{"title":"The Late Middle Ages: Athletes of Christ","authors":"","doi":"10.5040/9781788318112.ch-002","DOIUrl":"https://doi.org/10.5040/9781788318112.ch-002","url":null,"abstract":"","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"14 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76763028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent Studies of (+)-3-Carene Transformations with the Retention of the Native Framework","authors":"Curlat Serghei","doi":"10.19261/cjm.2019.616","DOIUrl":"https://doi.org/10.19261/cjm.2019.616","url":null,"abstract":"","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"34 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88268976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Livia Uncu, Elena Donici, V. Valica, Oxana Vîslouh, V. Gonciar, Sergiu Parii
{"title":"Development and Validation of an Assay Method for Ciprofloxacin Hydrochloride Determination in Combination Ear Drops","authors":"Livia Uncu, Elena Donici, V. Valica, Oxana Vîslouh, V. Gonciar, Sergiu Parii","doi":"10.19261/CJM.2019.607","DOIUrl":"https://doi.org/10.19261/CJM.2019.607","url":null,"abstract":"Development and validation of an assay method for ciprofloxacin hydrochloride determination in combination ear drops Uncu Livia, Donici Elena, Valica Vladimir, Vîslouh Oxana, Gonciar Veaceslav, Parii Sergiu ”Nicolae Testemițanu” State University of Medicine and Pharmacy Chemistry Journal of Moldova Nr. 2(14) / 2019 / ISSN 1857-1727 / ISSNe 2345-1688 Disponibil online 1 January, 2020. Descarcări-1. Vizualizări-23 ----------------------------------------------------------------------------------------------------------------------------------Development, physical-chemical characterization and in vitro antibacterial activity evaluation of a fixed-dose combination isohydrafural-methyluracil hydrophilic ointment Rus Lucia Maria1, Donici Elena2, Valica Vladimir2, Prisacari Viorel2, Tomuta Ioan1, Shepel Diana3, Heghes Simona Codruta1, Iuga Cristina Adela1, Uncu Livia2 1 Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, 2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy, 3 Institute of Chemistry","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"16 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84541668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Sîrcu, Gheorghii Țurcanu, N. Opopol, Iurie Pinzaru, Tatiana Manceva, Raisa Scurtu
{"title":"Pesticides Level Determination in Vegetables and Fruits Commonly Used in Republic of Moldova and Estimation of Human Intake","authors":"R. Sîrcu, Gheorghii Țurcanu, N. Opopol, Iurie Pinzaru, Tatiana Manceva, Raisa Scurtu","doi":"10.19261/cjm.2019.584","DOIUrl":"https://doi.org/10.19261/cjm.2019.584","url":null,"abstract":"The purpose of this research was to assess the residual concentrations of pesticides in fruits and vegetables and to estimate the health risk associated with the consumption of pesticide-contaminated vegetables and fruits. A total number of 5206 samples from twenty one different vegetables and fruits were collected during 2009-2017. Pesticides in concentrations exceeding the maximum residue levels were found in 1194 analysed samples (22.9% of total). Thirteen insecticides, four fungicides, two acaricides and one herbicide were detected in the analysed samples. The estimated daily intake (EDI) has been established between 0.000001 and 0.0002 mg/kg of body weight/day. Calculated values of EDIs are lower than the levels of acceptable daily intake. The calculated hazard indices ranged from 0.000004 up to 0.15 for the analysed pesticides and the highest value of hazard index was calculated for diazinon, being of 0.15. It might be concluded that the long-term consumption of vegetables and fruits could pose a health risk for the population of the Republic of Moldova, since the minimum norms used for risk estimation do not reflect real food consumption pattern in the Republic of Moldova.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"23 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85199182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Mohammedi, Samira Idjeri-Mecherara, F. Menaceur, A. Hassani
{"title":"The Effect of Solvents and Extraction Procedure on the Recovery of Phenolic Compounds and the Antioxidant Capacity of Algerian Bassia Muricata L. Extracts","authors":"H. Mohammedi, Samira Idjeri-Mecherara, F. Menaceur, A. Hassani","doi":"10.19261/cjm.2019.637","DOIUrl":"https://doi.org/10.19261/cjm.2019.637","url":null,"abstract":"This paper focuses on the study of the effect of extraction solvent choice on phenolic compounds contents and antioxidant activity of Bassia muricata. In this study, five different solvents namely: water, acetone, ethanol, methanol and hexane, and three extraction techniques were used to extract phenolic compounds: microwave-assisted extraction, Soxhlet and maceration. Total phenolics (TPC), total flavonoids (TFC) and condensed tannins contents (CTC) were determined. The results showed that different solvents with different polarity had a major effect on polyphenolic contents and antioxidant activity; the highest TPC (122.15-144.82 mg GAE/g), TFC (64.12-70.32 mg QE/g) and CTC (30.38-36.09 mg CE/g) were obtained with methanol. However, different extraction methods gave comparable results. In vitro antioxidant activities were evaluated using the DPPH radical scavenging ability, reducing capacity and β-carotene bleaching assay. The methanolic extract showed the highest scavenging abilities on DPPH radicals and lipid peroxidation, while the aqueous extract exhibited the strongest reducing power. Microwave-assisted extraction was the best suited for the extraction of antioxidant molecules when compared to Soxhlet and maceration.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"13 1","pages":"79-89"},"PeriodicalIF":0.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73036813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Jumina, Rizky Woro Styaningrum, D. Siswanta, Sugeng Triono, Yoga Priastomo, Harizal Harizal, E. N. Sholikhah, A. K. Zulkarnain
{"title":"Synthesis and Preliminary Evaluation of Several Chalcone Derivatives as Sunscreen Compounds","authors":"J. Jumina, Rizky Woro Styaningrum, D. Siswanta, Sugeng Triono, Yoga Priastomo, Harizal Harizal, E. N. Sholikhah, A. K. Zulkarnain","doi":"10.19261/cjm.2019.624","DOIUrl":"https://doi.org/10.19261/cjm.2019.624","url":null,"abstract":"Four chalcone derivatives containing chloro and methoxy substituents were synthesized and pre-evaluated as broad-spectrum UV protector with intrinsic antioxidant activity. UV absorbance of chalcones 1-4 showed a wide range of UV absorbance values in UVB and UVA regions (max= 310-360 nm) and molar absorptivity values (= 14,000-20,000 Mcm). Chalcones 3 and 4 showed better photostability than chalcones 1 and 2 because the lowering of their absorbance was smaller and slower under UVB irradiation. A combination of the spectra of chalcone derivatives 1-4 indicated that a formulation containing all four will provide a broad-spectrum sunscreen protecting the skin from UVA and UVB.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"6 1","pages":"90-96"},"PeriodicalIF":0.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74905830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and Antimicrobial Evaluation of Novel Pyrazole, Imidazole and Pyrimidine Derivatives Possessing Imidazo[4,5-b]indol Moiety","authors":"Nadia Ali Ahmed Elkanzi, A. Ghoneim, H. Hrichi","doi":"10.19261/cjm.2019.638","DOIUrl":"https://doi.org/10.19261/cjm.2019.638","url":null,"abstract":"In this study, new pyrazole, imidazole, pyrimidine derivatives having imidazo[4,5-b]indol moiety were successfully synthesized, elucidated by spectroscopic techniques, and evaluated as potential antimicrobial agents. The structure-activity relationship was investigated to obtain a better understanding of the relationship between the chemical structure of the synthesized compounds and their corresponding biological activity. Compounds 2b and 3b exhibited potent antibacterial activities against Bacillus subtilis bacteria comparable to that of Ampicillin standard. Structure-activity relationship studies revealed that the presence of withdrawing carbonyl group on 5-position of pyrazole moiety 2b, phenylpyrazole moiety 3b led to an enhancement in the antibacterial activity of pyrazole derivatives. Furthermore, the presence of carbonyl group on 2-position of the pyrimidine ring of compounds 4a, 5a and 6a has a significant effect on their antibacterial activity against Bacillus subtilis. The antifungal studies indicated that compounds 3b, 4b, 7 and 9 have comparable antifungal activity to that of standard Amphotericin B against Candida albicans and Aspergillus flavus fungi.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"17 1","pages":"105-116"},"PeriodicalIF":0.5,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81815664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryam Shokoohian, N. Hazeri, M. Maghsoodlou, M. Lashkari
{"title":"Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst","authors":"Maryam Shokoohian, N. Hazeri, M. Maghsoodlou, M. Lashkari","doi":"10.19261/cjm.2019.639","DOIUrl":"https://doi.org/10.19261/cjm.2019.639","url":null,"abstract":"","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"6 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74822757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Temperature on Green Synthesis of Silver Nanoparticles Using Vitex Agnus-castus Extract","authors":"O. Stavinskaya, I. Laguta, T. Fesenko, M. Krumova","doi":"10.19261/cjm.2019.636","DOIUrl":"https://doi.org/10.19261/cjm.2019.636","url":null,"abstract":"The Vitex agnus-castus leaves extract has been used for green synthesis of silver nanoparticles. The effect of the temperature on both silver ions reduction and silver nanoparticles formation was investigated. It was found that fast reduction of silver ions occurs even at 40C, while effective synthesis of silver nanoparticles requires elevated temperatures of 60-80C. It is concluded that the extract contains both strong reducing and effective stabilizing agents that provide rapid reduction of silver ions and hinder the fast particles growth, respectively.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":"11 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81588268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}