Chemistry Journal of Moldova最新文献_第8页

Facile and Efficient Synthesis of Xanthene Derivatives Mediated by Lanthanum(Iii) Nitrate Hexahydrate under Solvent Free Conditions 无溶剂条件下六水硝酸镧介导的杂蒽衍生物的快速高效合成

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Chemistry Journal of Moldova Pub Date : 2020-12-01 DOI: 10.19261/cjm.2020.774

K. Shaikh, Uddhav N. Chaudhar

引用次数: 0

Novel Β-lactams and Thiazolidinone Derivatives from 1,4-dihydroquinoxaline Schiff’s Base: Synthesis, Antimicrobial Activity and Molecular Docking Studies 1,4-二氢喹啉席夫碱的新型Β-lactams和噻唑烷酮衍生物:合成、抗菌活性和分子对接研究

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Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI: 10.19261/CJM.2019.647

H. Hrichi, Nadia Ali Ahmed Elkanzi, R. Bakr

引用次数: 9

Simultaneous Quantitative Estimation of Lisinopril and Hydrochlorothiazide Residues Using HPLC for Cleaning Validation 高效液相色谱法同时定量测定赖诺普利和氢氯噻嗪的残留

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Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI: 10.19261/cjm.2020.669

I. Rubashvili, Natela Karukhnishvili, Khatuna Makharadze

{"title":"Simultaneous Quantitative Estimation of Lisinopril and Hydrochlorothiazide Residues Using HPLC for Cleaning Validation","authors":"I. Rubashvili, Natela Karukhnishvili, Khatuna Makharadze","doi":"10.19261/cjm.2020.669","DOIUrl":"https://doi.org/10.19261/cjm.2020.669","url":null,"abstract":"The aim of this study was to develop and validate direct swab and indirect rinse sampling procedures and a high performance liquid chromatography (HPLC) method for simultaneous quantitative estimation of residues of active pharmaceutical ingredients (API) – lisinopril and hydrochlorothiazide (HCT) in cleaning control samples collected from pharmaceutical manufacturing equipment surfaces after manufacturing of lisinopril/hydrochlorothiazide 20/25 mg uncoated tablets. The swab and rinse sampling procedures were developed and validated in order to obtain a suitable and good recovery (>80%). The acceptance limits of the above-mentioned APIs on the manufacturing equipment surfaces have been established based on pharmacological and toxicological criteria. The new, rapid, specific and selective, developed HPLC method for simultaneous quantitative determination of lisinopril and HCT residues was validated with respect to robustness, system suitability test, specificity, linearity-range, precision, limits of detection and quantitation. The stability of APIs solutions and membrane filter compatibility were studied as well. The method validation was carried out according to ICH Q2 guideline and United States Pharamcopeia requirements. The limit of detection and the limit of quantitation for lisinopril were 0.039 μg/mL and 0.155 μg/mL and for HCT 0.012 μg/mL and 0.025 μg/mL, respectively.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"5 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76399639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organochlorine Pesticides Residues in Soil of Soroca District, Republic of Moldova 摩尔多瓦共和国索罗卡地区土壤中有机氯农药残留

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Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI: 10.19261/cjm.2020.672

Elena Culighin

引用次数: 0

Chromatographic Analysis of Orchid Extracts and Quantum Chemical Calculations of Individual Components Interaction with Silica 兰花提取物的色谱分析及各组分与二氧化硅相互作用的量子化学计算

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Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI: 10.19261/cjm.2020.694

O. Kazakova, R. Ivannikov, I. Laguta, O. Stavinskaya, V. Anishchenko, Olga Severinovska, L. Buyun

{"title":"Chromatographic Analysis of Orchid Extracts and Quantum Chemical Calculations of Individual Components Interaction with Silica","authors":"O. Kazakova, R. Ivannikov, I. Laguta, O. Stavinskaya, V. Anishchenko, Olga Severinovska, L. Buyun","doi":"10.19261/cjm.2020.694","DOIUrl":"https://doi.org/10.19261/cjm.2020.694","url":null,"abstract":"The aim of the work was to identify the main components of orchid extracts and to study their interaction with silica. Composition of sixteen orchid extracts was investigated by means of high performance liquid chromatography and laser desorption/ionization mass spectrometry; as it was shown in this study, flavonoids and phenolic acids were the main bioactive compounds available in the extracts. The interaction between various phenols and silica silanol groups was studied by quantum chemical method. Results show that the strength of interaction of phenols with silica increased in the following order: ferullic, feruloylquinic and fertaric acids< kaempferol, apingenin<< сhlorogenic and caffeic acids, rhamnetin, quercetin, luteolin, epicatechin gallate. The common feature of compounds characterized by the strongest interaction with silanol groups is the presence of a phenol ring with two neighbouring hydroxyl groups. The hydrogen bonds formed between these groups and silanol groups are much shorter (about 0.17 nm) than those formed by other hydroxyl groups of phenols (up to 0.28 nm).","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"4 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87602977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Design and Synthesis of Two Bicyclo[3.3.1]nonane-steroid Derivatives 两个双环[3.3.1]壬烷甾类衍生物的设计与合成

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Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI: 10.19261/cjm.2019.657

Lauro Figueroa, Alejandra Garcimarero, R. Garcia, Francisco Díaz, Marcela Rosas, Virginia Mateu, María I. López, Lenin Hau, Tomas Lopez, Abelardo Camacho, Yaritza Borges

引用次数: 0

Evaluation of the Thermal Behaviour of Agricultural Wastes for Possible Use in the Biomass Pellets Industry 对可能用于生物质颗粒工业的农业废弃物热行为的评价

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Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI: 10.19261/cjm.2020.717

A. Marcu, G. Lisa, I. Şofran, I. Anghel, M. Serban

引用次数: 2

Synthesis of Different Structural Types of Zeolites in the Halloysite-dolomite-obsidian System 高岭石-白云石-黑曜石体系中不同结构类型沸石的合成

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Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI: 10.19261/cjm.2020.664

G. Mamedova

{"title":"Synthesis of Different Structural Types of Zeolites in the Halloysite-dolomite-obsidian System","authors":"G. Mamedova","doi":"10.19261/cjm.2020.664","DOIUrl":"https://doi.org/10.19261/cjm.2020.664","url":null,"abstract":"Gismondine, laumontite and levyne type zeolites have been synthesized based on the natural minerals of Nakhchivan and the optimal crystallization conditions have been established. The influence of temperature, alkaline solution concentration, ratio of starting components and time of processing on the synthesis process has been studied. The mineral resources of Nakhchivan − halloysite deposits of Pirigel, dolomite deposits of Negram and obsidian deposits of Zangezur served as samples. The initial components and the reaction products have been examined by X-ray diffraction, thermogravimetric and elemental analysis. The optimal conditions for the synthesis of gismondine zeolite with a 100% crystallinity are as follows: temperature of 200°C, alkaline solution of 2 N NaOH, ratio of the initial components of halloysite (H):dolomite (D):obsidian (O)= 1:1:1, processing time of 50 hours. The optimal conditions for laumontite synthesis are: temperature of 220°C, alkaline solution of NaOH of 1 N, H:D:O= 1:3:1, processing time of 75 hours. The optimal conditions for levyne are: temperature of 200°C, alkaline solution of KOH of 4 N, H:D:O= 2:1:2, processing time of 100 hours. It was found that changes in the temperature, alkalinity, ratio of starting components and time of processing of the reaction have different effects on the rate of formation of products, on their degree of crystallinity and on the phase purity of the obtained zeolite.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"83 1","pages":"31-40"},"PeriodicalIF":0.5,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90355058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Toward a Multidisciplinary Strategy for the Classification and Reuse of Iron and Manganese Mining Wastes 铁矿和锰矿废弃物分类与再利用的多学科策略研究

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Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI: 10.19261/cjm.2019.650

D. Guglietta, G. Belardi, G. Cappai, B. Casentini, A. Godeas, S. Milia, D. Passeri, R. Salvatori, A. Scotti, V. Silvani, E. Tempesta, S. Ubaldini, Francesca Trapasso

{"title":"Toward a Multidisciplinary Strategy for the Classification and Reuse of Iron and Manganese Mining Wastes","authors":"D. Guglietta, G. Belardi, G. Cappai, B. Casentini, A. Godeas, S. Milia, D. Passeri, R. Salvatori, A. Scotti, V. Silvani, E. Tempesta, S. Ubaldini, Francesca Trapasso","doi":"10.19261/cjm.2019.650","DOIUrl":"https://doi.org/10.19261/cjm.2019.650","url":null,"abstract":"Mining and mineral-processing wastes have been giving a lot of concern in recent times. This paper has evaluated an integrated multidisciplinary strategy for mining wastes characterization, their possible recycling and reuse, and critical raw materials recovery. After the in situ sampling campaigns, mining wastes have been characterized and the acquired mineralogical, chemical and spectral information have been used to create a map of mining waste deposits by means of the new multispectral satellite Sentinel-2A classification. The use of Fe-Mn rich wastes in arsenic removal and phosphorus recovery from water was discussed. Furthermore, mycorrhizal-assisted phytoextraction of metals from contaminated soils classified as Class 1 to 4 by remote sensing showed a good potential for their possible recovery from biomass, and results indicated that the system was suitable for the uptake of several elements. Results are encouraging and the application of such approach can be important to develop a circular model for sustainable exploitation of mining wastes.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"39 1","pages":"21-30"},"PeriodicalIF":0.5,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76974563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Analysis of Heavy Metal Accumulation in Fishes from the Coast of Lautoka, Fiji 斐济劳托卡海岸鱼类重金属积累分析

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Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI: 10.19261/cjm.2020.701

S. S. Ghani, Aman Deo

引用次数: 0