacher
{"title":"Sustainable Materials: Production Methods and End-of-life Strategies.","authors":"Arpa Ghosh, Remy Buser, Florent Héroguel, Jeremy Luterbacher","doi":"10.2533/chimia.2023.848","DOIUrl":"https://doi.org/10.2533/chimia.2023.848","url":null,"abstract":"<p><p>All three natural polymers of biomass and the monomer platforms derived from them present multiple avenues to develop products from specialty to bulk markets, which could serve as entry points into the industry for bio based sustainable materials. However, several roadblocks still exist in the pathway of technology development of these materials due to challenges related to cost-competitiveness, scalability, performance and sustainability. This review outlines these major technical challenges as four key checkpoints (cost-competitive, scalability, sustainability, performance) to be addressed for successful market entry of a new sustainable material.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescently Labelled Tau Protein 荧光标记的 Tau 蛋白
IF 1.2 4区 化学
Chimia Pub Date : 2023-12-20 DOI: 10.2533/chimia.2023.
Saurabh Awasthi, Liviana Mummolo, Yuanjie Li, Louise Bryan, P. Nirmalraj, Sandor Balog, Jerry Yang, Michael Mayer
{"title":"Fluorescently Labelled Tau Protein","authors":"Saurabh Awasthi, Liviana Mummolo, Yuanjie Li, Louise Bryan, P. Nirmalraj, Sandor Balog, Jerry Yang, Michael Mayer","doi":"10.2533/chimia.2023.","DOIUrl":"https://doi.org/10.2533/chimia.2023.","url":null,"abstract":"","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SCNAT Ethics Series on Recognizing and Overcoming Bias 关于认识和克服偏见的 SCNAT 道德系列课程
IF 1.2 4区 化学
Chimia Pub Date : 2023-12-20 DOI: 10.2533/chimia.2023.883
Sandra Hofmann
{"title":"SCNAT Ethics Series on Recognizing and Overcoming Bias","authors":"Sandra Hofmann","doi":"10.2533/chimia.2023.883","DOIUrl":"https://doi.org/10.2533/chimia.2023.883","url":null,"abstract":"The Ethics Series is a workshop tour on the wide-ranging topic of ethics in chemistry organized on a regular basis by the Platform Chemistry of the Swiss Academy of Sciences (SCNAT). The Ethics Series addresses all researchers in chemistry and has the aim to sensitize the audience for timely topics on issues such as the previously addressed topics of scientific integrity, social responsibility or overselling in publications. Internationally renowned speakers are invited to give a series of lectures at Swiss universities and federal institutes of technology, jointly with local speakers.\u0000The format is similar to the \"world café\" style: short introductory lectures, break-out sessions to discuss specific topics, reports to the plenary followed by a discussion with audience participation. This year’s topic was on Recognizing and Overcoming Bias and took place from June 7 – June 9, 2023. Prof. Lee Penn and local panellists discussed a variety of questions arising around bias.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138956497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symposium of Theoretical Chemistry in Zurich 苏黎世理论化学研讨会
IF 1.2 4区 化学
Chimia Pub Date : 2023-12-20 DOI: 10.2533/chimia.2023.887
Jeremy O. Richardson, Sandra Luber
{"title":"Symposium of Theoretical Chemistry in Zurich","authors":"Jeremy O. Richardson, Sandra Luber","doi":"10.2533/chimia.2023.887","DOIUrl":"https://doi.org/10.2533/chimia.2023.887","url":null,"abstract":"In September 2023, the Symposium of Theoretical Chemistry (STC) was held at ETH Zurich. This was the 59th installment of the conference series held annually in Germany, Austria or Switzerland, although it had not previously been held in Zurich since 1966. This year’s event was organized by Sandra Luber (Univ. Zurich) and Jeremy Richardson (ETH Zurich) with a focus on quantum and classical dynamics in chemistry.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138956648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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