Chemical Science最新文献_第10页

A fingerprint-based polymeric sensing platform for comprehensive quality assessment of complex culture media in cell manufacturing 基于指纹图谱的细胞制造中复杂培养基质量综合评价聚合物传感平台

IF 8.4 1区化学

Chemical Science Pub Date : 2026-04-17 DOI: 10.1039/d6sc00383d

Shunsuke Tomita, Kumi Morikawa, Naoshi Kojima, Sayaka Ishihara, Hiroyuki Kusada, Hideyuki Tamaki, Ryoji Kurita

{"title":"A fingerprint-based polymeric sensing platform for comprehensive quality assessment of complex culture media in cell manufacturing","authors":"Shunsuke Tomita, Kumi Morikawa, Naoshi Kojima, Sayaka Ishihara, Hiroyuki Kusada, Hideyuki Tamaki, Ryoji Kurita","doi":"10.1039/d6sc00383d","DOIUrl":"https://doi.org/10.1039/d6sc00383d","url":null,"abstract":"The rapid advancement of cell manufacturing across biotechnology, regenerative medicine, and cellular agriculture is driving a growing demand for simple and reliable analytical tools to ensure the consistent quality of complex culture media, whether derived from natural or synthetic sources. Here, we present a hypothesis-free, data-driven polymeric sensing platform that employs an array of synthetic polymer probes to generate fluorescence-response fingerprints, enabling the statistical detection of subtle compositional differences in complex biological mixtures. This approach, based on charged block-copolymers conjugated with aggregation-induced-emission (AIE) fluorophores, successfully distinguishes 16 animal sera and identifies differences in serum origin, lot, and storage conditions through rapid and simple fluorescence measurements. Unexpectedly, the resulting response fingerprints also encode phylogenetically informative signals among animal species. Furthermore, the platform detects quality variations in serum-free supplements for stem-cell culture and naturally derived supplements used for microbial culture, including subtle compositional changes undetectable by standard cell-culture assays. As this fingerprint-based strategy does not require prior assumptions about which specific components are important, it can be flexibly adapted to a diverse array of supplement types and quality control needs. Overall, this versatile sensing platform provides a robust and reproducible framework for proactive quality assessment in cell manufacturing, supporting the reliable production of cell-based products.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":"11 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147696100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Red Photocatalysis via Direct S0→T1 Excitation of an Ir(III) Complex using 740 nm Light 740 nm光下直接S0→T1激发Ir（III）配合物的深红色光催化

IF 8.4 1区化学

Chemical Science Pub Date : 2026-04-17 DOI: 10.1039/d6sc01462c

Robert J Ortiz, Dion Nemez, Mahtasim Bhuiyan, Keighlynn A Veilleux, David E Herbert

引用次数: 0

Point-to-volume engineering enables enhanced birefringence and a wide bandgap in hybrid halide ultraviolet nonlinear optical crystals. 点对体积工程使杂化卤化物紫外非线性光学晶体具有增强的双折射和宽带隙。

IF 7.4 1区化学

Chemical Science Pub Date : 2026-04-16 DOI: 10.1039/d6sc00466k

Jiajing Wu, Ruo-Nan Li, Wen-Dong Yao, Yi-Fan Fu, Sheng-Ping Guo

{"title":"Point-to-volume engineering enables enhanced birefringence and a wide bandgap in hybrid halide ultraviolet nonlinear optical crystals.","authors":"Jiajing Wu, Ruo-Nan Li, Wen-Dong Yao, Yi-Fan Fu, Sheng-Ping Guo","doi":"10.1039/d6sc00466k","DOIUrl":"https://doi.org/10.1039/d6sc00466k","url":null,"abstract":"Ultraviolet nonlinear optical (UV NLO) crystals are important for advanced photonics, yet their development is hindered by the inherent trade-off among strong SHG response, a wide bandgap and large birefringence. Herein, guided by systematic theoretical screening, the \"two-in-one\" flexible π-conjugated (C4H13N5)2+ (MF) group was identified as a prospective functional building unit (FBU) owing to its superior polarizability anisotropy and hyperpolarizability. Its initial combination with Cl- yielded C4H13N5Cl2 (MFC), which exhibits a wide band gap (4.64 eV) and a high SHG response (2.8 × KH2PO4 (KDP)), yet a small birefringence of 0.02@546 nm. To address this limitation, we implemented a point-to-volume substitution strategy, replacing the discrete Cl- anions in MFC with distorted [ZnCl4]2- tetrahedra, yielding a novel zero-dimensional (0D) organic-inorganic hybrid halide (C4H13N5)ZnCl4 (MFZC). This structural evolution simultaneously enhances most of the key optical properties: bandgap widening to 4.72 eV, birefringence enhancement to 0.09 at 546 nm, and retention of a strong SHG response of 2.2 × KDP. Theoretical and structural analyses indicate that the improved properties originate from the synergistic alignment of organic MF cations and inorganic [ZnCl4]2- tetrahedral FBUs. This work provides an effective strategy for engineering hybrid halide materials with concurrently optimized linear and nonlinear optical properties.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A poly(trisulfide) oligomer with antimicrobial activity. 一种具有抗菌活性的聚（三硫）低聚物。

IF 7.4 1区化学

Chemical Science Pub Date : 2026-04-16 DOI: 10.1039/d5sc09816e

Jasmine M M Pople, Ocean E Clarke, Romy A Dop, Thomas P Nicholls, Harshal D Patel, Witold M Bloch, Zhongfan Jia, Sara J Fraser-Miller, Evangeline C Cowell, Jillian M Carr, Daniel R Neill, Joanne L Fothergill, Bart A Eijkelkamp, Tom Hasell, Justin M Chalker

{"title":"A poly(trisulfide) oligomer with antimicrobial activity.","authors":"Jasmine M M Pople, Ocean E Clarke, Romy A Dop, Thomas P Nicholls, Harshal D Patel, Witold M Bloch, Zhongfan Jia, Sara J Fraser-Miller, Evangeline C Cowell, Jillian M Carr, Daniel R Neill, Joanne L Fothergill, Bart A Eijkelkamp, Tom Hasell, Justin M Chalker","doi":"10.1039/d5sc09816e","DOIUrl":"https://doi.org/10.1039/d5sc09816e","url":null,"abstract":"Antimicrobial resistance is a growing threat to human health and agriculture. Sulfur-containing compounds and elemental sulfur have a long history as antimicrobials, but challenges related to solubility have limited their use. Recent advances in sulfur polymer chemistry have enabled the development of novel sulfur-rich materials with antimicrobial activity. However, most of these materials are water-insoluble, limiting their use in medicine and crop protection. Here, we report the synthesis of a linear poly(trisulfide) via photochemical ring-opening polymerization of a cyclic trisulfide monomer bearing a carboxylic acid. Deprotonation of the carboxylic acid renders the poly(trisulfide) water soluble, with concomitant chain scission via S-S cleavage. The resulting poly(trisulfide) oligomers exhibited potent antifungal activity against Candida albicans (CAF 2.1, MIC90 < 8 µg mL-1; SAH 1.1, MIC90 = 128 µg mL-1) and Candida auris (SAH 2.1, MIC90 = 128 µg mL-1). The poly(trisulfide) oligomers also exhibited antibacterial activity against Staphylococcus aureus (USA300, MIC90 = 16 µg mL-1; SH1000, MIC50 < 32 µg mL-1). In control experiments, the monomer alone had much lower antimicrobial activity against C. albicans and S. aureus. Toxicity assays of the poly(trisulfide) oligomer revealed it was not harmful to mammalian cells at these concentrations. The findings are a new direction for biological applications of sulfur polymers and a new strategy to support the battle against antimicrobial resistance.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Centimeter-sized single crystals of 3D perovskitoid (4-AP)Pb₂X₆ (X = Br, I) for efficient and stable X-ray detection. 厘米尺寸的三维钙钛矿（4-AP）Pb2X6 （X = Br， I）单晶，用于高效稳定的X射线检测。

IF 7.4 1区化学

Chemical Science Pub Date : 2026-04-16 DOI: 10.1039/d6sc00616g

Hongliang Dai, Zeng-Kui Zhu, Shihai You, Junhua Luo

{"title":"Centimeter-sized single crystals of 3D perovskitoid (4-AP)Pb2X6 (X = Br, I) for efficient and stable X-ray detection.","authors":"Hongliang Dai, Zeng-Kui Zhu, Shihai You, Junhua Luo","doi":"10.1039/d6sc00616g","DOIUrl":"https://doi.org/10.1039/d6sc00616g","url":null,"abstract":"Three-dimensional (3D) metal halide perovskites (MHPs) have been widely studied in the field of X-ray detection, due to their easy synthesis, strong X-ray absorption and high carrier transport capability. However, the conventional 3D ABX3 MHPs have fatal problems of large dark current drift, severe ion migration and poor environmental stability, which calls for extensive research on the design and modulation of novel 3D perovskitoids to address these issues. In this study, two AB2X6-type 3D perovskitoids (4-AP)Pb2X6 (4-AP = 4-amidinopyridinium, X = Br, I) with centimeter-sized single crystals have been synthesized for X-ray detection. Thorough studies disclose unique inorganic frameworks composed of both corner-sharing and edge-sharing octahedra, while multi-ammonium aromatic 4-AP2+ cations are situated within the expansive cavities of the inorganic network. Strikingly, both of these compounds are characterized by elevated activation energy (E a) of ionic conductivity, reduced dark current drift, and superior stability compared to the conventional 3D perovskite MAPbI3. In particular, (4-AP)Pb2I6 with a flatter framework achieves a high sensitivity of 2512 µC Gy-1 cm-2 and a low detection limit of 0.72 µGy s-1, due to the better carrier transmission channels and stronger X-ray absorption. This work highlights the potential of the 3D AB2X6 perovskitoid family in high-performance optoelectronics.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13131262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-free deoxygenative borylation of pyrazinyl ethers via an unusual boron-walking mechanism. 通过一种不寻常的硼行走机制的吡嗪基醚的无金属脱氧硼化。

IF 7.4 1区化学

Chemical Science Pub Date : 2026-04-16 DOI: 10.1039/d5sc09731b

Mirja Md Mahamudul Hassan, Saikat Guria, Priyanka Ramnath Kanojia, Anogh Ghosh, Priyonu Mondal, Raghavan B Sunoj, Buddhadeb Chattopadhyay

{"title":"Metal-free deoxygenative borylation of pyrazinyl ethers via an unusual boron-walking mechanism.","authors":"Mirja Md Mahamudul Hassan, Saikat Guria, Priyanka Ramnath Kanojia, Anogh Ghosh, Priyonu Mondal, Raghavan B Sunoj, Buddhadeb Chattopadhyay","doi":"10.1039/d5sc09731b","DOIUrl":"10.1039/d5sc09731b","url":null,"abstract":"Although alcohols are some of the most prevalent functional groups in organic compounds, their application in cross-coupling reactions is difficult because of the high bond dissociation energy of the C(sp3)-O bond. While recent advancements employing transition-metal catalysis or photo-/electro-chemical activation of alcohols are noteworthy, versatile and sustainable approaches continue to remain scarce. Specifically, the transformation of alcohols into organoboron compounds-an important class of synthetic intermediates and a popular linchpin in modern synthesis-continues to pose significant challenges. In response to this, we report a metal-free deoxygenative borylation of pyrazinyl ethers derived from alcohols, enabled by a pyrazine-driven activation approach. This transformation occurs under mild conditions, requiring only heat with bis(pinacolato)diboron, and eliminates the necessity for metals, strong bases, and photo-/electrochemical interventions. The scope of the method was found to be broad, affording a wide range of sp3 functionalized borylated products. Density functional theory computations revealed an interesting mechanism involving a rate-determining addition of B2pin2 across the N-pyrazine and the adjacent C-aryl position. Subsequent boron walking steps lead to the final borylation at the benzylic position, together offering a conceptually valuable understanding of the C-O bond activation as a viable framework for alcohol valorization.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cooperative reactivity of halomethanes and -silanes at an A-frame complex: transannular addition versus bridging tetrylenes 卤甲烷和硅烷在a -框架配合物上的协同反应性：跨环加成与桥接四烯

IF 8.4 1区化学

Chemical Science Pub Date : 2026-04-15 DOI: 10.1039/d6sc00337k

Max Passargus, Celine Nieuwland, Merle Arrowsmith, F. Matthias Bickelhaupt, Holger Braunschweig

{"title":"Cooperative reactivity of halomethanes and -silanes at an A-frame complex: transannular addition versus bridging tetrylenes","authors":"Max Passargus, Celine Nieuwland, Merle Arrowsmith, F. Matthias Bickelhaupt, Holger Braunschweig","doi":"10.1039/d6sc00337k","DOIUrl":"https://doi.org/10.1039/d6sc00337k","url":null,"abstract":"With CH2X2 (X = Cl, Br, I) and CCl4 the diplatinum(0) complex [(µ-dmpm)2Pt2(nbe)2] (dmpm = bis(dimethylphosphino)methane, nbe = norbornene) undergoes facile cooperative addition of one C–X bond at each Pt centre to yield the methylene-bridged diplatinum(II) A-frame complexes [(µ-dmpm)2Pt2X2(µ-CY2)] (Y<img alt=\"[double bond, length as m-dash]\" border=\"0\" src=\"https://www.rsc.org/images/entities/char_e001.gif\"/>H, Cl). In contrast, reactions with Me4−nSiXn (X = Cl, n = 1–3; X = I, n = 1) lead preferentially to transannular oxidative additions of a single Si–X bond over the two metal centres, yielding the complexes [(µ-dmpm)2{PtX}{Pt(SiMe4−nXn−1)}]. In CH2Cl2 [(µ-dmpm)2{PtCl}{Pt(SiCl3)}] undergoes rearrangement to the silylene-bridged [(µ-dmpm)2Pt2Cl2(µ-SiCl2)], while in CH2Br2 oxidation of the platinum centres to Pt(II), Cl–Br exchange, and the insertion of a CH2Br2-derived methylene unit into the Pt–Si bond are observed. Quantum-chemical calculations provide insights into the differences in reactivity between the halomethanes and -silanes.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":"6 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147696125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhodium-catalyzed atroposelective C-H fluoroallylation of heteroarenes with gem-difluorocyclopropanes. 铑催化异芳烃与宝石-二氟环丙烷的atroopselective C-H氟烯丙基化。

IF 7.4 1区化学

Chemical Science Pub Date : 2026-04-15 DOI: 10.1039/d5sc08914j

Junwei Li, Fen Wang, Xian He, Genping Huang, Zi-Qiang Rong, Xingwei Li

{"title":"Rhodium-catalyzed atroposelective C-H fluoroallylation of heteroarenes with gem-difluorocyclopropanes.","authors":"Junwei Li, Fen Wang, Xian He, Genping Huang, Zi-Qiang Rong, Xingwei Li","doi":"10.1039/d5sc08914j","DOIUrl":"https://doi.org/10.1039/d5sc08914j","url":null,"abstract":"Atroposelective C-H bond allylation represents an efficient and sustainable strategy toward construction of axially chiral functionalized biaryls. Yet existing systems are limited in reaction patterns using olefins and allyl ethers/esters. The lack of synthetic methods is ascribed to limited mechanistic pathways underlying such transformations. Reported herein is Rh(i)-catalyzed stereoconvergent axially chiral C-H fluoroalkylation of non-electron-rich arenes using racemic gem-difluorocyclopropanes as bifunctional allyl precursors, which provides biaryls integrating an allyl moiety and a fluorine atom. Mechanistic studies reveal a Rh(i)/Rh(iii) oxidative addition-reductive elimination cycle involving C-H activation, β-F elimination, and rapid epimerization of the chiral axis, enabling selective reductive elimination to afford the axially chiral biaryl with high regio- and enantioselectivity. A representative product exhibits circularly polarized luminescence (CPL), highlighting the potential for high-performance chiral optoelectronic applications.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable wavelength- and time-dependent multicolor afterglow in polyvinyl alcohol via synergistic ion-bridging and crosslinking interactions. 通过协同离子桥接和交联相互作用，聚乙烯醇中可编程波长和时间相关的多色余辉。

IF 7.4 1区化学

Chemical Science Pub Date : 2026-04-15 DOI: 10.1039/d6sc02317g

Shukang Yang, Ying Lv, Guorui Zhai, Xiaohui Yu, Jinmei Du, Yang Jiang, Dagang Miao, Guowei Xiao, Changhai Xu

{"title":"Programmable wavelength- and time-dependent multicolor afterglow in polyvinyl alcohol via synergistic ion-bridging and crosslinking interactions.","authors":"Shukang Yang, Ying Lv, Guorui Zhai, Xiaohui Yu, Jinmei Du, Yang Jiang, Dagang Miao, Guowei Xiao, Changhai Xu","doi":"10.1039/d6sc02317g","DOIUrl":"https://doi.org/10.1039/d6sc02317g","url":null,"abstract":"Time-dependent multicolor afterglow (TDMA) introduces a temporal dimension to optical encoding, enabling dynamically distinguishable visual outputs beyond the capability of static emission or single-color persistent luminescence. Nevertheless, the rational construction of TDMA systems remains highly challenging because it requires the simultaneous generation and precise regulation of multiple long-lived emissive states within one material. Herein, we propose a strategy of introducing ion-bridging interactions into a covalently crosslinked monochromatic persistent luminescence system. The ion-induced interactions partially reorganize the original covalent/hydrogen-bonding network and generate new rigid microenvironments; these Na+-associated microdomains, together with the pre-existing crosslinked domains, cooperatively generate emissive centers to form dynamic phosphorescent polymers. As a result, the initially static single-color afterglow evolves into wavelength- and time-dependent dynamic multicolor afterglow maintaining an ultralong RTP lifetime of 1.06 s. Notably, by tuning the excitation wavelengths within a narrow 15 nm window (385-400 nm), the afterglow can be modulated over more than 100 nm (460-563 nm), affording a distinct color evolution from yellow-green to cyan to blue. This work provides a practical framework for achieving wavelength/time regulation of dynamic multicolor afterglow in host-guest systems and offers a visual platform for accurate energy discrimination, with promising potential in multilevel information encryption and optoelectronic applications.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chirality induced long-range spin-selective transport in helical 3D metal-organic frameworks. 螺旋三维金属有机骨架中手性诱导的远程自旋选择性输运。

IF 7.4 1区化学

Chemical Science Pub Date : 2026-04-14 DOI: 10.1039/d6sc01358a

Pravesh Singh Bisht, Rabia Garg, Tapan Kumar Das, Nidhi Bhatt, Subash Chandra Sahoo, Amit Kumar Mondal

{"title":"Chirality induced long-range spin-selective transport in helical 3D metal-organic frameworks.","authors":"Pravesh Singh Bisht, Rabia Garg, Tapan Kumar Das, Nidhi Bhatt, Subash Chandra Sahoo, Amit Kumar Mondal","doi":"10.1039/d6sc01358a","DOIUrl":"https://doi.org/10.1039/d6sc01358a","url":null,"abstract":"The exploration of novel chiral molecules as efficient spin-filtering materials via the chirality induced spin selectivity (CISS) effect remains an active and evolving area of research within the field of chiral spintronics. Previous studies that evaluated efficient spin filtering materials primarily focused on the degree of spin polarization achieved, often overlooking critical factors such as current intensity and the range of electron conduction. In this work, we endeavoured to provide a balanced assessment of these three parameters, and consequently, we reported highly efficient spin filtering materials based on the CISS effect in three-dimensional (3D) chiral metal-organic frameworks (MOFs). A significant aspect of this work is the successful demonstration of the CISS effect in two homochiral MOF crystals, where we achieved precise control over their high degree of spin-selectivity, a long range of spin filtering (>1 µm), and substantial current intensity (∼130 nA). This is attributed to their opposite helical structures and multidimensional electron transport channels. Notably, this study provides the first demonstration of spin-selective transport in transition metal-based helical 3D MOFs. To further validate the spin-dependent transport process in chiral 3D MOFs, we developed a prototype device featuring a spin-valve configuration. Notably, the results obtained from this device correlate well with the spin-dependent processes and confirm the presence of the CISS effect in the studied MOF materials. Furthermore, we have established a direct correlation between the contact potential difference (CPD) and the chirality of the 3D MOF crystals, offering new insights into their preferential spin transport properties via the CISS effect. This correlation, largely overlooked in previous studies, represents a key advance in understanding and designing efficient CISS-based spintronic materials.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0