两个双环[3.3.1]壬烷甾类衍生物的设计与合成

IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Journal of Moldova Pub Date : 2020-06-01 DOI:10.19261/cjm.2019.657

Lauro Figueroa, Alejandra Garcimarero, R. Garcia, Francisco Díaz, Marcela Rosas, Virginia Mateu, María I. López, Lenin Hau, Tomas Lopez, Abelardo Camacho, Yaritza Borges

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引用次数: 0

摘要

一些合成双环[3.3.1]壬烷类似物的研究已经有报道，但是关于双环[3.3.1]壬烷甾类衍生物的制备的资料很少。因此，本研究的目的是通过醚化、加成、亲核取代和环化等反应，以雌二醇或雌酮为原料合成两种甾体-双环[3.3.1]壬烷类似物(11或12)。通过核磁共振波谱分析对其化学结构进行了评价。结果表明，11号的产量高于12号。值得注意的是，本研究中使用的试剂并不昂贵，也不需要特殊的处理条件。

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Design and Synthesis of Two Bicyclo[3.3.1]nonane-steroid Derivatives

Several studies for the synthesis of bicyclo[3.3.1]nonane analogues have been reported, however, there is little information on the preparation of bicyclo[3.3.1]nonane-steroid derivatives. In this way, the aim of this study was to synthesize two steroid-bicyclo[3.3.1]nonane analogues (11 or 12) from either estradiol or estrone using some reactions such as etherification, addition, nucleophilic substitution and cyclization. The chemical structure was evaluated through NMR spectroscopic analysis. The results showed higher yield for 11 compared with 12. It is noteworthy, that the reagents used in this investigation are not expensive and do not require special conditions for handling.

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来源期刊

Chemistry Journal of Moldova CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

12 weeks

期刊介绍： "Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry" seeks to publish experimental or theoretical research results of outstanding significance and timeliness in all fields of Chemistry, including Industrial and Ecological Chemistry. The main goal of this edition is strengthening the Chemical Society of Moldova, following development of research in Moldovan chemical institutions and promotion of their collaboration with international chemical community. Manuscripts are welcome from all countries.