几种查尔酮类防晒化合物的合成及初步评价

IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Journal of Moldova Pub Date : 2019-12-01 DOI:10.19261/cjm.2019.624

J. Jumina, Rizky Woro Styaningrum, D. Siswanta, Sugeng Triono, Yoga Priastomo, Harizal Harizal, E. N. Sholikhah, A. K. Zulkarnain

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引用次数: 6

摘要

合成了四种含氯和甲氧基取代基的查尔酮衍生物，并对其作为具有内在抗氧化活性的广谱紫外线保护剂进行了预评价。查尔酮1-4在UVB和UVA区域的紫外吸光度值(最大波长310 ~ 360 nm)和摩尔吸光度值(最大波长14000 ~ 20000 Mcm)范围广。在UVB照射下，查尔酮3和查尔酮4的吸光度下降速度更慢、幅度更小，因此其光稳定性优于查尔酮1和查尔酮2。查尔酮衍生物1-4的光谱组合表明，含有所有四种成分的配方将提供广谱防晒霜，保护皮肤免受UVA和UVB的伤害。

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Synthesis and Preliminary Evaluation of Several Chalcone Derivatives as Sunscreen Compounds

Four chalcone derivatives containing chloro and methoxy substituents were synthesized and pre-evaluated as broad-spectrum UV protector with intrinsic antioxidant activity. UV absorbance of chalcones 1-4 showed a wide range of UV absorbance values in UVB and UVA regions (max= 310-360 nm) and molar absorptivity values (= 14,000-20,000 Mcm). Chalcones 3 and 4 showed better photostability than chalcones 1 and 2 because the lowering of their absorbance was smaller and slower under UVB irradiation. A combination of the spectra of chalcone derivatives 1-4 indicated that a formulation containing all four will provide a broad-spectrum sunscreen protecting the skin from UVA and UVB.

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来源期刊

Chemistry Journal of Moldova CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

12 weeks

期刊介绍： "Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry" seeks to publish experimental or theoretical research results of outstanding significance and timeliness in all fields of Chemistry, including Industrial and Ecological Chemistry. The main goal of this edition is strengthening the Chemical Society of Moldova, following development of research in Moldovan chemical institutions and promotion of their collaboration with international chemical community. Manuscripts are welcome from all countries.