大环形成介导的活性氧生成的增强

IF 7.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Ao Liu, Youtao Xin, Yong-Kang Zhu, Yuan-Hang Jin, Yue Yang, Hongzhu Chen, Meng-Hao Li, Xin-Yue Lou, Xin Wang, Hui Gao, Ying-Wei Yang
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引用次数: 0

摘要

虽然亚甲基桥接荧光大环的合成引起了很大的研究兴趣,但它们产生活性氧(ROS)的能力仍相对未被探索。本文提出了一种通过骨架功能化构建多功能大环的策略,并成功合成了一类新的[2]- terphenyl-extended - pillar[6]芳烃。在加入苯并噻二唑后,获得了具有聚集诱导发射增强特性的高荧光大环,即[2]terphenyl-苯并噻二唑-扩展柱[6]芳烃。随后对调节侧链修饰的研究揭示了不同的单线态氧(1O2)生成能力。值得注意的是,与环氧基修饰的大环和无环构建块相比,季铵功能化的大环在光照射下表现出更低的量子产率,但更优越的1O2生成效率,同时保留了靶向荧光成像能力。值得注意的是,光动力作用和头孢替昔肟钠药物络合之间的超分子协同作用比单独的方式大大提高了抗菌效果。本研究强调了季铵功能化荧光大环在1O2生成中的潜力,为开发生物医学应用的抗菌药物提供了有希望的新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Macrocycle Formation-Mediated Augmentation in Reactive Oxygen Species Production
While the synthesis of methylene-bridged fluorescent macrocycles has attracted significant research interest, their ability to generate reactive oxygen species (ROS) remains relatively unexplored. Herein, we present a strategy for constructing multifunctional macrocycles through backbone functionalization and successfully synthesize a new class of [2]terphenyl-extended pillar[6]arenes. Upon incorporating benzothiadiazole, highly fluorescent macrocycles with aggregation-induced emission enhancement characteristics, i.e., [2]terphenyl-benzothiadiazole-extended pillar[6]arenes, were obtained. Subsequent studies on modulating side-chain modifications have revealed distinct singlet oxygen (1O2) generation capabilities. Notably, quaternary ammonium-functionalized macrocycles show lower quantum yields yet superior 1O2 generation efficiency under light irradiation compared to their ethoxy-modified counterparts and the acyclic building block, while retaining targeted fluorescence imaging capabilities. Significantly, the supramolecular synergy between photodynamic action and ceftizoxime sodium drug complexation drastically enhances antibacterial efficacy compared to individual modalities. This study highlights the potential of quaternary ammonium-functionalized fluorescent macrocycles in 1O2 generation and offers promising new avenues for developing antibacterial drugs for biomedical applications.
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来源期刊
Chemical Science
Chemical Science CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
14.40
自引率
4.80%
发文量
1352
审稿时长
2.1 months
期刊介绍: Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.
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