Chemical Engineering and Processing - Process Intensification最新文献

Development and optimization of a device for testing photocatalysts in continuous flow regime 光催化剂连续流测试装置的研制与优化

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-13 DOI: 10.1016/j.cep.2025.110596

Isabel S.O. Barbosa, Beatriz Oliveira, Margarida S.C.A. Brito, Yaidelin A. Manrique, Joaquim L. Faria, Cláudia G. Silva, Ricardo J. Santos, Maria J. Sampaio

{"title":"Development and optimization of a device for testing photocatalysts in continuous flow regime","authors":"Isabel S.O. Barbosa, Beatriz Oliveira, Margarida S.C.A. Brito, Yaidelin A. Manrique, Joaquim L. Faria, Cláudia G. Silva, Ricardo J. Santos, Maria J. Sampaio","doi":"10.1016/j.cep.2025.110596","DOIUrl":"10.1016/j.cep.2025.110596","url":null,"abstract":"<div><div>This work combines computational fluid dynamics (CFD) simulations with experimental validation to optimize a photocatalytic reactor for oxygen (O<sub>2</sub>) production. By addressing key chemical diffusion limitations in heterogeneous photocatalysis, the study aims to optimize reactor geometry and enhance its performance. CFD simulations were employed to assess the performance of three devices (DEVAW, DEVTR, and DEVTW) with different shapes and depths under similar operational conditions. Three-dimensional (3D) CFD simulations were conducted to analyze the hydrodynamic behavior and the Residence Time Distribution (RTD) at a flow rate of 10 cm<sup>3</sup> min<sup>-1</sup>. Results demonstrate that the DEVTW reactor, at a height of 5 mm, achieved superior molar fluxes and a higher O<sub>2</sub> concentration of 158 µM, compared with the DEVAW and DEVTR reactors of the same height, which reached 140 µM and 144 µM, respectively. The superior O<sub>2</sub> concentration is attributed to the increased velocity gradient near the catalytic plate, which facilitates mass transfer by improving convective transport of O<sub>2</sub> from the catalyst surface and promotes the diffusion of O<sub>2</sub> molecules. Mass transfer CFD simulations further indicate that the chemical reaction is the rate-limiting step, revealing that the DEVTW device is adequate for efficient photocatalyst screening in dissolved O<sub>2</sub> evolution reactions.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110596"},"PeriodicalIF":3.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145322468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidics-based hydrogel microspheres: Complex structure design and multidisciplinary applications 基于微流体的水凝胶微球：复杂结构设计和多学科应用

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-11 DOI: 10.1016/j.cep.2025.110595

Wenqi Dai, Yingchun Luo, Kaicheng Zhou, Zhongli Wu, Xiaomin Jian, Heng Xu, Wenjing He, Daohai Zhang

{"title":"Microfluidics-based hydrogel microspheres: Complex structure design and multidisciplinary applications","authors":"Wenqi Dai, Yingchun Luo, Kaicheng Zhou, Zhongli Wu, Xiaomin Jian, Heng Xu, Wenjing He, Daohai Zhang","doi":"10.1016/j.cep.2025.110595","DOIUrl":"10.1016/j.cep.2025.110595","url":null,"abstract":"<div><div>Hydrogel microspheres have emerged as multifunctional three-dimensional biomaterial platforms, garnering significant research attention in biomedical and analytical fields. Their applications now extend to cutting-edge domains including controlled drug delivery, regenerative medicine, and biosensing technologies. Conventional fabrication methods such as emulsion techniques, three-dimension (3D) printing, and spray drying face inherent limitations in producing structurally sophisticated microspheres, particularly regarding inadequate product uniformity, high production costs, and scalability challenges. The breakthrough development of microfluidic technology has revolutionized the controllable fabrication of hydrogel microspheres, establishing itself as the most promising technology in this field. This review systematically summarizes recent advancements in microfluidics-based hydrogel microsphere preparation technologies, with particular emphasis on innovative strategies for constructing complex architectures and methodological breakthroughs. This review highlights, as a key insight, the unique capability of microfluidics to engineer architecturally sophisticated microspheres and their role in fostering convergence across disciplines like biomedicine and materials science. By critically synthesizing these advances, this work provides a foundational guide for future research, outlining clear pathways for overcoming current scalability and biocompatibility challenges to advance the development of personalized and smart functional microspheres.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110595"},"PeriodicalIF":3.9,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145322467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-evaluating 2-heptanol as solvent for the extraction of 2,3-butanediol from water 重新评价2-庚醇作为萃取水中2,3-丁二醇的溶剂

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-10 DOI: 10.1016/j.cep.2025.110591

William Graf von Westarp, Janik Hense, Moritz Haas, Andreas Jupke

{"title":"Re-evaluating 2-heptanol as solvent for the extraction of 2,3-butanediol from water","authors":"William Graf von Westarp, Janik Hense, Moritz Haas, Andreas Jupke","doi":"10.1016/j.cep.2025.110591","DOIUrl":"10.1016/j.cep.2025.110591","url":null,"abstract":"<div><div>The performance of an extraction-distillation process for separating 2,3-butanediol from H<sub>2</sub>O was evaluated in a recent study, finding high efficeincy when using 2-heptanol as solvent for extraction. Since the study was based on liquid-liquid equilibrium (LLE) data mainly derived from molecular simulations, the aim of this communication was to consolidate the database by providing experimental phase equilibrium data and to re-evaluate 2-heptanol as solvent. Based on LLE experiments, a solvent-to-feed ratio (S/F) of 3.175 was required to recover 95 % of 2,3-BDO in a counter-current extraction column. This S/F is 21.9 times higher than the estimation derived from the data based on molecular simulations. The high S/F results in a strong dilution of 2,3-BDO in the extract. Experimental investigation of the boiling point data of the 2,3-BDO – 2-heptanol system for subsequent distillation revealed the presence of a temperature minimum azeotrope at low 2,3-BDO concentrations, which limits the feasibility of the overall process. Since the use of 2-heptanol as solvent is oftentimes referred to in the community of diol separation, the results presented in the work at hand are relevant to a broad readership.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110591"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145322470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turbulent fluid flow dynamics and aerosol particle deposition in spiral conduits via Eulerian-Lagrangian methodology 基于欧拉-拉格朗日方法的湍流流体流动动力学和气溶胶颗粒在螺旋导管中的沉积

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-10 DOI: 10.1016/j.cep.2025.110593

Farzana Akter, Sumon Saha

{"title":"Turbulent fluid flow dynamics and aerosol particle deposition in spiral conduits via Eulerian-Lagrangian methodology","authors":"Farzana Akter, Sumon Saha","doi":"10.1016/j.cep.2025.110593","DOIUrl":"10.1016/j.cep.2025.110593","url":null,"abstract":"<div><div>Understanding aerosol particle deposition in spiral pipes is crucial for optimizing air filtration systems and industrial processes. This study uses advanced numerical simulations to address the complex interaction between turbulence and particle accumulation within a corrugated, wavy-shaped helical conduit. The simulation utilizes the RNG (Renormalization Group) <em>k-ε</em> turbulence equation with enhanced wall treatment to simulate complex fluid dynamics accurately. At the same time, the Lagrangian particle tracking approach captures particle behavior and deposition patterns. The study explores a range of particle diameters from 1 to 20 μm and Reynolds numbers from 6 × 10<sup>3</sup> to 10<sup>4</sup> to capture a broad spectrum of flow circulation and particle interactions. Key indices such as helix diameter, number of spiral revolutions, and pipe diameter are systematically varied to assess their impact on deposition efficiency. The findings reveal that larger particle sizes and higher Reynolds numbers significantly enhance deposition rates due to intensified inertial forces and turbulence effects. Increasing the number of spiral revolutions and helix diameter improves deposition efficiency by enhancing particle-wall interactions. Conversely, the pipe diameter has a more nuanced effect, with optimal sizes balancing flow resistance and deposition efficiency. These findings provide insights into optimizing spiral pipe designs for improved aerosol particle control, which is crucial for enhancing system performance and lowering environmental impact.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110593"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145322469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential of digital twins in the food industry and their role in developing food formulations 探索数字孪生体在食品工业中的潜力及其在食品配方开发中的作用

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-09 DOI: 10.1016/j.cep.2025.110583

Maria J. Paris , O. Jiménez-González , J.E. González-Pérez , N. Ramírez-Corona

{"title":"Exploring the potential of digital twins in the food industry and their role in developing food formulations","authors":"Maria J. Paris , O. Jiménez-González , J.E. González-Pérez , N. Ramírez-Corona","doi":"10.1016/j.cep.2025.110583","DOIUrl":"10.1016/j.cep.2025.110583","url":null,"abstract":"<div><div>Digital twins have been used across various industries to reduce workload and costs while enhancing process efficiency, aligning with the goals of process intensification. Their application in the food industry is limited, particularly in the industrial-scale food product formulation. This review provides a comprehensive analysis of the current status, benefits, limitations, and prospects of DT applications in the food industry. Authors perform an extensive literature review for the last 20 years using different databases like Scopus, Pubmed, ResearchGate, and academic editorials. Food formulation using DTs allows for the development of personalized recipes tailored to specific nutritional profiles, sensory properties, and target groups. They also facilitate the optimization of food formulas to improve food security, shelf-life, and ingredient composition. Sensory evaluation can be enhanced using virtual environments, biometric sensors, and AI-generated food images. Challenges in DT implementation in the food industry include high digitalization requirements, data accessibility and ownership issues. The integration of DTs with AI, IoT, and big data analytics further enhances their capabilities in predictive maintenance, quality control, and supply chain optimization. Despite these challenges, the potential benefits of DTs in food formulation are considerable, demanding a multidisciplinary approach to effectively and swiftly address consumer demand and industry issues.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110583"},"PeriodicalIF":3.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The helical cell design for process intensification in centrifugal partition chromatography 离心分配色谱过程强化的螺旋池设计

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-08 DOI: 10.1016/j.cep.2025.110564

Stepan Sibirtsev, Simon Vlad Luca, Mirjana Minceva

{"title":"The helical cell design for process intensification in centrifugal partition chromatography","authors":"Stepan Sibirtsev, Simon Vlad Luca, Mirjana Minceva","doi":"10.1016/j.cep.2025.110564","DOIUrl":"10.1016/j.cep.2025.110564","url":null,"abstract":"<div><div>Centrifugal partition chromatography (CPC) is a liquid–liquid chromatography technique commonly used to separate natural products. Since increasing the CPC separation performance by operational conditions is limited, process intensification in CPC requires optimizing the CPC cell design. This study aims to experimentally investigate the performance of a miniLili CPC device with a novel helical cell design developed by LiliChro (Hungary) and compare it to conventional CPC cell designs. The miniLili CPC device has 80 cells and a volume of 36 mL. Performance is evaluated based on stationary phase retention, number of theoretical plates, and separation resolution. Additionally, “capacity utilization”, defined as a product of stationary phase retention and the cells’ efficiency, is introduced as a new metric to compare the overall performance of CPC devices of different volumes, cell numbers, and cell geometry. Experiments are performed using the Arizona N solvent system and methyl, ethyl, and propyl parabens as solutes. The novel cell design demonstrates high stationary phase retention of 0.9-0.95 at rotational speeds of 1000-1500 rpm and volume flow rates of 1-5 mL/min. Although the resolution in the miniLili CPC device is comparatively lower than that of conventional CPC devices, higher resolutions can be reached by increasing the rotational speed, flow rate, or number of physical cells. Despite this, the capacity utilization of the miniLili CPC device exceeds that of conventional designs within its operating flow rate range. These findings underscore the potential of advanced cell geometries to drive process intensification in CPC, marking a significant step forward in the evolution of high-efficiency CPC.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110564"},"PeriodicalIF":3.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing separation efficiency and secondary vapor quality in zinc gluconate evaporation: Application of a structurally innovative vapor–liquid separator 提高葡萄糖酸锌蒸发的分离效率和二次蒸汽质量：一种结构创新的汽液分离器的应用

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-08 DOI: 10.1016/j.cep.2025.110569

Jun Feng , Dianzheng Zhuang , Fengying Guo , Yu Liang , Shouli Zheng , Wanjun Liu

{"title":"Enhancing separation efficiency and secondary vapor quality in zinc gluconate evaporation: Application of a structurally innovative vapor–liquid separator","authors":"Jun Feng , Dianzheng Zhuang , Fengying Guo , Yu Liang , Shouli Zheng , Wanjun Liu","doi":"10.1016/j.cep.2025.110569","DOIUrl":"10.1016/j.cep.2025.110569","url":null,"abstract":"<div><div>To overcome the low secondary vapor quality and insufficient separation efficiency in zinc gluconate evaporation systems, a novel vapor–liquid separator integrating a bowl-shaped bottom plate and corrugated tubes was developed using CFD simulation. Three separator designs were evaluated: a conventional gravity-settling separator (Model 1), an improved version with a bowl-shaped bottom (Model 2), and a hybrid structure combining a bowl-shaped bottom with corrugated tubes (Model 3). Under varied flow rates, the internal flow characteristics, pressure distribution, separation efficiency, and pressure drop were systematically investigated. Results showed Model 2 improved separation efficiency by 17.2%–20.7% compared to Model 1. Model 3 achieved the highest efficiency of 84.78%, exceeding Model 1 by 26.37% and Model 2 by 6.84%, while maintaining a modest pressure drop increase (5%–7%). Analysis revealed that the combined ”contraction–expansion” channels and micro-vortices generated by the corrugated tubes enhanced droplet coalescence, stabilized interfaces, extended droplet residence time, and improved adaptability to flow fluctuations. This study provides valuable insights and practical guidance for optimizing vapor–liquid separator design and enhancing operational efficiency in zinc gluconate evaporation systems.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110569"},"PeriodicalIF":3.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on the performance of gas-liquid atomizing mixer in tubular flow channel with variable cross-section 变截面管状流道气液雾化混合器性能研究

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-05 DOI: 10.1016/j.cep.2025.110576

Huan Sun , Ling-zhen Kong , Jia-qing Chen , Yang Yang , Tong Xie , Qi Li , Chang-he Li

{"title":"Research on the performance of gas-liquid atomizing mixer in tubular flow channel with variable cross-section","authors":"Huan Sun , Ling-zhen Kong , Jia-qing Chen , Yang Yang , Tong Xie , Qi Li , Chang-he Li","doi":"10.1016/j.cep.2025.110576","DOIUrl":"10.1016/j.cep.2025.110576","url":null,"abstract":"<div><div>The tubular gas-liquid atomizing mixer is a compact and high-efficiency gas-liquid contact device. It generates high-speed gas flow through a variable cross-section channel, atomizes liquid absorbent into micro-nano droplets to enhance gas-liquid mass transfer, and its performance directly determines the achievement of design objectives. This study proposes a tubular gas-liquid atomizing mixer with a \"rhombic cone + boss\" structure. Combining CFD simulation and experimental tests, it investigates the effects of gas Weber number (<em>We<sub>g</sub></em>) and liquid-gas momentum flux ratio (<em>q</em>) on gas-liquid atomization and mixing characteristics. The results show that the variable cross-section channel can increase gas flow velocity and induce intense turbulence inside the tube, promoting the mixing of gas-microdroplet two phases. <em>We<sub>g</sub></em> has a significant impact on droplet size and volume concentration: when <em>Weg</em> increases from 212.46 to 524.64, the droplet size decreases by 46.1 % and the volume concentration increases by 170 %. <em>q</em> affects mixing performance by changing the penetration depth of the liquid jet, with the optimal performance achieved when <em>q</em>=28.79, but its influence on droplet characteristics is weaker than that of <em>Weg</em>. The structural layout of combining variable cross-section flow channel with central bluff body can provide a solution for high-efficiency tubular gas-liquid atomizing mixers, facilitating industrial applications such as natural gas water dew point control.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110576"},"PeriodicalIF":3.9,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep-learning-aided modifier adaptation: synergies with process intensification 深度学习辅助修饰语自适应：过程强化的协同效应

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-05 DOI: 10.1016/j.cep.2025.110581

Gabriel D. Patrón , Calvin Tsay , Luis Ricardez-Sandoval

{"title":"Deep-learning-aided modifier adaptation: synergies with process intensification","authors":"Gabriel D. Patrón , Calvin Tsay , Luis Ricardez-Sandoval","doi":"10.1016/j.cep.2025.110581","DOIUrl":"10.1016/j.cep.2025.110581","url":null,"abstract":"<div><div>Deep learning allows for functions, and their gradients, to be approximated to a high accuracy. Modifier adaptation is a real-time optimization method, which is used to optimize process economics online, and requires gradients to make first-order model corrections. In this work, backpropagated gradients are computed from neural networks trained on historical steady-state data, thus not explicitly requiring any gradient data for training. Data curation and convergence properties are discussed for the proposed method. The deep-learning-aided modifier adaptation is tested in analogous simulated integrated and intensified reactor-separator systems, where it is shown to reconcile plant and model optima in the presence of model mismatch. The case studies show better economics and constraint satisfaction when using the intensified system and the deep-learning-aided modifier adaptation. Further, intensification and deep-learning-aided modifier adaptation are observed to work in tandem as both accelerate the convergence of the plant to its true optima. The proposed method shows how historical data logs can be leveraged to address epistemic uncertainty and improve performance in model-based optimization, especially in intensified systems.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110581"},"PeriodicalIF":3.9,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145322471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioprocess strategies for intensification of microbial validamycin A production 强化微生物有效性霉素A生产的生物工艺策略

IF 3.9 3区工程技术

Chemical Engineering and Processing - Process Intensification Pub Date : 2025-10-05 DOI: 10.1016/j.cep.2025.110582

Ashish Yadav, Nand Kumar Singh, Rupika Sinha

{"title":"Bioprocess strategies for intensification of microbial validamycin A production","authors":"Ashish Yadav, Nand Kumar Singh, Rupika Sinha","doi":"10.1016/j.cep.2025.110582","DOIUrl":"10.1016/j.cep.2025.110582","url":null,"abstract":"<div><div>Validamycin A is an extensively used biopesticide, a trehalase inhibitor used to control various plant pathogens, such as <em>Rhizoctonia solani</em>. This potent molecule exhibits low plant toxicity and high efficacy against crop diseases, including sheath blight of rice, bottom rot on lettuce, and black scurf on potatoes. The large-scale application of this secondary metabolite produced by <em>Streptomyces hygroscopicus</em> has led to extensive research on its microbial production strategies. These include strain improvement through metabolic engineering, optimization of fermentation media and fermentation mode, and induced expression through stress signals. This review begins with detailed description of metabolic pathway for the production of validamycin A, which is critical for any production process development. This study includes an analysis of various strategies for enhancing the production of validamycin A. The effects of stress conditions, such as high alkalinity or pH, temperature shock, and supplementation of microbial agents, have been evaluated to determine their impact on secondary metabolites in general and validamycin A specifically. This opens a new avenue for applying controlled stress for secondary metabolism enhancement to achieve a high product yield. This report also encompasses bottlenecks and future perspectives on validamycin A production. It forecasts the future of validamycin A bioprocessing by the integration of advanced technologies such as Process Analytical Techniques (PAT), metabolomics by Multivariate Data Analysis (MVDA), and co-culture fermentation systems. The novelty of this report lies in the fact that limited literature is available that compiles bioprocess strategies for the production of this potent, commercially viable compound. The strategies discussed in this review can be evaluated and applied for production of other secondary metabolites by microbial systems.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":"219 ","pages":"Article 110582"},"PeriodicalIF":3.9,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0