Chinese Journal of Cancer Research最新文献

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Corrigendum to Efficacy and safety of low-dose cyclophosphamide combined with lenvatinib, pembrolizumab and TACE for unresectable hepatocellular carcinoma: A single-center, prospective, single-arm clinical trial. 低剂量环磷酰胺联合lenvatinib、pembrolizumab和TACE治疗不可切除肝细胞癌的疗效和安全性:一项单中心、前瞻性、单臂临床试验
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-04-30 DOI: 10.21147/j.issn.1000-9604.2025.02.14
{"title":"Corrigendum to Efficacy and safety of low-dose cyclophosphamide combined with lenvatinib, pembrolizumab and TACE for unresectable hepatocellular carcinoma: A single-center, prospective, single-arm clinical trial.","authors":"","doi":"10.21147/j.issn.1000-9604.2025.02.14","DOIUrl":"https://doi.org/10.21147/j.issn.1000-9604.2025.02.14","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21147/j.issn.1000-9604.2024.02.02.].</p>","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 2","pages":"296"},"PeriodicalIF":7.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing management of sentinel lymph node limited residual tumor after neoadjuvant therapy for breast cancer: Balancing of act. 乳腺癌新辅助治疗后前哨淋巴结有限残余肿瘤的优化处理:平衡行为。
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-04-30 DOI: 10.21147/j.issn.1000-9604.2025.02.13
Jing Sun, Zhiqiang Shi, Zhao Bi, Pengfei Qiu
{"title":"Optimizing management of sentinel lymph node limited residual tumor after neoadjuvant therapy for breast cancer: Balancing of act.","authors":"Jing Sun, Zhiqiang Shi, Zhao Bi, Pengfei Qiu","doi":"10.21147/j.issn.1000-9604.2025.02.13","DOIUrl":"https://doi.org/10.21147/j.issn.1000-9604.2025.02.13","url":null,"abstract":"","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 2","pages":"293-295"},"PeriodicalIF":7.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Context-dependent roles of 5-HT and its receptors in tumor growth and wound healing: Mechanisms and therapeutic implications. 5-羟色胺及其受体在肿瘤生长和伤口愈合中的环境依赖性作用:机制和治疗意义。
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-04-30 DOI: 10.21147/j.issn.1000-9604.2025.02.11
Qingya Zeng, Jiaojiao Zhu, Zongyun He, Hong Qin, Wenhu Zhou, Fangqi Hua, Jin Yang
{"title":"Context-dependent roles of 5-HT and its receptors in tumor growth and wound healing: Mechanisms and therapeutic implications.","authors":"Qingya Zeng, Jiaojiao Zhu, Zongyun He, Hong Qin, Wenhu Zhou, Fangqi Hua, Jin Yang","doi":"10.21147/j.issn.1000-9604.2025.02.11","DOIUrl":"https://doi.org/10.21147/j.issn.1000-9604.2025.02.11","url":null,"abstract":"<p><p>Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter known for its roles in the central nervous system, showing dual effects in various pathological conditions, including tumor progression and wound healing. This review explores the complex and context-dependent actions of 5-HT, highlighting its contrasting roles in promoting tumor growth and facilitating wound repair. 5-HT can enhance tumor growth, survival, and metastasis via its receptors, but it also accelerates wound healing by stimulating cell proliferation, migration, and angiogenesis. This duality emphasizes the intricate balance of 5-HT and its receptors in the body. We discuss the synthesis, storage, secretion, and metabolism of 5-HT, as well as the classification and mechanisms of its receptors (5-HTRs) in different cell types under pathological conditions. We further examine the potential roles of 5-HT in both tumor progress and wound healing, proposing targeted strategies for each disease state. For tumors, \"blocking therapy\" involving receptor antagonists or gene silencing may inhibit tumor progression, while \"activation therapy\" can stimulate wound healing by enhancing receptor activation on skin cells. Challenges in clinical application, including issues related to targeting, specificity, and dosage, are addressed, alongside the promise of nanotechnology for improving targeted drug delivery. The review also explores emerging research on 5-HT's interaction with the immune system, offering insights into potential immunotherapeutic strategies for both cancer and wound healing. By balancing 5-HT's diverse effects, personalized treatments can be developed to optimize therapeutic outcomes in both contexts.</p>","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 2","pages":"268-288"},"PeriodicalIF":7.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming of fatty acid metabolism in thyroid cancer: Potential targets and mechanisms. 甲状腺癌中脂肪酸代谢的重编程:潜在的靶点和机制。
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-04-30 DOI: 10.21147/j.issn.1000-9604.2025.02.09
Pengbin Ping, Yuhong Ma, Xiaoying Xu, Juan Li
{"title":"Reprogramming of fatty acid metabolism in thyroid cancer: Potential targets and mechanisms.","authors":"Pengbin Ping, Yuhong Ma, Xiaoying Xu, Juan Li","doi":"10.21147/j.issn.1000-9604.2025.02.09","DOIUrl":"https://doi.org/10.21147/j.issn.1000-9604.2025.02.09","url":null,"abstract":"<p><p>Thyroid cancer (TC) is one of the most common endocrine system tumors, and its incidence continues to increase worldwide. Although most TC patients have a good prognosis, especially with continuous advancements in surgery, radioactive iodine therapy, chemotherapy, endocrine therapy and targeted therapy, the effectiveness of disease treatment has significantly improved. However, there are still some cases with a higher risk of death and greater aggressiveness. In these more challenging advanced or highly aggressive cases, tyrosine kinase inhibitors appear to be an effective treatment option. Unfortunately, these drugs are less than ideal in terms of efficacy because of their toxicity and potential for intrinsic or acquired resistance. Therefore, exploring new strategies targeting the metabolic characteristics of TC cells and overcoming drug resistance barriers in existing treatments have become key topics in the current field of TC research. In recent years, lipid metabolic reprogramming has gained attention as an important aspect of cancer development. Lipid metabolic reprogramming not only participates in the formation of the cell membrane structure, but also plays an important role in signal transduction and promoting cell proliferation. In particular, fatty acid (FA) metabolic reprogramming has attracted widespread attention and plays an important role in multiple aspects such as tumor growth, metastasis, enhanced invasive ability, immune escape, and drug resistance. Although TC is considered a disease that is highly dependent on specific types of metabolic activities, a comprehensive understanding of the specific mechanism of action of FA metabolic reprogramming in this process is lacking. This article aims to review how FA metabolic reprogramming participates in the occurrence and development of TC, focusing on the impact of abnormal FA metabolic pathways and changes in the expression and regulation of related genes over the course of this disease. By examining the complex interactions between FA metabolic disorders and carcinogenic signaling pathways in depth, we aim to identify new therapeutic targets and develop more precise and effective treatments for TC.</p>","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 2","pages":"227-249"},"PeriodicalIF":7.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep learning-based multi-task prediction of response to neoadjuvant chemotherapy using multiscale whole slide images in breast cancer: A multicenter study. 基于深度学习的多任务预测对乳腺癌新辅助化疗反应的多尺度全幻灯片图像:一项多中心研究
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-01-30 DOI: 10.21147/j.issn.1000-9604.2025.01.03
Qin Wang, Feng Zhao, Haicheng Zhang, Tongpeng Chu, Qi Wang, Xipeng Pan, Yuqian Chen, Heng Zhou, Tiantian Zheng, Ziyin Li, Fan Lin, Haizhu Xie, Heng Ma, Lan Liu, Lina Zhang, Qin Li, Weiwei Wang, Yi Dai, Ruijun Tang, Jigang Wang, Ping Yang, Ning Mao
{"title":"Deep learning-based multi-task prediction of response to neoadjuvant chemotherapy using multiscale whole slide images in breast cancer: A multicenter study.","authors":"Qin Wang, Feng Zhao, Haicheng Zhang, Tongpeng Chu, Qi Wang, Xipeng Pan, Yuqian Chen, Heng Zhou, Tiantian Zheng, Ziyin Li, Fan Lin, Haizhu Xie, Heng Ma, Lan Liu, Lina Zhang, Qin Li, Weiwei Wang, Yi Dai, Ruijun Tang, Jigang Wang, Ping Yang, Ning Mao","doi":"10.21147/j.issn.1000-9604.2025.01.03","DOIUrl":"10.21147/j.issn.1000-9604.2025.01.03","url":null,"abstract":"<p><strong>Objective: </strong>Early predicting response before neoadjuvant chemotherapy (NAC) is crucial for personalized treatment plans for locally advanced breast cancer patients. We aim to develop a multi-task model using multiscale whole slide images (WSIs) features to predict the response to breast cancer NAC more finely.</p><p><strong>Methods: </strong>This work collected 1,670 whole slide images for training and validation sets, internal testing sets, external testing sets, and prospective testing sets of the weakly-supervised deep learning-based multi-task model (DLMM) in predicting treatment response and pCR to NAC. Our approach models two-by-two feature interactions across scales by employing concatenate fusion of single-scale feature representations, and controls the expressiveness of each representation via a gating-based attention mechanism.</p><p><strong>Results: </strong>In the retrospective analysis, DLMM exhibited excellent predictive performance for the prediction of treatment response, with area under the receiver operating characteristic curves (AUCs) of 0.869 [95% confidence interval (95% CI): 0.806-0.933] in the internal testing set and 0.841 (95% CI: 0.814-0.867) in the external testing sets. For the pCR prediction task, DLMM reached AUCs of 0.865 (95% CI: 0.763-0.964) in the internal testing and 0.821 (95% CI: 0.763-0.878) in the pooled external testing set. In the prospective testing study, DLMM also demonstrated favorable predictive performance, with AUCs of 0.829 (95% CI: 0.754-0.903) and 0.821 (95% CI: 0.692-0.949) in treatment response and pCR prediction, respectively. DLMM significantly outperformed the baseline models in all testing sets (P<0.05). Heatmaps were employed to interpret the decision-making basis of the model. Furthermore, it was discovered that high DLMM scores were associated with immune-related pathways and cells in the microenvironment during biological basis exploration.</p><p><strong>Conclusions: </strong>The DLMM represents a valuable tool that aids clinicians in selecting personalized treatment strategies for breast cancer patients.</p>","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 1","pages":"28-47"},"PeriodicalIF":7.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer. 单细胞和大量转录组的综合分析揭示了人类前列腺癌临床相关的分子亚型。
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-01-30 DOI: 10.21147/j.issn.1000-9604.2025.01.07
Tao Ding, Lina He, Guowen Lin, Lei Xu, Yanjun Zhu, Xinan Wang, Xuefei Liu, Jianming Guo, Fanghong Lei, Zhixiang Zuo, Jianghua Zheng
{"title":"Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer.","authors":"Tao Ding, Lina He, Guowen Lin, Lei Xu, Yanjun Zhu, Xinan Wang, Xuefei Liu, Jianming Guo, Fanghong Lei, Zhixiang Zuo, Jianghua Zheng","doi":"10.21147/j.issn.1000-9604.2025.01.07","DOIUrl":"10.21147/j.issn.1000-9604.2025.01.07","url":null,"abstract":"<p><strong>Objective: </strong>Prostate cancer (PCa) is a complex disease characterized by diverse cellular ecosystems within the tumor microenvironment (TME) and high tumor heterogeneity, which challenges clinically stratified management and reinforces the need for novel strategies to fight against castration-resistant PCa (CRPC).</p><p><strong>Methods: </strong>We performed single-cell RNA sequencing (scRNA-seq) on 10 untreated primary PCa tissues and integrated public scRNA-seq resources from three normal prostate tissues, two untreated primary PCa tissues, and six CRPC tumors to portray a comprehensive cellular and molecular interaction atlas of PCa. We further integrated the single-cell and bulk transcriptomes of PCa to establish a molecular classification system.</p><p><strong>Results: </strong>scRNA-seq profiles revealed substantial inter- and intra-tumoral heterogeneity across different cell subpopulations in untreated PCa and CRPC tumors. In the malignant epithelial reservoir, cells evolved along decoupled paths in treatment-naive PCa and CRPC tumors, and distinct transcriptional reprogramming processes were activated, highlighting anti-androgen therapy-induced lineage plasticity. Based on the specifically expressed markers of the epithelial subpopulations, we conducted unsupervised clustering analysis in The Cancer Genome Atlas prostate adenocarcinoma (TCGA-PRAD) cohort and identified three molecularly and clinically distinct subtypes. The C1 subtype, characterized by high enrichment of CRPC-enriched epithelial cells, had a high risk of rapid development of anti-androgen resistance and might require active surveillance and additional promising intervention treatments, such as integrin A3 (<i>ITGA3</i>) + integrin B1 (<i>ITGB1</i>) inhibition. The C2 subtype resembled the immune-modulated subtype that was most likely to benefit from anti-LAG3 immunotherapy. The C3 subtype had a favorable prognosis.</p><p><strong>Conclusions: </strong>Our study provides a comprehensive and high-resolution landscape of the intricate architecture of the PCa TME, and our trichotomic molecular taxonomy could help facilitate precision oncology.</p>","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 1","pages":"90-114"},"PeriodicalIF":7.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci. 通过从全基因组关联研究中确定的位点得出的多基因风险评分来改善神经母细胞瘤风险预测。
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-01-30 DOI: 10.21147/j.issn.1000-9604.2025.01.01
Wenli Zhang, Jinhong Zhu, Mengzhen Zhang, Jiaming Chang, Jiabin Liu, Liping Chen, Xinxin Zhang, Haiyan Wu, Chunlei Zhou, Jing He
{"title":"Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci.","authors":"Wenli Zhang, Jinhong Zhu, Mengzhen Zhang, Jiaming Chang, Jiabin Liu, Liping Chen, Xinxin Zhang, Haiyan Wu, Chunlei Zhou, Jing He","doi":"10.21147/j.issn.1000-9604.2025.01.01","DOIUrl":"10.21147/j.issn.1000-9604.2025.01.01","url":null,"abstract":"<p><strong>Objective: </strong>Neuroblastoma is the most common extracranial solid tumor in children and has complex genetic underpinnings. Previous genome-wide association studies (GWASs) have identified many loci associated with neuroblastoma susceptibility; however, their application in risk prediction for Chinese children has not been systematically explored. This study seeks to enhance neuroblastoma risk prediction by validating these loci and evaluating their performance in polygenic risk models.</p><p><strong>Methods: </strong>We validated 35 GWAS-identified neuroblastoma susceptibility loci in a cohort of Chinese children, consisting of 402 neuroblastoma patients and 473 healthy controls. Genotyping these polymorphisms was conducted via the TaqMan method. Univariable and multivariable logistic regression analyses revealed the genetic loci significantly associated with neuroblastoma risk. We constructed polygenic risk models by combining these loci and assessed their predictive performance via area under the curve (AUC) analysis. We also established a polygenic risk scoring (PRS) model for risk prediction by adopting the PLINK method.</p><p><strong>Results: </strong>Fourteen loci, including ten protective polymorphisms from <i>CASC15</i>, <i>BARD1</i>, <i>LMO1</i>, <i>HSD17B12</i>, and <i>HACE1</i>, and four risk variants from <i>BARD1</i>, <i>RSRC1</i>, <i>CPZ</i> and <i>MMP20</i> were significantly associated with neuroblastoma risk. Compared with single-gene model, the 8-gene model (AUC=0.72) and 13-gene model (AUC=0.73) demonstrated superior predictive performance. Additionally, a PRS incorporating six significant loci achieved an AUC of 0.66, effectively stratifying individuals into distinct risk categories regarding neuroblastoma susceptibility. A higher PRS was significantly associated with advanced International Neuroblastoma Staging System (INSS) stages, suggesting its potential for clinical risk stratification.</p><p><strong>Conclusions: </strong>Our findings validate multiple loci as neuroblastoma risk factors in Chinese children and demonstrate the utility of polygenic risk models, particularly the PRS, in improving risk prediction. These results suggest that integrating multiple genetic variants into a PRS can enhance neuroblastoma risk stratification and potentially improve early diagnosis by guiding targeted screening programs for high-risk children.</p>","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 1","pages":"1-11"},"PeriodicalIF":7.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer after curative surgery: Final results of a phase II trial. 局部晚期胃癌术后预防性腹腔热化疗:一项II期试验的最终结果
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-01-30 DOI: 10.21147/j.issn.1000-9604.2025.01.05
Biao Fan, Hao Su, Lingqian Wang, Xin Ji, Yinan Zhang, Ziyu Jia, Ji Zhang, Zhaode Bu, Xiaojiang Wu
{"title":"Prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer after curative surgery: Final results of a phase II trial.","authors":"Biao Fan, Hao Su, Lingqian Wang, Xin Ji, Yinan Zhang, Ziyu Jia, Ji Zhang, Zhaode Bu, Xiaojiang Wu","doi":"10.21147/j.issn.1000-9604.2025.01.05","DOIUrl":"10.21147/j.issn.1000-9604.2025.01.05","url":null,"abstract":"<p><strong>Objective: </strong>The trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin for patients with locally advanced gastric cancer (LAGC).</p><p><strong>Methods: </strong>Between March 2015 and November 2016, a phase II clinical trial was performed. Fifty consecutive patients with LAGC were randomly assigned to two groups: the experimental group (radical gastrectomy + HIPEC with cisplatin + adjuvant chemotherapy) and the control group (radical gastrectomy + adjuvant chemotherapy). Survival rates were closely monitored.</p><p><strong>Results: </strong>The 5-year overall survival (OS) rate of all patients was 80.0%. The 5-year OS rate in the experimental group was lower than that in the control group, at 75.8% and 88.2%, respectively, with no statistical significance. In addition, 5-year recurrence-free survival (RFS) rates of patients who underwent HIPEC or not were also 75.8% and 88.2%, respectively. In the multivariate analysis, only pT stage [risk ratio (RR)=7.079, P=0.018] was significantly associated with prognosis. The most common recurrence pattern was peritoneal recurrence in both groups. The experimental group had a lower incidence of peritoneal recurrence than the control group with no statistical significance.</p><p><strong>Conclusions: </strong>This trial clearly revealed that prophylactic HIPEC with cisplatin neither decrease the risk of peritoneal recurrence nor improve the prognosis of patients with LAGC. Thus, HIPEC with cisplatin is not recommended as a prophylactic treatment for peritoneal recurrence of LAGC after radical gastrectomy.</p>","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 1","pages":"66-72"},"PeriodicalIF":7.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composite score of PD-1 + CD8 + tumor-infiltrating lymphocytes and CD57 + CD8 + tumor ascites lymphocytes is associated with prognosis and tumor immune microenvironment of patients with advanced high-grade serous ovarian cancer. PD-1 + CD8 +肿瘤浸润淋巴细胞和CD57 + CD8 +肿瘤腹水淋巴细胞的综合评分与晚期高级别浆液性卵巢癌患者的预后和肿瘤免疫微环境相关。
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-01-30 DOI: 10.21147/j.issn.1000-9604.2025.01.06
Tianhui He, Jie Zhang, Lin Zeng, Zhongnan Yin, Bo Yu, Xi Zhang, Xiaoxue Yang, Chunliang Shang, Lixiang Xue, Hongyan Guo
{"title":"Composite score of PD-1 <sup><b>+</b></sup> CD8 <sup><b>+</b></sup> tumor-infiltrating lymphocytes and CD57 <sup><b>+</b></sup> CD8 <sup><b>+</b></sup> tumor ascites lymphocytes is associated with prognosis and tumor immune microenvironment of patients with advanced high-grade serous ovarian cancer.","authors":"Tianhui He, Jie Zhang, Lin Zeng, Zhongnan Yin, Bo Yu, Xi Zhang, Xiaoxue Yang, Chunliang Shang, Lixiang Xue, Hongyan Guo","doi":"10.21147/j.issn.1000-9604.2025.01.06","DOIUrl":"10.21147/j.issn.1000-9604.2025.01.06","url":null,"abstract":"<p><strong>Objective: </strong>The expression of programmed death 1 (PD-1) on CD8<sup>+</sup> T cells is associated with their activation and exhaustion, while CD57 serves as a senescence marker. The impact of PD-1<sup>+</sup> and CD57<sup>+</sup>CD8<sup>+</sup> T cells on the prognosis of patients with advanced high-grade serous ovarian cancer (HGSOC) remain unclear.</p><p><strong>Methods: </strong>We assessed the percentages of PD-1<sup>+</sup> and CD57<sup>+</sup>CD8<sup>+</sup> T cells in tumor-infiltrating lymphocytes (TILs, n=85) and tumor ascites lymphocytes (TALs, n=87) using flow cytometry. The optimal cutoffs for these markers in TILs and TALs were determined through the log-rank maximization method. Gene expression analysis elucidated the tumor immune microenvironment (TIME, n=36).</p><p><strong>Results: </strong>Patients with higher PD-1<sup>+</sup>CD8<sup>+</sup> TILs (>87.8%) exhibited longer platinum-free interval (PFI) and overall survival (OS). In contrast, those with elevated CD57<sup>+</sup>CD8<sup>+</sup> TALs (>28.69%) were more likely to experience chemotherapy and had lower complete remission rates, shorter PFI and OS. PD-1<sup>+</sup>CD8<sup>+</sup> TILs are primarily displayed an effector memory state with strong proliferative and secretory capabilities. Approximately 50% of CD57<sup>+</sup>CD8<sup>+</sup> TALs were terminally differentiated, exhibiting significantly impaired proliferation. Based on the proportions of PD-1<sup>+</sup>CD8<sup>+</sup> TILs and CD57<sup>+</sup>CD8<sup>+</sup> TALs, patients were categorized into good, median and poor prognosis groups, with median PFI of 47.78, 27.29 and 11.96 months, respectively (P<0.0001). Median OS for these groups was not reach, 49.23 and 30.92 months, respectively (P<0.0001). Patients with poor prognosis exhibit significantly reduced CD8<sup>+</sup> T cell proportion and increased M2 macrophage in the TIME, alongside downregulation of multiple T cell activation-related pathways.</p><p><strong>Conclusions: </strong>Lower levels of PD-1<sup>+</sup>CD8<sup>+</sup> TILs and higher CD57<sup>+</sup>CD8<sup>+</sup> TALs, assessed prior to treatment, correlated with poor prognosis and suppressive TIME in advanced HGSOC.</p>","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 1","pages":"73-89"},"PeriodicalIF":7.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to National validation of laparoscopic approach for locally advanced gastric cancer: Comparison of a randomized controlled trial and real-world practice results. 更正:国家验证腹腔镜入路治疗局部晚期胃癌的勘误表:随机对照试验和现实世界实践结果的比较。
IF 7 2区 医学
Chinese Journal of Cancer Research Pub Date : 2025-01-30 DOI: 10.21147/j.issn.1000-9604.2025.01.09
{"title":"Corrigendum to National validation of laparoscopic approach for locally advanced gastric cancer: Comparison of a randomized controlled trial and real-world practice results.","authors":"","doi":"10.21147/j.issn.1000-9604.2025.01.09","DOIUrl":"10.21147/j.issn.1000-9604.2025.01.09","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21147/j.issn.1000-9604.2024.06.11.].</p>","PeriodicalId":9882,"journal":{"name":"Chinese Journal of Cancer Research","volume":"37 1","pages":"118"},"PeriodicalIF":7.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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