Chinese clinical oncology最新文献

{"title":"Anterolateral thigh flap harvested from paralyzed limbs in post-polio syndrome for tongue reconstruction-a case report and a review of the literature.","authors":"Wenya Du, Siyi Li, Lei Wang, Bilal Msallem, Xiangjun Li, Longwei Hu","doi":"10.21037/cco-24-112","DOIUrl":"https://doi.org/10.21037/cco-24-112","url":null,"abstract":"<p><strong>Background: </strong>Poliomyelitis is an acute infectious disease caused by poliovirus in childhood. After the onset of acute poliomyelitis, weakness of limbs occurs 15 to 30 years later, which is defined as post-polio syndrome. Poliomyelitis accompanying head and neck cancer is rare. Microvascular reconstruction is a well-established procedure following extensive tumor resection. Donor-site selection for flap harvest is a very important issue in paralyzed patients, particularly in patients with post-polio syndrome. To date, limited information is available regarding flap harvest in paralyzed patients.</p><p><strong>Case description: </strong>We present a case of a 70-year-old male who presented with oral squamous cell carcinoma of the tongue, with both lower extremities paralyzed due to childhood poliomyelitis. Reconstruction was successfully performed with an anterolateral thigh flap despite extensive muscle atrophy. The sizes of the vascular pedicle and the cutaneous perforators were anatomically similar to the ones of healthy limbs. Both donor and recipient sites healed uneventfully; however, a postoperative complication due to pneumonia occurred.</p><p><strong>Conclusions: </strong>The present case demonstrates that flap harvest from paralyzed limbs in post-polio syndrome is safe, which is in line with the sparse evidence from the literature. However, our attention should be drawn to postoperative respiratory complications and management. In order to avoid postoperative complications, it is essential to undertake a precise preoperative assessment.</p>","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"22"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare cases of atraumatic splenic rupture managed conservatively in patients with myeloid neoplasms: a report of two cases and literature review.","authors":"Meng Chen, Moqin Jiang, Weifeng Zhang, Lei Zhao, Ying Zhang","doi":"10.21037/cco-24-122","DOIUrl":"https://doi.org/10.21037/cco-24-122","url":null,"abstract":"<p><strong>Background: </strong>Atraumatic splenic rupture (ASR) is rare and typically attributed to underlying pathological conditions, with neoplastic diseases being the main etiologies. Traditionally, surgical intervention has been the standard approach for managing ASR in the majority of patients. However, reports on the outcomes of conservative management, especially for ASR related to myeloid neoplasms, are scarce.</p><p><strong>Case description: </strong>Here, we present two case reports involving ASR associated with myeloid neoplasms. The first patient, suffering from chronic myelomonocytic leukemia (CMML) harboring CBL and ASXL1 mutations, developed ASR shortly after receiving treatment with the hypomethylating agent 5-azacytidine. The second patient, in the blast phase of myeloproliferative neoplasms (MPN), experienced ASR during the progression of their disease. In the initial case, despite experiencing intense abdominal pain and hypovolemic shock, the patient responded favorably to prompt fluid resuscitation and blood transfusion upon, thanks to a timely diagnosis. A non-operative management approach successfully averted the need for splenectomy or arterial embolism, leading to a favorable outcome. In the second case, the patient presented with progressive abdominal pain but remained hemodynamic stability throughout the ASR episode. We opted for a cautious approach, prioritizing resuscitation, close monitoring, and a watchful waiting strategy. Regrettably, the patient's condition deteriorated, marked by increasing splenomegaly, unchecked leukocytosis, and recurrent parenchymal hemorrhages.</p><p><strong>Conclusions: </strong>Here, we report two cases of ASR in myeloid neoplasms, demonstrating that patients may achieve acceptable outcomes with conservative management.</p>","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"21"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating treatment outcome of Glioblastoma with Stupp's regimen: an experienced in single Institute.","authors":"Dang Van Nguyen, Nhung Thi Thu Nguyen, Phan Huy Nguyen, Hang Thi Nguyen, Thanh Cam Do","doi":"10.21037/cco-24-103","DOIUrl":"https://doi.org/10.21037/cco-24-103","url":null,"abstract":"<p><strong>Background: </strong>The current conventional treatment approach for newly diagnosed glioblastomas (GBMs) entails the complete removal of the tumor, followed by the implementation of Stupp's procedure. The main purpose of this study was to analyze the results of Stupp's treatment protocol in real-world practice and examine certain prognostic markers associated with survival, which could offer empirical evidence in the treatment of GBM.</p><p><strong>Methods: </strong>A total of 64 patients diagnosed with newly developed GBM underwent treatment with irradiation and temozolomide (TMZ) at Vietnam National Cancer Hospital (VNCH) from January 2020 to September 2022. The study provided information on the demographic and clinical features of the patients, as well as their overall survival (OS) and progression-free survival (PFS) outcomes. The analysis of survival and related variables involved the utilization of Kaplan-Meier curves, Cox regression, and the log-rank test.</p><p><strong>Results: </strong>The retrospective analysis comprised 64 participants. The vast majority of patients were in favorable performance status. The median OS and PFS were 21.91 and 9.39 months, respectively. Several factors, such as female patients, gross tumor resection/subtotal tumor resection (GTR/STR), time to start radiotherapy (RT) within 8 weeks postoperative, no progressive disease after concurrent chemoradiotherapy (CCRT), no dexamethasone required and Ki-67 level below 15%, were associated with increased OS. Regarding PFS, characteristics such as age <40 years old, GTR/STR and no disease progression following CCRT were substantially related to improved survival. Nearly half of patients received TMZ 50 mg/m2 in combination with bevacizumab following the initial progressive illness.</p><p><strong>Conclusions: </strong>Multidisciplinary collaboration, as well as advancements in diagnosis and customized treatment strategies, are critical in the treatment of GBM patients. In actual life, completing the entire Stupp's protocol significantly improves GBM survival.</p>","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"18"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxing out with chemoimmunotherapy in extensive-stage small cell lung cancer.","authors":"Kubra Canaslan, Lu Xiao, Ticiana Leal","doi":"10.21037/cco-25-5","DOIUrl":"https://doi.org/10.21037/cco-25-5","url":null,"abstract":"","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"24"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloprotection with trilaciclib in Chinese patients with extensive-stage small cell lung cancer.","authors":"Mumtu Lalla, Haiying Cheng","doi":"10.21037/cco-24-114","DOIUrl":"https://doi.org/10.21037/cco-24-114","url":null,"abstract":"","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"23"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncoplastic surgery in the treatment of breast cancer: a review of evolution and surgical training.","authors":"Francisco Pimentel Cavalcante, Felipe Pereira Zerwes, Eduardo Camargo Millen, André Mattar, Marcelo Antonini, Fabrício Palermo Brenelli, Antonio Luiz Frasson, René Aloisio da Costa Vieira","doi":"10.21037/cco-24-140","DOIUrl":"https://doi.org/10.21037/cco-24-140","url":null,"abstract":"<p><p>Oncoplastic breast surgery (OBS) has undergone significant advancement in recent decades, transforming breast cancer (BC) treatment by facilitating increased rates of breast-conserving surgery (BCS) through volume displacement techniques and enabling immediate reconstruction via volume replacement following mastectomy. This approach has demonstrably improved cosmetic outcomes and health-related quality of life metrics for patients undergoing oncological intervention. The progression of surgical methodology from Halsted's radical mastectomy to contemporary oncoplastic techniques constitutes a fundamental paradigm shift in surgical approach. Meta-analyses and prospective cohort studies have established that oncoplastic techniques maintain oncological safety when compared with conventional BCS and mastectomy, demonstrating comparable local recurrence (LR) rates and disease-free survival (DFS) outcomes. Multiple classification systems for oncoplastic procedures have been established based on quantifiable metrics including percentage of breast volume resected, surgical complexity indices, and technical approach parameters, providing evidence-based frameworks for clinical decision-making. The breast surgeon currently functions as the critical nexus in multidisciplinary treatment of BC, integrating optimized surgical techniques with multimodal treatment protocols, particularly systemic therapeutic agents. The implementation of neoadjuvant chemotherapy (NCT) regimens has expanded the indications for breast conservation in cases previously requiring mastectomy, leading to the development of the \"extreme oncoplasty\" concept for selected patients. Nevertheless, significant implementation barriers persist globally, predominantly related to educational infrastructure limitations and the absence of standardized oncoplastic surgical training curricula for breast surgeons. Diverse training methodologies have emerged internationally, including simulation-based learning, subspecialty fellowships, and curricular integration in surgical residency programs, though outcome-based standardization remains elusive. This non-systematic review analyzes the developmental trajectory of breast cancer surgery, examining the evolution and validation of oncoplastic techniques, standardized classification systems, applications in challenging clinical scenarios, and the current status of surgical education, emphasizing the pivotal role of professional societies in developing evidence-based educational initiatives to broaden access to these advanced surgical techniques.</p>","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"20"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is preoperative immunotherapy promising for patients with proficient mismatch repair or microsatellite stable locally advanced rectal cancer?-a commentary on TORCH randomized phase 2 trial.","authors":"Yuichiro Tsukada, Masaaki Ito","doi":"10.21037/cco-25-16","DOIUrl":"https://doi.org/10.21037/cco-25-16","url":null,"abstract":"","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"25"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of tumor infiltration length along the bile duct mucosa and submucosa in hilar cholangiocarcinoma.","authors":"Taifeng Zhu, Zhijuan Li, Qibin Tang, Xianhuan Yu, Guangzi Shi, Hong Zeng, Xinting Sang, Chao Liu, Xiangde Shi","doi":"10.21037/cco-24-123","DOIUrl":"https://doi.org/10.21037/cco-24-123","url":null,"abstract":"<p><strong>Background: </strong>Radical resection remains the mainstay of treatment for patients with hilar cholangiocarcinoma (HCCA), however, the scope of resection remains controversial. This study investigates the influence of tumor infiltration length along the mucosa and submucosa of the bile duct on curative resection.</p><p><strong>Methods: </strong>The clinical and pathological data of 31 HCCA patients who underwent en bloc and extended liver resection in the Department of Biliary-Pancreatic Surgery of Sun Yat-sen Memorial Hospital from January 2020 to December 2021 were retrospectively analyzed. First, the gross tumor boundary and bile duct resection margin were marked with ink before the specimen was fixed in formalin solution. Subsequently, the specimens were embedded and sectioned longitudinally along the bile duct. Finally, the length of tumor invasion was calculated according to the marked macroscopic and microscopic boundaries. SPSS statistical software was used for statistical analysis.</p><p><strong>Results: </strong>The average infiltration length in the proximal bile duct mucosa and submucosa were 8.5±5.2 and 8.6±4.9 mm, while the average infiltration length in the distal bile duct mucosa and submucosa were 12.8±7.5 and 11.5±7.2 mm, respectively. The accuracy of the Bismuth-Corlette classification for type III lesions was 68.4% (13/19).</p><p><strong>Conclusions: </strong>Imaging examinations may underestimate the extent of HCCA growth along the bile duct. The R0 resection rate can be increased by extended hepatectomy including more than half of the liver volume.</p>","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"17"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of perioperative immunotherapy with chemotherapy in muscle-invasive bladder cancer (MIBC).","authors":"Min Woo Hwang, Jeanny B Aragon-Ching","doi":"10.21037/cco-25-8","DOIUrl":"https://doi.org/10.21037/cco-25-8","url":null,"abstract":"","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"26"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for bone metastasis in patients with prostate cancer: a retrospective study based on single-center data and SEER database.","authors":"Xuechun Hu, Tao Zhou, Zongpan Ke, Ping Xiang, Jun Xiao, Changming Wang, Yixun Liu","doi":"10.21037/cco-24-78","DOIUrl":"https://doi.org/10.21037/cco-24-78","url":null,"abstract":"<p><strong>Background: </strong>Bone metastasis in prostate cancer (PCa) has been considered a significant determinant of both patient survival and quality of life. However, the factors contributing to the incidence of bone metastasis remain unidentified. This study primarily aims to elucidate the risk factors associated with bone metastasis in individuals diagnosed with PCa.</p><p><strong>Methods: </strong>A total of 177 patients who had undergone radical prostatectomy at our institution were included in the analysis. These patients were categorized into two groups based on the results of whole-body bone emission computed tomography (ECT) scanning: the bone metastasis group and the non-bone metastasis group. Univariate and multivariate logistic regression analyses were conducted to determine the independent risk factors for bone metastasis. Additionally, receiver operating characteristic (ROC) curves were employed to compare the diagnostic efficacy of the clinical variables. Additional data from the Surveillance, Epidemiology, and End Results (SEER) database, consisting of 96,497 patients, were analyzed for external validation.</p><p><strong>Results: </strong>The findings indicated that among the diagnosed patients with PCa, 18.64% (33/177) exhibited bone metastasis. Through multivariate logistic regression analysis, it was determined that prostate-specific antigen (PSA), Gleason score, percentage of monocyte (M%), and N stage were identified as independent risk factors for bone metastasis in PCa. The study found that the sensitivities for PSA and Gleason score were 66.67% and 69.70%, respectively, while the specificities were 85.42% and 65.97%, respectively. Additionally, the analysis of data from the SEER database confirmed that both PSA, Gleason score and N stage were independent risk factors. Furthermore, the Chi-squared test revealed a positive correlation between the primary histological grade and the rate of bone metastasis.</p><p><strong>Conclusions: </strong>The present study ascertained that PSA, Gleason score and N stage served as prognostic indicators for bone metastasis in PCa. The investigation of the significance of M% and the primary histological grade in the diagnosis of bone metastasis in PCa warranted further exploration.</p>","PeriodicalId":9945,"journal":{"name":"Chinese clinical oncology","volume":"14 2","pages":"16"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}